GB2021111A - Nitrofuryl-vinylene-thiazole N-oxides as antitumour agents - Google Patents
Nitrofuryl-vinylene-thiazole N-oxides as antitumour agentsInfo
- Publication number
- GB2021111A GB2021111A GB7917473A GB7917473A GB2021111A GB 2021111 A GB2021111 A GB 2021111A GB 7917473 A GB7917473 A GB 7917473A GB 7917473 A GB7917473 A GB 7917473A GB 2021111 A GB2021111 A GB 2021111A
- Authority
- GB
- United Kingdom
- Prior art keywords
- nitrofuryl
- vinylene
- oxides
- thiazole
- antitumour agents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000000259 anti-tumor effect Effects 0.000 title 1
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 abstract 2
- KFSLWBXXFJQRDL-UHFFFAOYSA-N Peracetic acid Chemical compound CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Certain nitrofuryl-vinylene- thiazole N-oxides having the formula <IMAGE> wherein R<1> and R<2> each independently represent hydrogen (C1-C4) alkyl or alkoxycarbonyl or R<1> and R<2> together with the carbon atoms to which they are bonded represent a cycloalkenyl group are provided for use in the treatment of cancer in mammals. These N-oxides may be administered in the form of a pharmaceutical composition containing a pharmaceutically acceptable excipient. The compounds are made by oxidation (hydrogen peroxide or peracetic acid) of corresponding nitrofuryl-vinylene-thiazoles.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5975978A JPS54151134A (en) | 1978-05-19 | 1978-05-19 | Antitumorigenic agent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB2021111A true GB2021111A (en) | 1979-11-28 |
| GB2021111B GB2021111B (en) | 1982-11-03 |
Family
ID=13122504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB7917473A Expired GB2021111B (en) | 1978-05-19 | 1979-05-18 | Nitro - furyl - vinylene - thiazole n-oxides as antitumour agents |
Country Status (6)
| Country | Link |
|---|---|
| JP (1) | JPS54151134A (en) |
| CH (1) | CH640850A5 (en) |
| DE (1) | DE2920247C2 (en) |
| FR (1) | FR2426052A1 (en) |
| GB (1) | GB2021111B (en) |
| IT (1) | IT1114243B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2004177A4 (en) * | 2006-03-16 | 2009-11-18 | Women And Infants Hospital Of | NITROFURAN COMPOUNDS FOR THE TREATMENT OF CANCER AND ANGIOGENESIS |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0413498U (en) * | 1990-05-24 | 1992-02-03 | ||
| US8563592B2 (en) | 2001-11-01 | 2013-10-22 | Spectrum Pharmaceuticals, Inc. | Bladder cancer treatment and methods |
| CA2789114C (en) | 2001-11-01 | 2014-03-25 | Spectrum Pharmaceuticals, Inc. | Medical compositions for intravesical treatment of bladder cancer |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1545606A1 (en) * | 1965-07-29 | 1969-08-07 | Boehringer Mannheim Gmbh | Process for the preparation of new 5-nitrofuran derivatives |
| JPS5239033B1 (en) * | 1971-05-04 | 1977-10-03 | ||
| JPS5239033A (en) * | 1975-09-22 | 1977-03-26 | Meidensha Electric Mfg Co Ltd | An engine controlling device |
| GB2079568A (en) * | 1980-07-02 | 1982-01-20 | Hewlett Packard Co | Data compression apparatus and method |
| JPS5742662A (en) * | 1980-08-29 | 1982-03-10 | Chugai Pharmaceut Co Ltd | Benzoic acid amide derivative |
-
1978
- 1978-05-19 JP JP5975978A patent/JPS54151134A/en active Granted
-
1979
- 1979-05-16 CH CH454979A patent/CH640850A5/en not_active IP Right Cessation
- 1979-05-16 IT IT22723/79A patent/IT1114243B/en active
- 1979-05-17 FR FR7912549A patent/FR2426052A1/en active Granted
- 1979-05-18 GB GB7917473A patent/GB2021111B/en not_active Expired
- 1979-05-18 DE DE2920247A patent/DE2920247C2/en not_active Expired
Non-Patent Citations (1)
| Title |
|---|
| NONE * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2004177A4 (en) * | 2006-03-16 | 2009-11-18 | Women And Infants Hospital Of | NITROFURAN COMPOUNDS FOR THE TREATMENT OF CANCER AND ANGIOGENESIS |
| AU2007227692B2 (en) * | 2006-03-16 | 2012-09-13 | Women And Infants Hospital Of Rhode Island, Inc. | Nitrofuran compounds for the treatment of cancer and angiogenesis |
| US8470815B2 (en) | 2006-03-16 | 2013-06-25 | Brown University | Nitrofuran compounds for the treatment of cancer and angiogenesis |
Also Published As
| Publication number | Publication date |
|---|---|
| IT7922723A0 (en) | 1979-05-16 |
| DE2920247A1 (en) | 1979-11-22 |
| CH640850A5 (en) | 1984-01-31 |
| GB2021111B (en) | 1982-11-03 |
| IT1114243B (en) | 1986-01-27 |
| JPS6136493B2 (en) | 1986-08-19 |
| FR2426052B1 (en) | 1983-04-08 |
| FR2426052A1 (en) | 1979-12-14 |
| DE2920247C2 (en) | 1985-09-19 |
| JPS54151134A (en) | 1979-11-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 711A | Proceeding under section 117(1) patents act 1977 | ||
| PCNP | Patent ceased through non-payment of renewal fee |