GB2326167A

GB2326167A - Skin cleansing composition

Info

Publication number: GB2326167A
Application number: GB9812542A
Authority: GB
Inventors: Brian Bergin; Gerald O'shea
Original assignee: Cussons International Ltd
Current assignee: Cussons International Ltd
Priority date: 1997-06-11
Filing date: 1998-06-11
Publication date: 1998-12-16
Anticipated expiration: 2018-06-11
Also published as: GB9712064D0; GB9812542D0; GB2326167B

Abstract

A rinse-off cleansing composition comprises a surfactant together with an anti-bacterial agent and a synthetic phospholipid. Prefered synthetic phospholipids include fatty acid amidopropyl PG-dimonium chlorides. The anti bacterial may be triclosan, chlorohexidine, trichlorocarbanilide, xylenol, PVP-I, quaternary ammonium compounds or mixtures thereof.

Description

SKIN CLEANSING COMPOSITION The present invention relates to skin cleansing compositions and, more particularly, to rinse-off skin cleansing compositions which have anti-bacterial activity.

For skin cleansing compositions convenience is of upmost importance. It is further becoming increasingly important to keep the skin clean and protected from bacteria at all times. It is now commonplace to use convenient rinse-off systems which combine cleansing ofthe skin via the presence of a surfactant, together with the deposition of an anti-bacterial agent.

The traditional route to achieving such a benefit is to incorporate an anti-bacterial agent in the formulation to deliver an anti-bacterial benefit e.g. triclosan. T;tilisation of an anti-bacterial agent in a rinse-off system results in much of the anti-bacterial agent being rinsed off during use, resulting in an expensive and wasteful product.

In order to improve skin feel, various emollients, polymers and moisturising ingredients can be included in the formulation. Their effectiveness can be limited as they can be washed off during use and cannot act on the skin as a cream or lotion formulation does.

It appears on the whole, that the actual effectiveness of the anti-bacterial agent seems lower in some instances in rinse-off systems than other types of formulations.

The present invention has been made from a consideration of this.

According to the present invention there is provided a rinse-off cleansing composition comprising at least one surfactant together with at least one anti-bacterial agent and at least one synthetic phospholipid. For the avoidance of doubt the term "anti-bacterial agent" used herein does not relate to the aforementioned phospholipid which itself exhibits anti-bacterial activity.

The present invention thus includes a surfactant based formulation containing a synthetic phospholipid which provides a rinse-off system delivering anti-bacterial efficacy.

The compositions of the invention provide a rinse-off system with more effective antibacterial activity.

According to a preferred embodiment, the rinse-off cleansing composition of the invention contains a cationic synthetic phospholipid and ideally a synthetic cationic phospholipid, of the general formula:

rORMULA 1 where R = cocamidopropyl stearamidopropyl linoleamidopropyl borageatnidopropyl and where x + y =3 Preferably the synthetic phospholipid is present in an amount in the range from 0.01 to 10%, more preferably from 0.01 to 1.9% and even further preferably 0.2 to 0.8% by weight, relative to the weight of the rinse-off composition.

In a preferred embodiment of the invention, the said anti-bacterial agent comprises any of the following either alone or in combination: triclosan; chlorohexidine digluconate, trichlorocarbanilide, p-chloro-m-Xylenol, Polyvinylpyrrolidone-iodine complex and quaternary ammonium compounds such as cetrimonium bromide and benzalkonium chloride or mixtures thereof Triclosan is preferred in that Triclosan and the cationic phospholipid act synergistically to provide a composite having excellent anti-bacterial activity.

The anti-bacterial agent is preferably added in an amount from 0.01 to 2% by weight, relative to the weight of the composition and most preferably from 0.05 to 0.5% by weight.

