GB1355804A - Penicillins and cephalosporinesters - Google Patents
Penicillins and cephalosporinestersInfo
- Publication number
- GB1355804A GB1355804A GB1355804DA GB1355804A GB 1355804 A GB1355804 A GB 1355804A GB 1355804D A GB1355804D A GB 1355804DA GB 1355804 A GB1355804 A GB 1355804A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- group
- amino
- acid
- dec
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229930182555 Penicillin Natural products 0.000 title abstract 3
- 150000002960 penicillins Chemical class 0.000 title abstract 2
- 150000002148 esters Chemical class 0.000 abstract 3
- 229930186147 Cephalosporin Natural products 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 2
- 229940124587 cephalosporin Drugs 0.000 abstract 2
- -1 cephalosporin esters Chemical class 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 abstract 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000005278 alkyl sulfonyloxy group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000005279 aryl sulfonyloxy group Chemical group 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- YGBFLZPYDUKSPT-MRVPVSSYSA-N cephalosporanic acid Chemical compound S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)C[C@H]21 YGBFLZPYDUKSPT-MRVPVSSYSA-N 0.000 abstract 1
- 150000001780 cephalosporins Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000003678 cyclohexadienyl group Chemical group C1(=CC=CCC1)* 0.000 abstract 1
- 125000000596 cyclohexenyl group Chemical group C1(=CCCCC1)* 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000001240 enamine group Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- YAMHXTCMCPHKLN-UHFFFAOYSA-N imidazolidin-2-one Chemical group O=C1NCCN1 YAMHXTCMCPHKLN-UHFFFAOYSA-N 0.000 abstract 1
- RBKMMJSQKNKNEV-RITPCOANSA-N penicillanic acid Chemical compound OC(=O)[C@H]1C(C)(C)S[C@@H]2CC(=O)N21 RBKMMJSQKNKNEV-RITPCOANSA-N 0.000 abstract 1
- 229940049954 penicillin Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Abstract
1355804 Esters of penicillins and cephalosporins BEECHAM GROUP Ltd 2 Dec 1971 [4 Dec 1970] 57619/70 Heading C2A Novel penicillin and cephalosporin esters having the general Formula (I) and acid addition salts thereof, wherein R is a cyclohexyl, cyclohexadienyl or cyclohexenyl ring; R<SP>1</SP> is an alkyl, cycloalkyl, aralkyl, aryl or heterocyclic group; X is an amino, protonated amino, azido, phthalimido or enamine group, or is condensed with a C 1 -C 6 alkyl-methyl ketone to form an imidazolidinone ring, and A represents a divalent radical of Formula (II) wherein R<SP>2</SP> is hydrogen, hydroxy, acyloxy or 1- pyridinium, are prepared by either (a) acylating an appropriate 6-aminopenicillanic ester or 7- aminocephalosporanic ester, of Formula (V) with an N-acylating derivative of a carboxylic acid of Formula (VI) wherein Y is protected amino, and optionally then converting the protected amino group to an amino group; or (b) esterifying an appropriate penicillanic acid or cephalosporanic acid, of Formula (VII) - with a compound of Formula (VIII) in which Z is halogen, alkylsulphonyloxy or arylsulphonyloxy.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5761970 | 1970-12-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1355804A true GB1355804A (en) | 1974-06-05 |
Family
ID=10479609
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1355804D Expired GB1355804A (en) | 1970-12-04 | 1970-12-04 | Penicillins and cephalosporinesters |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1355804A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2480753A1 (en) * | 1980-04-17 | 1981-10-23 | Dobfar Spa | CEPHALOSPORINE DESACETOXY ESTERS, THEIR SALTS AND METHODS OF MAKING SAME |
| DE3108237A1 (en) * | 1980-03-14 | 1982-04-01 | Dobfar S.p.A., 20059 Vimercate, Milano | CEPHAPIRINESTER, THEIR SALTS AND METHOD FOR THE PRODUCTION THEREOF |
| EP0336511A3 (en) * | 1988-04-08 | 1991-07-03 | SCLAVO S.p.A. | Method of protection of the carboxy groups in the chemistry of beta-lactam compounds |
-
1970
- 1970-12-04 GB GB1355804D patent/GB1355804A/en not_active Expired
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3108237A1 (en) * | 1980-03-14 | 1982-04-01 | Dobfar S.p.A., 20059 Vimercate, Milano | CEPHAPIRINESTER, THEIR SALTS AND METHOD FOR THE PRODUCTION THEREOF |
| FR2480753A1 (en) * | 1980-04-17 | 1981-10-23 | Dobfar Spa | CEPHALOSPORINE DESACETOXY ESTERS, THEIR SALTS AND METHODS OF MAKING SAME |
| DE3115244A1 (en) * | 1980-04-17 | 1982-05-13 | Dobfar S.p.A., 20059 Vimercate, Milano | ESTERS OF DESACETOXYCEPHALOSPORINES, THEIR PHARMACEUTICAL SAFE SALTS AND METHOD FOR THE PRODUCTION THEREOF |
| EP0336511A3 (en) * | 1988-04-08 | 1991-07-03 | SCLAVO S.p.A. | Method of protection of the carboxy groups in the chemistry of beta-lactam compounds |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |