GB1209138A - IMPROVEMENTS IN OR RELATING TO A NEW alpha-NAPHTHOXY-ISOBUTYRIC ACID DERIVATIVE, PROCESS FOR ITS PREPARATION AND THERAPEUTICAL COMPOSITION CONTAINING SAME - Google Patents
IMPROVEMENTS IN OR RELATING TO A NEW alpha-NAPHTHOXY-ISOBUTYRIC ACID DERIVATIVE, PROCESS FOR ITS PREPARATION AND THERAPEUTICAL COMPOSITION CONTAINING SAMEInfo
- Publication number
- GB1209138A GB1209138A GB3013669A GB3013669A GB1209138A GB 1209138 A GB1209138 A GB 1209138A GB 3013669 A GB3013669 A GB 3013669A GB 3013669 A GB3013669 A GB 3013669A GB 1209138 A GB1209138 A GB 1209138A
- Authority
- GB
- United Kingdom
- Prior art keywords
- naphthoxy
- isobutyric acid
- relating
- preparation
- composition containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- WGXRLJQIXNXFSY-UHFFFAOYSA-N 2-methyl-2-naphthalen-1-yloxypropanoic acid Chemical class C1=CC=C2C(OC(C)(C)C(O)=O)=CC=CC2=C1 WGXRLJQIXNXFSY-UHFFFAOYSA-N 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- KJCVRFUGPWSIIH-UHFFFAOYSA-N 1-naphthol Chemical compound C1=CC=C2C(O)=CC=CC2=C1 KJCVRFUGPWSIIH-UHFFFAOYSA-N 0.000 abstract 2
- DZCPSVQCXLAEKZ-UHFFFAOYSA-N 2-methyl-2-naphthalen-1-yloxypropanoyl chloride Chemical compound C1=CC=C2C(OC(C)(C)C(Cl)=O)=CC=CC2=C1 DZCPSVQCXLAEKZ-UHFFFAOYSA-N 0.000 abstract 2
- IDZCGRYTQBOJHK-UHFFFAOYSA-N 6-[(2-methyl-2-naphthalen-1-yloxypropanoyl)amino]hexanoic acid Chemical compound C1(=CC=CC2=CC=CC=C12)OC(C(=O)NCCCCCC(=O)O)(C)C IDZCGRYTQBOJHK-UHFFFAOYSA-N 0.000 abstract 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229960002684 aminocaproic acid Drugs 0.000 abstract 1
- 230000002484 anti-cholesterolemic effect Effects 0.000 abstract 1
- 239000000731 choleretic agent Substances 0.000 abstract 1
- 230000001989 choleretic effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1,209,138. N - (α - naphthoxy - isobutyryl) - 6 - aminohexanoic acid. PHARMA CHEMIE. 13 June, 1969, No. 30136/69. Heading C2C. N - (α - naphthoxy - isobutyryl) - 6 - aminohexanoic acid and its salts is prepared by reaction of 6-aminohexanoic acid with α-naphthoxy-isobutyric acid chloride. α - Naphthoxy - isobutyric acid is prepared from α-naphthol, acetone, chloroform and NaOH. α-Naphthoxy-isobutyric acid chloride is prepared from the free acid and SOCl 2 . Pharmaceutical compositions having choleretic, anti-cholesterolemic and anti-atherosclerous activity and in conventional forms for oral, rectal or parenteral administration comprise an above novel compound or salt and a carrier therefor.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3013669A GB1209138A (en) | 1969-06-13 | 1969-06-13 | IMPROVEMENTS IN OR RELATING TO A NEW alpha-NAPHTHOXY-ISOBUTYRIC ACID DERIVATIVE, PROCESS FOR ITS PREPARATION AND THERAPEUTICAL COMPOSITION CONTAINING SAME |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3013669A GB1209138A (en) | 1969-06-13 | 1969-06-13 | IMPROVEMENTS IN OR RELATING TO A NEW alpha-NAPHTHOXY-ISOBUTYRIC ACID DERIVATIVE, PROCESS FOR ITS PREPARATION AND THERAPEUTICAL COMPOSITION CONTAINING SAME |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1209138A true GB1209138A (en) | 1970-10-21 |
Family
ID=10302888
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3013669A Expired GB1209138A (en) | 1969-06-13 | 1969-06-13 | IMPROVEMENTS IN OR RELATING TO A NEW alpha-NAPHTHOXY-ISOBUTYRIC ACID DERIVATIVE, PROCESS FOR ITS PREPARATION AND THERAPEUTICAL COMPOSITION CONTAINING SAME |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1209138A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2622977A1 (en) * | 1976-05-21 | 1977-12-22 | Kotobuki Seiyaku Co Ltd | (p)-Chlorophenoxy-isobutyryl-glycinamide - for use as lipid metaboliser |
| EP1306094A4 (en) * | 2000-08-01 | 2006-04-12 | Shionogi & Co | Preventives or remedies for obesity or fatty liver |
-
1969
- 1969-06-13 GB GB3013669A patent/GB1209138A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2622977A1 (en) * | 1976-05-21 | 1977-12-22 | Kotobuki Seiyaku Co Ltd | (p)-Chlorophenoxy-isobutyryl-glycinamide - for use as lipid metaboliser |
| EP1306094A4 (en) * | 2000-08-01 | 2006-04-12 | Shionogi & Co | Preventives or remedies for obesity or fatty liver |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1432576A (en) | Substituted phenylacetic acids | |
| GB1438265A (en) | ||
| GB1436978A (en) | Choline derivatives and pharmaceutical compositions containing the same | |
| GB1363719A (en) | Diglycidyl derivatives of compounds containing two n-heterocyclic rings processes for the production of the derivatives and the use thereof | |
| GB1308028A (en) | Thiazolylbenzoic acid derivatives and a process for their manufactur | |
| GB1188154A (en) | New Pyridine Derivatives and process for their preparation | |
| GB1314830A (en) | Pharmaceutically useful benzomorphanes and their production | |
| GB1209138A (en) | IMPROVEMENTS IN OR RELATING TO A NEW alpha-NAPHTHOXY-ISOBUTYRIC ACID DERIVATIVE, PROCESS FOR ITS PREPARATION AND THERAPEUTICAL COMPOSITION CONTAINING SAME | |
| GB1378068A (en) | Citric acid derivatives | |
| GB1292410A (en) | Thienobenzothiazepine derivatives | |
| GB1245549A (en) | (thienylideneamino)oxy-alkanoic acid and derivatives thereof | |
| GB1411700A (en) | Penicillins and production thereof | |
| GB1369580A (en) | Tricyclic diphenylamine derivatives | |
| GB1299201A (en) | Medicaments derived from thiazolidine carboxylic acid | |
| GB1283632A (en) | Phenylethanolamine derivatives | |
| GB1299566A (en) | Bis-basic ethers of 2,6- and 2,7-dihydroxyanthraquinones | |
| GB1254270A (en) | Benzoxazepine derivatives | |
| GB1428933A (en) | 5-phenyl-sulphinyl-2-benzimidazolyl-carbamic acid esters and process for their manufacture | |
| ES380714A1 (en) | Antifibrinolytic compounds | |
| GB1252540A (en) | ||
| GB1341612A (en) | Theophylline isobutyrate salts and process for the preparation thereof | |
| GB1468333A (en) | Ketoglutaric acid derivatives | |
| GB1258726A (en) | ||
| GB1304164A (en) | ||
| ES286809A1 (en) | Novel benzoxazepine derivatives and a process for the manufacture thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |