[go: up one dir, main page]

GB2636364A - Arabinogalactan - Google Patents

Arabinogalactan Download PDF

Info

Publication number
GB2636364A
GB2636364A GB2318732.1A GB202318732A GB2636364A GB 2636364 A GB2636364 A GB 2636364A GB 202318732 A GB202318732 A GB 202318732A GB 2636364 A GB2636364 A GB 2636364A
Authority
GB
United Kingdom
Prior art keywords
backbone
linked
residue
residues
arabinofuranose
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
GB2318732.1A
Other versions
GB202318732D0 (en
Inventor
Desmond Green Brian
De Castro Cristina
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aramune Tech Ltd
Original Assignee
Aramune Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aramune Tech Ltd filed Critical Aramune Tech Ltd
Priority to GB2318732.1A priority Critical patent/GB2636364A/en
Publication of GB202318732D0 publication Critical patent/GB202318732D0/en
Priority to PCT/GB2024/053045 priority patent/WO2025120326A1/en
Publication of GB2636364A publication Critical patent/GB2636364A/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0057—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Xylans, i.e. xylosaccharide, e.g. arabinoxylan, arabinofuronan, pentosans; (beta-1,3)(beta-1,4)-D-Xylans, e.g. rhodymenans; Hemicellulose; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/40—Mineral licks, e.g. salt blocks
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0036—Galactans; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Food Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Sustainable Development (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

A polysaccharide, or a composition thereof, wherein the polysaccharide comprises a backbone of beta-(1-6)-linked galactose residues and terminal residues, and wherein one or both of the following apply: the backbone comprises one or more first galactose residues and one or more second galactose residues, also comprising one or more first sidechain comprising one or two arabinofuranose residues alpha-(1-3)-linked to a first galactose residue of the backbone, and one or more second sidechain comprising three or more alpha-(1-5)-linked arabinofuranose residues alpha-(1-3)-linked to a second galactose residue of the backbone; and/or at least one terminal residue of the backbone is a glucuronic acid residue. The composition of the arabinogalactan polysaccharide is preferably edible, most preferably a feed supplement e.g., mineral lick. A method of purifying a polysaccharide from a plant of the Malvales order is also disclosed, comprising extraction from plant material, preferably Malva Sylvestris. Extraction may comprise hot aqueous extraction, size exclusion chromatography, or ultrafiltration. A polysaccharide for use in a method of treatment is disclosed, comprising a backbone of alpha-(1-5)-linked arabinofuranose residues, a first side chain of single alpha-arabinofuranose residue (1-2)-linked to the backbone, a second side chain of a single alpha-arabinofuranose residue (1-3)-linked to the same arabinofuranose backbone residue.
GB2318732.1A 2023-12-07 2023-12-07 Arabinogalactan Pending GB2636364A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB2318732.1A GB2636364A (en) 2023-12-07 2023-12-07 Arabinogalactan
PCT/GB2024/053045 WO2025120326A1 (en) 2023-12-07 2024-12-06 Arabinogalactan

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2318732.1A GB2636364A (en) 2023-12-07 2023-12-07 Arabinogalactan

Publications (2)

Publication Number Publication Date
GB202318732D0 GB202318732D0 (en) 2024-01-24
GB2636364A true GB2636364A (en) 2025-06-18

Family

ID=89575728

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2318732.1A Pending GB2636364A (en) 2023-12-07 2023-12-07 Arabinogalactan

Country Status (2)

Country Link
GB (1) GB2636364A (en)
WO (1) WO2025120326A1 (en)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005105852A1 (en) * 2004-04-30 2005-11-10 Fuji-Sangyo Co., Ltd. Novel arabinogalactan, substance with antidiabetic activity and method of use thereof
JP2008208102A (en) * 2007-02-28 2008-09-11 Osaka Prefecture Univ Intestinal immunity stimulator and antiallergic agent
WO2015172040A2 (en) * 2014-05-08 2015-11-12 Immunexcite, Inc. IMMUNOMODULATING β-1,6-D-GLUCANS
CN105218697A (en) * 2015-11-13 2016-01-06 谢镜国 A kind of method extracting gumbo polysaccharide from okra
WO2022090735A1 (en) * 2020-10-30 2022-05-05 The Queen's University Of Belfast Immunomodulatory agent
WO2022090734A1 (en) * 2020-10-30 2022-05-05 The Queen's University Of Belfast Neurodegenerative treatment

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4166452A (en) 1976-05-03 1979-09-04 Generales Constantine D J Jr Apparatus for testing human responses to stimuli
US4356108A (en) 1979-12-20 1982-10-26 The Mead Corporation Encapsulation process
US4265874A (en) 1980-04-25 1981-05-05 Alza Corporation Method of delivering drug with aid of effervescent activity generated in environment of use

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005105852A1 (en) * 2004-04-30 2005-11-10 Fuji-Sangyo Co., Ltd. Novel arabinogalactan, substance with antidiabetic activity and method of use thereof
JP2008208102A (en) * 2007-02-28 2008-09-11 Osaka Prefecture Univ Intestinal immunity stimulator and antiallergic agent
WO2015172040A2 (en) * 2014-05-08 2015-11-12 Immunexcite, Inc. IMMUNOMODULATING β-1,6-D-GLUCANS
CN105218697A (en) * 2015-11-13 2016-01-06 谢镜国 A kind of method extracting gumbo polysaccharide from okra
WO2022090735A1 (en) * 2020-10-30 2022-05-05 The Queen's University Of Belfast Immunomodulatory agent
WO2022090734A1 (en) * 2020-10-30 2022-05-05 The Queen's University Of Belfast Neurodegenerative treatment

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Carbohydrate Research, vol. 198, 1990, Gonda et al., "Structure and anticomplementary activity of an acidic polysaccharide from the leaves of Malva sylvestris var. mauritiana", pages 323-329. *
Carbohydrate Research, vol. 339, no. 11, 2004, Li A et al., Syntheses of arabinogalactans consisting of beta-(1->6)-linked d-galactopyranosyl backbone and alpha-(1->3)-linked l-arabinofuranosyl side chains, pages 1847-1856. *
Carbohydrate Research, vol. 340, no. 4, 2005, Brecker L et al., "Structural and immunological properties of arabinogalactan polysaccharides from pollen of timothy grass (Phleum pratense L.)", pages 657-663. *
International Journal of Biological Macromolecules, vol. 60, 2013, Samavati et al., "Polysaccharide extraction from Malva sylvestris and its anti-oxidant activity", pages 427-436. *

Also Published As

Publication number Publication date
WO2025120326A1 (en) 2025-06-12
GB202318732D0 (en) 2024-01-24

Similar Documents

Publication Publication Date Title
Villanueva-Suárez et al. Sequential extraction of polysaccharides from enzymatically hydrolyzed okara byproduct: physicochemical properties and in vitro fermentability
NZ334845A (en) Beta-glucan products and extraction processes from cereals
WO2001074176A3 (en) Gelled and gellable compositions for food products
ZA200306175B (en) 2-arylamino-pyrimidines for the treatment of gsk3-related disorders
MY135683A (en) Compositions for improving fertility
KR900013863A (en) Manufacturing method of soluble cocoa product
IL180740A0 (en) Nutritional compositions and methods for treating or preventing osteoporosis
KR930019699A (en) Process for preparing hydrogenated non-digestible polysaccharide
AU9157301A (en) Grain fractionation methods and products
MXPA01008283A (en) Polysaccharide compositions and uses thereof.
WO2020245809A2 (en) Identification and selection of a plant starting material of a plant chondroitin sulfate and hyaluronic acid, and transformation of such plant starting material to obtain ingredients for use in foods, supplements, medical devices or drugs
WO2020038905A1 (en) Process to extract components of cacao pod husks and to utilize cacao fruit soluble extract obtained thereof and its applications
AU8369198A (en) Method of preparation and pharmaceutical composition of an uncaria water solubleextract
JP5146312B2 (en) Method for producing pectin, gelling agent and gelled food using the same
GB2636364A (en) Arabinogalactan
Strasser et al. Pectic substances from red beet (Beta vulgaris conditiva). Part I. Structural analysis of rhamnogalacturonan I using enzymic degradation and methylation analysis
CA2479357A1 (en) Building additives based on purified hydrophobically modified hydroxyalkyl guar
EP4162062A1 (en) Process for extracting a hyaluronic acid from a fungus, a hyaluronic acid of plant origin and use thereof
PT1531686E (en) Tomato products
BG102731A (en) Method for starch oxidation
IL130076A0 (en) Method for improving the exploitability and processability of guar endosperm and products obtained using said method
WO2005002343A3 (en) Beta-glucan-containing products, methods of making same, and uses therefor
MX2022006828A (en) Formulations comprising a mineral and/or a vitamin and a polysaccharide, compositions thereof and use thereof in supplementing said mineral and/or vitamin.
EP1745705A1 (en) Process for preparing uronic acid oligosaccharides by extrusion
EP2884854A1 (en) A method for reducing the content of gluten proteins in a cereal fraction