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GB2017103A - Cephalosporin analogues - Google Patents

Cephalosporin analogues

Info

Publication number
GB2017103A
GB2017103A GB7910507A GB7910507A GB2017103A GB 2017103 A GB2017103 A GB 2017103A GB 7910507 A GB7910507 A GB 7910507A GB 7910507 A GB7910507 A GB 7910507A GB 2017103 A GB2017103 A GB 2017103A
Authority
GB
United Kingdom
Prior art keywords
cephalosporin analogues
analogues
cephalosporin
novel
acyloxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7910507A
Other versions
GB2017103B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP3469678A external-priority patent/JPS54128591A/en
Priority claimed from JP12240278A external-priority patent/JPS5549375A/en
Priority claimed from JP12702778A external-priority patent/JPS5553290A/en
Priority claimed from JP13307178A external-priority patent/JPS5559185A/en
Priority claimed from JP53162007A external-priority patent/JPS5936915B2/en
Priority claimed from JP16200678A external-priority patent/JPS5587789A/en
Priority claimed from JP54008409A external-priority patent/JPS5936917B2/en
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Publication of GB2017103A publication Critical patent/GB2017103A/en
Application granted granted Critical
Publication of GB2017103B publication Critical patent/GB2017103B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568—Four-membered rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Novel antibiotic cephalosporin analogues are provided being compounds of the formula <IMAGE> where X is acyl, R<1> is H or an esterifying group and R<2> is H, alkyl or acyloxy, and their pharmaceutically acceptable salts. Also disclosed are pharmaceutical compositions containing the novel cephalosporin analogues and methods for preparing them.
GB7910507A 1978-03-25 1979-03-26 Cephalosporin analogues Expired GB2017103B (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
JP3469678A JPS54128591A (en) 1978-03-25 1978-03-25 Cephalosporin analog
JP12240278A JPS5549375A (en) 1978-10-04 1978-10-04 Cephalosporin analog
JP12702778A JPS5553290A (en) 1978-10-16 1978-10-16 Cephalosporin analogue
JP13307178A JPS5559185A (en) 1978-10-28 1978-10-28 Cephalosporin analog
JP53162007A JPS5936915B2 (en) 1978-12-26 1978-12-26 Cephalosporin analogs
JP16200678A JPS5587789A (en) 1978-12-26 1978-12-26 Sephalosporin analog
JP54008409A JPS5936917B2 (en) 1979-01-27 1979-01-27 Cephalosporin analogs

Publications (2)

Publication Number Publication Date
GB2017103A true GB2017103A (en) 1979-10-03
GB2017103B GB2017103B (en) 1982-09-08

Family

ID=27563451

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7910507A Expired GB2017103B (en) 1978-03-25 1979-03-26 Cephalosporin analogues

Country Status (10)

Country Link
AU (1) AU527128B2 (en)
CA (1) CA1178956A (en)
CH (1) CH640855A5 (en)
DE (1) DE2911787C2 (en)
DK (1) DK120179A (en)
FR (1) FR2420538A1 (en)
GB (1) GB2017103B (en)
IT (1) IT1165187B (en)
NL (1) NL7902321A (en)
NO (1) NO790956L (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0014476A1 (en) * 1979-02-10 1980-08-20 Kyowa Hakko Kogyo Co., Ltd Optically active acylated cephalosporin analogs, processes for their preparation and pharmaceutical compositions comprising them
US4708956A (en) * 1985-12-12 1987-11-24 Kyowa Hakko Kogyo Co., Ltd. 3-position halogenated cephalosporin analogs and pharmaceutical compositions
US4734494A (en) * 1979-11-14 1988-03-29 Kyowa Hakko Kogyo Co., Ltd. Optically active 3-halo carbacephems

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0791291B2 (en) * 1985-12-30 1995-10-04 イ−ライ・リリ−・アンド・カンパニ− 1-carbacef allosporin antibiotic

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2714880A1 (en) * 1977-04-02 1978-10-26 Hoechst Ag CEPHEMDER DERIVATIVES AND PROCESS FOR THEIR PRODUCTION
US4140688A (en) * 1978-04-03 1979-02-20 Smithkline Corporation Tricyclic (azeto-isoquinoline) β-lactams

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0014476A1 (en) * 1979-02-10 1980-08-20 Kyowa Hakko Kogyo Co., Ltd Optically active acylated cephalosporin analogs, processes for their preparation and pharmaceutical compositions comprising them
US4734494A (en) * 1979-11-14 1988-03-29 Kyowa Hakko Kogyo Co., Ltd. Optically active 3-halo carbacephems
US4708956A (en) * 1985-12-12 1987-11-24 Kyowa Hakko Kogyo Co., Ltd. 3-position halogenated cephalosporin analogs and pharmaceutical compositions

Also Published As

Publication number Publication date
CH640855A5 (en) 1984-01-31
NO790956L (en) 1979-09-26
NL7902321A (en) 1979-09-27
AU4536879A (en) 1979-10-04
DE2911787C2 (en) 1985-06-05
DE2911787A1 (en) 1979-09-27
GB2017103B (en) 1982-09-08
AU527128B2 (en) 1983-02-17
CA1178956A (en) 1984-12-04
FR2420538B1 (en) 1982-10-15
IT1165187B (en) 1987-04-22
DK120179A (en) 1979-09-26
FR2420538A1 (en) 1979-10-19
IT7967623A0 (en) 1979-03-26

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19930326