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GB202406051D0 - Segmented poly(a) tails - Google Patents

Segmented poly(a) tails

Info

Publication number
GB202406051D0
GB202406051D0 GBGB2406051.9A GB202406051A GB202406051D0 GB 202406051 D0 GB202406051 D0 GB 202406051D0 GB 202406051 A GB202406051 A GB 202406051A GB 202406051 D0 GB202406051 D0 GB 202406051D0
Authority
GB
United Kingdom
Prior art keywords
tails
segmented poly
segmented
poly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
GBGB2406051.9A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oxford University Innovation Ltd
Original Assignee
Oxford University Innovation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oxford University Innovation Ltd filed Critical Oxford University Innovation Ltd
Priority to GBGB2406051.9A priority Critical patent/GB202406051D0/en
Publication of GB202406051D0 publication Critical patent/GB202406051D0/en
Priority to PCT/EP2025/061920 priority patent/WO2025229103A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/50—Vector systems having a special element relevant for transcription regulating RNA stability, not being an intron, e.g. poly A signal

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
GBGB2406051.9A 2024-04-30 2024-04-30 Segmented poly(a) tails Pending GB202406051D0 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GBGB2406051.9A GB202406051D0 (en) 2024-04-30 2024-04-30 Segmented poly(a) tails
PCT/EP2025/061920 WO2025229103A1 (en) 2024-04-30 2025-04-30 Segmented poly(a) tails

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB2406051.9A GB202406051D0 (en) 2024-04-30 2024-04-30 Segmented poly(a) tails

Publications (1)

Publication Number Publication Date
GB202406051D0 true GB202406051D0 (en) 2024-06-12

Family

ID=91375581

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB2406051.9A Pending GB202406051D0 (en) 2024-04-30 2024-04-30 Segmented poly(a) tails

Country Status (2)

Country Link
GB (1) GB202406051D0 (en)
WO (1) WO2025229103A1 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015005324A1 (en) 2013-07-09 2015-01-15 京セラ株式会社 Mobile communication system, user terminals and network devices
WO2016005324A1 (en) 2014-07-11 2016-01-14 Biontech Rna Pharmaceuticals Gmbh Stabilization of poly(a) sequence encoding dna sequences
WO2016091391A1 (en) 2014-12-12 2016-06-16 Curevac Ag Artificial nucleic acid molecules for improved protein expression
WO2020074642A1 (en) 2018-10-11 2020-04-16 Ethris Gmbh Plasmid containing a sequence encoding an mrna with a segmented poly(a) tail

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020532961A (en) * 2017-08-15 2020-11-19 インテリア セラピューティクス，インコーポレイテッド Stable nucleic acid encoding messenger ribonucleic acid (mRNA)
CN117701602A (en) * 2022-08-26 2024-03-15 深圳瑞吉生物科技有限公司 Multi-segmented PolyA polynucleotides stably existing in host cells and application thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015005324A1 (en) 2013-07-09 2015-01-15 京セラ株式会社 Mobile communication system, user terminals and network devices
WO2016005324A1 (en) 2014-07-11 2016-01-14 Biontech Rna Pharmaceuticals Gmbh Stabilization of poly(a) sequence encoding dna sequences
WO2016091391A1 (en) 2014-12-12 2016-06-16 Curevac Ag Artificial nucleic acid molecules for improved protein expression
WO2020074642A1 (en) 2018-10-11 2020-04-16 Ethris Gmbh Plasmid containing a sequence encoding an mrna with a segmented poly(a) tail

Non-Patent Citations (14)

* Cited by examiner, † Cited by third party
Title
ALANINE, D. G. W ET AL.: "Human Antibodies that Slow Erythrocyte Invasion Potentiate Malaria-Neutralizing Antibodies", CELL, vol. 178, no. 1, 2019, pages 216 - 228
BAER, B. W.KORNBERG, R. D: "The protein responsible for the repeating structure of cytoplasmic poly(A)-ribonucleoprotein", JOURNAL OF CELL BIOLOGY, vol. 96, no. 3, 1983, pages 717 - 721
CHANG, H. ET AL., MOLECULAR CELL RESOURCE TAIL-SEQ: GENOME-WIDE DETERMINATION OF POLY(A) TAIL LENGTH AND 3 0 END MODIFICATIONS, 2014
DEO, R.C. ET AL.: "Recognition of polyadenylate RNA by the poly (A)-binding protein", CELL, vol. 98, no. 6, 1999, pages 835 - 845, XP055542371, DOI: 10.1016/S0092-8674(00)81517-2
GRIER, A. E. ET AL.: "pEVL: A Linear Plasmid for Generating mRNA IVT Templates With Extended Encoded Poly(A) Sequences", MOLECULAR THERAPY - NUCLEIC ACIDS, 2016
HOLTKAMP, S. ET AL.: "Modification of antigen-encoding RNA increases stability, translational efficacy, and T-cell stimulatory capacity of dendritic cells.", BLOOD, vol. 108, no. 13, 2006, pages 4009 - 4017, XP055044965, DOI: 10.1182/blood-2006-04-015024
HOU, X ET AL.: "Lipid nanoparticles for mRNA delivery", NAT REV MATER, vol. 6, 2021, pages 1078 - 1094, XP037634156, DOI: 10.1038/s41578-021-00358-0
LIM, J. ET AL.: "Mixed tailing by TENT4A and TENT4B shields mRNA from rapid deadenylation", SCIENCE, vol. 361, no. 6403, 2018, pages 701 - 704, XP055526201, DOI: 10.1126/science.aam5794
ROHNER, E. ET AL., UNLOCKING THE PROMISE OF MRNA THERAPEUTICS., 2022, Retrieved from the Internet <URL:https://doi.org/10.1038/s41587-022-01491-z>
SAWAZAKI, R. ET AL.: "Characterization of the multimeric structure of poly(A)-binding protein on a poly(A) tail", SCIENTIFIC REPORTS, vol. 8, no. 1, 2018, pages 1 - 13
STADLER ET AL.: "Elimination of large tumors in mice by mRNA-encoded bispecific antibodies", NATURE MEDICINE, vol. 23, no. 7, 2017, pages 815 - 817, XP055800353, DOI: 10.1038/nm.4356
TREPOTEC, Z. ET AL.: "Segmented poly(A) tails significantly reduce recombination of plasmid DNA without affecting mRNA translation efficiency or half-life", RNA, vol. 25, no. 4, 2019, pages 507 - 518, XP009517039, DOI: 10.1261/rna.069286.118
VOGEL, A. B. ET AL.: "BNT162b vaccines protect rhesus macaques from SARS-CoV-2", NATURE, vol. 592, no. 7853, 2021, pages 283 - 289, XP037417629, DOI: 10.1038/s41586-021-03275-y
YI, H. ET AL.: "PABP Cooperates with the CCR4-NOT Complex to Promote mRNA Deadenylation and Block Precocious Decay", MOLECULAR CELL, vol. 70, no. 6, 2018, pages 1081 - 1088, XP085410638, DOI: 10.1016/j.molcel.2018.05.009

Also Published As

Publication number Publication date
WO2025229103A1 (en) 2025-11-06

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