GB1430684A - Prolonged release lozenges - Google Patents
Prolonged release lozengesInfo
- Publication number
- GB1430684A GB1430684A GB2973173A GB2973173A GB1430684A GB 1430684 A GB1430684 A GB 1430684A GB 2973173 A GB2973173 A GB 2973173A GB 2973173 A GB2973173 A GB 2973173A GB 1430684 A GB1430684 A GB 1430684A
- Authority
- GB
- United Kingdom
- Prior art keywords
- active ingredient
- methyl cellulose
- june
- humidity
- prolonged
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000002035 prolonged effect Effects 0.000 title abstract 3
- 239000007937 lozenge Substances 0.000 title abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract 2
- BLFLLBZGZJTVJG-UHFFFAOYSA-N benzocaine Chemical compound CCOC(=O)C1=CC=C(N)C=C1 BLFLLBZGZJTVJG-UHFFFAOYSA-N 0.000 abstract 2
- 239000012876 carrier material Substances 0.000 abstract 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 abstract 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 abstract 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 abstract 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 abstract 2
- KJFMBFZCATUALV-UHFFFAOYSA-N phenolphthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2C(=O)O1 KJFMBFZCATUALV-UHFFFAOYSA-N 0.000 abstract 2
- DBAKFASWICGISY-BTJKTKAUSA-N Chlorpheniramine maleate Chemical compound OC(=O)\C=C/C(O)=O.C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Cl)C=C1 DBAKFASWICGISY-BTJKTKAUSA-N 0.000 abstract 1
- 102000009338 Gastric Mucins Human genes 0.000 abstract 1
- 108010009066 Gastric Mucins Proteins 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- PQMWYJDJHJQZDE-UHFFFAOYSA-M Methantheline bromide Chemical compound [Br-].C1=CC=C2C(C(=O)OCC[N+](C)(CC)CC)C3=CC=CC=C3OC2=C1 PQMWYJDJHJQZDE-UHFFFAOYSA-M 0.000 abstract 1
- SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 abstract 1
- 239000000006 Nitroglycerin Substances 0.000 abstract 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 abstract 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 abstract 1
- 229910021502 aluminium hydroxide Inorganic materials 0.000 abstract 1
- 229940024545 aluminum hydroxide Drugs 0.000 abstract 1
- 229960003116 amyl nitrite Drugs 0.000 abstract 1
- 229960005070 ascorbic acid Drugs 0.000 abstract 1
- 235000010323 ascorbic acid Nutrition 0.000 abstract 1
- 239000011668 ascorbic acid Substances 0.000 abstract 1
- 229960005274 benzocaine Drugs 0.000 abstract 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract 1
- 239000001768 carboxy methyl cellulose Substances 0.000 abstract 1
- 229940046978 chlorpheniramine maleate Drugs 0.000 abstract 1
- 239000008121 dextrose Substances 0.000 abstract 1
- GXGAKHNRMVGRPK-UHFFFAOYSA-N dimagnesium;dioxido-bis[[oxido(oxo)silyl]oxy]silane Chemical compound [Mg+2].[Mg+2].[O-][Si](=O)O[Si]([O-])([O-])O[Si]([O-])=O GXGAKHNRMVGRPK-UHFFFAOYSA-N 0.000 abstract 1
- 229960001031 glucose Drugs 0.000 abstract 1
- 229960003711 glyceryl trinitrate Drugs 0.000 abstract 1
- 230000005923 long-lasting effect Effects 0.000 abstract 1
- 239000000391 magnesium silicate Substances 0.000 abstract 1
- 229940099273 magnesium trisilicate Drugs 0.000 abstract 1
- 229910000386 magnesium trisilicate Inorganic materials 0.000 abstract 1
- 235000019793 magnesium trisilicate Nutrition 0.000 abstract 1
- CSDTZUBPSYWZDX-UHFFFAOYSA-N n-pentyl nitrite Chemical compound CCCCCON=O CSDTZUBPSYWZDX-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229960005382 phenolphthalein Drugs 0.000 abstract 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 abstract 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
- C08L1/08—Cellulose derivatives
- C08L1/26—Cellulose ethers
- C08L1/28—Alkyl ethers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
1430684 Prolonged release lozenge H LOWEY 22 June 1973 [26 June 1972] 29731/73 Heading A5B A shaped and compressed pharmaceutical composition comprises a pharmaceutically active ingredient incorporated in a carrier material which is hydroxypropyl methyl cellulose or a mixture of hydroxypropyl methyl cellulose and sodium carboxy methyl cellulose, the carrier material having been humidity- and heat-treated at a temperature between 110 and 120‹F at a humidity of 85 to 90% for a minimum of 24 hours and the carrier and pharmaceutically active ingredient having been compressed into shape at a pressure of from 7 to 13 kg/sq. inch, the composition having a longlasting slow disintegration rate to give a prolonged and regular release pattern. The active ingredient may be gastric mucin, aluminium hydroxide, magnesium trisilicate, nitroglycerin. amyl nitrite, ascorbic acid, chlorpheniramine maleate, benzocaine, phenolphthalein and dextrose, or mixtures thereof.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26645272A | 1972-06-26 | 1972-06-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1430684A true GB1430684A (en) | 1976-03-31 |
Family
ID=23014648
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2973173A Expired GB1430684A (en) | 1972-06-26 | 1973-06-22 | Prolonged release lozenges |
Country Status (8)
| Country | Link |
|---|---|
| JP (1) | JPS4954519A (en) |
| BR (1) | BR7304698D0 (en) |
| CA (1) | CA1018456A (en) |
| DE (1) | DE2332484C2 (en) |
| DK (1) | DK146434C (en) |
| FR (1) | FR2190409B1 (en) |
| GB (1) | GB1430684A (en) |
| NL (1) | NL183808C (en) |
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2133284A (en) * | 1983-01-07 | 1984-07-25 | English Grains Limited | Resilient pharmaceutical unit for treating mouth ulcers |
| US4680323A (en) * | 1983-12-01 | 1987-07-14 | Hans Lowey | Method and composition for the preparation of controlled long-acting pharmaceuticals for oral administration |
| US4775535A (en) * | 1986-04-04 | 1988-10-04 | Hans Lowey | Method of preparing controlled long-acting pharmaceutical formulations in unit dosage form having uniform and comparable bioavailability characteristics |
| US4855143A (en) * | 1986-04-04 | 1989-08-08 | Hans Lowey | Method of preparing controlled long-acting pharmaceutical formulations in unit dosage form having uniform and comparable bioavailability characteristics |
| US5316773A (en) * | 1990-07-19 | 1994-05-31 | Otsuka Pharmaceutical Co., Ltd. | Particulate preparation containing a flourracil derivative and hydroxypropylmethyl-cellulose |
| US5948437A (en) * | 1996-05-23 | 1999-09-07 | Zeneca Limited | Pharmaceutical compositions using thiazepine |
| WO2004028507A1 (en) * | 2002-09-24 | 2004-04-08 | Akzo Nobel N.V. | Method to improve pharmaceutical tablets having a matrix of cellulose ether |
| US8298581B2 (en) | 2003-03-26 | 2012-10-30 | Egalet A/S | Matrix compositions for controlled delivery of drug substances |
| US8609143B2 (en) | 2001-09-21 | 2013-12-17 | Egalet Ltd. | Morphine polymer release system |
| US8617605B2 (en) | 2001-09-21 | 2013-12-31 | Egalet Ltd. | Polymer release system |
| US8877241B2 (en) | 2003-03-26 | 2014-11-04 | Egalet Ltd. | Morphine controlled release system |
| US9005660B2 (en) | 2009-02-06 | 2015-04-14 | Egalet Ltd. | Immediate release composition resistant to abuse by intake of alcohol |
| US9023394B2 (en) | 2009-06-24 | 2015-05-05 | Egalet Ltd. | Formulations and methods for the controlled release of active drug substances |
| US9044402B2 (en) | 2012-07-06 | 2015-06-02 | Egalet Ltd. | Abuse-deterrent pharmaceutical compositions for controlled release |
| US9642809B2 (en) | 2007-06-04 | 2017-05-09 | Egalet Ltd. | Controlled release pharmaceutical compositions for prolonged effect |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| YU43437B (en) * | 1976-05-05 | 1989-08-31 | Lowey Hans | Process for obtaining tablets containing an active component with long lasting effect |
| FR2455459A1 (en) * | 1979-05-02 | 1980-11-28 | Sertog | Carboxy:methylcellulose matrix for slow release of volatile cpd. - contains tri:ethanolamine, stearin and an alcohol e.g. cetyl is esp. useful for perfumes, insect repellents eczema treatment etc. |
| US4226849A (en) * | 1979-06-14 | 1980-10-07 | Forest Laboratories Inc. | Sustained release therapeutic compositions |
| US4357469A (en) | 1979-06-14 | 1982-11-02 | Forest Laboratories, Inc. | Carrier base material for prolonged release therapeutic compositions |
| US4259314A (en) * | 1979-12-10 | 1981-03-31 | Hans Lowey | Method and composition for the preparation of controlled long-acting pharmaceuticals |
| CH652025A5 (en) * | 1981-09-14 | 1985-10-31 | Hoffmann La Roche | Pharmaceutical preparation. |
| US4369172A (en) * | 1981-12-18 | 1983-01-18 | Forest Laboratories Inc. | Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose |
| JPH0729927B2 (en) * | 1983-04-09 | 1995-04-05 | 日研化学株式会社 | Theophylline sustained release formulation |
| JPH0662404B2 (en) * | 1983-06-14 | 1994-08-17 | シンテックス・ファーマシユーテイカルズ・インターナシヨナル・リミテツド | Controlled-release naproxen and naproxen sodium tablets |
| JPH07112934A (en) * | 1993-10-15 | 1995-05-02 | Taiyo Yakuhin Kogyo Kk | Sustained release preparation of pentoxyphylline and its production |
| EP0746310B1 (en) | 1994-02-23 | 1998-11-18 | BM Research A/S | Controlled release composition |
| ES2221370T3 (en) | 1998-04-03 | 2004-12-16 | Egalet A/S | COMPOSITION OF CONTROLLED RELEASE. |
| AU2003275953A1 (en) | 2002-11-08 | 2004-06-07 | Egalet A/S | Controlled release carvedilol compositions |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1171691A (en) * | 1967-02-24 | 1969-11-26 | Forest Laboratories | Lond-Acting Oral Carrier |
| GB1279214A (en) * | 1970-01-22 | 1972-06-28 | Forest Laboratories | Long-acting oral carrier |
-
1973
- 1973-06-22 GB GB2973173A patent/GB1430684A/en not_active Expired
- 1973-06-22 CA CA174,779A patent/CA1018456A/en not_active Expired
- 1973-06-26 DE DE19732332484 patent/DE2332484C2/en not_active Expired
- 1973-06-26 JP JP7216673A patent/JPS4954519A/ja active Pending
- 1973-06-26 DK DK353073A patent/DK146434C/en not_active IP Right Cessation
- 1973-06-26 BR BR469873A patent/BR7304698D0/en unknown
- 1973-06-26 FR FR7323309A patent/FR2190409B1/fr not_active Expired
- 1973-06-26 NL NL7308859A patent/NL183808C/en active Search and Examination
Cited By (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2133284A (en) * | 1983-01-07 | 1984-07-25 | English Grains Limited | Resilient pharmaceutical unit for treating mouth ulcers |
| US4680323A (en) * | 1983-12-01 | 1987-07-14 | Hans Lowey | Method and composition for the preparation of controlled long-acting pharmaceuticals for oral administration |
| US4775535A (en) * | 1986-04-04 | 1988-10-04 | Hans Lowey | Method of preparing controlled long-acting pharmaceutical formulations in unit dosage form having uniform and comparable bioavailability characteristics |
| US4855143A (en) * | 1986-04-04 | 1989-08-08 | Hans Lowey | Method of preparing controlled long-acting pharmaceutical formulations in unit dosage form having uniform and comparable bioavailability characteristics |
| US5316773A (en) * | 1990-07-19 | 1994-05-31 | Otsuka Pharmaceutical Co., Ltd. | Particulate preparation containing a flourracil derivative and hydroxypropylmethyl-cellulose |
| US5948437A (en) * | 1996-05-23 | 1999-09-07 | Zeneca Limited | Pharmaceutical compositions using thiazepine |
| US8808745B2 (en) | 2001-09-21 | 2014-08-19 | Egalet Ltd. | Morphine polymer release system |
| US9694080B2 (en) | 2001-09-21 | 2017-07-04 | Egalet Ltd. | Polymer release system |
| US8609143B2 (en) | 2001-09-21 | 2013-12-17 | Egalet Ltd. | Morphine polymer release system |
| US8617605B2 (en) | 2001-09-21 | 2013-12-31 | Egalet Ltd. | Polymer release system |
| US9707179B2 (en) | 2001-09-21 | 2017-07-18 | Egalet Ltd. | Opioid polymer release system |
| WO2004028507A1 (en) * | 2002-09-24 | 2004-04-08 | Akzo Nobel N.V. | Method to improve pharmaceutical tablets having a matrix of cellulose ether |
| US9375428B2 (en) | 2003-03-26 | 2016-06-28 | Egalet Ltd. | Morphine controlled release system |
| US8298581B2 (en) | 2003-03-26 | 2012-10-30 | Egalet A/S | Matrix compositions for controlled delivery of drug substances |
| US8877241B2 (en) | 2003-03-26 | 2014-11-04 | Egalet Ltd. | Morphine controlled release system |
| US9884029B2 (en) | 2003-03-26 | 2018-02-06 | Egalet Ltd. | Morphine controlled release system |
| US9642809B2 (en) | 2007-06-04 | 2017-05-09 | Egalet Ltd. | Controlled release pharmaceutical compositions for prolonged effect |
| US9358295B2 (en) | 2009-02-06 | 2016-06-07 | Egalet Ltd. | Immediate release composition resistant to abuse by intake of alcohol |
| US9005660B2 (en) | 2009-02-06 | 2015-04-14 | Egalet Ltd. | Immediate release composition resistant to abuse by intake of alcohol |
| US9023394B2 (en) | 2009-06-24 | 2015-05-05 | Egalet Ltd. | Formulations and methods for the controlled release of active drug substances |
| US9044402B2 (en) | 2012-07-06 | 2015-06-02 | Egalet Ltd. | Abuse-deterrent pharmaceutical compositions for controlled release |
| US9549899B2 (en) | 2012-07-06 | 2017-01-24 | Egalet Ltd. | Abuse deterrent pharmaceutical compositions for controlled release |
Also Published As
| Publication number | Publication date |
|---|---|
| DE2332484C2 (en) | 1984-11-15 |
| NL183808C (en) | 1989-02-01 |
| BR7304698D0 (en) | 1974-09-24 |
| DK146434C (en) | 1984-03-19 |
| FR2190409A1 (en) | 1974-02-01 |
| DE2332484A1 (en) | 1974-01-10 |
| CA1018456A (en) | 1977-10-04 |
| JPS4954519A (en) | 1974-05-27 |
| NL7308859A (en) | 1973-12-28 |
| NL183808B (en) | 1988-09-01 |
| DK146434B (en) | 1983-10-10 |
| FR2190409B1 (en) | 1977-04-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PE20 | Patent expired after termination of 20 years |
Effective date: 19930621 |