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GB2433258A - Novel crystalline forms of 6alpha, 9alpha-difluoro-11beta hydroxy-16al-pha-methyl-3-oxo-17alpha-propionyloxy-androsta-1, 4-diene-17beta-carbyoxylic acid - Google Patents

Novel crystalline forms of 6alpha, 9alpha-difluoro-11beta hydroxy-16al-pha-methyl-3-oxo-17alpha-propionyloxy-androsta-1, 4-diene-17beta-carbyoxylic acid

Info

Publication number
GB2433258A
GB2433258A GB0703687A GB0703687A GB2433258A GB 2433258 A GB2433258 A GB 2433258A GB 0703687 A GB0703687 A GB 0703687A GB 0703687 A GB0703687 A GB 0703687A GB 2433258 A GB2433258 A GB 2433258A
Authority
GB
United Kingdom
Prior art keywords
6alpha
11beta
17alpha
17beta
difluoro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB0703687A
Other versions
GB0703687D0 (en
Inventor
Carmen Iustain
Itai Adin
Yuri Futerman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wavelength Pharmaceuticals Ltd
Original Assignee
Chemagis Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemagis Ltd filed Critical Chemagis Ltd
Priority claimed from PCT/IL2005/000802 external-priority patent/WO2006011148A2/en
Publication of GB0703687D0 publication Critical patent/GB0703687D0/en
Publication of GB2433258A publication Critical patent/GB2433258A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)

Abstract

Novel crystalline forms II, III, IV, V, VI, VII and VIII of 6alpha,9 alpha -difluoro-11beta-hydroxy-16alpha-methyl-3-oxo-17alpha-propionyloxyandrosta-1,4-diene-17beta-carboxylic acid, a chemical intermediate useful in the preparation of fluticasone propionate, and novel methods of making these forms, substantially free of water, are disclosed.
GB0703687A 2004-07-26 2005-07-26 Novel crystalline forms of 6alpha, 9alpha-difluoro-11beta hydroxy-16al-pha-methyl-3-oxo-17alpha-propionyloxy-androsta-1, 4-diene-17beta-carbyoxylic acid Withdrawn GB2433258A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50992004P 2004-07-26 2004-07-26
US59987504P 2004-08-10 2004-08-10
PCT/IL2005/000802 WO2006011148A2 (en) 2004-07-26 2005-07-26 Novel crystalline forms of 6alpha, 9alpha-difluoro-11beta hydroxy-16alpha-methyl-3-oxo-17alpha-propionyloxy-androsta-1,4-diene-17beta-carboxylic acid and processes for preparation thereof

Publications (2)

Publication Number Publication Date
GB0703687D0 GB0703687D0 (en) 2007-04-04
GB2433258A true GB2433258A (en) 2007-06-20

Family

ID=37945725

Family Applications (1)

Application Number Title Priority Date Filing Date
GB0703687A Withdrawn GB2433258A (en) 2004-07-26 2005-07-26 Novel crystalline forms of 6alpha, 9alpha-difluoro-11beta hydroxy-16al-pha-methyl-3-oxo-17alpha-propionyloxy-androsta-1, 4-diene-17beta-carbyoxylic acid

Country Status (1)

Country Link
GB (1) GB2433258A (en)

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Not yet advised *

Also Published As

Publication number Publication date
GB0703687D0 (en) 2007-04-04

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Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)