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GB2588505B - Preparation of psilocybin - Google Patents

Preparation of psilocybin Download PDF

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Publication number
GB2588505B
GB2588505B GB2012911.0A GB202012911A GB2588505B GB 2588505 B GB2588505 B GB 2588505B GB 202012911 A GB202012911 A GB 202012911A GB 2588505 B GB2588505 B GB 2588505B
Authority
GB
United Kingdom
Prior art keywords
psilocybin
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
GB2012911.0A
Other versions
GB2588505A (en
GB202012911D0 (en
Inventor
Brown Christopher
John Londesbrough Derek
Moore Gillian
E Nichols David
Scott Northen Julian
Patil Hemant
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Compass Pathfinder Ltd
Original Assignee
Compass Pathfinder Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB1716505.1A external-priority patent/GB2571696B/en
Application filed by Compass Pathfinder Ltd filed Critical Compass Pathfinder Ltd
Publication of GB202012911D0 publication Critical patent/GB202012911D0/en
Publication of GB2588505A publication Critical patent/GB2588505A/en
Application granted granted Critical
Publication of GB2588505B publication Critical patent/GB2588505B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B63/00—Purification; Separation; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB2012911.0A 2017-10-09 2018-10-09 Preparation of psilocybin Active GB2588505B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1716505.1A GB2571696B (en) 2017-10-09 2017-10-09 Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced
GB1810588.2A GB2572023C2 (en) 2017-10-09 2018-06-28 Crystaline psilocybin polymorph A, a formulation and uses thereof together with a method of preparation
GB1816438.4A GB2576059B (en) 2017-10-09 2018-10-09 A pharmaceutical formulation comprising psilocybin

Publications (3)

Publication Number Publication Date
GB202012911D0 GB202012911D0 (en) 2020-09-30
GB2588505A GB2588505A (en) 2021-04-28
GB2588505B true GB2588505B (en) 2022-08-03

Family

ID=72615505

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2012911.0A Active GB2588505B (en) 2017-10-09 2018-10-09 Preparation of psilocybin

Country Status (1)

Country Link
GB (1) GB2588505B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH12022553135A1 (en) 2020-05-19 2024-03-04 Cybin Irl Ltd Deuterated tryptamine derivatives and methods of use
EP4155306A1 (en) 2021-01-15 2023-03-29 Beckley Psytech Limited Neuroactive ergoline analogue
WO2023105222A1 (en) * 2021-12-07 2023-06-15 Beckley Psytech Limited Pharmaceutical composition
EP4486448A1 (en) 2022-03-04 2025-01-08 Reset Pharmaceuticals, Inc. Co-crystals or salts comprising psilocin
US12264131B2 (en) 2022-08-19 2025-04-01 Beckley Psytech Limited Pharmaceutically acceptable salts and compositions thereof
US12246005B2 (en) 2023-06-13 2025-03-11 Beckley Psytech Limited 5-methoxy-n,n-dimethyltryptamine (5-MeO-DMT) formulations
GB202313750D0 (en) * 2023-09-08 2023-10-25 Psyence Group Inc A process for obtaining a purified psychoactive alkaloid

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Journal of Natural Products, Vol. 66(6), 2003, (Shirota, Osamu et al), pages 885-887, ISSN: 0163-3864. *
Synthesis Vol. 6, 1999, (Nichols, David E. et al), pages 935-938, ISSN: 0039-7881. *

Also Published As

Publication number Publication date
GB2588505A (en) 2021-04-28
GB202012911D0 (en) 2020-09-30

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