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GB1369247A - Amines the preparation thereof and their use in pharmaceutical compositions - Google Patents

Amines the preparation thereof and their use in pharmaceutical compositions

Info

Publication number
GB1369247A
GB1369247A GB3652271A GB3652271A GB1369247A GB 1369247 A GB1369247 A GB 1369247A GB 3652271 A GB3652271 A GB 3652271A GB 3652271 A GB3652271 A GB 3652271A GB 1369247 A GB1369247 A GB 1369247A
Authority
GB
United Kingdom
Prior art keywords
alkyl
carbon atoms
alkoxy
hydroxyalkyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3652271A
Inventor
Timothy Henry Cronin
Hermann Faubl
William Wheeler Hoffman
James Joseph Korst
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Pfizer Inc
Original Assignee
Pfizer Corp Belgium
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium, Pfizer Inc filed Critical Pfizer Corp Belgium
Publication of GB1369247A publication Critical patent/GB1369247A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C275/14—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
    • C07C291/04—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds containing amino-oxide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1369247 Diamine and triamine derivatives PFIZER Inc 3 Aug 1971 [7 Aug 1970 24 May 1971] 36522/71 Heading C2C [Also in Division A5] The invention comprises novel therapeutic compounds (I) and the di-N-oxides, methonium iodides and non- toxic acid addition salts thereof wherein R 1 is alkyl of from 1 to 20 carbon atoms, aralkyl, aryloxyalkyl, hydroxyalkyl of from 2 to 8 carbon atoms or R 2 is alkyl of from 6 to 20 carbon atoms, aralkyl or aryloxyalkyl of from 12 to 24 carbon atoms or as Formula II above, R‹ is alkoxy of from 1 to 18 carbon atoms; each of R<SP>1</SP> and R<SP>11</SP> is hydrogen, alkyl, or alkoxy of from 1 to 18 carbon atoms; or R<SP>1</SP> and R<SP>11</SP>; when taken together, are methylenedioxy; provided that the total number of carbon atoms in R‹, R<SP>1</SP> and R<SP>11</SP> is from 5 to 48; R 3 is hydrogen, alkyl of from 1 to 20 carbon atoms, hydroxyalkyl of from 2 to 8 carbon atoms, phenylcarbamoyloxy-(alkyl), #- carboxyalkanoyloxy-(alkyl), allyl, alkanoyl of from 1 to 6 carbon atoms, alkanoyloxy-(alkyl), carbo alkoxy alkyl, carboxy (alkyl), alkoxy (alkyl) or gem-di-(alkoxy) alkyl; R 4 is hydrogen, alkyl of from 1 to 8 carbon atoms, hydroxyalkyl of from 2 to 8 carbon atoms, carbo alkoxy alkyl, alkanoyloxy-(alkyl), carboxy-(alkyl), alkoxy- (alkyl), phenylcarbamoyloxy-(alkyl), #-carboxyalkanoyloxy-(alkyl), allyl, dihydroxyalkyl of from 3 to 8 carbon atoms or morpholinoethyl; R 3 and R 4 when taken together with the nitrogen to which they are attached are morpholino; X is straight chain alkylene of from 2 to 6 carbon atoms or X<SP>1</SP> is X, phenylenedimethylene or m is 0 or 1, with the provisos that only one of X and X<SP>1</SP> is and when X<SP>1</SP> is phenylenedimethylene, m is 0; and when X is alkylene, m is 1 and each of R 1 and R 2 is as Formula II. They are made by standard methods.
GB3652271A 1970-08-07 1971-08-03 Amines the preparation thereof and their use in pharmaceutical compositions Expired GB1369247A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6219270A 1970-08-07 1970-08-07
US14654871A 1971-05-24 1971-05-24

Publications (1)

Publication Number Publication Date
GB1369247A true GB1369247A (en) 1974-10-02

Family

ID=26741969

Family Applications (4)

Application Number Title Priority Date Filing Date
GB1725673A Expired GB1369249A (en) 1970-08-07 1971-08-03 Amines the preparation thereof and their use in pharmaceutical compositions
GB3652271A Expired GB1369247A (en) 1970-08-07 1971-08-03 Amines the preparation thereof and their use in pharmaceutical compositions
GB1725773A Expired GB1369250A (en) 1970-08-07 1971-08-03 Amines the preparation thereof and their use in pharmacejtical compositions
GB1725573A Expired GB1369248A (en) 1970-08-07 1971-08-03 Amides the preparation thereof and their use in pharmacjeutical compositions

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB1725673A Expired GB1369249A (en) 1970-08-07 1971-08-03 Amines the preparation thereof and their use in pharmaceutical compositions

Family Applications After (2)

Application Number Title Priority Date Filing Date
GB1725773A Expired GB1369250A (en) 1970-08-07 1971-08-03 Amines the preparation thereof and their use in pharmacejtical compositions
GB1725573A Expired GB1369248A (en) 1970-08-07 1971-08-03 Amides the preparation thereof and their use in pharmacjeutical compositions

Country Status (13)

