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GB1454247A - - Google Patents

Info

Publication number
GB1454247A
GB1454247A GB2329775A GB2329775A GB1454247A GB 1454247 A GB1454247 A GB 1454247A GB 2329775 A GB2329775 A GB 2329775A GB 2329775 A GB2329775 A GB 2329775A GB 1454247 A GB1454247 A GB 1454247A
Authority
GB
United Kingdom
Prior art keywords
hydroxy
nitro
methoxy
methyl
coumarins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2329775A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Priority to GB2329775A priority Critical patent/GB1454247A/en
Publication of GB1454247A publication Critical patent/GB1454247A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
    • C07D311/44—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 with one hydrogen atom in position 3
    • C07D311/46—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 with one hydrogen atom in position 3 unsubstituted in the carbocyclic ring
    • C07D311/50—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 with one hydrogen atom in position 3 unsubstituted in the carbocyclic ring with elements other than carbon and hydrogen in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1454247 4-Hydroxy-3-nitro-coumarins BEECHAM GROUP Ltd 19 April 1974 [19 April 1973] 23297/75 Divided out of 1432809 Heading C2C Novel compounds of the Formula I or pharmaceutically acceptable salts thereof, in which R 1 , R 2 , R 3 and R 4 each are H, C 1-6 -alkyl or alkoxy, phenoxy, benzyloxy, phenyl, benzyl, pyridyl, hydroxy, nitro or halogen and any adjacent two of the groups R 1 , R 2 , R 3 and R 4 taken together represent a butadienylene or tetramethylene, but excluding 4-hydroxy-3- nitro-coumarins, in which R 1 to R 4 are all hydrogen or the R substituent(s) is 6-methyl, 6,8-dimethyl, 7-isopropyl-5-methyl, 8-isopropyl- 5 - methyl, 6 - chloro, 7 - chloro, 7 - bromo, 7-hydroxy, 7-hydroxy-6-nitro, 7-hydroxy-8-nitro, 7 - hydroxy - 6,8 - dinitro, 5 - methoxy, 6 - methoxy, 7 - methoxy, 7 - methoxy - 8- methyl or 6-nitro-, may be prepared by nitration of a compound II Pharmaceutical compositions of the compounds I are claimed in Specification 1,432,809.
GB2329775A 1973-04-19 1973-04-19 Expired GB1454247A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB2329775A GB1454247A (en) 1973-04-19 1973-04-19

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2329775A GB1454247A (en) 1973-04-19 1973-04-19

Publications (1)

Publication Number Publication Date
GB1454247A true GB1454247A (en) 1976-11-03

Family

ID=10193361

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2329775A Expired GB1454247A (en) 1973-04-19 1973-04-19

Country Status (1)

Country Link
GB (1) GB1454247A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0010392A1 (en) * 1978-10-20 1980-04-30 Beecham Group Plc Heterocyclic coumarin derivatives, their preparation and pharmaceutical compositions comprising said derivatives
US4405620A (en) 1980-01-19 1983-09-20 Beecham Group Limited Piperazine derivatives

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0010392A1 (en) * 1978-10-20 1980-04-30 Beecham Group Plc Heterocyclic coumarin derivatives, their preparation and pharmaceutical compositions comprising said derivatives
US4405620A (en) 1980-01-19 1983-09-20 Beecham Group Limited Piperazine derivatives

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee