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GB2006196A - Phenylacetamides with analgesic activity - Google Patents

Phenylacetamides with analgesic activity

Info

Publication number
GB2006196A
GB2006196A GB7838905A GB7838905A GB2006196A GB 2006196 A GB2006196 A GB 2006196A GB 7838905 A GB7838905 A GB 7838905A GB 7838905 A GB7838905 A GB 7838905A GB 2006196 A GB2006196 A GB 2006196A
Authority
GB
United Kingdom
Prior art keywords
carbon atoms
analgesic activity
hydrogen atom
different
alkyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB7838905A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kissei Pharmaceutical Co Ltd
Original Assignee
Kissei Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kissei Pharmaceutical Co Ltd filed Critical Kissei Pharmaceutical Co Ltd
Publication of GB2006196A publication Critical patent/GB2006196A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A phenylacetamide compound of the general formula (I): <IMAGE> wherein each of R1 and R2, which are the same or different, represents an alkyl group having 1 to 3 carbon atoms or R1 and R2 together form a ring with the nitrogen atom to which they are attached; R3 represents a hydrogen atom or an alkyl group having 1 to 3 carbon atoms; X represents an alkoxy group having 1 to 3 carbon atoms; Y represents a hydrogen atom or an alkoxyl group having 1 to 3 carbon atoms; and each of n and m, which are the same or different, is 0, 1 or 2; or a pharmaceutically acceptable salt thereof, has a strong analgesic activity with very weak physical dependence liability, and which is useful as a therapeutically active agent for various types of pain.
GB7838905A 1977-10-05 1978-10-02 Phenylacetamides with analgesic activity Withdrawn GB2006196A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11978077A JPS5455544A (en) 1977-10-05 1977-10-05 Pheylacetamide derivatives

Publications (1)

Publication Number Publication Date
GB2006196A true GB2006196A (en) 1979-05-02

Family

ID=14770030

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7838905A Withdrawn GB2006196A (en) 1977-10-05 1978-10-02 Phenylacetamides with analgesic activity

Country Status (8)

Country Link
JP (1) JPS5455544A (en)
BE (1) BE870992A (en)
DE (1) DE2843328A1 (en)
FR (1) FR2405240A1 (en)
GB (1) GB2006196A (en)
IT (1) IT1106921B (en)
NL (1) NL7810053A (en)
SE (1) SE7810421L (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1244437A4 (en) * 1999-12-06 2005-02-09 Euro Celtique Sa Tertiary amino compounds having opioid receptor affinity

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0017376A1 (en) * 1979-03-30 1980-10-15 Kissei Pharmaceutical Co. Ltd Phenylacetamide compounds and an analgesic composition containing them
JPH01265080A (en) * 1988-04-15 1989-10-23 Nippon Chemiphar Co Ltd Novel alkylenediamine derivative and glutamic acid blocker

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1101711A (en) * 1964-01-23 1968-01-31 Bellon Labor Sa Roger New amides

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1244437A4 (en) * 1999-12-06 2005-02-09 Euro Celtique Sa Tertiary amino compounds having opioid receptor affinity
US6984664B2 (en) * 1999-12-06 2006-01-10 Euro-Celtique, S.A. Tertiary amino compounds having opioid receptor affinity

Also Published As

Publication number Publication date
BE870992A (en) 1979-02-01
FR2405240A1 (en) 1979-05-04
JPS575219B2 (en) 1982-01-29
NL7810053A (en) 1979-04-09
DE2843328A1 (en) 1979-04-19
SE7810421L (en) 1979-04-06
IT1106921B (en) 1985-11-18
JPS5455544A (en) 1979-05-02
IT7851365A0 (en) 1978-10-04

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Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)