GB456525A - Manufacture of glycerole mono-lactate - Google Patents
Manufacture of glycerole mono-lactateInfo
- Publication number
- GB456525A GB456525A GB1112335A GB1112335A GB456525A GB 456525 A GB456525 A GB 456525A GB 1112335 A GB1112335 A GB 1112335A GB 1112335 A GB1112335 A GB 1112335A GB 456525 A GB456525 A GB 456525A
- Authority
- GB
- United Kingdom
- Prior art keywords
- benzene
- glycerol
- alcohol
- lactate
- monolactate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- RSGINGXWCXYMQU-UHFFFAOYSA-N 2,3-dihydroxypropyl 2-hydroxypropanoate Chemical compound CC(O)C(=O)OCC(O)CO RSGINGXWCXYMQU-UHFFFAOYSA-N 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 12
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 abstract 2
- 238000009835 boiling Methods 0.000 abstract 2
- LZCLXQDLBQLTDK-UHFFFAOYSA-N ethyl 2-hydroxypropanoate Chemical compound CCOC(=O)C(C)O LZCLXQDLBQLTDK-UHFFFAOYSA-N 0.000 abstract 2
- LPEKGGXMPWTOCB-UHFFFAOYSA-N 8beta-(2,3-epoxy-2-methylbutyryloxy)-14-acetoxytithifolin Natural products COC(=O)C(C)O LPEKGGXMPWTOCB-UHFFFAOYSA-N 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 1
- RQPZNWPYLFFXCP-UHFFFAOYSA-L barium dihydroxide Chemical compound [OH-].[OH-].[Ba+2] RQPZNWPYLFFXCP-UHFFFAOYSA-L 0.000 abstract 1
- 229910001863 barium hydroxide Inorganic materials 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 238000004821 distillation Methods 0.000 abstract 1
- ODQWQRRAPPTVAG-GZTJUZNOSA-N doxepin Chemical compound C1OC2=CC=CC=C2C(=C/CCN(C)C)/C2=CC=CC=C21 ODQWQRRAPPTVAG-GZTJUZNOSA-N 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 125000004494 ethyl ester group Chemical group 0.000 abstract 1
- 229940116333 ethyl lactate Drugs 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 150000003903 lactic acid esters Chemical class 0.000 abstract 1
- 229940057867 methyl lactate Drugs 0.000 abstract 1
- 238000006386 neutralization reaction Methods 0.000 abstract 1
- 230000003472 neutralizing effect Effects 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
- 239000000376 reactant Substances 0.000 abstract 1
- 235000011121 sodium hydroxide Nutrition 0.000 abstract 1
- 229910052938 sodium sulfate Inorganic materials 0.000 abstract 1
- 235000011152 sodium sulphate Nutrition 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000001117 sulphuric acid Substances 0.000 abstract 1
- 235000011149 sulphuric acid Nutrition 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/03—Preparation of carboxylic acid esters by reacting an ester group with a hydroxy group
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Glycerol monolactate is made by heating glycerol with a lactic acid ester of an alcohol boiling below 100 DEG C. The reactants in about equimolecular proportions may be heated in the presence of an esterification catalyst, the temperature being kept below 100 DEG C. A solvent or diluent boiling below 100 DEG C. may be present which facilitates removal of the liberated alcohol. In an example, ethyl lactate, glycerol, benzene, and sulphuric acid are boiled together under a fractionating column, the vapours of alcohol and benzene which distil being condensed, washed with water, and the separating benzene continuously returned. After neutralization with caustic soda, benzene is removed by distillation. The glycerol monolactate contains a trace of sodium sulphate. To avoid this, barium hydroxide may be used in neutralizing and the precipitate separated. Methyl lactate may replace the ethyl ester. Specification 346,486 is referred to.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1112335A GB456525A (en) | 1935-04-10 | 1935-04-10 | Manufacture of glycerole mono-lactate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1112335A GB456525A (en) | 1935-04-10 | 1935-04-10 | Manufacture of glycerole mono-lactate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB456525A true GB456525A (en) | 1936-11-10 |
Family
ID=9980449
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1112335A Expired GB456525A (en) | 1935-04-10 | 1935-04-10 | Manufacture of glycerole mono-lactate |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB456525A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2584998A (en) * | 1948-06-18 | 1952-02-12 | Edward M Filachione | Mixed glycerol esters and their acylation products |
| CN102675103A (en) * | 2012-04-27 | 2012-09-19 | 孝感市易生新材料有限公司 | Method for producing menthyl lactate with high content and high optical purity by using two-step method |
-
1935
- 1935-04-10 GB GB1112335A patent/GB456525A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2584998A (en) * | 1948-06-18 | 1952-02-12 | Edward M Filachione | Mixed glycerol esters and their acylation products |
| CN102675103A (en) * | 2012-04-27 | 2012-09-19 | 孝感市易生新材料有限公司 | Method for producing menthyl lactate with high content and high optical purity by using two-step method |
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