GB2498363A - A dosage measuring and administration device based on two parameters - Google Patents
A dosage measuring and administration device based on two parameters Download PDFInfo
- Publication number
- GB2498363A GB2498363A GB1200416.4A GB201200416A GB2498363A GB 2498363 A GB2498363 A GB 2498363A GB 201200416 A GB201200416 A GB 201200416A GB 2498363 A GB2498363 A GB 2498363A
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- GB
- United Kingdom
- Prior art keywords
- scale
- text
- substance
- treatment
- dose
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Links
- 238000011282 treatment Methods 0.000 claims abstract description 13
- 239000000126 substance Substances 0.000 claims abstract description 12
- 241001465754 Metazoa Species 0.000 claims abstract description 6
- 238000011321 prophylaxis Methods 0.000 claims abstract description 4
- 238000012423 maintenance Methods 0.000 claims abstract description 3
- 239000003607 modifier Substances 0.000 claims 2
- 238000005259 measurement Methods 0.000 abstract description 4
- 230000003115 biocidal effect Effects 0.000 description 9
- 239000003814 drug Substances 0.000 description 9
- 229940079593 drug Drugs 0.000 description 7
- 239000008280 blood Substances 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 208000015181 infectious disease Diseases 0.000 description 4
- 208000035473 Communicable disease Diseases 0.000 description 3
- 208000008589 Obesity Diseases 0.000 description 3
- 230000036760 body temperature Effects 0.000 description 3
- 235000020824 obesity Nutrition 0.000 description 3
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 229960005489 paracetamol Drugs 0.000 description 2
- UIOFUWFRIANQPC-JKIFEVAISA-N Floxacillin Chemical compound N([C@@H]1C(N2[C@H](C(C)(C)S[C@@H]21)C(O)=O)=O)C(=O)C1=C(C)ON=C1C1=C(F)C=CC=C1Cl UIOFUWFRIANQPC-JKIFEVAISA-N 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 230000036765 blood level Effects 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000036984 extensively drug-resistant tuberculosis Diseases 0.000 description 1
- 238000009313 farming Methods 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 201000009671 multidrug-resistant tuberculosis Diseases 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 208000011117 substance-related disease Diseases 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
- A61J7/0015—Devices specially adapted for taking medicines
- A61J7/0053—Syringes, pipettes or oral dispensers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31525—Dosing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
- A61M5/31551—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe including axial movement of dose setting member
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/31556—Accuracy improving means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M2005/3125—Details specific display means, e.g. to indicate dose setting
- A61M2005/3126—Specific display means related to dosing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Vascular Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
A dose measuring and/or administration device, which utilises a personal physiological biometric scale 2 e.g. age or weight, to measure and make available for administration, consumption or use a substance for the treatment, maintenance or prophylaxis of a person or animal, referenced to a datum point or mark which is varied by a secondary biometric scale 3 e.g. height, temperature, or use of the substance. The syringe type device has a first scale 2 on the plunger 1 and a second scale 3 on a rotating collar 4, which may be clear or have the second gradation provided on its edge. The dose measurement according to the first scale, for example based on the age of the patient, is modified by the second scale, for example based on the weight of the patient.
Description
The invention is a biometric based dosage measuring and administration device.
It relates to the measurement and administration, usually orally, of substances for the treatment, maintenance and prophylaxis of persons or animals calculated from their personal physiological biometrics observed at the time of dosage.
Background
When medication is used in treatment or prophylaxis of disease the dose has to be administered in fixed amounts which vary according to the personal physiological characteristics of the patient, biometrics. With liquid medication for oral use this dose is currently expressed in millilitres, ml, or in portions or multiples of a standard SmI spoon.
Additional information either on the label or accompanying leaflet will specify the correct amount to be administered for given age ranges or weights of patients as well as the frequency of administration.
For ease of use and to limit patient or carer confusion dosages are split into age or weight ranges. These ranges lead to abrupt changes in the dosage when the patient moves from one range to another.
Example. The dosages currently recommended in the United Kingdom for Paracetamol Infant Suspension l2Omg/5m1 are; * 2-3 months 2.5m1 usually once, but a second dose permitted 4-6 hours later * 3-6 months 2.5m1 -up to 4 times a day * 5-24 months SmI -up to 4 times a day * 2-4 years 7.5m1 -up to 4 times a day * 4-6 years lOmI up to 4 times a day From this table it is clear that a child of 5 months and 3 weeks will be given 2.Sml per dose but this will double to SmI per dose two weeks later. A small for age child may easily receive a greater than optimal dose and similarly a tall, well muscled, heavier child may receive a dosage that is inadequate.
This becomes even more important when considering the administration of antibiotics where drug blood levels are crucial to the success of treatment and the relevant biometrics would be the patient's weight. For dose sensitive antibiotics used in the treatment of acute life threatening illness Body Mass Index, blood volume or other biometrics would be used.
The Invention To overcome this the proposed invention proposes a dose measuring device which is calibrated directly with a physiological biometric scale. At each administration of substance the appropriate volume is measured into the device by direct correlation to the biometric scale measured against a datum mark which is modified by an independent scale that is either another biometric or a specific use of the substance.
In the above example for paracetamol the amount measured would be a volume correlated to the age of the patient on the primary graduated scale. The secondary scale would move the datum of the primary scale in correlation to another patient biometric or substance use. Body temperature could be used to increase the datum point increasing the dose in relation to the body temperature recorded immediately prior to dose administration.
Using this invention more accurate dosing will be achieved and there will be a reduction in errors in transposing information from an external reference and converting the reading to a volumetric measurement the appropriate biometric for the treatment being used directly to determine the dose at the point and time of administration. In the above example the suitable scales would be the weight of the child modified by the secondary scale body temperature datum shifter.
A more important use will be in the administration of antibiotic liquids for children. For antibiotic solutions to give optimal results in eliminating infection it is important that adequate blood concentrations are achieved. Regular dosing at even intervals is important but the crucial factor is that an adequate quantity of the antibiotic is given to achieve clinically significant results at each dose. This is best done by correlating the amount of drug administered with the blood volume of the patient.
Blood volume is in direct relationship to weight and height. Increased incidence of patient obesity has made age related dosing inadequate and ineffective.
Using the invention both weight and height can be used to determine the volume of any given antibiotic mixture and therefore the optimal dose can be given in any situation without the need for complex calculation of blood volume.
Antibiotic dosage is sometime different depending on the nature of the condition or the vascularisation of the area to be treated. E.g. the optimal dosage of Flucloxicillin is lower for treatment of infections of the lung, with a rich blood supply, than it is for an infection of the outer cornified (Stratum Corneum) layer of the skin which is poorly vasculated. The secondary datum shifter could be arranged so that it is stepped and the scale altered to represent the condition being treated or a single tertiary device could be added which moves the datum shifter a fixed amount appropriate for the condition permitting the secondary biometric scale shifter to continue to be used from an elevated reference point.
Description
The invention will now be described solely by way of example with reference to Figure 1.
It is similar to a dosage syringe with a plunger (1) that fits with a body (7) with no needle attaching device but a simple entry orifice (9). The biometric scale (2) is marked on the plunger which is a close fit with the bore of the syringe (7). The datum shifter (5) is a device, which enables the secondary scale (3), to be presented to the primary scale, in the example a collar (4), with either a) an edge that is the datum line for the secondary biometric scale orb) a clear collar with markings to represent the datum line. The secondary scale may be presented on the datum shift device (5) or elsewhere on the body (7) and read with an indexing device on the datum shifter (5). The tertiary datum shifter (6) would be a simple collar or similar device that raises the primary datum shifter(s).
As each device will be specific to one strength and preparation of substance the complex calculations required to calculate the optimal dosage for a substance can be reduced to a scale, which may be non linear and complex, yet easily read from the device.
Other than the use in clinically appropriate medicine dosage measurement the device could be used extensively in animal medicine where breed and weight are the principle biometrics. In external applications where age and area to be treated are the biometrics.
E.g. Child! hand, adult/arm etc. In farming, milk yield/breed or weight to determine feed volume.
References 1. Adjustment of dosing of antimicrobial agents for bodyweight in adults, Els Mehuys,Egide Kayitare.
chris Vervaet, Jean-Paul Remon, The Lancet Vol. 375 No. 9719, March 202010 2. Best drug treatment for multidrug-resistant and extensively drug-resistant tuberculosis, Dr José A caminero MD, Giovanni Sotgiu PhD) Alimuddin Zumla FRcP, Giovanni Battista Migliori MD. The Luncet Infectious Diseases, Vol. lONo. 9 pp 621-629. Sep 2010 3. Protecting our futures -preventing antibiotic resistance Niall Hunt Chemist and Druggist 18 November 4. Antibiotic Tissue Concentrations and Obesity From the Division of Pharmacy Practice) college of Pharmacy) university of New Mexico, Albuquerque) New Mexico (Dr. Pai); and the Department of Pharmacy Practice) college of Pharmacy, Oregon State University, Portland, Oregon (Dr. Dearden).
