GB2017080A - Benzothiazepines - Google Patents
BenzothiazepinesInfo
- Publication number
- GB2017080A GB2017080A GB7904882A GB7904882A GB2017080A GB 2017080 A GB2017080 A GB 2017080A GB 7904882 A GB7904882 A GB 7904882A GB 7904882 A GB7904882 A GB 7904882A GB 2017080 A GB2017080 A GB 2017080A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- formula
- hydrogen atom
- compounds
- alkyl group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000007657 benzothiazepines Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- KJFRSZASZNLCDF-UHFFFAOYSA-N 1,5-benzothiazepine Chemical class S1C=CC=NC2=CC=CC=C12 KJFRSZASZNLCDF-UHFFFAOYSA-N 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000001078 anti-cholinergic effect Effects 0.000 abstract 1
- 230000000767 anti-ulcer Effects 0.000 abstract 1
- 229940124575 antispasmodic agent Drugs 0.000 abstract 1
- 239000000812 cholinergic antagonist Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The Specification discloses cis or trans-1,5-benzo-thiazepine compounds of the formula (I): <IMAGE> wherein R1 represents a hydrogen atom, a halogen atom, an alkyl group or an alkoxy group and R2 represents a hydrogen atom, an alkyl group or a hydroxyalkyl group and the pharmaceutically acceptable acid addition salts and quaternary ammonium salts thereof which exhibit anticholinergic activity and are useful as anti-ulcer, gastric secretion inhibiting and anti- spasmodic agents in mammals. The compounds (I) are prepared by a route involving a novel class of intermediates of the formula (I) except in that the substituent in the 3-position is a hydroxymethyl group.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1580078A JPS5840954B2 (en) | 1978-02-14 | 1978-02-14 | 1,5↓-benzothiazepine derivatives and their salts |
| JP1741478A JPS5840955B2 (en) | 1978-02-17 | 1978-02-17 | 2,3↓-dihydro↓-1,5↓-benzothiazepine derivative |
| JP9299878A JPS5519249A (en) | 1978-07-29 | 1978-07-29 | Optically active 1,5-benzothiazepine derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB2017080A true GB2017080A (en) | 1979-10-03 |
| GB2017080B GB2017080B (en) | 1982-07-21 |
Family
ID=27281143
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB7904882A Expired GB2017080B (en) | 1978-02-14 | 1979-02-12 | Benzothiazepines |
Country Status (6)
| Country | Link |
|---|---|
| CA (1) | CA1114818A (en) |
| CH (1) | CH639660A5 (en) |
| DE (1) | DE2905637C3 (en) |
| ES (1) | ES477709A1 (en) |
| FR (1) | FR2416890A1 (en) |
| GB (1) | GB2017080B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4477464A (en) * | 1983-02-10 | 1984-10-16 | Ciba-Geigy Corporation | Hetero-benzazepine derivatives and their pharmaceutical use |
| US4694002A (en) * | 1986-08-21 | 1987-09-15 | E. R. Squibb & Sons, Inc. | Benzothiazepine derivatives |
| JP2871811B2 (en) * | 1990-02-28 | 1999-03-17 | サントリー株式会社 | 7-membered condensed ring compound |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3089872A (en) * | 1961-03-31 | 1963-05-14 | Olin Mathieson | Benzothiazine and benzothiazepine compounds |
-
1979
- 1979-02-12 GB GB7904882A patent/GB2017080B/en not_active Expired
- 1979-02-13 CA CA321,396A patent/CA1114818A/en not_active Expired
- 1979-02-14 DE DE19792905637 patent/DE2905637C3/en not_active Expired
- 1979-02-14 CH CH142479A patent/CH639660A5/en not_active IP Right Cessation
- 1979-02-14 ES ES477709A patent/ES477709A1/en not_active Expired
- 1979-02-14 FR FR7903753A patent/FR2416890A1/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| DE2905637A1 (en) | 1979-08-16 |
| CH639660A5 (en) | 1983-11-30 |
| FR2416890A1 (en) | 1979-09-07 |
| CA1114818A (en) | 1981-12-22 |
| ES477709A1 (en) | 1979-10-16 |
| DE2905637B2 (en) | 1980-07-03 |
| DE2905637C3 (en) | 1981-05-21 |
| GB2017080B (en) | 1982-07-21 |
| FR2416890B1 (en) | 1981-11-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PCNP | Patent ceased through non-payment of renewal fee |