GB2006759A - omega -Mercapto-propionamides and Pharmaceutical Preparations containing them - Google Patents
omega -Mercapto-propionamides and Pharmaceutical Preparations containing themInfo
- Publication number
- GB2006759A GB2006759A GB7838509A GB7838509A GB2006759A GB 2006759 A GB2006759 A GB 2006759A GB 7838509 A GB7838509 A GB 7838509A GB 7838509 A GB7838509 A GB 7838509A GB 2006759 A GB2006759 A GB 2006759A
- Authority
- GB
- United Kingdom
- Prior art keywords
- lower alkyl
- hydrogen atom
- pharmaceutical preparations
- propionamides
- mercapto
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000825 pharmaceutical preparation Substances 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- -1 cycloalkyl radical Chemical class 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- ATTZFSUZZUNHBP-UHFFFAOYSA-N Piperonyl sulfoxide Chemical compound CCCCCCCCS(=O)C(C)CC1=CC=C2OCOC2=C1 ATTZFSUZZUNHBP-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 230000003276 anti-hypertensive effect Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000005840 aryl radicals Chemical class 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 239000002934 diuretic Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 229940124549 vasodilator Drugs 0.000 abstract 1
- 239000003071 vasodilator agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Novel omega -mercapto propionamides of the general formula (I> <IMAGE> (in which R is a hydrogen atom, a lower alkyl, lower alkenyl, aryl lower alkyl or an aryl radical, R2 is a hydrogen atom or a lower alkyl or lower cycloalkyl radical, Z is a sulphur atom or a sulphoxide or a sulphonyl group, R3 is a hydrogen atom or a lower alkyl radical, m is 1 or 2, n is 1 or 2, p is 0, 1 or 2, and X is a hydroxy, lower alkoxy or an amino group) have an important anti-hypertensive action and accordingly may be made up with suitable carriers into pharmaceutical preparations which advantageously may also contain diuretic agent and/or vasodilators.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7729109A FR2404635A1 (en) | 1977-09-28 | 1977-09-28 | NEW THIOPROPRIONYLAMIDES, THEIR OBTAINING PROCEDURES AND THEIR USE IN THERAPEUTICS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB2006759A true GB2006759A (en) | 1979-05-10 |
Family
ID=9195844
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB7838509A Withdrawn GB2006759A (en) | 1977-09-28 | 1978-09-28 | omega -Mercapto-propionamides and Pharmaceutical Preparations containing them |
Country Status (5)
| Country | Link |
|---|---|
| BE (1) | BE870801A (en) |
| FR (1) | FR2404635A1 (en) |
| GB (1) | GB2006759A (en) |
| SU (1) | SU803859A3 (en) |
| ZA (1) | ZA785509B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4450275A (en) * | 1978-10-05 | 1984-05-22 | Yoshitomi Pharmaceutical Industries, Ltd. | Cyclic iminocarboxylic acid derivatives |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU528115B2 (en) * | 1978-04-08 | 1983-04-14 | Santen Pharmaceutical Co. Ltd. | Antihypertensive 4-thiazolidine/carboxylic acids |
| ZA783013B (en) * | 1978-05-22 | 1979-06-27 | Squibb & Sons Inc | Derivatives of thiazolidinecarboxylic acids and related acids |
| JPS5531022A (en) * | 1978-08-24 | 1980-03-05 | Yoshitomi Pharmaceut Ind Ltd | Hydroxamic acid derivative and its preparation |
-
1977
- 1977-09-28 FR FR7729109A patent/FR2404635A1/en active Granted
-
1978
- 1978-09-27 BE BE190741A patent/BE870801A/en unknown
- 1978-09-28 GB GB7838509A patent/GB2006759A/en not_active Withdrawn
- 1978-09-28 SU SU782669405A patent/SU803859A3/en active
- 1978-09-28 ZA ZA00785509A patent/ZA785509B/en unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4450275A (en) * | 1978-10-05 | 1984-05-22 | Yoshitomi Pharmaceutical Industries, Ltd. | Cyclic iminocarboxylic acid derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2404635A1 (en) | 1979-04-27 |
| SU803859A3 (en) | 1981-02-07 |
| FR2404635B1 (en) | 1980-08-01 |
| ZA785509B (en) | 1979-08-29 |
| BE870801A (en) | 1979-03-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| WAP | Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1) |