S. Rising obesity prompts higher antibiotic doses call Emma Wilkinson, Health reporter, BBC News 15 January 2010 6. Antimicrobial Dosing in Obese Patients Rebecca Wurtz, Gail Itokazu, and Keith Rodvold From the Department of Medicine, Evanston Hospital, Evanston; and the Department of Medicine, Northwestern university Medical School, Cook County Hospital, and University of Illinois at Chicago College of Pharmacy, Chicago, Illinois. clinical Infectious Diseases 1997;25:112-8 7. Optimal antibiotic dosing for obese patients a challenge for clinicians Elizabeth Dodds Ashley, INFECTIOUS DISEASE NEwsJune 2007 http://www.infectiousdiseasenews.com/view.aspx?rid=33615
Prior Art is detailed separately
END 11/01/2012
Claims (1)
- <claim-text>A physiological biometric based dosage measuring and administration device. Claim1. A dose measuring device which references a personal physiological biometric e.g. age, weight, to measure and make available for administration, consumption or use a substance for the treatment, maintenance or prophylaxis of a person or animal cross referenced to a datum point or mark which is varied by a secondary biometric e.g. height, temperature, or use of the substance.</claim-text> <claim-text>2. A measuring device according to claimi, which has incorporated a delivery mechanism for direct administration of the substance.</claim-text> <claim-text>3. A dose measuring device according to claim 1, which has a datum modifier for the secondary biometric that is applied modify the dose measured according to the use of the substance, the nature of the treatment, the condition being treated, the location of the treatment or the nature of the person or animal.</claim-text> <claim-text>4. A dose measuring device according to claim 2, which has a datum modifier for the secondary biometric that is applied modify the dose measured according to the use of the substance, the nature of the treatment, the condition being treated, the location of the treatment or the nature of the person or animal.</claim-text>
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1200416.4A GB2498363A (en) | 2012-01-11 | 2012-01-11 | A dosage measuring and administration device based on two parameters |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1200416.4A GB2498363A (en) | 2012-01-11 | 2012-01-11 | A dosage measuring and administration device based on two parameters |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB201200416D0 GB201200416D0 (en) | 2012-02-22 |
| GB2498363A true GB2498363A (en) | 2013-07-17 |
Family
ID=45788767
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1200416.4A Withdrawn GB2498363A (en) | 2012-01-11 | 2012-01-11 | A dosage measuring and administration device based on two parameters |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB2498363A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104224547A (en) * | 2013-06-14 | 2014-12-24 | 李爱民 | Medicine taking device for point application therapy |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4308450A (en) * | 1978-12-22 | 1981-12-29 | Baxter Travenol Laboratories, Inc. | Two-piece slide calculator for determining metabolic requirements and parenteral feeding dosages |
| US20040024372A1 (en) * | 1989-08-04 | 2004-02-05 | Grogan Jack Raymond | Dose by weight medicine dropper |
| WO2004077363A1 (en) * | 2003-02-25 | 2004-09-10 | Rosti A/S | Method and apparatus for controlling a dispensing apparatus for dispensing medication |
| US20070225656A1 (en) * | 2006-03-24 | 2007-09-27 | Hoyle John D Jr | Dosage Control Syringe |
| US20080306438A1 (en) * | 2006-03-16 | 2008-12-11 | Ferrara Kenneth D | System for facilitating preparation of medication doses |
-
2012
- 2012-01-11 GB GB1200416.4A patent/GB2498363A/en not_active Withdrawn
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4308450A (en) * | 1978-12-22 | 1981-12-29 | Baxter Travenol Laboratories, Inc. | Two-piece slide calculator for determining metabolic requirements and parenteral feeding dosages |
| US20040024372A1 (en) * | 1989-08-04 | 2004-02-05 | Grogan Jack Raymond | Dose by weight medicine dropper |
| WO2004077363A1 (en) * | 2003-02-25 | 2004-09-10 | Rosti A/S | Method and apparatus for controlling a dispensing apparatus for dispensing medication |
| US20080306438A1 (en) * | 2006-03-16 | 2008-12-11 | Ferrara Kenneth D | System for facilitating preparation of medication doses |
| US20070225656A1 (en) * | 2006-03-24 | 2007-09-27 | Hoyle John D Jr | Dosage Control Syringe |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104224547A (en) * | 2013-06-14 | 2014-12-24 | 李爱民 | Medicine taking device for point application therapy |
Also Published As
| Publication number | Publication date |
|---|---|
| GB201200416D0 (en) | 2012-02-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| WAP | Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1) |