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GB2118189B - An automatic synthesizer for dna - Google Patents

An automatic synthesizer for dna

Info

Publication number
GB2118189B
GB2118189B GB08305205A GB8305205A GB2118189B GB 2118189 B GB2118189 B GB 2118189B GB 08305205 A GB08305205 A GB 08305205A GB 8305205 A GB8305205 A GB 8305205A GB 2118189 B GB2118189 B GB 2118189B
Authority
GB
United Kingdom
Prior art keywords
dna
automatic synthesizer
synthesizer
automatic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB08305205A
Other versions
GB8305205D0 (en
GB2118189A (en
Inventor
Yoshiaki Ohsugi
Kenichi Miyoshi
Tohru Fuwa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shimadzu Corp
Wakunaga Pharmaceutical Co Ltd
Original Assignee
Shimadzu Corp
Wakunaga Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP3088782A external-priority patent/JPS58148896A/en
Priority claimed from JP57030889A external-priority patent/JPS58148898A/en
Priority claimed from JP3088882A external-priority patent/JPS58148897A/en
Priority claimed from JP3991782A external-priority patent/JPS58157799A/en
Application filed by Shimadzu Corp, Wakunaga Pharmaceutical Co Ltd filed Critical Shimadzu Corp
Publication of GB8305205D0 publication Critical patent/GB8305205D0/en
Publication of GB2118189A publication Critical patent/GB2118189A/en
Application granted granted Critical
Publication of GB2118189B publication Critical patent/GB2118189B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00281—Individual reactor vessels
    • B01J2219/00286—Reactor vessels with top and bottom openings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00389—Feeding through valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00423—Means for dispensing and evacuation of reagents using filtration, e.g. through porous frits
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/0059—Sequential processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B01J2219/00689—Automatic using computers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00695—Synthesis control routines, e.g. using computer programs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
GB08305205A 1982-02-26 1983-02-24 An automatic synthesizer for dna Expired GB2118189B (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP3088782A JPS58148896A (en) 1982-02-26 1982-02-26 Automated microsynthesizer for dna or the like
JP57030889A JPS58148898A (en) 1982-02-26 1982-02-26 Dna synthesizer
JP3088882A JPS58148897A (en) 1982-02-26 1982-02-26 Automated dna microsynthesizer
JP3991782A JPS58157799A (en) 1982-03-12 1982-03-12 DNA synthesizer

Publications (3)

Publication Number Publication Date
GB8305205D0 GB8305205D0 (en) 1983-03-30
GB2118189A GB2118189A (en) 1983-10-26
GB2118189B true GB2118189B (en) 1985-05-15

Family

ID=27459338

Family Applications (1)

Application Number Title Priority Date Filing Date
GB08305205A Expired GB2118189B (en) 1982-02-26 1983-02-24 An automatic synthesizer for dna

Country Status (3)

Country Link
CA (1) CA1199776A (en)
DE (1) DE3306770A1 (en)
GB (1) GB2118189B (en)

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7349158B2 (en) 2002-09-12 2008-03-25 Cyvera Corporation Diffraction grating-based encoded micro-particles for multiplexed experiments
US7375890B2 (en) 2002-09-12 2008-05-20 Cyvera Corporation Method of manufacturing of a diffraction grating-based optical identification element
US7399643B2 (en) 2002-09-12 2008-07-15 Cyvera Corporation Method and apparatus for aligning microbeads in order to interrogate the same
US7433123B2 (en) 2004-02-19 2008-10-07 Illumina, Inc. Optical identification element having non-waveguide photosensitive substrate with diffraction grating therein
US7441703B2 (en) 2002-08-20 2008-10-28 Illumina, Inc. Optical reader for diffraction grating-based encoded optical identification elements
US7508608B2 (en) 2004-11-17 2009-03-24 Illumina, Inc. Lithographically fabricated holographic optical identification element
US7602952B2 (en) 2004-11-16 2009-10-13 Illumina, Inc. Scanner having spatial light modulator
US7604173B2 (en) 2004-11-16 2009-10-20 Illumina, Inc. Holographically encoded elements for microarray and other tagging labeling applications, and method and apparatus for making and reading the same
US7619819B2 (en) 2002-08-20 2009-11-17 Illumina, Inc. Method and apparatus for drug product tracking using encoded optical identification elements
US7623624B2 (en) 2005-11-22 2009-11-24 Illumina, Inc. Method and apparatus for labeling using optical identification elements characterized by X-ray diffraction
US7659983B2 (en) 2003-01-22 2010-02-09 Electronics And Telecommunications Resarch Institute Hybrid random bead/chip based microarray
US7830575B2 (en) 2006-04-10 2010-11-09 Illumina, Inc. Optical scanner with improved scan time
US7872804B2 (en) 2002-08-20 2011-01-18 Illumina, Inc. Encoded particle having a grating with variations in the refractive index
US7901630B2 (en) 2002-08-20 2011-03-08 Illumina, Inc. Diffraction grating-based encoded microparticle assay stick
US7900836B2 (en) 2002-08-20 2011-03-08 Illumina, Inc. Optical reader system for substrates having an optically readable code
US7923260B2 (en) 2002-08-20 2011-04-12 Illumina, Inc. Method of reading encoded particles
US8081792B2 (en) 2003-08-20 2011-12-20 Illumina, Inc. Fourier scattering methods for encoding microbeads and methods and apparatus for reading the same
US8470605B2 (en) 2002-09-12 2013-06-25 Illumina, Inc. Optical reader for reading encoded microparticles

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2544720B1 (en) * 1983-04-19 1987-11-27 California Inst Of Techn IMPROVED INSTALLATION AND METHOD FOR THE SYNTHESIS OF CHEMICAL COMPOUNDS, IN PARTICULAR OLIGONUCLEOTIDES
JPS6054398A (en) * 1983-09-02 1985-03-28 Nippon Zeon Co Ltd polynucleotide synthesizer
JPS6130597A (en) * 1984-07-20 1986-02-12 Nippon Zeon Co Ltd polynucleotide synthesizer
AU1999092A (en) * 1991-05-24 1992-12-30 Walter Gilbert Method and apparatus for rapid nucleic acid sequencing
US5368823A (en) * 1993-02-11 1994-11-29 University Of Georgia Research Foundation, Inc. Automated synthesis of oligonucleotides
US5641459A (en) * 1995-08-17 1997-06-24 Pharmacia Biotech Ab Machine for synthesizing oligonucleotides
US20030153006A1 (en) * 2000-05-22 2003-08-14 Masao Washizu Novel method for forming polymer pattern
WO2007065807A2 (en) * 2005-12-06 2007-06-14 F. Hoffmann-La Roche Ag Automated solid phase synthesis
CN111943999B (en) * 2020-07-31 2021-12-17 北京擎科生物科技有限公司 DNA synthesizer

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3531258A (en) * 1967-11-16 1970-09-29 Us Health Education & Welfare Apparatus for the automated synthesis of peptides
JPS4820995B1 (en) * 1968-07-08 1973-06-25
FR2485003A1 (en) * 1980-06-23 1981-12-24 Clin Midy AUTOMATED APPARATUS FOR USE IN THE SYNTHESIS OF SOLID-STATE PEPTIDES

Cited By (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7619819B2 (en) 2002-08-20 2009-11-17 Illumina, Inc. Method and apparatus for drug product tracking using encoded optical identification elements
US7923260B2 (en) 2002-08-20 2011-04-12 Illumina, Inc. Method of reading encoded particles
US7901630B2 (en) 2002-08-20 2011-03-08 Illumina, Inc. Diffraction grating-based encoded microparticle assay stick
US7872804B2 (en) 2002-08-20 2011-01-18 Illumina, Inc. Encoded particle having a grating with variations in the refractive index
US7441703B2 (en) 2002-08-20 2008-10-28 Illumina, Inc. Optical reader for diffraction grating-based encoded optical identification elements
US8614852B2 (en) 2002-08-20 2013-12-24 Illumina, Inc. Elongated microparticles having an optically detectable code configured to at least one of reflect or filter light
US8498052B2 (en) 2002-08-20 2013-07-30 Illumina, Inc. Composition including an item and an encoded optical substrate and a method for identifying an item
US7900836B2 (en) 2002-08-20 2011-03-08 Illumina, Inc. Optical reader system for substrates having an optically readable code
US8333325B2 (en) 2002-08-20 2012-12-18 Illumina, Inc. Optical reader system for substrates having an optically readable code
US7375890B2 (en) 2002-09-12 2008-05-20 Cyvera Corporation Method of manufacturing of a diffraction grating-based optical identification element
US7349158B2 (en) 2002-09-12 2008-03-25 Cyvera Corporation Diffraction grating-based encoded micro-particles for multiplexed experiments
US8470605B2 (en) 2002-09-12 2013-06-25 Illumina, Inc. Optical reader for reading encoded microparticles
US7898735B2 (en) 2002-09-12 2011-03-01 Illumina, Inc. Methods and systems for writing an optical code within or on a fiber substrate
US7399643B2 (en) 2002-09-12 2008-07-15 Cyvera Corporation Method and apparatus for aligning microbeads in order to interrogate the same
US7659983B2 (en) 2003-01-22 2010-02-09 Electronics And Telecommunications Resarch Institute Hybrid random bead/chip based microarray
US8049893B2 (en) 2003-01-22 2011-11-01 Illumina, Inc. Methods of identifying analytes and using encoded particles
US7843567B2 (en) 2003-01-22 2010-11-30 Illumina, Inc. Methods of identifying an analyte and nucleic acid analysis
US9268983B2 (en) 2003-01-22 2016-02-23 Illumina, Inc. Optical system and method for reading encoded microbeads
US8081792B2 (en) 2003-08-20 2011-12-20 Illumina, Inc. Fourier scattering methods for encoding microbeads and methods and apparatus for reading the same
US8565475B2 (en) 2003-08-20 2013-10-22 Illumina, Inc. Optical system and method for reading encoded microbeads
US7791802B2 (en) 2004-02-19 2010-09-07 Illumina, Inc. Optical identification element having a non-waveguide substrate
US7433123B2 (en) 2004-02-19 2008-10-07 Illumina, Inc. Optical identification element having non-waveguide photosensitive substrate with diffraction grating therein
US7604173B2 (en) 2004-11-16 2009-10-20 Illumina, Inc. Holographically encoded elements for microarray and other tagging labeling applications, and method and apparatus for making and reading the same
US7602952B2 (en) 2004-11-16 2009-10-13 Illumina, Inc. Scanner having spatial light modulator
US7796333B2 (en) 2004-11-17 2010-09-14 Illumina, Inc. Encoded microparticles and a method for fabricating
US7508608B2 (en) 2004-11-17 2009-03-24 Illumina, Inc. Lithographically fabricated holographic optical identification element
US7623624B2 (en) 2005-11-22 2009-11-24 Illumina, Inc. Method and apparatus for labeling using optical identification elements characterized by X-ray diffraction
US7830575B2 (en) 2006-04-10 2010-11-09 Illumina, Inc. Optical scanner with improved scan time

Also Published As

Publication number Publication date
CA1199776A (en) 1986-01-28
GB8305205D0 (en) 1983-03-30
DE3306770A1 (en) 1983-09-15
GB2118189A (en) 1983-10-26

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19990224