GB1303019A - - Google Patents
Info
- Publication number
- GB1303019A GB1303019A GB5771271A GB5771271A GB1303019A GB 1303019 A GB1303019 A GB 1303019A GB 5771271 A GB5771271 A GB 5771271A GB 5771271 A GB5771271 A GB 5771271A GB 1303019 A GB1303019 A GB 1303019A
- Authority
- GB
- United Kingdom
- Prior art keywords
- reacting
- antiarhythmic
- delalande
- trimethoxyacetophenone
- choleretic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 abstract 2
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- VUGQIIQFXCXZJU-UHFFFAOYSA-N 3,4,5-trimethoxyacetophenone Chemical compound COC1=CC(C(C)=O)=CC(OC)=C1OC VUGQIIQFXCXZJU-UHFFFAOYSA-N 0.000 abstract 1
- 208000001953 Hypotension Diseases 0.000 abstract 1
- 229910021627 Tin(IV) chloride Inorganic materials 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000000731 choleretic agent Substances 0.000 abstract 1
- 230000001989 choleretic effect Effects 0.000 abstract 1
- 239000000812 cholinergic antagonist Substances 0.000 abstract 1
- 150000004862 dioxolanes Chemical class 0.000 abstract 1
- GKIPXFAANLTWBM-UHFFFAOYSA-N epibromohydrin Chemical compound BrCC1CO1 GKIPXFAANLTWBM-UHFFFAOYSA-N 0.000 abstract 1
- 208000021822 hypotensive Diseases 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 230000002093 peripheral effect Effects 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- -1 piperidino, morpholino Chemical group 0.000 abstract 1
- 230000002048 spasmolytic effect Effects 0.000 abstract 1
- HPGGPRDJHPYFRM-UHFFFAOYSA-J tin(iv) chloride Chemical compound Cl[Sn](Cl)(Cl)Cl HPGGPRDJHPYFRM-UHFFFAOYSA-J 0.000 abstract 1
- 230000000304 vasodilatating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/28—Radicals substituted by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1303019 Dioxolanes DELALANDE SA 13 Dec 1971 [7 Jan 1971] 57712/71 Heading C2C Compounds of the general formula (R 1,2 =C 1-3 alkyl or -NR 1 R 2 = 1-pyrrolidinyl, piperidino, morpholino) and their acid addition salts are prepared by reacting epibromohydrin with 3,4,5-trimethoxyacetophenone in the presence of stannic chloride and in carbon tetrachloride, and reacting the resulting 2-methyl- 4 - bromomethyl - 2 - (3<SP>1</SP>,4<SP>1</SP>,5<SP>1</SP> - trimethoxyphenyl)-dioxolane with R 1 R 2 NH., optionally followed by salt formation. The above compounds possess spasmolytic, choleretic, hypotensive, peripheral vasodilatory and antiarhythmic properties, and may be administered in the form of pharmaceutical preparations containing them in association with a carrier.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7100277A FR2121371B1 (en) | 1971-01-07 | 1971-01-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1303019A true GB1303019A (en) | 1973-01-17 |
Family
ID=9069890
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5771271A Expired GB1303019A (en) | 1971-01-07 | 1971-12-13 |
Country Status (10)
| Country | Link |
|---|---|
| JP (1) | JPS5425035B1 (en) |
| BE (1) | BE776421A (en) |
| CA (1) | CA989837A (en) |
| CH (1) | CH535759A (en) |
| DE (1) | DE2200766C3 (en) |
| ES (1) | ES398628A1 (en) |
| FR (1) | FR2121371B1 (en) |
| GB (1) | GB1303019A (en) |
| LU (1) | LU64459A1 (en) |
| NL (1) | NL7200285A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3305769A1 (en) * | 1982-06-04 | 1983-12-08 | Bayer Ag, 5090 Leverkusen | PEST CONTROL |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2445393A (en) * | 1944-03-08 | 1948-07-20 | Rhone Poulenc Sa | New amino-derivatives of dioxa-cyclopentane |
-
1971
- 1971-01-07 FR FR7100277A patent/FR2121371B1/fr not_active Expired
- 1971-12-08 BE BE776421A patent/BE776421A/en unknown
- 1971-12-13 GB GB5771271A patent/GB1303019A/en not_active Expired
- 1971-12-14 CH CH1827571A patent/CH535759A/en not_active IP Right Cessation
- 1971-12-14 LU LU64459D patent/LU64459A1/xx unknown
-
1972
- 1972-01-05 ES ES398628A patent/ES398628A1/en not_active Expired
- 1972-01-06 CA CA131,848A patent/CA989837A/en not_active Expired
- 1972-01-07 JP JP436972A patent/JPS5425035B1/ja active Pending
- 1972-01-07 NL NL7200285A patent/NL7200285A/xx unknown
- 1972-01-07 DE DE19722200766 patent/DE2200766C3/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| LU64459A1 (en) | 1972-08-23 |
| CA989837A (en) | 1976-05-25 |
| NL7200285A (en) | 1972-07-11 |
| JPS5425035B1 (en) | 1979-08-24 |
| DE2200766A1 (en) | 1972-07-20 |
| DE2200766B2 (en) | 1975-05-07 |
| FR2121371A1 (en) | 1972-08-25 |
| BE776421A (en) | 1972-06-08 |
| CH535759A (en) | 1973-04-15 |
| FR2121371B1 (en) | 1974-08-30 |
| ES398628A1 (en) | 1975-06-01 |
| DE2200766C3 (en) | 1976-01-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |