GB499798A - Manufacture of molecular compounds - Google Patents
Manufacture of molecular compoundsInfo
- Publication number
- GB499798A GB499798A GB21158/37A GB2115837A GB499798A GB 499798 A GB499798 A GB 499798A GB 21158/37 A GB21158/37 A GB 21158/37A GB 2115837 A GB2115837 A GB 2115837A GB 499798 A GB499798 A GB 499798A
- Authority
- GB
- United Kingdom
- Prior art keywords
- ascorbic
- quinidine
- quinine
- iso
- molecular compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- LOUPRKONTZGTKE-WZBLMQSHSA-N Quinine Chemical compound C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-WZBLMQSHSA-N 0.000 abstract 4
- LOUPRKONTZGTKE-UHFFFAOYSA-N cinchonine Natural products C1C(C(C2)C=C)CCN2C1C(O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-UHFFFAOYSA-N 0.000 abstract 4
- LOUPRKONTZGTKE-LHHVKLHASA-N quinidine Chemical compound C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@H]2[C@@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-LHHVKLHASA-N 0.000 abstract 4
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 235000001258 Cinchona calisaya Nutrition 0.000 abstract 2
- 235000010323 ascorbic acid Nutrition 0.000 abstract 2
- 235000010350 erythorbic acid Nutrition 0.000 abstract 2
- 229960001404 quinidine Drugs 0.000 abstract 2
- 229960000948 quinine Drugs 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- CIWBSHSKHKDKBQ-DUZGATOHSA-N D-isoascorbic acid Chemical compound OC[C@@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-DUZGATOHSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229960005070 ascorbic acid Drugs 0.000 abstract 1
- 239000011668 ascorbic acid Substances 0.000 abstract 1
- 238000000354 decomposition reaction Methods 0.000 abstract 1
- 238000007689 inspection Methods 0.000 abstract 1
- 229940026239 isoascorbic acid Drugs 0.000 abstract 1
- 230000008018 melting Effects 0.000 abstract 1
- 238000002844 melting Methods 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 230000001376 precipitating effect Effects 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/62—Three oxygen atoms, e.g. ascorbic acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Molecular compounds of ascorbic acid or iso-ascorbic acid and quinine are prepared by melting the components together, or by dissolving them in a solvent and precipitating the product, or by double decomposition of their salts in solution. For preserving purposes, an excess of the acid may be used. The products, which are readily water-soluble, are useful therapeutically. Examples are given in which the preparation is effected in an atmosphere of nitrogen. Specification 469,335 is referred to. The Specification as open to inspection under Sect. 91 also describes the use of quinidine and states that ascorbic and iso-ascorbic acids are capable of forming salts with both quinine and quinidine in the molecular proportions of 1 : 1 and 2 : 1. Two further examples are given. This subject-matter does not appear in the Specification as accepted.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE499798X | 1936-07-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB499798A true GB499798A (en) | 1939-01-30 |
Family
ID=6545523
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB21158/37A Expired GB499798A (en) | 1936-07-30 | 1937-07-30 | Manufacture of molecular compounds |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB499798A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1143204B (en) * | 1958-08-05 | 1963-02-07 | Mundipharma Ag | Process for the preparation of quinidine galacturonate and quinidine polygalacturonate |
-
1937
- 1937-07-30 GB GB21158/37A patent/GB499798A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1143204B (en) * | 1958-08-05 | 1963-02-07 | Mundipharma Ag | Process for the preparation of quinidine galacturonate and quinidine polygalacturonate |
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