Country Link
JP (1) JPS5950646B1 (en)
AR (1) AR194346A1 (en)
AU (1) AU465751B2 (en)
BE (1) BE770966A (en)
CA (1) CA1001158A (en)
CH (2) CH568959A5 (en)
DE (2) DE2139545C2 (en)
ES (2) ES393965A1 (en)
FR (2) FR2102116B1 (en)
GB (4) GB1369249A (en)
NL (1) NL172615C (en)
PH (1) PH13755A (en)
SE (3) SE399701B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0008696A1 (en) * 1978-08-30 1980-03-19 Asta-Werke Aktiengesellschaft Chemische Fabrik Basically substituted urea compounds, process for producing the same and pharmaceutical compositions containing the same
US4987130A (en) * 1987-02-06 1991-01-22 Takeda Chemical Industries, Ltd. Substituted amine derivatives, their production and use
US5763495A (en) * 1996-09-30 1998-06-09 Albemarle Corporation Widely-bridged alcohol polyethoxylates and their use

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4166132A (en) * 1977-08-18 1979-08-28 Pfizer Inc. Antiviral amine derivatives of glycerol and propanediols
EP0018741A3 (en) * 1979-05-08 1981-05-27 Imperial Chemical Industries Plc Long chain amine derivatives and process for their preparation
FR2507083A1 (en) * 1981-06-04 1982-12-10 Pos Lab AMINO-1 DODECYCLOXY-3-PROPANE COLLYRY COMPOSITION FOR THE TREATMENT OF CONJUNCTIVITIS AND KERATIVES
US4480092A (en) * 1982-02-19 1984-10-30 The B. F. Goodrich Company Alkylated polyalkylenepolyamines, substituted oxo-piperazinyl-triazines
FI832935A7 (en) * 1982-08-20 1984-02-21 Midit DERIVAT AV W-AMINOSYROR, DERAS FRAMSTAELLNING SAMT DESSA DERIVAT INNEHAOLLANDE BLANDNINGAR
US4504484A (en) * 1982-11-04 1985-03-12 Chevron Research Company Certain N,N-di-substituted-pyridine carboxamides, fungicidal compositions and fungicidal method of use
JP2756000B2 (en) * 1989-08-25 1998-05-25 花王株式会社 Tertiary amino alcohol and method for producing the same
GB9118105D0 (en) * 1991-08-22 1991-10-09 Exxon Chemical Patents Inc Compounds and fuel compositions
AT400566B (en) * 1993-01-22 1996-01-25 Chemie Linz Gmbh Use and process for the preparation of N-cyclic and N,N'- dicyclic ureas
DE4302860A1 (en) * 1993-01-22 1994-08-04 Chemie Linz Deutschland N-Cyclic and N, N'dicyclic ureas
RU2445094C1 (en) * 2010-10-05 2012-03-20 Общество С Ограниченной Ответственностью "Научно-Исследовательская Компания "Медбиофарм" Interferon-inducing agent for treating acute respiratory viral infections (arvd)
WO2025232898A1 (en) * 2024-05-10 2025-11-13 Yoltech Therapeutics Co., Ltd Lipid compounds and lipid nanoparticle compositions

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3355355A (en) * 1965-02-05 1967-11-28 Smith Kline French Lab Antiviral cycloalkylamine compositions and method
US3531489A (en) * 1968-10-18 1970-09-29 Richardson Merrell Inc Bis-basic esters and thioesters of fluoranthene

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0008696A1 (en) * 1978-08-30 1980-03-19 Asta-Werke Aktiengesellschaft Chemische Fabrik Basically substituted urea compounds, process for producing the same and pharmaceutical compositions containing the same
US4987130A (en) * 1987-02-06 1991-01-22 Takeda Chemical Industries, Ltd. Substituted amine derivatives, their production and use
US5763495A (en) * 1996-09-30 1998-06-09 Albemarle Corporation Widely-bridged alcohol polyethoxylates and their use
US5902772A (en) * 1996-09-30 1999-05-11 Albemarle Corporation Widely-bridged alcohol polyethoxylates and their use

Also Published As

Publication number Publication date
DE2167223C2 (en) 1982-11-18
FR2102116A1 (en) 1972-04-07
CH568959A5 (en) 1975-11-14
CH586184A5 (en) 1977-03-31
AR194346A1 (en) 1973-07-13
AU465751B2 (en) 1973-02-08
FR2102116B1 (en) 1978-08-18
SE7501333L (en) 1975-02-06
FR2258848B1 (en) 1978-07-07
DE2139545C2 (en) 1986-03-27
GB1369250A (en) 1974-10-02
CA1001158A (en) 1976-12-07
DE2139545A1 (en) 1972-03-30
NL172615B (en) 1983-05-02
GB1369248A (en) 1974-10-02
GB1369249A (en) 1974-10-02
ES419681A1 (en) 1976-05-16
NL7110906A (en) 1972-02-09
SE399701B (en) 1978-02-27
PH13755A (en) 1980-09-17
NL172615C (en) 1983-10-03
SE425657B (en) 1982-10-25
SE7501332L (en) 1975-02-06
ES393965A1 (en) 1974-07-01
AU3200771A (en) 1973-02-08
FR2258848A1 (en) 1975-08-22
JPS5950646B1 (en) 1984-12-10
BE770966A (en) 1972-02-07
SE425658B (en) 1982-10-25

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee