[go: up one dir, main page]

GB2006193A - Inclusion complexes of prostacyclin and its derivatives, their preparation and pharmaceutical compositions containing them - Google Patents

Inclusion complexes of prostacyclin and its derivatives, their preparation and pharmaceutical compositions containing them

Info

Publication number
GB2006193A
GB2006193A GB7837834A GB7837834A GB2006193A GB 2006193 A GB2006193 A GB 2006193A GB 7837834 A GB7837834 A GB 7837834A GB 7837834 A GB7837834 A GB 7837834A GB 2006193 A GB2006193 A GB 2006193A
Authority
GB
United Kingdom
Prior art keywords
prostacyclin
pharmaceutical compositions
inclusion complexes
complexes
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7837834A
Other versions
GB2006193B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chinoin Private Co Ltd
Original Assignee
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt filed Critical Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Publication of GB2006193A publication Critical patent/GB2006193A/en
Application granted granted Critical
Publication of GB2006193B publication Critical patent/GB2006193B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nanotechnology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Diabetes (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Prostacyclin and prostacyclin derivatives form inclusion complexes with cyclodextrins. The complexes may be prepared by contacting an aqueous solution of the cyclodextrin with prostacyclin or a derivative thereof, preferably in organic solvent solution. The inclusion complexes have an improved stability, especially in aqueous solution, compared to the uncomplexed compounds and are extremely potent in inhibiting thrombus formation and inducing the disaggregation of thrombi already formed. The complexes can be formulated into pharmaceutical compositions in conventional manner.
GB7837834A 1977-09-23 1978-09-22 Nclusion complexes of prostacyclin and its derivatives their preparation and pharmaceutical compositions containing them Expired GB2006193B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU77CI1770A HU179141B (en) 1977-09-23 1977-09-23

Publications (2)

Publication Number Publication Date
GB2006193A true GB2006193A (en) 1979-05-02
GB2006193B GB2006193B (en) 1982-05-26

Family

ID=10994670

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7837834A Expired GB2006193B (en) 1977-09-23 1978-09-22 Nclusion complexes of prostacyclin and its derivatives their preparation and pharmaceutical compositions containing them

Country Status (20)

Country Link
JP (1) JPS5456685A (en)
AT (1) AT369362B (en)
BE (1) BE870646A (en)
CH (1) CH637388A5 (en)
CS (1) CS200242B2 (en)
DD (1) DD138600A5 (en)
DE (1) DE2840142A1 (en)
DK (1) DK420778A (en)
FI (1) FI65912C (en)
FR (1) FR2404006A1 (en)
GB (1) GB2006193B (en)
GR (1) GR65001B (en)
HU (1) HU179141B (en)
IL (1) IL55569A (en)
IT (1) IT1160661B (en)
NL (1) NL7809643A (en)
PL (1) PL121664B1 (en)
SE (1) SE447574B (en)
SU (1) SU847914A3 (en)
YU (1) YU220678A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2124489A (en) * 1982-07-19 1984-02-22 Ciba Geigy Ag Medicinal composition containing pirprofen and cyclodextrin
FR2623807A1 (en) * 1987-11-27 1989-06-02 Schering Ag CLATHRATES FORMED BY CYCLODEXTRIN AND CYANO-5 PROSTACYCLINE DERIVATIVES AND MEDICAMENTS CONTAINING THE SAME
EP0229844B1 (en) * 1985-06-17 1992-04-08 Teijin Limited Fat emulsion of prostaglandin i 2?
EP1710244A4 (en) * 2004-01-29 2009-06-17 Eisai R&D Man Co Ltd METHOD FOR STABILIZING A MACROLIDE COMPOUND

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53136513A (en) * 1977-05-06 1978-11-29 Ono Pharmaceut Co Ltd Stabilization of prostaglandin-x-related compounds
US4352793A (en) * 1979-04-26 1982-10-05 Sumitomo Chemical Company, Limited Pharmaceutical composition comprising bencyclane fumarate and cyclodextrin
DE3608088C2 (en) * 1986-03-07 1995-11-16 Schering Ag Pharmaceutical preparations containing cyclodextrin clathrates of carbacyclin derivatives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS503362B1 (en) * 1970-06-10 1975-02-04
US3953435A (en) * 1974-01-10 1976-04-27 Ono Pharmaceutical Company Aldehyde derivatives of prostaglandins
JPS5395958A (en) * 1977-01-31 1978-08-22 Ono Pharmaceut Co Ltd Prostaglandin analogues and process for their preparation
US4178367A (en) * 1977-02-21 1979-12-11 Ono Pharmaceutical Co. Ltd. Prostaglandin I2 analogues
JPS53136513A (en) * 1977-05-06 1978-11-29 Ono Pharmaceut Co Ltd Stabilization of prostaglandin-x-related compounds

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2124489A (en) * 1982-07-19 1984-02-22 Ciba Geigy Ag Medicinal composition containing pirprofen and cyclodextrin
EP0229844B1 (en) * 1985-06-17 1992-04-08 Teijin Limited Fat emulsion of prostaglandin i 2?
FR2623807A1 (en) * 1987-11-27 1989-06-02 Schering Ag CLATHRATES FORMED BY CYCLODEXTRIN AND CYANO-5 PROSTACYCLINE DERIVATIVES AND MEDICAMENTS CONTAINING THE SAME
BE1001327A3 (en) * 1987-11-27 1989-09-26 Schering Ag Clathrates DERIVATIVES 5-CYANO-PROSTACYCLIN WITH CYCLODEXTRIN DRUGS AND THEIR USE AS.
GB2231045A (en) * 1987-11-27 1990-11-07 Schering Ag Cyclodextrin clathrates of 5-cyano-prostacycline derivatives and their use as drugs
US5010065A (en) * 1987-11-27 1991-04-23 Schering Aktiengesellschaft Cyclodextrin clathrates of 5-cyanoprostacyclin derivatives and their use as pharmaceutical agents
GB2231045B (en) * 1987-11-27 1992-04-29 Schering Ag Cyclodextrin clathrates of 5-cyano-16 -methylprostacyclin and their use in pharmacetical compositions
EP1710244A4 (en) * 2004-01-29 2009-06-17 Eisai R&D Man Co Ltd METHOD FOR STABILIZING A MACROLIDE COMPOUND
US7655442B2 (en) 2004-01-29 2010-02-02 Eisai R&D Management Co., Ltd. Method for stabilizing macrolide compounds

Also Published As

Publication number Publication date
NL7809643A (en) 1979-03-27
HU179141B (en) 1982-08-28
IT1160661B (en) 1987-03-11
YU220678A (en) 1983-10-31
JPS5456685A (en) 1979-05-07
SE447574B (en) 1986-11-24
BE870646A (en) 1979-01-15
GB2006193B (en) 1982-05-26
DD138600A5 (en) 1979-11-14
IL55569A0 (en) 1978-12-17
CH637388A5 (en) 1983-07-29
PL121664B1 (en) 1982-05-31
PL209773A1 (en) 1979-06-04
DK420778A (en) 1979-03-24
SE7809946L (en) 1979-03-24
IL55569A (en) 1981-12-31
FR2404006B1 (en) 1981-07-31
AT369362B (en) 1982-12-27
FI65912B (en) 1984-04-30
DE2840142A1 (en) 1979-04-05
FI782878A7 (en) 1979-03-24
CS200242B2 (en) 1980-08-29
ATA677478A (en) 1982-05-15
SU847914A3 (en) 1981-07-15
FR2404006A1 (en) 1979-04-20
GR65001B (en) 1980-06-12
FI65912C (en) 1984-08-10
IT7869160A0 (en) 1978-09-19