The surfactant may be anionic, amphoteric, cationic, zwitterionic, non-ionic or a combination thereof. Preferably, the surfactant is anionic, amphoteric or non-ionic and is added to the formulation in an amount in the range from 0.1 and 60% by weight relative to the total weight of the rinse-off cleansing composition into which the surfactant is incorporated. The surfactant may comprise at least one soap. The compositions of the present invention may be in the form of soap bars, in which case it is found to be highly advantageous to utilise higher levels of surfactants, i.e. from substantially 50% to substantially 90% by weight.

The surfactant preferably comprises any of the following either alone or in combination: alkali metal alkyl ether sulphates, alkyl sulphates, sulphosuccinates, acyl glutamates; alkyl polyglucosides, isethionates, carboxylates, soaps, alkyl sulphates, ethoxylated and non-ethoxylated metal alkyl sulphanates, sultanes, taurates, sarcosinates, sulphonates, ether carboxylates, glycinates, quatemary ammonium compounds, polysorbates, sugar esters, alkyl phosphates, propionates, amino acid surfactants, glycinates, glysides, alkanolamides and betaines.

According to a further aspect of the present invention there is provided a method of manufacturing a rinse-off cleansing composition comprising mixing together at least one of surfactant, at least one anti-bacterial agent and at least one synthetic phospholipid.

The compositions of the invention may also contain a polymeric skin or hair conditioning agent at a level preferably in the range from substantially 0.01% to 5%, more preferably from substantially 0.05% to 3% and especially from substantially 0.1% to 2% by weight. Suitable polymeric agents are the cationic, nonionic, amphoteric, and anionic polymers useful in the cosmetic field. Preferred are cationic and nonionic polymers used in the cosmetic fields as hair or skin conditioning agents.

Representative classes of these polymeric agents include cationic and nonionic polysaccharides; cationic and nonionic homopolymers and copolymers derived from acrylic and/or methacrylic acid; cationic and nonionic cellulose resins; cationic copolymers of dimethyldiallylammonium chloride and acrylamide and/or acrylic acid; cationic homopolymers of dimethyldiallylammonium chloride; cationic polyalkylene and ethoxypolyalkylene imines; quaternized silicones, and mixtures thereof.

By way of exemplification, cationic polymers suitable for use herein include cationic guar gums such as hydroxypropyl trimethyl ammonium guar gum (d.s. of from 0.11 to 0.22) available commercially under the trade names Jaguar C-162(RTM), Jaguar C-14-S(RTM) and Jaguar C-17(RTM) and also Jaguar C-16(RTM), which contains hydroxypropyl substituents (d.s. of from 0.8-1.1) in addition to the above-specified cationic groups, and quaternized cellulose ethers available commercially under the trade names Ucare Polymer JR30M, JR-400 and Celquat. other suitable cationic polymers are homopolymers of dimethyldiallylammonium chloride available commercially under the trade name Merquat 100, copolymers of dimethyl aminoethylmethacrylate and acrylamide, copolymers of dimethyldiallylammonium chloride and acrylamide, available commercially under the trade manes Merquat 550 and Merquat S, acrylic acid/dimethyldiallylammonium chloridelacrylamide copolymers available under the trade name Merquat 3300, quaternized vinyl pyrrolidone acrylate or methacrylate copolymers of amino alcohol available commercially under the trade name Gafquat, for example Polyquaternium 11, 23 and 28 (quaternized copolymers of vinyl pyrrolidone and dimethyl aminoethylmethacrylate - Gafquat 75sun and HS-100), vinyl pyrrolidone'vinyl imidazolium methochloride copolymers available under the trade names Luviquat HM552, Polyquaternium 2, and polyalkyleneimines such as polyethlenimine and ethoxyl ated polyethylenimine.

The viscosity ofthe final composition (Brookfield RVT/DCP, 1 rpm with cone CP41 or CP52, 25"C, neat) is preferably at least approximately 500 cps, more preferably from approximately 1,000 to approximately 50,000 cps, especially from approximately 2,000 to approximately 30,000 cps.

The rinse-off cleansing compositions can optionally include additional hair or skin moisturizers which are soluble or suspended in the cleansing composition matrix. The preferred level of such moisturizers is from approximately 0.5% to approximately 20% by weight. In preferred embodiments, the moisturizer is selected from: 1. Suspended materials e.g. silicone oils; 2. water-soluble liquid polyols; 3. essential amino acid compounds found naturally occurring in the stratum corneum of the skin; and 4. water-soluble nonpolyol nonocclusives and mixtures thereof.

Some examples of more preferred nonocclusive moisturizers are glycerine, polybutene, squalane, polyethylene glycol, propylene glycol, sorbitol, polyethylene glycol and propylene glycol ethers of methyl glucose (e.g. ethyl glucam E-20 and propylglucan P-10), polyethylene glycol and propylene glycol ethers of lanolin alcohol (e.g. Solulan-75), sodium pyrrolidone carboxylic acid, L-proline, guanidine, pyrrolidone, hydrolyzed protein and other collagen-derived proteins, aloe vera gel and acetamide MEA and mixtures thereof. Of the above, glycerine is highly preferred.

Suitable suspended materials include silicone oils and liposomes.

A number of additional optional materials can be added to the cleansing compositions.

Such materials include proteins and polypeptides and derivatives thereof; water-soluble or solubilizable preservatives such as DMDM Hydantoin, Germall 1 15, methyl, ethyl, propyl and butyl esters of hydroxybenzoic acid, EDTA, Euxyl (RIM) K400, benzyl alcohol, sodium benzoate and 2-phenoxyethanol; solvents such as hexylene glycol and propylene glycol, low temperature phase modifiers such as ammonium ion sources (e.g. NH4 Cl); viscosity control agents such as magnesium sulfate and other electrolytes; colouring agents; pearlescers and opacifiers such as ethylene glycol distearate, TiO2 and TiO2-coated mica; perfumes and perfume solubilizers. Water is present at a level preferably from approximately 30% to approximately 94%, preferably at least approximately 60% by weight of the compositions herein.

The pH ofthe composition is preferably from approximately 4 to approximately 10, further preferably from approximately 5 to 8.

Measurement of the anti-bacterial activity is described in the test set out below.

The invention will be described in more detail by way of the example presented hereinafter.

The following experimental results demonstrate the improved antimicrobial effect of the present invention.

EXAMPLE 1 Suspension Test.

Product concentration: 90% Temperature: 350C +/- 1 C Recovery of viable bacteria: Via serial dilution in Tryptone Soya Broth containing inactivators, (100/o Tween 80 + 3% lecithin + 0.5% Sodium Thiosulphate + 0.1% histidine).

Recovery media: Plate Count Agar containing 3% Tween 80 + 0.3% lecithin.

Incubation of plates: 48hrs at 37 C.

Test Bacteria: Pseudomonas Aeruginosa ATCC 15442 Suspension Test Results against Pseudomonas Aeruginosa ATCC 15442

Formulation % Reduction Log Reduction % P-TC % Triclosan 1 99.66 2.47 0.5 0.125 2 90.44 1.02 0.5 0 3 88.09 0.92 0 0.125 4 83.82 L 0.79 0 0 The test results demonstrate a synergistic effect for the cationic phospholipid when used with triclosan against typical gram(-ve) bacteria. The table above illustrates the antimicrobial effects for compositions with different levels of antimicrobial active. It can be clearly seen that the combination of triclosan and Phospholipid P-TC (Formulation 1) gives a log reduction that is considerably higher than that which we would expect based on the sum ofthe log reductions that are achieved by incorporating either active singly into the same base formulation.

Formulation 1 Formulation 2 Formulation 3 Formulation 4 Ingredients Parts by Weight Parts by Weight Parts by Weight Parts by Weight Propylene Glycol 2.00 2.00 2.00 2.00 PEG 120 Methyl Glucose Dioleate 0.30 0.30 0.30 0.30 Hydroxypropyl Guar Hydroxypropyltrimonium Chloride 0.30 0.30 0.30 0.30 Aqua Disodium EDTA 0.20 0.20 0.20 0.20 CI 42051 0.23 0.23 0.23 0.23 Cocamidopropyl Betaine 3.12 3.12 3.12 3.12 Glycerin 1.00 1.00 1.00 1.00 Sodium Laureth Sulfate 28.05 28.05 28.05 28.05 Parfum 0.70 0.70 0.70 0.70 Triclosan 0.125 0.125 Cocamidopropyl PG Dimonium Chloride 0.50 0.50 Phosphate Cocamide DEA 3.00 3.00 3.00 3.00 Phenoxyethanol & Methyldibromoglutaronitrile 0.08 0.08 0.08 0.08 Sodium Chloride 0.15 0.15 0.15 0.15 TOTAL 100.00 100.00 100.00 100.00 The invention is not restricted to the embodiments described in the specification.

Many variations and modifications can be made.

Claims

CLAIMS 1. A rinse-off cleansing composition comprising at least one surfactant together with at least one anti-bacterial agent and at least one synthetic phospholipid.
2. A rinse-off cleansing composition as claimed in claim 1, wherein the said antibacterial agent includes any of the following either alone or in combination: triclosan; chlorohexidine digluconate, trichlorocarbanilide, p-chloro-m-Xylenol, Polyvinylpyrrolidoneiodine complex and quaternary ammonium compounds such as cetrimonium bromide and benaalkonium chloride or mixtures thereof.
3. A rinse-off cleansing composition as claimed in claim 1, wherein the said anti-bacterial agent is triclosan.
4. A rinse-off cleansing composition as claimed in any preceding claim, wherein the said anti-bacterial agent is added in an amount from 0.01 to 2% by weight, relative to the weight ofthe rinse-off composition.
5. A rinse-off cleansing composition as claimed in any preceding claim, wherein the said phospholipid is cationic.
6. A rinse-off cleansing composition as claimed in any preceding claim, wherein the said phospholipid is ofthe general formula:

where R = cocamidopropyl stearamidopropyl linoieamidopropyl borageamidopropyl and where x + y =3
7. A rinse-off cleansing composition as claimed in any preceding claim, wherein the said phospholipid is present in an amount from 0.01 to 10% by weight, relative to the weight of the rinse-off composition.
8. A rinse-off cleansing composition as claimed in any preceding claim, wherein the said phospholipid is present in an amount from 0.01 to 1.9% by weight, relative to the weight of the rinse-off composition.
9. A rinse-off cleansing composition as claimed in any preceding claim, wherein the said phospholipid is present in an amount from 0.2 to 0.8% by weight, relative to the weight of the rinse-off composition.
10. A rinse-off cleansing composition as claimed in any preceding claim, wherein the surfactant comprises any of the following either alone or in combination: alkali metal alkyl ether sulphates, alkyl sulphates, sulphosuccinates, acyl glutamates; alkyl polyglucosides, isethionates, carboxylates, soaps, alkyl sulphates, ethoxylated and non-ethoxylated metal alkyl sulphanates, sultanes, taurates, sarcosinates, sulphonates, ether carboxylates, glycinates, quaternary ammonium compounds, polysoibates, sugar esters, alkyl phosphates, propionates, amino acid surfactants, glycinates, glysides, alkanolamides and betaines.
11. A rinse-off cleansing composition as claimed in any preceding claim, wherein the amount of surfactant is in the range from 0 1 to 60% by weight relative to the weight of the rinse-off composition.
12. A rinse-off cleansing composition as claimed in any of claims 1 to 11, wherein the composition is in the form of a bar and the amount of surfactant is in the range from 50% to 90% by weight.
13. A method of manufacturing a rinse-off cleansing composition comprising mixing together at least one surfactant, at least one anti-bacterial agent and at least one synthetic phospholipid.