GB2496227B - Polycondensation of lactic acid for medical biodegradable polylactic acid catalyzed by creatinine - Google Patents
Polycondensation of lactic acid for medical biodegradable polylactic acid catalyzed by creatinineInfo
- Publication number
- GB2496227B GB2496227B GB1209095.7A GB201209095A GB2496227B GB 2496227 B GB2496227 B GB 2496227B GB 201209095 A GB201209095 A GB 201209095A GB 2496227 B GB2496227 B GB 2496227B
- Authority
- GB
- United Kingdom
- Prior art keywords
- creatinine
- polycondensation
- biodegradable polylactic
- lactic acid
- polylactic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 title 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 title 2
- 229940109239 creatinine Drugs 0.000 title 1
- 235000014655 lactic acid Nutrition 0.000 title 1
- 239000004310 lactic acid Substances 0.000 title 1
- 229920000747 poly(lactic acid) Polymers 0.000 title 1
- 238000006068 polycondensation reaction Methods 0.000 title 1
- 239000004626 polylactic acid Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/78—Preparation processes
- C08G63/82—Preparation processes characterised by the catalyst used
- C08G63/823—Preparation processes characterised by the catalyst used for the preparation of polylactones or polylactides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
- C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/78—Preparation processes
- C08G63/82—Preparation processes characterised by the catalyst used
- C08G63/87—Non-metals or inter-compounds thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Polyesters Or Polycarbonates (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2011/081723 WO2012122807A1 (en) | 2011-03-14 | 2011-11-03 | Process for synthesizing medical biodegradable polylactic acid by creatinine catalysed lactic acid condensation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| GB201209095D0 GB201209095D0 (en) | 2012-07-04 |
| GB2496227A GB2496227A (en) | 2013-05-08 |
| GB2496227B true GB2496227B (en) | 2015-11-04 |
Family
ID=46546550
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1209095.7A Expired - Fee Related GB2496227B (en) | 2011-11-03 | 2011-11-03 | Polycondensation of lactic acid for medical biodegradable polylactic acid catalyzed by creatinine |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB2496227B (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1556128A (en) * | 2004-01-08 | 2004-12-22 | 南开大学 | Process method for catalytic synthesis of medical biodegradable materials by biomass organic guanidine compounds |
| CN102161752A (en) * | 2011-03-14 | 2011-08-24 | 南京大学 | Process method for synthesizing medical biodegradable polylactic acid by polycondensation of lactic acid in presence of creatinine catalyst |
| WO2013000226A1 (en) * | 2011-06-30 | 2013-01-03 | 南京大学 | High molecular weight polylactic acid synthesized by using method for synthesizing and catalytically-polycondensing bionic creatinine guanidinium chloride |
-
2011
- 2011-11-03 GB GB1209095.7A patent/GB2496227B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1556128A (en) * | 2004-01-08 | 2004-12-22 | 南开大学 | Process method for catalytic synthesis of medical biodegradable materials by biomass organic guanidine compounds |
| CN102161752A (en) * | 2011-03-14 | 2011-08-24 | 南京大学 | Process method for synthesizing medical biodegradable polylactic acid by polycondensation of lactic acid in presence of creatinine catalyst |
| WO2013000226A1 (en) * | 2011-06-30 | 2013-01-03 | 南京大学 | High molecular weight polylactic acid synthesized by using method for synthesizing and catalytically-polycondensing bionic creatinine guanidinium chloride |
Non-Patent Citations (2)
| Title |
|---|
| C.WANG et al., Ring opening polymerization of L-lactide initiated by creatinine, Biomaterials 2004,Vol. 25, pages 5797-5801. * |
| SOHIA MALBERG et al,. Bio-safe synthesis of linear and branched PLLA, Jounal of Polymer Science; Part A; Polymer Chemistry; 2010, Vol 48, pages 1214-1219. * |
Also Published As
| Publication number | Publication date |
|---|---|
| GB201209095D0 (en) | 2012-07-04 |
| GB2496227A (en) | 2013-05-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 789A | Request for publication of translation (sect. 89(a)/1977) |
Ref document number: 2012122807 Country of ref document: WO |
|
| PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 20201103 |