GB1364312A - Biologically active imidazoles - Google Patents
Biologically active imidazolesInfo
- Publication number
- GB1364312A GB1364312A GB324371A GB324371A GB1364312A GB 1364312 A GB1364312 A GB 1364312A GB 324371 A GB324371 A GB 324371A GB 324371 A GB324371 A GB 324371A GB 1364312 A GB1364312 A GB 1364312A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compounds
- biologically active
- jan
- imidazoles
- division
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000002460 imidazoles Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- -1 1-Substituted imidazoles Chemical class 0.000 abstract 2
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 2
- SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 230000000871 hypocholesterolemic effect Effects 0.000 abstract 1
- 125000002883 imidazolyl group Chemical class 0.000 abstract 1
- 125000001421 myristyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Steroid Compounds (AREA)
Abstract
1364312 1-Substituted imidazoles BEECHAM GROUP Ltd 25 Jan 1972 [27 Jan 1971] 3243/71 Heading C2C [Also in Division A5] The invention comprises compounds of formula and their acid addition salts, wherein R is C 10 or C 15 alkyl or alkenyl. Otherwise specified are compounds where R<SP>1</SP> is dodecyl, tetradecyl and dodec-11-ynyl. These compounds are prepared by N-substitution of imidazole; they have hypocholesterolaemic activity (see Division A5).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB324371A GB1364312A (en) | 1972-01-25 | 1972-01-25 | Biologically active imidazoles |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB324371A GB1364312A (en) | 1972-01-25 | 1972-01-25 | Biologically active imidazoles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1364312A true GB1364312A (en) | 1974-08-21 |
Family
ID=9754659
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB324371A Expired GB1364312A (en) | 1972-01-25 | 1972-01-25 | Biologically active imidazoles |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1364312A (en) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0000951A1 (en) * | 1977-08-26 | 1979-03-07 | The Wellcome Foundation Limited | Pharmaceutical Formulations comprising 1-substituted imidazoles, 1-substituted imidazoles and 1-substituted imidazoles for use in the treatment or prophylaxis of thrombo-embolic disorders |
| EP0003211A1 (en) * | 1977-11-09 | 1979-08-08 | BASF Aktiengesellschaft | Process to control pests with imidazole derivatives |
| EP0009944A3 (en) * | 1978-10-02 | 1980-11-12 | Merck & Co. Inc. | Lysosomotropic detergent therapeutic agents and use thereof |
| EP0028757A1 (en) * | 1979-11-06 | 1981-05-20 | Bayer Ag | Cycloheptatrienylimidazole derivatives, process for their preparation and their use in medicaments |
| US4317830A (en) * | 1977-08-26 | 1982-03-02 | Burroughs Wellcome Co. | Treatment of shock |
| US4528195A (en) * | 1978-02-01 | 1985-07-09 | Thorogood Peter B | Imidazole derivatives and salts thereof, their synthesis and intermediates and pharmaceutical formulations |
| DE3726109A1 (en) * | 1986-08-07 | 1988-07-14 | Puetter Medice Chem Pharm | Pharmaceutical preparations |
| EP0260429A3 (en) * | 1986-08-07 | 1991-04-17 | MEDICEChem.-Pharm. Fabrik Pütter GmbH & Co. KG | N-alkylated quaternary nitrogen-containing heterocycles, process for their preparation and their use in pharmaceutical compositions |
| US5250194A (en) * | 1991-02-13 | 1993-10-05 | Buckman Laboratories International, Inc. | N-dodecyl heterocyclic compounds useful as industrial microbicides and preservatives |
| US6297268B1 (en) * | 1999-11-30 | 2001-10-02 | Schering Corporation | Imidazoles as cholesterol lowering agents |
-
1972
- 1972-01-25 GB GB324371A patent/GB1364312A/en not_active Expired
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0000951A1 (en) * | 1977-08-26 | 1979-03-07 | The Wellcome Foundation Limited | Pharmaceutical Formulations comprising 1-substituted imidazoles, 1-substituted imidazoles and 1-substituted imidazoles for use in the treatment or prophylaxis of thrombo-embolic disorders |
| US4284641A (en) | 1977-08-26 | 1981-08-18 | Burroughs Wellcome Co. | Pharmaceutically active imidazole derivatives |
| US4317830A (en) * | 1977-08-26 | 1982-03-02 | Burroughs Wellcome Co. | Treatment of shock |
| EP0003211A1 (en) * | 1977-11-09 | 1979-08-08 | BASF Aktiengesellschaft | Process to control pests with imidazole derivatives |
| US4282238A (en) | 1977-11-09 | 1981-08-04 | Basf Aktiengesellschaft | Insecticidal process |
| US4528195A (en) * | 1978-02-01 | 1985-07-09 | Thorogood Peter B | Imidazole derivatives and salts thereof, their synthesis and intermediates and pharmaceutical formulations |
| EP0009944A3 (en) * | 1978-10-02 | 1980-11-12 | Merck & Co. Inc. | Lysosomotropic detergent therapeutic agents and use thereof |
| EP0055991A3 (en) * | 1978-10-02 | 1982-08-11 | Merck & Co. Inc. | Lysosomotropic detergent therapeutic agents, compositions containing them and their uses |
| EP0028757A1 (en) * | 1979-11-06 | 1981-05-20 | Bayer Ag | Cycloheptatrienylimidazole derivatives, process for their preparation and their use in medicaments |
| DE3726109A1 (en) * | 1986-08-07 | 1988-07-14 | Puetter Medice Chem Pharm | Pharmaceutical preparations |
| EP0260429A3 (en) * | 1986-08-07 | 1991-04-17 | MEDICEChem.-Pharm. Fabrik Pütter GmbH & Co. KG | N-alkylated quaternary nitrogen-containing heterocycles, process for their preparation and their use in pharmaceutical compositions |
| US5250194A (en) * | 1991-02-13 | 1993-10-05 | Buckman Laboratories International, Inc. | N-dodecyl heterocyclic compounds useful as industrial microbicides and preservatives |
| US6297268B1 (en) * | 1999-11-30 | 2001-10-02 | Schering Corporation | Imidazoles as cholesterol lowering agents |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |