GB2126587A

GB2126587A - Fungicidal thiophene derivatives

Info

Publication number: GB2126587A
Application number: GB08324169A
Authority: GB
Inventors: Rudolf Sandmeier; Karl Seckinger
Original assignee: Sandoz AG
Current assignee: Sandoz AG
Priority date: 1982-09-13
Filing date: 1983-09-09
Publication date: 1984-03-28
Also published as: GB8324169D0

Abstract

Novel compounds of formula I <IMAGE> wherein R1, R2 and R3, independently, are H, C1-4alkyl, C1- 4alkoxy, C1-4alkylthio, F, Cl or Br X is -CH(R4)-R5 or -N(R6)- COOR7, in which R4 is H or C1-4alkyl, R5 is COZR8, CO- N(R9)OR10, CN, CHO, <IMAGE> C@C-R14, allenyl; or is 2,2-dihalo-1-cyclopropyl unsubstituted or substituted by C1-4alkyl; or is phenyl unsubstituted or substituted, R6 is C1-3alkyl, R7 is C1-6alkyl, C3-6alkenyl or C3-6alkinyl, or R6 and R7 may be linked together to form CH2-CH2; Z and Z min are O or S R8 is C1-4alkyl, C3-5- alkenyl, or C3-6alkinyl, or ZR8 may be linked with R4 to form the bridge ZCH(R15)-CH2 in which Z is as defined above and R15 is H or CH3; R9, R min 9 and R min min 9 are H or C1-4alkyl, R10, R min 10 and R min min 10 are C1-4alkyl, or R9 may be linked with R10, R min 9 with R min 10, or R min min 9 with R sec 10 and signify alkylene, to form a 5- or 6- membered heterocyclic ring, R11, R12, R13, independently, are H, C1-4alkyl, F, Cl or Br, R14 is H, C1-4alkyl, Cl, Br, or I, and Y is H; C1-6alkyl, C2-6alkenyl or C2- 6alkinyl unsubstituted or substituted by F, Cl, Br, or CN; C2-6epoxyalkylene; C3-6cycloalkyl; a 5- membered heterocyclic ring comprising 1 to 3 heteroatoms selected from O, S and N, which in unsubstituted or substituted by C1-4alkyl, F, Cl or Br; (A)n-Az; (A)n-Y1- NR9aR10a; (A)nZ1H and esters or ethers thereof; benzyl unsubstituted or substituted, in which A is CH2 or CH(CH3> n is 0 or 1, Az is a 1-azolyl comprising 1 to 3 nitrogen atoms, Y1 is a covalent bond or NH, R9a is H or C1-4alkyl, R10a is C1-4alkyl, and Z1 is O or S, possess fungicidal properties.n

Description

SPECIFICATION Novel thiophene derivatives The present invention relates to novel thiophene derivatives, their use as fungicides, compositions for facilitating such use and the preparation of these thiophene derivatives and of compositions containing such compounds The invention provides compounds of formula I

wherein R1, R2 and R3, independently, are H, C1-4alkyl, C1.4-alkoxy, C1-4alkylthio or halogen selected from F, Cl and Br, Xis selected from a group -CH(R4)-R5 or a group -N(R6)-COOR7, in which R4 is H or 01.4alkyl, R5 is COZR8, CO-N(R9)OR10, CN, CHO,

C=C-R14, allenyl; or is 2,2-dihalo-1-cyclopropyl unsubstituted or substituted by C14-alkyl; or is phenyl unsubstituted or substituted, F6 is C1.3alkyl, R7 is 01.6alkyl, C36alkenyl or C3.6alkinyl, whereby F6 and R7 may be linked together to form CH2-CH2; and wherein Z and Z' are 0 or S R8 is C1-6alkyl, C3.6alkenyl, or C3 6al ki nyl, and whereby ZR8 may be linked with R4 to form the bridge ZCH(R15)-CH2 in which Z is as defined above and R15 is H or CH3; R9, R'9 and R"g are H or C1-4alkyl, R10, R'10 and R"10 are C1.4alkyl, whereby Rg may be linked with R10, resp.

R'g with R'10, resp. R"g with R"10 and signify alkylene, to form a 5- or 6- membered heterocyclic ring, R11, R12, R13, independently, are H, C1 4-alkyl, or halogen selected from F, Cl or Br, R14 is H, C1-4alkyl or halogen selected from Cl, Br or andYisH; a hydrocarbon selected from C1.6alkyl, C2.6alkenyl and C2.6alkinyl unsubstituted or substituted by halogen, selected from F, Cl or Br, or by CN; C2.6epoxyalkylene; C3 6cycloalkyl; a 5-membered heterocyciic ring comprising 1 to 3 heteroatoms selected from 0, S and N, which in unsubstituted or substituted by C1-4alkyl or halogen selected from F, Cl or Br; (A)n-Az; (A)n-Y1-NR9aR10a; (A)nZ1H and esters or ethers thereof; benzyl unsubstituted or substituted, in which A is CH2 or CH(CH3) n n is 0 or 1, Az is a 1-azolyl comprising 1 to 3 nitrogen atoms, Y1 is a covalent bond or NH, Rga is H or C1-4alkyl, Rioa is C1 4alkyl, Z1 is O or S.

Where any of R1, R2, R3 and R4 is or comprises C1.4alkyl, this is preferably CH3.

Where F5 is 2,2-dihalo-1-cyclopropyl both halogens comprised therein signify F, Cl or Br, particularly Cl or Br, especially Cl; both halogens are preferably identical. Any C1-4alkyl substituent of 2,2-dihalo-l -cyclopropyl signifies preferably CH3.

Where R5 is substituted phenyl, it is conveniently mono- or disubstituted. Suitable substituents of phenyl are e.g. C1-4alkyl (CH3), C1 4alkoxy (OCH3) and halogen (F, Cl, Br).

F6 is preferably CH3.

Where any of R7 and F8 is C1 6alkyl, it is conveniently C1 3-alkyl, preferably CH3.

Where any of Rg, R'g, F"9, Rlo, R'10 and Rn1o is C1.4alkyl, it is e.g. CH3.

Where Rg and R10, resp. '6 and RB1o resp. R"g and R'10 are linked together and represent alkylene, such alkylene is conveniently unbranched.

Where any of R11, R12 and R13 is C1.4alkyi, this is preferably CH3.

Where any of R11, R12 and R13 is halogen, this is preferably Cl or Br, particularly Cl.

Where R14 is C1- -4alkyl, this may be straight or branched and signifies for example CH3.

Where Y is hydrocarbon substituted by halogen, such halogen is conveniently Cl or Br.

Where Y is substituted hydrocarbon, the hydrocarbon signifies preferably C1 6alkyl, particularly C1-3alkyl.

Where Y is C1 6alkyl, unsubstituted, it is preferably C3 5-alkyl, particularly unbranched C3 5alkyl or 2-methyl-l-butyl.

Where Y is C3 6alkenyl, it is preferably CH=CH-CH3.

Where Y is C3-6cycloalkyl, it is preferably cyclopropyl or cyclobutyl.

Where Y is a 5-membered heterocycle, this may be aromatic oder hydrogenated; examples of suitable heterocyclic radicals are furyl (e.g. 2-furyl), tetrahydrofuryl, thienyl, isoxazyl and thiadiazolyl. Suitable substituents of such heterocyclic groups are particularly Cl, Br, CH3. Any substituted heterocycle is particularly mono-substituted.

Suitable significances of Az are e.g. pyrazol-1 -yl, imidazol-1 -yl and 1 H,1,2,4-triazol-1-yl.

Where Rga is C1- 4alkyl, this is especially CH3 or C2H5.

R10a signifies preferably CH3.

Suitable examples of compounds of formula I, wherein Yis esterified (A)nZ1H are esters with an alkane carboxylic acids (such as CH3COOH), an alkane sulfonic acid (e.g. CH3SO2OH), a dialkylsulfamic acid (e.g.

(CH3)2NSO2OH), a functional derivative of a carbonic acid etc.

Suitable examples of compounds of formula I, wherein Y is etherified (A)nZ1H are e.g. compounds of formula I, wherein Y is (A)nZ1W, in which A, n and Z1 are as defined above and W is a group selected from C1.8alkyl (particularly CH3, C2H5), C3 6-alkenyl (particularly CH2-CH=CH2), C3 6alkinyl (particularly CH2CCH), C1-4alkoxy-C1-3alkyl, (particularly CH2OCH3), C1.4alkylthio-C1.3-alkyl (particularly CH2SCH3) unsubstituted or substituted by halogen (F, Cl, Br) or a pyranyl group.

Preferred compounds of formula I have one or more of the following features: - the group N(X)-COY is in the 3-position of the thiophene ring - R3 is hydrogen, Cl or Br, -R3 is Br, - R1 is in o-position of N(X)-COY, - R1 and R2 are in o,o'-position of N(X)COY, - R1 and R2 are selected from CH3, Cl, OCH3 and SCH3, - at least one of R1 and R2 is OCH3 or SCH3 - X is CH(R4)COZR8, N(CH3)-COOC1-6alkyl, -R4 is CH3, -Z and Z' are O, - R8 is C1 6alkyl, - R8 is linked with R4 to form CH2CH2, - X is CH(CH3)COOCH3, - X is tetrahydro-2-furanone-3-yl, - X is 2-oxo-3-oxazolidinyl, - X is N(CH3)COOCH3, -Y is CH2OH, CH2OCH3, CH2OC2H5, CH2O-CH2CH=CH2, CH2O-CH2-C=-OH, CH2-OCH2OCH3, OH2O- SO2N(CH3)2, CH2CI, n-C3H7, n-C4H9, cyclopropyl, CH=CH-CH3, 24uryl, benzyl or 2-tetrahydrofuryl.

The invention also provides processes for the production of compounds of formula I, which comprises: a) obtaining a compound of formula la

wherein R'5 has the meaning of R5, defined above, with the exception of allenyl, Y' has the meaning of Y, defined above, with the exception of CH2Z1H,AY1NRgaR1oa and C26epoxyalkylene, and R1, R2, R3, R4, Z1,A,Y1, R9a and Rioa are as defined above by N-acylating a compound of formula II,

wherein R1, R2, R3, R4 and R5 are as defined above, with a compound of formula Ill Y'-CO-E Ill wherein E is halogen or Y' -COO, and Y' is as defined above, b) obtaining a compound of formula la, as defined above, by reacting a compound of formula IV

wherein R1, R2, R3 and Y' are as defined above, with a compound of formula V R'8-CH(R4)-L V wherein R4 and R'5 are as defined above and Lisa leaving group capable of being split off under the reaction conditions, c) obtaining a compound of formula Ib

wherein R1, R2, R3 and Y' are as defined above, and R'5 and R'7 are as defined above, with the exception that R'6 and R'7 are not CH2-CH2, by N-alkylating a compound of formula VI

wherein R1, R2, R3, R'7 and Y' are as defined above, in salt form, with a compound of formula VII R'6-L VII wherein R'8 and L are as defined above, d) obtaining a compound of formula Ic

wherein R1, R2, R3 and Y' are as defined above, by subjecting a compound of formula Vlil

wherein R1, R2, R3 and L are as defined above in any chosen order to os) an N-acylation, using the compound of formula III, defined above as acylating agent and to a a base promoted ring closure, e) obtaining a compound of formula Id

wherein R1, R2, R3, R4 and Y are as defined above, by treating a compound of formula le

wherein R1, R2, R3, R4 and Y are as defined above with CH2O, under the conditions necessary for the conversion of an acetylene group to an allene group, f) obtaining a compound of formula If

wherein R1, R2, R3, Z1 and X are as defined above, by base catalysed alcoholysis of the corresponding esters (hereinafter compounds of formula Ig), g) obtaining a compound of formula Ih

wherein R1, R2, R3, A, R9a, R10a, Y1 and X are as defined above by nucleophilic substitution of the group L in a compound of formula IX

wherein R1, R2, R3, A, X and L are as defined above by reaction with the nucleophile of formula X R9aR10aNY'1 X wherein Rga and R10a are as defined above, Y'1 is H or NH2, h) obtaining a compound of formula li

wherein Y" is C28-epoxyalkylene and X, R1, R2 and F3 are as defined above, by epoxydation of the corresponding alkenyl compounds of formula Ij

wherein R1, R2, R3 and X are as defined above and Y"' is C2 6alkenyl, i) obtaining a compound of formula Ik

wherein R1, R2, R3, R4 and Y are as defined above and Hal is halogen selected from Cl, Br and I, by substituting in a compound of formula le, as defined above, the acetylenic hydrogen by Hal.

The processes of the invention may be carried out in conventional manner.

The N-acylation according to process a) is conveniently effected in a solvent which is inert under the reaction conditions. Suitable solvents are e.g. aromatic or halogenated hydrocarbons such as toluene and chlorobenzene or dichloromethane. Where E is halogen, this signifies preferably chlorine. The presence of a base such as NaHCO3, triethylamine is advantageous, particularly where E is halogen. A suitable reaction temperature is from 0 to 1100C, e.g. 20 to 30"C.

The compounds of formula IV, when reacted according to process b) may be used in free (acid) form or salt form, e.g. the alkali-metal salt form (such as the Na salt). Such salt forms are obtained from the corresponding amides of formula IV in acid form by reaction with an appropriate base, e.g. sodium hydride, in a solvent which is inert under the reaction conditions, such as a dialkylamide of a carboxylic acid or an aromatic hydrocarbon, e.g. dimethylformamide ortoluene. The reaction of the compound of formula IV in salt form with a compound of formula V proceeds smoothly, in general even at room temperature; it is suitably effected by adding a compound of formula V to the above described solution of the compound of formula IV in salt form.

Examples of appropriate meanings of L (compounds of formula V) are halogen, particularly Cl or Br, or alkyl-SO2O (e.g. mesyloxy) resp. aryl-SO2O (e.g. tosyloxy).

Process c) can be effected under similar conditions as indicated for process b), using the compounds of formula VI in salt form (e.g. Na salt form).

The N-acylation of compounds of formula VIII is also suitably effected in a solvent which is inert under the reaction conditions e.g. toluene, chlorobenzene at a temperature of from about 50 to 1200, e.g. 80"C.

The ring closure of process d) (step ii)) may be carried out in a water free medium which is inert under the reaction conditions (e.g. dimethoxyethane, toluene) in the presence of an acid binding agent (e.g. sodium hydride, sodium amide, sodium ethylate). The ring closure may, alternatively, also be carried out in an aqueous/organic two-phase system in the presence of an anorganic base (e.g. sodium hydroxide) and, optionally, of a catalytic amount of a phase transfer catalyst.

The conversion of an acetylene compound to an allene compound by reaction with formaldehyde indicated in process e), is a reaction type known per se (see e.g. EPA 44482). It is conveniently effected in the presence of an amine, e.g. diisopropylamine, and of a suitable catalyst, for example a copper compound such as copper (i) bromide.

The base catalysed alcoholysis according to process f) is conveniently carried out under mild conditions, e.g. at ambient temperature, preferably in a large excess of an alcohol e.g. methanol and in the presence of a catalytic amount of a sodium alcoholate, e.g. sodium methanolate.

The nucleophilic substitution according to process g) is conveniently carried out in a solvent which is inert under the reaction conditions, (e.g. an alcohol, hydrocarbon, nitrile or amide such as ethanol, toluene, acetonitril, dimethylformamide) at a temperature between 20 and 110 , e.g. 80"C. The reaction is suitably carried out in the presence of an acid binding agent, such as an organic tert. base. or an inorganic base, e.g.

K2CO3, or an excess of the compound of formula X.

The epoxydation of compounds of formula Ij according to process h) is suitably carried out with an organic peroxiacid such as m-chloroperbenzoic acid or with a mixture of hydrogen peroxide and an inorganic base, as e.g. sodium hydroxide.

The substitution of the acetylenic hydrogen in a compound of formula le according to process i) is conveniently effected with the aid of the corresponding hypohalogenic acid which is conveniently prepared in situ, in a manner known per sue by reaction of the halogen with an alkali metal hydroxide, such as NaOH.

The compounds of formula I may be recovered from the reaction mixture in which they are formed by working up by established procedures.

As will be appreciated, interconversion of one compound of formula I to another compound of formula I may be carried out in conventional manner.

Compounds of formula I having an aldehyde function may, for example be obtained by conventional manner from the corresponding acetal, such as its ethylenglycol acetal, by acid catalysed hydrolysis (e.g.

withp-toluensulphonic acid in acetone/water). Compounds of formula I having an oximefunction may be obtained by reacting the corresponding aldehyde with the appropriate hydroxylamine. Compounds of formula I having a 2,2-dihalocyclopropyl group may be obtained from the corresponding unsaturated compounds of formula I by reacting with OHOl3 in the presence of sodiumhydroxide. Where appropriate, compounds of formula If may also be esterified to give the corresponding esters.

The compounds of formula 11 and IV, which are new, may be obtained from the appropriate amine of formula Xl

wherein R1, R2 and R3 are as defined above, in conventional manner.

The compounds of formula VI and VIII are obtained in conventional manner from compounds of formula XII

wherein R1, R2 and R3 are as defined above.

The compounds of formula XII are also new.

They may be obtained in conventional manner from the corresponding amines of formula Xl, e.g. by conversion of formula Xl to its diazonium salt by the reaction with sodium nitrite in a hydrochloric acid/water mixture, and reducing the formed diazonium salt in situ with suitable reducing agents, such as Snow2, or preferably Na2S03.

The starting materials and reagents employed in the processes described above are either known or, insofar as they are not known, they may be produced in analogous manner to the processes described herein orto known processes.

The compounds of formula I have useful fungicidal activity, particularly against phytopathogenicfungi, especially against fungi of the class Oomycetes as indicated by a significant fungicidal effect in tests against Phytophthora infestans in potatoes (test description, see Test A hereinafter) and against Plasmopara viticola in grape vine (test description, see Test B hereinafter) with concentrations of 8 ppm to 125 ppm, e.g. 8 ppm, 32 ppm and 125 ppm. In view of the test results they are in particular indicated to be useful against resistant Phytophthora and/or Plasmorpara systems. Representative compounds show also interesting activity against Pythium aphanidermatum after soil treatment with concentrations of 10 to 160 ppm, e.g. 32 and 125 ppm (see Test C hereinafter).The compounds of formula I are essentially non-phytotoxicatfungicidally effective doses in plants subject to such fungi and are further indicated to be of particular interest for combatting fungi by systemic, curative and eradicative action (Test D, E and F hereinafter). They are also indicated to be useful against particularly resistant Phytophthora and Plasmopara systems.

TEST A Fungicidal effect against Phytophthora infestans Young potted potato plants (3-5 leaf stage) are sprayed until the run off with an aqueous spray suspension containing 0.01% to 0.0008% (weight/volume) of a compound of formula I, formulated for example in accordance with Formulation Example i hereinafter. Two hours later, the treated plants are inoculated with a spore suspension of Phytophthora infestans (approx. 105 sporangia/ml) and the plants are then transferred to a tent providing 100% relative atmospheric humidity at an ambient temperature of 16"C and 16 hours daylight/day. Disease control is evaluated 4-5 days later by comparing the treated plants with untreated, similarly inoculated plants.

TEST B Fungicidal effect against Plasm opara viticola Young potted plants of grape vine (3-6 leaf stage) are sprayed until the run off with an aqueous spray suspension containing 0.01% to 0.0008% (weight/volume) of a compound of formula I formulated for example in accordance with Formulation Example I hereinafter. Two hours later, the treated plants are inoculated by spray application to the plant of a spore suspension of about 105 sporangia/ml of Plasmopara viticola and the plants are then transferred to a tent providing 100% relative atmospheric humidity at an ambient temperature of 15-22O (fluctuating over a 24hr-period) and 16 hours daylight/day. Disease control is evaluated 6 days after inoculation by comparing the treated plants with untreated, similarly inoculated plants.

TEST C Soil treatment In vivo, employing Pythium aphanidermatum. The fungus is cuitivated in a sterile mixture of sand and corn meal (93:3 v/v), to which water is added in a ratio of about 1 :4(v/v); cultivation lasts for 4 days at 25 C.

The fungus is then mixed into a semi-sterile mixture of peat and sand which then is treated with a suspension containing the formulated active ingredient to give concentration of 10 to 160 ppm (e.g. 10,40 and 160 ppm) pots of 5 cm diameter which are seeded with cucumber seeds. The planted pots are incubated at 24"C and 60 - 70% relative humidity in an incubation chamber for 7 days, after which disease attack is evaluated by a visual determination of the number of heaithy emerged plants compared with that in untreated, similarly inoculated check pots.

The compounds of the invention of formula I are therefore indicated for use as fungicide.

The invention therefore also provides a method of combatting phytopathogenicfungi, especially of the class Oomycetes, in a locus (plants, seeds or soil) with a fungicidally effective amount of a compound of formula I.

Fungi of the class Oomycetes, against which the method of the invention is indicated to be particularly effective, are those of the genus Phytophthora in plants such as potatoes, tomatoes, tobacco, citrus, cacao, rubber, apples, strawberries, vegetables and ornamentals, e.g. Phytophthora infestans in potatoes and tomatoes; of the genus Plasmopora in plants such as grape vines and sunflower e.g. Plasmopara viticola in grape vines; of the genus Peronospora in plants such as tobacco, e.g. Peronospora tabacina in tobacco; of the genus Pseudoperonospora in plants such as hops and cucumber, e.g. Pseudoperonospora tumuli in hops; of the genus Bremia in plants such as lettuce, e.g.Bremia lactucae in lettuce; of the genus Pythium causing damping-off and root rots in a great number of plants, such as vegetables, sugar beets, ornamentals and conifers, e.g. Pythium aphanidermatum in sugar beets; of the genus Sclerospora in plants such as sorghum and corn, e.g. Sclerospora sorghis in sorghum.

For use in the method of the invention, the amount to be employed will vary depending on such factors as the species of fungi to be combatted, the time and nature of application and the amount and nature of the compound of formula I employed.

However, in general, satisfactory results are obtained when applied to a locus, e.g. on crops orto soil with a dosage rate in the range of from 0.05 to 5 kg, preferably from 0.1 to 3 kg particularly from 0.1 to 0.5kg of a compound of formula I/ha treated locus, the application being repeated as required. When employed as a seed dressing, satisfactory results are obtained when applied at a rate of from about 0.05 to 0.5, preferably about 0.1 to 0.3 g compound of formula l/kg seed.

Depending on the circumstances, the compouns of formula I may be used in association with other pesticides e.g. fungicides, bactericides, insecticides, acaricides, herbicides or plant growth regulating agents in order to enhance their activity or to widen their spectrum or activity.

Fungicides particularly indicated for use in association with a compound of formula I are one or more compounds selected from a copper fungicide, fentin acetate, captan, folpet, mancozeb, maneb, zineb, propineb, cymoxanil, chlorothalonil, dichlofluanid and phosetyl-Al. Particularly useful associations comprise a compound of formula I, a compound selected from cymoxanil and phosetyl-Al and one or two compounds selected from copper4ungicide, captan, folpet, mancozeb, maneb, zineb, propineb, chlorothalonil, fentin acetate.

Examples of copper fungicides suitable for use in association with a compound of formula I are e.g. copper (II) carbonat, copper (Il) sulphate and derivatives thereof such as copper (II) calcium sulphate, Bordeaux mixture and Burgundy mixture; copper (II) oxychloride and derivatives thereof such as copper (II) calcium oxychloride; tetracupric oxychloride, cuprous oxide, cupric hydroxide and also copper complexes such as copper triethanolamine hydroxide of the formula [Cu N(CH2CH2OH)3] -(OH)2, or bis(ethylenediamine)copper (II) sulphate of the formula [Cu(H2NCH2CH2NH2)2]SO4, and mixtures thereof.

Fentin acetate, Chlorothalonil, Captan, Folpet, Mancozeb, Maneb, Zineb, Propineb, Dichlofluanid cymoxanil and phosetyl-Al are common names of known fungicides.

The compounds of formula I are conveniently employed as fungicidal compositions in association with agriculturally acceptable diluents. Such compositions also form part of the present invention. They may contain, aside from a compound of formula I as active agent, other active agents, such as fungicides. They may be employed in either solid or liquid forms e.g. in the form of a wettable powder, an emulsion concentrate, a water dispersible suspension concentrate ("flowable"), a dusting powder, a granulate, a delayed release form, incorporating conventional diluents. Such compositions may be produced in conventional manner, e.g. by mixing the active ingredient with a diluent and optionally other formulating ingredients such as surfactants.

The term diluents as used herein means any liquid or solid agriculturally acceptable material which may be added to the active constituent to bring it in an easier or improved applicable form, respectively to a usable or desirable strength of activity. It can for example be talc, kaolin, diatomaceous earth, xylene, or water.

Particuiarly formulations to be applied in spraying forms such as water dispersible concentrates or wettable powders may contain surfactants such as wetting and dispersing agents, e.g. the condensation product of formaldehyde with naphthalene sulphonate, an alkylarylsulphonate, a lignin sulphonate, a fatty alkyl sulphate, an ethoxylated alkylphenol and an ethoxylated fatty alcohol.

in general, the formulations include from 0.01 to 90% by weight of active agent from 0 to 20% by weight of agriculturally acceptable surfactant and 99.99 to 10% by weight (solid or liquid) diluent(s), the active agent consisting either of at least one compound of formula I or mixtures thereof with other active agents, such as fungicides. Concentrate forms of compositions generally contain between about 2 and 90%, preferably between about 5 and 70% by weight of active agent. Application forms of formulation may for example contain from 0.01 to 20% by weight, preferably from 0.01 to 5% by weight of active agent.

The invention is illustrated by the following examples wherein parts and percentages are by weight and temperatures are in "C.

FORMULATION EXAMPLE I Wettable powder 25 Parts of the compound of Example 1 hereinafter are ground with 3 parts of lauryl sulphate, 5 parts sodium lignin sulphonate, 22 parts of silica and 45 parts of finely divided kaolinite until the mean particle size is below 5 microns. The resulting wettable powder so obtained is diluted with water before use to a concentration of between 0.01% to 5% active agent.

The resulting spray liquor may be applied by foliar spray as well as by root drench application.

FORMULATION EXAMPLE 2 Granules 0.5 Parts by weight of a binder (non-ionic tenside) is sprayed onto 94.5 parts by weight of quartz sand in a tumbler mixer and the whole thoroughly mixed. 5 Parts by weight of the compound of Example 1, hereinafter, are then added and thoroughly mixing continued to obtain a granulate formulation with a particle size in the range of from 0.3 to 0.7 mm. The granules may be applied by incorporation into the soil adjacent the plants to be treated.

FORMULATION EXAMPLE 3 Emulsion concentrate 25 Parts of a compound of formula I, e.g. the compound of Example 1, hereinafter, 65 parts of xylene, 10 parts of the reaction product of an alkylphenol with ethyleneoxide and calciumdodecylbenzene sulphonate are thoroughly mixed until a homogeneous solution is obtained. The resulting emulsion concentrate is diluted with water before use.

FINAL PRODUCTS EXAMPLE 1 N- (2-Buten 0 yl)-N- (2,4-dim eth ylthien-3-yl)-alaninemeth ylester To 6.39 g (0.03 mol) of N-(2,4-dimethylthien-3-yl-alaninemethylester, 4.15 g (0.03 mol) of K2CO3, 10 ml of water and 100 ml of dichloromethane are added without cooling 3.14 g (0.03 mol) 2-butenoyl chloride.

After the exothermic reaction has subsided, stirring is continued for a further hour. Then the organic layer is separated, washed with water, dried over anhydrous Na2SO4 and evaporated in vacuo, to yield the title compound, nD = 1.5356.

EXAMPLE 2 N-fMethoxyacetyll-N-(2, 4-dimeth ylthien-3-yll-alanine-m eth ylester 5 g (0.025 mol) of N-(2,4-dimethylthien-3-yl)-methoxyacetamide in 45 ml of dry dimethylformamide (=DMF) are added dropwise to a well stirred suspension of 0.9 g (0.03 mol) of sodium hydride (80% dispersion in mineral oil) in 12 ml of dry DMF.

After the exothermic reaction (33 ) has subsided the solution of the sodium salt is allowed to reach room temperature and then treated with 4.17 g (0.025 mol) of methyl-2-bromopropionate.

After the addition is completed the reaction mixture is heated at 500 for three hours and then evaporated to dryness. The residue is taken up with 100 ml fo diethyl ether and filtered. The residual oil left on evaporating the filtrate is chromatographed on a silica gel column. Elution with diethylether-hexane 1: 5 affords the title compound, having a m.p. of 42-43".

EXAMPLE 3 Following the procedure of either Example 1 or 2 but employing the appropriate compounds of formulae II and Ill (wherein Y' is Cl) or of formulae IV and V (wherein L is Br) resp.

A. The following compounds of formula Im are obtained:

Ex. (Formula Im)Y Ex. (Formula Im)Y 3.1 CH2CH2CH3 (nD =1.5128) 3.6 CH2OCH2CH=CH2 3.7 CH2OCH2CCH 3.2 > (nD =1.5242) 3.8 CH2-1 ,2,4-triazol-l-yl 3.3 / (nD =1.5570) 3.9 CH2-OSO2 CH3 (m.p. 91-93) 3.9 CH1-OSO1 CH3 (m.p. 91-93") 3.4 ç 3.10 CH2OC2H5 (b.p. 149-1510/0.02Torr) 3.5 CH2O-COCH3 (nD =1.5090) B. The following compounds of formula In

are obtained:

Ex. (Formula In) X Ex. (Formula In) X 3.11 CH(CH3)CN (nD =1.5263) 3.16 CH(CH3)-CONHOCH3 3.12 CH(OH3)-C-=CH (nD =1.5374) 3.17 CH2-C6H5 (nD =1.5647) 3.13 CH(CHS)-CH=CH2 (nD =1.5297) 3.18 3.14 CH2COOCH3 (nD = 1.5228 -CH 0Y 3.15 CH(CH3)-C\I$ C. The following compounds of formula lo

are obtained: Ex. (Formula lo) Y Ex. (Formula lo) Y 3.19 CH2OCH3 m.p.131-134 3.23 2-furyl 3.20 CH2OC2H5 3.24 CH2-SOH3 3.21 CH2CH2CH2CH3 (nD =1.5338) 3.25 CH2-C6H5 3.22 cyclopropyl (very sticky 3.26 CH2CI (m.p.117-119 ) honey) D.The following compounds of formula Ip

Ex. (Formula Ip) R1 R2 R3 m.p./b.p./nD 3.27 CH3 OCH3 H 75-76" 3.28 CH3 OCH3 Br 56-58" 3.29 SOH3 CH3 H 142 /0.001 Torr 3.30 H CH3 H 3.31 Br CH3 Br 3.32 CH3 CH3 Br 3.33 SCH3 CH3 Br 85" 3.34 O2H5 C2H5 H nD = 1.5204 3.35 O2H5 CH3 CH3 3.36 CH3 CH3 CH3 nD = 1.5193 3.37 CH3 OCH3 Cl 3.38 CH3 CH3 Cl 3.39 CH3 CH3 COOCH3 82-83" 3.40 COOCH3 CH3 H 53-55" E.The compound of formula I wherein Xis tetrahydro-2-furanone-3-yl and Y is CH2OCH3: 3.41 R1 = 2-SOH3, R2 = 4-CH3 and R3 = H (m.p. 120") 3.42 R1 = 2-SCH3, R2 = 4-CH3 and R3 = 5-Br (m.p. 990) 3.43 R1 = 2-SCH3, R2 = 4-CH3 and R3 = 5-Cl (m.p. 102-103") F. The following compounds of formula I wherein X is CH(CH3)COOCH3 and Y is n-propyl: 3.44 R1 = 2-CH3, R2 = 4-OCH3 and R3 = H 3.45 R1 = 2-CH3, R2 = 4-OCH3 and R3 = 5-CI 3.46 R1 = 2-CH3, R2 = 4-OCH3 and R3 = 5-Br.

EXAMPLE 4 Methyl 2-(2,4-dimeth ylthien-3-yl)-2-(methoxyacetyl)- 1-methyl-hydrazinecarboxylate (process c) 0.73 g (0.03 mol) NaH and 7.95 (0.03 mol) methyl 2-(2,4-dimethylthien-3-yl)-2-(methoxyacetyl)hydrazinecarboxylate in 100 ml dry toluene are heated under reflux for 3 hours. The reaction mixture is then, together with 9.52 g (0.067 mol) CH3J, transferred into a sealed cylinder and heated 20 hours at 1100. The mixture is, after cooling, diluted with diethylether, washed with water, dried and evaporated to yield the title compound.

EXAMPLE 5 2-Methoxy-N-(2,4-dimethylthien-3-yl)-N-2-oxo-3-oxazolidinyl)-acetamide (process d) Step of A solution of 24.85 g (0.1 mol) 2-chloroethyl 2-(2,4-dimethylthien-3-yl)-hydrazinecarboxylate in 150 ml dry toluene is treated with 10.85 g (0.1 mol) methoxyacetylchloride, and the mixture is heated to 80" for 2 hours, vigorous HCI-formation starting at approx. 50"O. The mixture is cooled to room temperature, washed subsequently with water, 10% aqueous NaHCO3-solution and water, dried over MgSO4 and evaporated in vacuo to yield the compound 2-chloroethyl-2-(methoxyacetyl)-2-(2,4-dimethylthien-3-yl)- hydrazinecarboxylate, which may be directly reacted with NaOCH3 (see Step ,3).

Step ss A solution of 32.05 g (0.1 mol) of 2-chloroethyl 2-(methoxyacetyl)-2-(2,4-dimethylthien-3-yl)- hydrazinecarboxylate in 150 ml methanol is slowly added to a solution of 5.4 g (0.1 mol) sodium methanolate in 50 ml methanol at room temperature. The mixture is stirred for 1 hour at room temperature, and then concentrated in vacuo. The residue is dissolved in dichloromethane, washed with water, dried over Na2SO4, and the solvent evaporated in vacuo to yield the title compound.

EXAMPLE 6 As described in Examples, but using the appropriate starting materials, the following compounds of the formula Iq are prepared.

EXAMPLE 7 2-Methoxy-N-{2,4-dimethylthien-3-yl)-N-(1,2-pentadien-4-yl)-acetamide (process e) To a solution of 10.0 g (0.04 mol) 2-methoxy-N-(2,4-dimethylthien-3-yl)-N-(1-butin-3-yl)acetamide in 80 ml dioxan are added 1.92 g (0.064 mol) paraformaldehyde, 4.85 g (0.048 mol) diisopropylamine and 1.89 g cuprous bromide and the mixture heated to reflux for 6 hours. The mixture is cooled to room temperature, filtered, evaporated in vacuo, the residue partitioned between ethylacetate and 1M aqueous citric acid solution, the organic phase separated, washed subsequently with a saturated aqueous NaHCO3-solution, water, is dried over MgSO4 and the solvent evaporated in vacuo.

EXAMPLE 8 N-(h ydroxyacetyl)-N-(2, 4-dimeth ylthien-3-yl)-alanine-methylester (process fl A solution of 5.4 g (0.1 mol) sodium methanolate in 50 ml dry methanol is slowly added to a mixture of 62.6 g (0.2 mol) N-(acetoxyacetyl)-N-(2,4-dimethylthien-3-yl)-alanine methylester (=Ex. 3.5) in 750 ml dry methanol with stirring. The mixture is stirred for two hours at room temperature, then freed of solvent in vacuo. The residue is poured into water and the pH adjusted to pH 2 with 2N aqueous HCI. The product is extracted with CHC13, the organic phase washed with water, dried over Na2SO4, and evaporated in vacuo to yield the title compound, m.p. 69-70".

EXAMPLE 9 N- (2,2- dim eth ylh ydrazin o-acetyl)-N-(2,4-dimethylthien-3-yl)-alanine-meth ylester (process g) A mixture of 8.5 g (0.02 mol) N-[(4-methylphenyl)-sulphonyloxyacetyl]-N-(2,4-dimethylthien-3-yl)-alanine- methylester (=Ex. 3.9) and 2.4 g (0.04 mol), 1,1-dimethylhydrazine in 150 ml ethanol is refluxed forfour hours, when evaporated in vacuo, the residue taken up in dichloromethane, washed subsequently with water, aqueous 1N HCI and water, dried over MgSO4, and evaporated in vacuo to yield the title compound.

EXAMPLE 10 N-(2,3-Oxidobutano yl)-N- (2, 4-dimeth ylthien-3-yl)-alanin e-methylester (process h) 3.9 g (13.9 mmol) N-(2-butenoyl-N-2,4-dimethylthien-3-yl)-alanine-methylester in 40 ml methanol and 3.5 g hydrogen peroxide (40% solution in water) are cooled to 15 with stirring, while a solution of 0.28 g (7 mmol) sodium hydroxide in 12 ml water is slowly added. The mixture is stirred for one hour at 20 , then poured into 500 ml water, extracted with dichloromethane, the organic phase washed with water, dried over Na2SO4, and the solvent evaporated in vacuo to yield the title compound, (nD = 1.5243).

EXAMPLE 11 2-Meth oxy-N-(2,4-dimeth ylthien-3-yl)-N-(14o do4-butin-3-yl)-acetamide (process i) A mixture of 2.51 g (0.01 mol) 2-methoxy-N-(2,4-dimethylthien-3-yl)-N-(1 -butin-3-yl)-acetamide. 1.3 g (0.0325 mol) NaOH and 100 ml methanol are cooled with stirring to 10 , and 2.65 g (0.01 mol) powdered iodine is then slowly added. The mixture is then stirred for 3 hours at room temperature, neutralized with methanolic HCI-solution, and the solvent evaporated to yield, after chromatography, the title compound.

EXAMPLE 12 N-(Dimethylaminosulohonyloxyacetyl)-N-(2,4-dimethylthien.3-yl)-alaninemethy/ester 8.13 g (0.03 mol) N-(hydroxyacetyl)-N-(2,4-dimethylthien-3-yl)-alanine-methylester is added in portions to a slurry of 1.05 g (0.035 mol) sodium hydride (80% in mineral oil) in 50 ml dry dimethoxyethane with stirring at 10-15" under a blanket of nitrogen. The mixture is stirred at room temperature for half an hour, and then are added 4.3 g (0.03 mol) dimethylsulphamic acid chloride. The mixture is stirred for 18 hours at 50", then cooled to room temperature, filtered, concentrated in vacuo, the residue taken up in CHC13, washed thoroughly with water, dried over MgSO4 and evaporated in vacuo to yield the title compound.

INTERMEDIATES EXAMPLE 13 N-(2,4-Dimeth ylthien-3-yl)-methoxyacetamide To 12.7 g (0.1 mol) of 2,4-dimethyl-3-aminothiophene, 13.84 g (0.1 mol) of K2CO3, 50 ml of water and 160 ml of methylene chloride are added without cooling 10.8 g (0.1 mol) of methoxyacetyl chloride.

After the exothermic reaction has subsided stirring is continued for a further hour. Then the organic layer is separated, washed with water, dried over an hydros Na2SO4 and evaporated in vacuo. The crystalline residue is triturated with diethyl ether, yielding the analytically pure title compound, m.p. 62-63".

EXAMPLE 14 N- (2, 4- dim eth ylthien-3-yl)-alanine-meth ylester A mixture of 12.7 g (0.1 mol) 2,4-dimethyl-1-3-aminothiophene, 13.84 g (0.1 mol) K2CO3 and 16.7 g (0.1 mol) methyl 2-bromopropionate in 200 ml dimethylformamide are stirred over night at 80". The mixture is cooled, filtered, evaporated, the residue dissolved in dichloromethane, washed with water, dried and evaporated to yield the title compound, m.p. 33-34".

EXAMPLE 15 2,4-Dimeth yl-3-amino thiophene To 890 ml (3 mols) of sodium bis(2-methoxyethoxy)aluminium hydride (70% solution in toluene) and 600 ml of dry toluene is added dropwise with vigorous stirring a solution of 100 g (0.58 mols) of methyl 3-amino-4-methylthiophene-2-carboxylate (DAS 1,083,830) in 700 ml of dry toluene at such a rate that the temperature does not rise above 55".

After the addition is complete stirring is continued for a further 30 minutes and the reaction mixture then cautiously added in small portions at 0"to 1200 ml of 20% potassium hydroxide solution.

The toluene layer is separated, dried (MgSO4) and evaporated in vacuo. The residual brown liquid is distilled under diminished pressure, affording the analytically pure title compound, b.p. 49-52"/0.01 Torr.

EXAMPLE 16 Methyl 2-12,4-dim eth ylthien-3-yll-hydrazin ecarb oxyla te To a mixture of 35.5 g (0.25 mol) 2,4-dimethylthien-3-yl-hydrazine, 27.6 g (0.35 mol) pyridine and 83 ml water are added within 15 minutes at room temperature 23.6 g (0.25 mol) methyl chloroformiate. 83 ml Water are further added, and the mixture is stirred for 3 hours at room temperature. After the addition of 300 ml diethylether, the mixture is acidified with 2N HCI, the organic phase separated, washed with water, dried and concentrated.

EXAMPLE 17 Analogous to Example 16, but using 2-chloroethyl chloroformiate instead of methyl chloroformiate, 2-chloroethyl 2-(2,4-dimethylthien-3-yl)-hydrazinecarboxylate is obtained.

Claims

1. Acompound of formula I

wherein R1, R2 and R3, independently, are H, C14alkyl, C14-alkoxy, C14alkylthio or halogen selected from F, Cl and Br, Xis selected from a group -CH(R4)-Rs or a group -N(R6)-COOR7, in which R4 is H or C1-4alkyl, R5 is COZR8, OO-N(R6)OR10, CN, CHO,

CC-R14, allenyl; or is 2,2-dihalo-1-cyclopropyl unsubstituted or substituted by Ca 4-alkyl; or is phenyl unsubstituted or substituted, R6 is C1-3alkyl, R7 is Ca 6alkyl, C3 6alkenyl or C3.5alkinyl, whereby R6 and R7 may be linked together to form CH2-CH2; and wherein Z and Z' are 0 or S R8 is C1 6alkyl, C3-6alkenyl, or C3-6alkinyl, and whereby ZR8 may be linked with R4 to form the bridge ZCH(R15)-CH2 in which Z is as defined above and R15 is H or CH3; R8, R'g and R"g are H or C1-4alkyl, R10, R'10 and R"1O are C1-4alkyl, whereby Rg may be linked with R10, resp.

R'g with R'1O, resp. R"9 with R"o and signify alkylene, to form a 5- or 6-membered heterocyclic ring, R11, R12, R13, independently, are H, C1-4-alkyl, or halogen selected from F, Cl or Br, R14 is H, C14alkyl or halogen selected from Cl, Br or I, and YisH; a hydrocarbon selected from C1.8alkyl, C2 6alkenyl and C2-6alkinyl unsubstituted or substituted by halogen, selected from F, Cl or Br, or by CN; C2.6epoxyalkylene; C3 6cycloalkyl; a 5-membered heterocyclic ring comprising 1 to 3 heteroatoms selected from 0, S and N, which in unsubstituted or substituted by C1.4alkyl or halogen selected from F, Cl or Br; (A)-Az; (A)n-Yi-NR8aR1oa; (A)nZ1H and esters or ethers thereof; benzyl unsubstituted or substituted, in which A is CH2 or CH(CH3) n is 0 or 1, Az is a 1-azolyl comprising 1 to 3 nitrogen atoms, Y1 is a covalent bond or NH, R9a, is H or C1-4alkyl, R10a is C, 4alkyl, Z1 isOorS.

2. A compound of Claim 1, wherein -N(X)CCIY is in the 3-position of the thiophene ring, R1 and R2 are in 2,4-position of the thiophene ring and are selected from CH3, Cl, OCH3 and SCH3 and R3 is H, Cl or Br.

3. A compound of Claim 2, wherein X is CH(CH3)COOCH3 or tetrahydro-2-furanone-3-yl.

4. A compound of Claim 2, wherein X is 2-oxo-3-oxazolidinyl or N(CH3)COOCH3.

5. A compound of Claim 3 or 4, wherein Y is CH2OH, CH2OCH3, CH2OC2H5, CH2OCH2CH =CH2, CH2OCH2C=CH, CH2OCH2OCH3, CH2OSO2N(CH3)2, CH2CI, n-C3H7, n-C4Hg, cyclopropyl, CH=CH-CH3, 2-furyl, benzyl or 2-tetrahydrofuryl.

6. A compound of Claim 5, wherein X is CH(CH3)COOCH3, R1 is 2-SCH3, R2 is 4-CH3 and R3 is H.

7. A compound of Claim 5, wherein X is CH(CH3)COOCH3, R1 is 2-CH3, R2 is 4-OCH3 and R3 is 5-Br.

8. A compound of Claim 5, wherein X is CH(CH3)COOCH3, R, is 2-SCH3, R2 is 4-CH3 and R3 is 5-Br.

9. A method of combatting phytopathogenic fungi which comprises applying to the locus thereof a fungicidally effective amount of a compound claimed in any one of Claims 1 to 8.

10. Afungicidal composition comprising a compound of formula las defined in any one of Claims 1 to 8 in association with an agriculturally acceptable diluent.

11. Processes for the production of a compound of formula I defined in Claim I, which comprise a) obtaining a compound of formula la

wherein R'5 has the meaning of R5, defined above, with the exception of allenyl, Y' has the meaning of Y, defined above, with the exception of CH2Z1H,AY1NR9aR10a and C26epoxyalkylene, and R1, R2, R3, R4, Z1,A,Y1, R10a are as defined above by N-acylating a compound of formula II,

wherein R1, R2, R3, R4 and R5 are as defined above, with a compound of formula Ill Y'-CO-E Ill wherein E is halogen orY'-COO, and Y' is as defined above, b) obtaining a compound of formula la, as defined above, by reacting a compound of formula IV

wherein R1, R2, R3 and Y' are as defined above, with a compound of formula V R'5-OH(R4)-L V wherein R4 and R'5 are as defined above and L is a leaving group capable of being split off under the reaction conditions, c) obtaining a compound of formula Ib

wherein R1, R2, R3 and Y' are as defined above, and R'8 and R'7 are as defined above, with the exception that R'8 and R'7 are not CH2-CH2, by N-alkylating a compound of formula VI

wherein Rr, R2, R3, R'7 and Y' are as defined above, in salt form, with a compound of formula VII R'6-L VII wherein R'e and L are as defined above, d) obtaining a compound of formula IC

wherein R1, R2, R3 and Y' are as defined above, by subjecting a compound of formula VIII

wherein R1, R2, R3 and L are as defined above in any chosen order to a) an N-acylation, using the compound of formula Ill, defined above as acylating agent and to ) a base promoted ring closure, e) obtaining a compound of formula Id

wherein R1, R2, R3, Z1 and X are as defined above, by base catalysed alcoholysis of the corresponding esters, g) obtaining a compound of formula Ih

wherein R1, R2, R3, A, R9a, Rioa, Y1 and X are as defined above by nucleophilic substitution of the group L in a compound of formula IX

wherein R1, R2, R3, A, X and L are as defined above by reaction with the nucleophile of formula X R6aR10aNY'1 X wherein R > a and Rioa are as defined above, Y'1 is H or NH2, h) obtaining a compound of formula li wherein Y" is C2.5epoxyalkylene

and X, R1, R2 and R3 are as defined above, by epoxydation of the corresponding alkenyl compounds, i) obtaining a compound of formula Ik

12. A process for the production of a compound of formula I substantially as hereinbefore described with reference to any one of the Examples 1 to 12.

13. A compound of formula I whenever produced by a process according to Claim 11 or 12.