GB865311A - Process for continuous resolution of racemic amino acids - Google Patents
Process for continuous resolution of racemic amino acidsInfo
- Publication number
- GB865311A GB865311A GB31736/59A GB3173659A GB865311A GB 865311 A GB865311 A GB 865311A GB 31736/59 A GB31736/59 A GB 31736/59A GB 3173659 A GB3173659 A GB 3173659A GB 865311 A GB865311 A GB 865311A
- Authority
- GB
- United Kingdom
- Prior art keywords
- resolution
- crystals
- solution
- towers
- grown
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001413 amino acids Chemical class 0.000 title abstract 3
- 239000013078 crystal Substances 0.000 abstract 12
- 239000000243 solution Substances 0.000 abstract 4
- 239000000203 mixture Substances 0.000 abstract 3
- 230000003287 optical effect Effects 0.000 abstract 3
- 239000004927 clay Substances 0.000 abstract 2
- 229920001971 elastomer Polymers 0.000 abstract 2
- WHUUTDBJXJRKMK-UHFFFAOYSA-N glutamic acid Chemical compound OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 abstract 2
- 239000002245 particle Substances 0.000 abstract 2
- 239000012047 saturated solution Substances 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 abstract 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric Acid Chemical compound [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 abstract 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0036—Crystallisation on to a bed of product crystals; Seeding
Landscapes
- Chemical & Material Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Racemic amino acids such as DL-glutamic acid and DL-threonine are continuously resolved by introducing a saturated solution of said racemic acid into the bottom of a resolution tower at such a rate as to fluidize crystal seeds of one of the optically active isomers of said compound fed in at the top, extracting grown and precipitated crystals in the solution at the bottom and causing said solution which contains the other optical isomer to overflow at the top at such a rate that it removes with it any fine crystals of racemate or of the other optically active isomer which might be formed. The process may be conducted in a number of resolution towers for L- and D-isomers connected alternately in series, or in a number of pairs of D- and L- resolution towers in parallel connection connected in series. Grown crystals may be crushed and screened or reduced in size by partially dissolving them in a solvent in order to provide seed crystals. Seed crystals coated on nuclei of clay or rubber particles may also be used. Specification 844,952 is referred to.ALSO:A racemic mixture of amino acids is continuously resolved by introducing a saturated solution of said racemic mixture into the bottom of a resolution tower at such a rate as to fluidize crystal seeds of one of the optically active isomers of said mixture fed in at the top, extracting grown and precipitated crystals in the solution at the bottom and causing said solution which contains the other optical isomer to overflow at the top at such a rate that it removes with it any fine crystals of racemate or of the other optical isomer which might be formed. The process may be conducted in a number of resolution towers for L- and D-isomers connected alternately in series, or in a number of pairs of D- and L-resolution towers in parallel connection connected in series. Grown crystals may be crushed and screened or reduced in size by partially dissolving them in a solvent in order to provide seed crystals. Seed crystals coated on nuclei of clay or rubber particles may also be used. Specification 844,952 is referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP865311X | 1958-09-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB865311A true GB865311A (en) | 1961-04-12 |
Family
ID=13889558
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB31736/59A Expired GB865311A (en) | 1958-09-28 | 1959-09-17 | Process for continuous resolution of racemic amino acids |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB865311A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998001204A1 (en) * | 1996-07-05 | 1998-01-15 | Bayer Aktiengesellschaft | Crystallization process and device |
| EP1034826A1 (en) * | 1999-03-05 | 2000-09-13 | Reuter Chemische Apparatebau | Co-crystallization process |
| WO2010012746A2 (en) | 2008-07-29 | 2010-02-04 | Poxel | Process of isolating enantiomer components from enantiomer mixtures by particle-size-controlled crystallization |
-
1959
- 1959-09-17 GB GB31736/59A patent/GB865311A/en not_active Expired
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998001204A1 (en) * | 1996-07-05 | 1998-01-15 | Bayer Aktiengesellschaft | Crystallization process and device |
| US6315966B1 (en) | 1996-07-05 | 2001-11-13 | Haarmann & Reimer Gmbh | Crystallization process and device |
| EP1034826A1 (en) * | 1999-03-05 | 2000-09-13 | Reuter Chemische Apparatebau | Co-crystallization process |
| WO2000053283A1 (en) * | 1999-03-05 | 2000-09-14 | Reuter Chemische Apparatebau Kg | Co-crystallization process |
| US6570036B1 (en) | 1999-03-05 | 2003-05-27 | Reuter Chemische Apparatebau Kg [De/De] | Co-crystallization process |
| WO2010012746A2 (en) | 2008-07-29 | 2010-02-04 | Poxel | Process of isolating enantiomer components from enantiomer mixtures by particle-size-controlled crystallization |
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