GB1398918A - Substituted aminoalkyl guanidines - Google Patents
Substituted aminoalkyl guanidinesInfo
- Publication number
- GB1398918A GB1398918A GB5142972A GB5142972A GB1398918A GB 1398918 A GB1398918 A GB 1398918A GB 5142972 A GB5142972 A GB 5142972A GB 5142972 A GB5142972 A GB 5142972A GB 1398918 A GB1398918 A GB 1398918A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- compound
- group
- carbon atoms
- prepared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 aminoalkyl guanidines Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 6
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- XZMCDFZZKTWFGF-UHFFFAOYSA-N Cyanamide Chemical compound NC#N XZMCDFZZKTWFGF-UHFFFAOYSA-N 0.000 abstract 1
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 abstract 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 229940124630 bronchodilator Drugs 0.000 abstract 1
- 230000001813 broncholytic effect Effects 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 150000002118 epoxides Chemical class 0.000 abstract 1
- 230000002349 favourable effect Effects 0.000 abstract 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052737 gold Inorganic materials 0.000 abstract 1
- 239000010931 gold Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000003944 halohydrins Chemical class 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052709 silver Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/12—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
1398918 Aminoalkylguanidines DEUTSCHE GOLD - UND SILBER - SCHEIDEANSTALT 8 Nov 1972 [8 Nov 1971] 51429/72 Heading C2C Novel compounds of Formula I in which R<SP>1</SP> represents a hydrogen atom or a hydroxy group, R<SP>2</SP> represents a hydroxy group, a hydroxymethyl group or an alkyl group with 1 to 6 carbon atoms, R<SP>3</SP> represents a hydrogen atom or an alkyl group with 1 to 4 carbon atoms and Alk represents a linear or branched alkylene group with 2 to 6 carbon atoms, and their acid addition salts are prepared by one of the following methods; (a) reacting a compound of formula with an S-alkylisothiourea, cyanamide, or guanidine; (b) a compound of Formula III wherein X is halogen or is linked via the OH group to form an epoxide is reacted with or (c) by reduction of the ketone corresponding to the OH in a compound of Formula I. Intermediates of Formula II above are prepared by reacting the compound of formula NH 2 AlkNH 2 a with halohydrin of Formula IV, R 1 and R 2 may be as above or benzyloxy. Intermediates of Formula I above wherein R 1 and R 2 are benzyloxy are prepared in method (a) above. Pharmaceutical compositions in conventional forms for enteral, parenteral or perlingual administration and having broncholytic and favourable circulatory activity comprise an above novel compound and a carrier or diluent.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT960671A AT316576B (en) | 1971-11-08 | 1971-11-08 | Process for the preparation of new substituted aminoalkyl guanidines and their acid addition salts |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1398918A true GB1398918A (en) | 1975-06-25 |
Family
ID=3615648
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5142972A Expired GB1398918A (en) | 1971-11-08 | 1972-11-08 | Substituted aminoalkyl guanidines |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US3821301A (en) |
| JP (1) | JPS5243827B2 (en) |
| AT (1) | AT316576B (en) |
| BE (1) | BE791013A (en) |
| CA (1) | CA979925A (en) |
| CH (1) | CH573903A5 (en) |
| DD (1) | DD104292A5 (en) |
| DE (1) | DE2254091C3 (en) |
| FR (1) | FR2159365B1 (en) |
| GB (1) | GB1398918A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4317832A (en) | 1978-09-06 | 1982-03-02 | Klingler Karl Heinz | Indolyl and methylindolyl substituted aminoalkyl guanidines |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2656608B1 (en) * | 1989-12-28 | 1992-04-24 | Roussel Uclaf | NOVEL BENZOYLATED POLYAMINES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS FUNGICIDES. |
-
0
- BE BE791013D patent/BE791013A/en unknown
-
1971
- 1971-11-08 AT AT960671A patent/AT316576B/en active
-
1972
- 1972-10-19 CH CH1526872A patent/CH573903A5/xx not_active IP Right Cessation
- 1972-10-31 US US00302411A patent/US3821301A/en not_active Expired - Lifetime
- 1972-11-04 DE DE2254091A patent/DE2254091C3/en not_active Expired
- 1972-11-06 JP JP47111078A patent/JPS5243827B2/ja not_active Expired
- 1972-11-07 DD DD166711A patent/DD104292A5/xx unknown
- 1972-11-08 FR FR7239505A patent/FR2159365B1/fr not_active Expired
- 1972-11-08 CA CA155,985A patent/CA979925A/en not_active Expired
- 1972-11-08 GB GB5142972A patent/GB1398918A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4317832A (en) | 1978-09-06 | 1982-03-02 | Klingler Karl Heinz | Indolyl and methylindolyl substituted aminoalkyl guanidines |
Also Published As
| Publication number | Publication date |
|---|---|
| DE2254091A1 (en) | 1973-05-24 |
| FR2159365B1 (en) | 1975-06-20 |
| US3821301A (en) | 1974-06-28 |
| CH573903A5 (en) | 1976-03-31 |
| AT316576B (en) | 1974-07-25 |
| JPS4856640A (en) | 1973-08-09 |
| JPS5243827B2 (en) | 1977-11-02 |
| DE2254091B2 (en) | 1981-07-23 |
| DD104292A5 (en) | 1974-03-05 |
| DE2254091C3 (en) | 1982-04-22 |
| BE791013A (en) | 1973-05-07 |
| CA979925A (en) | 1975-12-16 |
| FR2159365A1 (en) | 1973-06-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |