GB885570A - Pyridazone compounds - Google Patents
Pyridazone compoundsInfo
- Publication number
- GB885570A GB885570A GB2507/60A GB250760A GB885570A GB 885570 A GB885570 A GB 885570A GB 2507/60 A GB2507/60 A GB 2507/60A GB 250760 A GB250760 A GB 250760A GB 885570 A GB885570 A GB 885570A
- Authority
- GB
- United Kingdom
- Prior art keywords
- phenyl
- pyridazone
- salts
- methoxy
- piperazino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 abstract 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- FFEUJVKTVREMIG-UHFFFAOYSA-N C(C1=CC=CC=C1)S(=O)(=O)O.C1=CC=CC=C1 Chemical class C(C1=CC=CC=C1)S(=O)(=O)O.C1=CC=CC=C1 FFEUJVKTVREMIG-UHFFFAOYSA-N 0.000 abstract 1
- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Chemical class CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 abstract 1
- 150000001242 acetic acid derivatives Chemical class 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000001754 anti-pyretic effect Effects 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 239000006172 buffering agent Substances 0.000 abstract 1
- 230000003139 buffering effect Effects 0.000 abstract 1
- 239000008298 dragée Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- 150000003840 hydrochlorides Chemical class 0.000 abstract 1
- 150000004701 malic acid derivatives Chemical class 0.000 abstract 1
- 150000002690 malonic acid derivatives Chemical class 0.000 abstract 1
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 abstract 1
- 150000002823 nitrates Chemical class 0.000 abstract 1
- 239000002674 ointment Substances 0.000 abstract 1
- 150000003891 oxalate salts Chemical class 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 235000021317 phosphate Nutrition 0.000 abstract 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 abstract 1
- 239000003755 preservative agent Substances 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 239000003381 stabilizer Substances 0.000 abstract 1
- 150000003890 succinate salts Chemical class 0.000 abstract 1
- 150000003456 sulfonamides Chemical class 0.000 abstract 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
- 150000003892 tartrate salts Chemical class 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 150000003567 thiocyanates Chemical class 0.000 abstract 1
- 238000011200 topical administration Methods 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
- 238000009736 wetting Methods 0.000 abstract 1
- 239000000080 wetting agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/22—Nitrogen and oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises compounds of the formula <FORM:0885570/IV (b)/1> (in which R11 represents an aliphatically etherified hydroxyl group, and in which the phenyl groups may be substituted by lower alkoxy, alkyl, or nitro groups or halogen atoms) and their salts. Examples detail the preparation of 1-phenyl-3-methoxy - 5 - N - (b - phenylethyl) - piperazino - pyridazone (6), its 3-ethoxy analogue and their hydrochlorides from the 3-chloro-analogue, and also of the 3-methoxy compound from 1-phenyl-3-methoxy-5-chloropyridazone-(6) and from 1-phenyl-3-methoxy-5-piperazino-pyridazone-(6). 1 - Phenyl - 3 - chloro - 5 - N - (b - phenylethyl) - piperazino-pyridazone-(6) is prepared by refluxing 1-phenyl-3,5-dichloro-pyridazone-(6) with N-(b -phenylethyl)-piperazine in ethanol. Specification 826,640 is referred to.ALSO:Pharmaceutical compositions having an analgesic and antipyretic action and capable of increasing the resistance of animal organisms to bacterial and virus infections comprise pyridazones of the formula <FORM:0885570/VI/1> (in which R11 represents an aliphatically etherified hydroxyl group and in which the phenyl groups may be substituted by lower alkoxy, alkyl or nitro groups or halogen atoms) or salts thereof together with a suitable carrier for enteral, parenteral or topical administration. The preparations may take the form, e.g. of tablets, dragees, salves, solutions, suspensions or emulsions and may incorporate preserving, buffering, wetting and stabilizing agents and other therapeutic agents, e.g. sulphonamides. Specified salts are hydrohalides, sulphates, nitrates, phosphates, thiocyanates, acetates, propionates, oxalates, malonates, tartrates, succinates, malates, methane-, ethane-, hydroxyethane-, benzene- and toluene-sulphonates, and salts with theropeutically-active acids. Specification 826,640 is referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR816241A FR1285235A (en) | 1960-01-21 | 1960-01-21 | Process for the preparation of new diazines, in particular of 1-aryl-3-r-5-r'pyridazones- (6) in which r represents an aliphatically etherified hydroxyl and r 'represents an n- (beta-aryl-ethyl) - group piperazino |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB885570A true GB885570A (en) | 1961-12-28 |
Family
ID=4545248
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2507/60A Expired GB885570A (en) | 1960-01-21 | 1960-01-22 | Pyridazone compounds |
Country Status (2)
| Country | Link |
|---|---|
| FR (1) | FR1285235A (en) |
| GB (1) | GB885570A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2262526A (en) * | 1991-12-20 | 1993-06-23 | Egis Gy Gyszergyar | 3(2h)-pyridazinone derivatives |
-
1960
- 1960-01-21 FR FR816241A patent/FR1285235A/en not_active Expired
- 1960-01-22 GB GB2507/60A patent/GB885570A/en not_active Expired
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2262526A (en) * | 1991-12-20 | 1993-06-23 | Egis Gy Gyszergyar | 3(2h)-pyridazinone derivatives |
| GB2262526B (en) * | 1991-12-20 | 1995-07-26 | Egis Gyugyszergyar | 3(2H)-pyridazinone derivatives and process for the preparation thereof |
| ES2108595A1 (en) * | 1991-12-20 | 1997-12-16 | Egyt Gyogyszervegyeszeti Gyar | DERIVATIVES OF 3 (2H) -PIRIDACINONE AND PROCEDURE FOR ITS PREPARATION. |
Also Published As
| Publication number | Publication date |
|---|---|
| FR1285235A (en) | 1962-02-23 |
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