GB1169027A - Azetidine Derivatives - Google Patents
Azetidine DerivativesInfo
- Publication number
- GB1169027A GB1169027A GB5191766A GB5191766A GB1169027A GB 1169027 A GB1169027 A GB 1169027A GB 5191766 A GB5191766 A GB 5191766A GB 5191766 A GB5191766 A GB 5191766A GB 1169027 A GB1169027 A GB 1169027A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- compound
- halogen
- alkyl
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001539 azetidines Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 101100037762 Caenorhabditis elegans rnh-2 gene Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000001691 aryl alkyl amino group Chemical group 0.000 abstract 1
- 125000005279 aryl sulfonyloxy group Chemical group 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- -1 hydroxy halide Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract 1
- 238000006798 ring closing metathesis reaction Methods 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1,169,027. Azetidine derivatives. BEECHAM GROUP Ltd. 6 Dec., 1967 [19 Nov., 1966], No. 51917/66. Heading C2C. Novel compounds of Formula I and acid addition and quaternary ammonium salts thereof, wherein R is H, aralkyl or alkyl each optionally substituted by an OH, acyloxy, amino, optionally substituted by alkyl or aralkyl groups, or guanidinoalkyl group; R 1 is halogen or OH and R 2 is halogen, OH, NH 2 or aralkylamino, or R 1 and R 2 together form -O-, provided that when R is H and R 2 is amino R 1 is not OH, are prepared (1) by ring closure by reaction with RNH 2 of a compound of Formula where X and Y are each halogen or alkyl or aryl sulphonyloxy; or (2) by reaction of an appropriate reagent AB with a compound of formula to give a compound of Formula I, where R 1 is BO and R 2 is A, an example of AB being a hydroxy halide; or (3) by cyclization of a compound of formula where Z is HSO 4 or X. Intermediates of Formula II are prepared by various methods. Pharmaceutical compositions, optionally in unit dosage form, comprise an above novel compound and a carrier therefore.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5191766A GB1169027A (en) | 1966-11-19 | 1966-11-19 | Azetidine Derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5191766A GB1169027A (en) | 1966-11-19 | 1966-11-19 | Azetidine Derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1169027A true GB1169027A (en) | 1969-10-29 |
Family
ID=10461916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5191766A Expired GB1169027A (en) | 1966-11-19 | 1966-11-19 | Azetidine Derivatives |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1169027A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4634554A (en) * | 1983-10-21 | 1987-01-06 | Shell Oil Company | N-benzyl,3-hydroxymethyl and 3-alkanoyloxymethyl azetidine derivatives |
| EP0199413A3 (en) * | 1985-04-16 | 1987-05-06 | Shell Internationale Researchmaatschappij B.V. | Process for preparing azetidine derivatives and novel intermediates therein |
| US4665197A (en) * | 1984-06-19 | 1987-05-12 | Shell Oil Company | Process for preparing azetidine derivatives and intermediates thereof |
| JP2007070270A (en) * | 2005-09-06 | 2007-03-22 | Ube Ind Ltd | Method for producing 3-aminomethyloxetane compound |
| WO2012153154A1 (en) | 2011-05-06 | 2012-11-15 | Richter Gedeon Nyrt. | Oxetane substituted thieno pyrimidinones |
-
1966
- 1966-11-19 GB GB5191766A patent/GB1169027A/en not_active Expired
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4634554A (en) * | 1983-10-21 | 1987-01-06 | Shell Oil Company | N-benzyl,3-hydroxymethyl and 3-alkanoyloxymethyl azetidine derivatives |
| US4665197A (en) * | 1984-06-19 | 1987-05-12 | Shell Oil Company | Process for preparing azetidine derivatives and intermediates thereof |
| EP0199413A3 (en) * | 1985-04-16 | 1987-05-06 | Shell Internationale Researchmaatschappij B.V. | Process for preparing azetidine derivatives and novel intermediates therein |
| JP2007070270A (en) * | 2005-09-06 | 2007-03-22 | Ube Ind Ltd | Method for producing 3-aminomethyloxetane compound |
| WO2012153154A1 (en) | 2011-05-06 | 2012-11-15 | Richter Gedeon Nyrt. | Oxetane substituted thieno pyrimidinones |
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