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GB2009180A - 25-Alkyl Cholesterol Derivatives - Google Patents

25-Alkyl Cholesterol Derivatives

Info

Publication number
GB2009180A
GB2009180A GB7834881A GB7834881A GB2009180A GB 2009180 A GB2009180 A GB 2009180A GB 7834881 A GB7834881 A GB 7834881A GB 7834881 A GB7834881 A GB 7834881A GB 2009180 A GB2009180 A GB 2009180A
Authority
GB
United Kingdom
Prior art keywords
group
formula
image
carbon atoms
hydrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7834881A
Other versions
GB2009180B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Publication of GB2009180A publication Critical patent/GB2009180A/en
Application granted granted Critical
Publication of GB2009180B publication Critical patent/GB2009180B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compounds of formula (A): <IMAGE> wherein R2 is an alkyl group having from 1 to 4 carbon atoms, R is a hydrogen atom, an alkanoyl group having from 2 to 7 carbon atoms, or a radical of the formula: <IMAGE> in which n is a positive integer less than 4, Y is a methylene or carbonyl group, provided that when Y is a carbonyl group, R1 is a hydrogen atom, and when Y is a methylene group, R1 is the group OX in which X is a hydrogen atom, an alkanoyl group having from 2 to 7 carbon atoms, or a radical of the formula: <IMAGE> in which n is a positive integer less than 4, and the wavy line represents R or S stereochemistry, processes for their preparation, pharmaceutical and veterinary formulations containing them, and their uses as inhibitors of the activity of HMGCoA reductase and as antiprotozoal agents.
GB7834881A 1977-08-29 1978-08-29 25-alkylcholestrerol derivatives Expired GB2009180B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US82838577A 1977-08-29 1977-08-29

Publications (2)

Publication Number Publication Date
GB2009180A true GB2009180A (en) 1979-06-13
GB2009180B GB2009180B (en) 1982-05-26

Family

ID=25251653

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7834881A Expired GB2009180B (en) 1977-08-29 1978-08-29 25-alkylcholestrerol derivatives

Country Status (9)

Country Link
JP (1) JPS5448751A (en)
AU (1) AU520334B2 (en)
CA (1) CA1113086A (en)
CH (1) CH643566A5 (en)
DE (1) DE2837414A1 (en)
ES (1) ES472877A1 (en)
FR (1) FR2401935A1 (en)
GB (1) GB2009180B (en)
IT (1) IT1106121B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1385868A4 (en) * 2001-02-08 2004-12-08 Univ Chicago STEROID DERIVATIVES
US7078396B2 (en) 2001-05-03 2006-07-18 Arch Development Corporation Method of treating disorder related to high cholesterol concentration
US8829213B2 (en) 2009-07-29 2014-09-09 The University Of Chicago Liver X receptor agonists

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4225525A (en) * 1979-02-08 1980-09-30 Hoffmann-La Roche Inc. Vitamin D3 metabolite derivatives
US4230626A (en) * 1979-07-30 1980-10-28 G. D. Searle & Co. 25-Halocholest-5-ene-3β,22-diols and esters thereof
US4329295A (en) * 1981-06-29 1982-05-11 G. D. Searle & Co. 24-Cyclopropylcholene-3β, 22-diols and esters thereof
US4348328A (en) * 1981-11-09 1982-09-07 G.D. Searle & Co. 25-Substituted-5α-cholestane-3β,22S-diol
IL105050A0 (en) * 1992-03-27 1993-07-08 Lilly Co Eli Steroid derivatives
ES2188515T3 (en) 1999-03-09 2003-07-01 Akzo Nobel Nv DERIVATIVES OF 22R-HYDROXICOLESTA-8,14-DIENO WITH INHIBITING ACTIVITY OF THE MEIOSIS.

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1385868A4 (en) * 2001-02-08 2004-12-08 Univ Chicago STEROID DERIVATIVES
US7078396B2 (en) 2001-05-03 2006-07-18 Arch Development Corporation Method of treating disorder related to high cholesterol concentration
US8829213B2 (en) 2009-07-29 2014-09-09 The University Of Chicago Liver X receptor agonists

Also Published As

Publication number Publication date
CA1113086A (en) 1981-11-24
AU3931878A (en) 1980-03-06
DE2837414C2 (en) 1987-09-03
IT7850879A0 (en) 1978-08-28
CH643566A5 (en) 1984-06-15
JPS6259720B2 (en) 1987-12-12
FR2401935A1 (en) 1979-03-30
JPS5448751A (en) 1979-04-17
AU520334B2 (en) 1982-01-28
FR2401935B1 (en) 1981-07-10
ES472877A1 (en) 1979-02-16
IT1106121B (en) 1985-11-11
GB2009180B (en) 1982-05-26
DE2837414A1 (en) 1979-03-08

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee