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GB884029A - A method of producing l-malic acid by fermentation - Google Patents

A method of producing l-malic acid by fermentation

Info

Publication number
GB884029A
GB884029A GB426260A GB426260A GB884029A GB 884029 A GB884029 A GB 884029A GB 426260 A GB426260 A GB 426260A GB 426260 A GB426260 A GB 426260A GB 884029 A GB884029 A GB 884029A
Authority
GB
United Kingdom
Prior art keywords
malic acid
salt
acid
produced
aspergillus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB426260A
Inventor
Shiego Abe
Takeshi Saito
Ken Ichiro Takayama
Akira Furuya
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to GB426260A priority Critical patent/GB884029A/en
Publication of GB884029A publication Critical patent/GB884029A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44—Polycarboxylic acids
    • C12P7/46—Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L-malic acid is produced by cultivating under aerobic conditions a 1-malic acid-producing strain of Aspergillus parasiticus spheare, Aspergillus flavus Link or Aspergillus oryzae (ahlburg) Cohn in a culture medium containing assimilable sources of carbohydrate, nitrogen and inorganic salts, adding calcium carbonate and/or magnesium carbonate whereby the pH of the medium is maintained within the rante of 5.0 to 7.5, until a substantial amount of 1-malic acid salt is produced, recovering said salt, and converting it to 1-malic acid by any known method. An organic acid such as pyruvic or fumaric acid, or a salt thereof, may be added as may at least one of the salts FeSO4, MnCl2, Al2(SO4)3 and K2Cr2O7. Liquid or solid media may be used. Temperatures of 20 DEG C.-35 DEG C. are suitable.
GB426260A 1960-02-05 1960-02-05 A method of producing l-malic acid by fermentation Expired GB884029A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB426260A GB884029A (en) 1960-02-05 1960-02-05 A method of producing l-malic acid by fermentation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB426260A GB884029A (en) 1960-02-05 1960-02-05 A method of producing l-malic acid by fermentation

Publications (1)

Publication Number Publication Date
GB884029A true GB884029A (en) 1961-12-06

Family

ID=9773798

Family Applications (1)

Application Number Title Priority Date Filing Date
GB426260A Expired GB884029A (en) 1960-02-05 1960-02-05 A method of producing l-malic acid by fermentation

Country Status (1)

Country Link
GB (1) GB884029A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4734368A (en) * 1984-03-23 1988-03-29 Huels Aktiengesellschaft Process for the bioconversion of fumarate to L-malate
CN108300740A (en) * 2017-01-13 2018-07-20 山东阜丰发酵有限公司 A method of preparing L MALIC ACID

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4734368A (en) * 1984-03-23 1988-03-29 Huels Aktiengesellschaft Process for the bioconversion of fumarate to L-malate
CN108300740A (en) * 2017-01-13 2018-07-20 山东阜丰发酵有限公司 A method of preparing L MALIC ACID
CN108300740B (en) * 2017-01-13 2021-08-03 山东阜丰发酵有限公司 Method for preparing L-malic acid

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