GB1426039A - Haptoglobin in aqueous solution and process for tits preparation - Google Patents
Haptoglobin in aqueous solution and process for tits preparationInfo
- Publication number
- GB1426039A GB1426039A GB804874A GB804874A GB1426039A GB 1426039 A GB1426039 A GB 1426039A GB 804874 A GB804874 A GB 804874A GB 804874 A GB804874 A GB 804874A GB 1426039 A GB1426039 A GB 1426039A
- Authority
- GB
- United Kingdom
- Prior art keywords
- haptoglobin
- tits
- preparation
- aqueous solution
- ammonium sulphate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 102000014702 Haptoglobin Human genes 0.000 title abstract 5
- 108050005077 Haptoglobin Proteins 0.000 title abstract 5
- 239000007864 aqueous solution Substances 0.000 title abstract 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 abstract 2
- 229910052921 ammonium sulfate Inorganic materials 0.000 abstract 2
- 235000011130 ammonium sulphate Nutrition 0.000 abstract 2
- 239000001166 ammonium sulphate Substances 0.000 abstract 2
- 102000002572 Alpha-Globulins Human genes 0.000 abstract 1
- 108010068307 Alpha-Globulins Proteins 0.000 abstract 1
- 102000006734 Beta-Globulins Human genes 0.000 abstract 1
- 108010087504 Beta-Globulins Proteins 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 238000005194 fractionation Methods 0.000 abstract 1
- 230000002949 hemolytic effect Effects 0.000 abstract 1
- 150000002500 ions Chemical class 0.000 abstract 1
- 208000017169 kidney disease Diseases 0.000 abstract 1
- 201000006370 kidney failure Diseases 0.000 abstract 1
- 210000002381 plasma Anatomy 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
To prepare purified human serum haptoglobin, aqueous solutions of alpha - and beta -globulin fractions from human blood plasma are subjected to ammonium sulphate fractionation. The precipitates which separate out at ammonium sulphate concentrations of 30 to 40 % are collected and dissolved in water and contacted with an anion exchanger, whereupon the haptoglobin is chemically bound thereto. To obtain the pure haptoglobin, it is eluted from the ion exchanger. The haptoglobin is suitable for preventing or treating haemolytic kidney disorders.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12860673A JPS5322139B2 (en) | 1973-11-15 | 1973-11-15 | |
| JP12860573A JPS5337406B2 (en) | 1973-11-15 | 1973-11-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1426039A true GB1426039A (en) | 1976-02-25 |
Family
ID=26464211
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB804874A Expired GB1426039A (en) | 1973-11-15 | 1974-02-21 | Haptoglobin in aqueous solution and process for tits preparation |
Country Status (5)
| Country | Link |
|---|---|
| CH (1) | CH608190A5 (en) |
| DE (1) | DE2409650C3 (en) |
| ES (1) | ES423697A1 (en) |
| FR (1) | FR2251314B1 (en) |
| GB (1) | GB1426039A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014055552A1 (en) * | 2012-10-03 | 2014-04-10 | Csl Behring Llc | A method of purifying proteins |
| US9145448B2 (en) | 2004-10-19 | 2015-09-29 | Bio Products Laboratory Limited | Method for the isolation of haptoglobin |
| AU2013203930B2 (en) * | 2012-10-03 | 2016-01-28 | Csl Behring Ag | A method of purifying proteins |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS52128205A (en) * | 1976-04-16 | 1977-10-27 | Green Cross Corp:The | Prophylactic and therapeutic drugs for cerebro-vascular contraction |
-
1974
- 1974-02-21 GB GB804874A patent/GB1426039A/en not_active Expired
- 1974-02-26 CH CH268074A patent/CH608190A5/en not_active IP Right Cessation
- 1974-02-27 ES ES423697A patent/ES423697A1/en not_active Expired
- 1974-02-28 FR FR7406943A patent/FR2251314B1/fr not_active Expired
- 1974-02-28 DE DE19742409650 patent/DE2409650C3/en not_active Expired
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9145448B2 (en) | 2004-10-19 | 2015-09-29 | Bio Products Laboratory Limited | Method for the isolation of haptoglobin |
| WO2014055552A1 (en) * | 2012-10-03 | 2014-04-10 | Csl Behring Llc | A method of purifying proteins |
| CN104968676A (en) * | 2012-10-03 | 2015-10-07 | 美国杰特贝林生物制品有限公司 | A method of purifying protein |
| AU2013203930B2 (en) * | 2012-10-03 | 2016-01-28 | Csl Behring Ag | A method of purifying proteins |
| US9534029B2 (en) | 2012-10-03 | 2017-01-03 | Csl Behring Ag | Method of purifying proteins |
| US9937229B2 (en) | 2012-10-03 | 2018-04-10 | Csl Behring Ag | Methods of treatment using hemopexin compositions |
| US10918696B2 (en) | 2012-10-03 | 2021-02-16 | Csl Behring Ag | Methods of treatment using hemopexin compositions |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2251314B1 (en) | 1978-07-07 |
| DE2409650B2 (en) | 1979-03-22 |
| CH608190A5 (en) | 1978-12-29 |
| DE2409650C3 (en) | 1979-11-08 |
| ES423697A1 (en) | 1976-04-16 |
| DE2409650A1 (en) | 1975-05-28 |
| FR2251314A1 (en) | 1975-06-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PE20 | Patent expired after termination of 20 years |
Effective date: 19940220 |