GB201103828D0 - Evaluation of therapeutic agent - Google Patents
Evaluation of therapeutic agentInfo
- Publication number
- GB201103828D0 GB201103828D0 GB201103828A GB201103828A GB201103828D0 GB 201103828 D0 GB201103828 D0 GB 201103828D0 GB 201103828 A GB201103828 A GB 201103828A GB 201103828 A GB201103828 A GB 201103828A GB 201103828 D0 GB201103828 D0 GB 201103828D0
- Authority
- GB
- United Kingdom
- Prior art keywords
- therapeutic agent
- candidate therapeutic
- cell
- proteins
- predicting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000003814 drug Substances 0.000 title abstract 6
- 229940124597 therapeutic agent Drugs 0.000 title abstract 6
- 238000011156 evaluation Methods 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 230000001988 toxicity Effects 0.000 abstract 3
- 231100000419 toxicity Toxicity 0.000 abstract 3
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
Abstract
The present invention relates to a method of predicting toxicity of a candidate therapeutic agent and to a test kit for performing such a method. More particularly, a method of predicting toxicity of a candidate therapeutic agent comprising the steps of:- a. administering the candidate therapeutic agent to a cell; b. identifying the number of proteins that show change in the level of expression in the cell following step a); c. comparing the number of proteins identified in step b) with a known number of proteins that show a change in the level of expression in a second cell following administration of a reference therapeutic agent to the second cell; and d. predicting the toxicity of the candidate therapeutic agent based on the comparison made in step c).
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201103828A GB201103828D0 (en) | 2011-03-07 | 2011-03-07 | Evaluation of therapeutic agent |
| PCT/GB2012/050507 WO2012120301A1 (en) | 2011-03-07 | 2012-03-07 | Evaluation of therapeutic agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201103828A GB201103828D0 (en) | 2011-03-07 | 2011-03-07 | Evaluation of therapeutic agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB201103828D0 true GB201103828D0 (en) | 2011-04-20 |
Family
ID=43923303
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB201103828A Ceased GB201103828D0 (en) | 2011-03-07 | 2011-03-07 | Evaluation of therapeutic agent |
Country Status (2)
| Country | Link |
|---|---|
| GB (1) | GB201103828D0 (en) |
| WO (1) | WO2012120301A1 (en) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004503256A (en) * | 2000-06-14 | 2004-02-05 | ビスタジェン インコーポレイテッド | Toxicity classification using liver stem cells |
-
2011
- 2011-03-07 GB GB201103828A patent/GB201103828D0/en not_active Ceased
-
2012
- 2012-03-07 WO PCT/GB2012/050507 patent/WO2012120301A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2012120301A1 (en) | 2012-09-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AT | Applications terminated before publication under section 16(1) |