Similar Documents

Publication Publication Date Title
IT7826174A0 (en) PROCEDURE FOR THE PREPARATION OF BODIES OF REGENERATED CELLULOSE FROM SOLUTIONS OF CELLULOSE DERIVATIVES IN DIMETHYL SULPHOXIDE.
EP0214647A3 (en) Inclusion complexes of 7-isopropoxy-isoflavone and cyclodextrins, process for their preparation and pharmaceutical preparations containing these complexes
GB1144905A (en) Substituted bis-(2-carboxy-chromonyl-oxy) derivatives and preparation and pharmaceutical compositions thereof
NO810684L (en) PROCEDURE FOR THE PREPARATION OF INDANDER DERIVATIVES.
MX174656B (en) PEROXIACID CLATRATES
GB2006193A (en) Inclusion complexes of prostacyclin and its derivatives, their preparation and pharmaceutical compositions containing them
KR940002301A (en) 5,10-methylenetetrahydrofolic acid-cyclodextrin inclusion compound
IT7822011A0 (en) PROCEDURE FOR THE PREPARATION OF LYSERGOLE DERIVATIVES.
MD679F1 (en) Inclusion complex of N-ethoxycarbonyl-3-morpholinsydnonimine or salts thereof with cyclodextrin or its derivatives, preparation thereof and pharmaceutical compositions containing them, method of preparation thereof and treatment method
ES8100283A1 (en) Derivatives of 4,5-dihydro-4-oxofuran-2-carboxylic acid, especially for use as hypolipidemic agents, processes for their preparation, pharmaceutical compositions comprising them, tetrahydropyran-2,3,5-triones useful in the preparation of the said derivatives and a process for preparing these tetrahydropyran-2,3,5-triones.
MD776C2 (en) Inclusion complexes of 3-morpholinesydnonimine or its salts, or its tautomeric isomer with cyclodextrine or its derivatives, method for preparation thereof, pharmaceutical composition thereof, method for preparation thereof and for treatment of stenocardia or ishemic desease
IT7924851A0 (en) HYDROQUINONE DERIVATIVES AND RELATED PROCEDURE FOR THEIR PRODUCTION.
IT1172085B (en) STEROID DERIVATIVES 3- AMINATED AND THEIR SALTS, RELATIVE PROCESS OF PRODUCTION AND USE OF COMPOUNDS OBTAINED AS MEDICATIONS
IL59295A (en) Dehydrophenylalanyl-tryptophan derivatives,their production and pharmaceutical compositions containing them
FR2396010A1 (en) PROCESS FOR PREPARING 5,6-DIHYDRO-2-METHYL-1,4-OXATHIINE (I) DERIVATIVES
JPS55100376A (en) Novel analogue of prostacycline and its manufacture
IT7823102A0 (en) DERIVATIVES OF AZOLYL-ALKAN-CARBOXYLIC ACIDS, PROCEDURE FOR THEIR PREPARATION AND THEIR USE AS FUNGICIDES.
IT7922548A0 (en) DERIVATIVES OF 1,5-DIMETHYLBICYCLO(3.2.1.)-OCTANE, PREPARATION OF THESE COMPOUNDS AND THEIR USE AS COMPOUNDS FOR PERFUMES.
JPS5536484A (en) Novel 1*44dihydropyridazinee33carboxylic acid derivative
DE3166683D1 (en) Solvate of amoxicillin, process for the preparation thereof and process for the preparation of injectable preparations from this solvate
ES8500057A1 (en) PROCEDURE FOR THE OBTAINING OF DERIVATIVES OF 1,4-DIHIDROPIRIDINA.
IT7928306A0 (en) PROCEDURE FOR THE PREPARATION OF BODIES OF REGENERATED CELLULOSE FROM SOLUTIONS OF CELLULOSE DERIVATIVES IN ORGANIC SOLVENTS.
IT7923464A0 (en) HALOGENATED DERIVATIVES OF VINCAMINE, THEIR PROCEDURE FOR OBTAINMENT AND THEIR APPLICATION AS MEDICINAL PRODUCTS.
IT7922109A0 (en) IMPROVEMENTS TO THE PROCEDURE FOR THE PREPARATION OF BODIES OF REGENERATED CELLULOSE FROM SOLUTIONS OF CELLULOSE DERIVATIVES IN ORGANIC SOLVENTS.
IT7826175A0 (en) PROCEDURE FOR THE PREPARATION OF BODIES OF REGENERATED CELLULOSE FROM SOLUTIONS OF CELLULOSE DERIVATIVES IN ORGANIC SOLVENTS.

Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee