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GB1160925A - 2-Substituted Benzofuran Derivatives - Google Patents

2-Substituted Benzofuran Derivatives

Info

Publication number
GB1160925A
GB1160925A GB593567A GB593567A GB1160925A GB 1160925 A GB1160925 A GB 1160925A GB 593567 A GB593567 A GB 593567A GB 593567 A GB593567 A GB 593567A GB 1160925 A GB1160925 A GB 1160925A
Authority
GB
United Kingdom
Prior art keywords
diethylaminoethyl
case
methyl
reaction
alcohol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB593567A
Inventor
Mario Ghelardoni
Filippo Russo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
A Menarini SAS
Original Assignee
A Menarini SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by A Menarini SAS filed Critical A Menarini SAS
Priority to GB593567A priority Critical patent/GB1160925A/en
Publication of GB1160925A publication Critical patent/GB1160925A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Furan Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1,160,925. Benzofurancarbinol derivatives. A. MENARINI S.A.S. 8 Feb., 1967, No. 5935/67. Heading C2C. Novel pharmaceutically active compounds of Formula I wherein R is methyl or phenyl optionally substituted in the para position by Br, Cl, or I or NO 2 , and R<SP>1</SP> is hemisuccinyl, hemiphthalyl, nicotinyl, diethylaminoethyl or may be hydrogen if R is not methyl, are prepared as follows (a) in the case of the alcohols (R<SP>1</SP> = H) by reduction of the corresponding ketones, (b) in the case of the esters by esterification of the aforementioned alcohols, and (c) in the case of the ether, either by reaction of the alcohol with diethylaminoethyl halide or by reaction of diethylaminoethyl alcohol with a 2-benzofuryl chloro methane derivative.
GB593567A 1967-02-08 1967-02-08 2-Substituted Benzofuran Derivatives Expired GB1160925A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB593567A GB1160925A (en) 1967-02-08 1967-02-08 2-Substituted Benzofuran Derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB593567A GB1160925A (en) 1967-02-08 1967-02-08 2-Substituted Benzofuran Derivatives

Publications (1)

Publication Number Publication Date
GB1160925A true GB1160925A (en) 1969-08-06

Family

ID=9805383

Family Applications (1)

Application Number Title Priority Date Filing Date
GB593567A Expired GB1160925A (en) 1967-02-08 1967-02-08 2-Substituted Benzofuran Derivatives

Country Status (1)

Country Link
GB (1) GB1160925A (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2463135A1 (en) * 1979-08-10 1981-02-20 Menarini Sas NOVEL USE IN THERAPY OF THE PRODUCT (2-BENZOFURYL) - (P-CHLOROPHENYL) -CARBINOL (CLORIDAROL, DCI) AS A NORMOLIPIDEMIANT AND ANTIAGRANT PLATELET
FR2493845A1 (en) * 1980-11-12 1982-05-14 Menarini Sas SUBSTITUTED BENZOFURAN-2 DERIVATIVES USEFUL AS MEDICAMENTS AND METHODS OF PREPARATION
WO2004017964A1 (en) 2002-08-19 2004-03-04 Pfizer Products Inc. Combination therapy for hyperproliferative diseases
WO2007062314A2 (en) 2005-11-23 2007-05-31 Bristol-Myers Squibb Company Heterocyclic cetp inhibitors
WO2008070496A2 (en) 2006-12-01 2008-06-12 Bristol-Myers Squibb Company N- ( (3-benzyl) -2, 2- (bis-phenyl) -propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases
EP2392567A1 (en) 2005-10-21 2011-12-07 Bristol-Myers Squibb Company Benzothiazine derivatives and their use as lxr modulators
WO2014170786A1 (en) 2013-04-17 2014-10-23 Pfizer Inc. N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
WO2020150473A2 (en) 2019-01-18 2020-07-23 Dogma Therapeutics, Inc. Pcsk9 inhibitors and methods of use thereof

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2463135A1 (en) * 1979-08-10 1981-02-20 Menarini Sas NOVEL USE IN THERAPY OF THE PRODUCT (2-BENZOFURYL) - (P-CHLOROPHENYL) -CARBINOL (CLORIDAROL, DCI) AS A NORMOLIPIDEMIANT AND ANTIAGRANT PLATELET
US4296124A (en) 1979-08-10 1981-10-20 A. Menarini S.A.S. Pharmaceutical methods
FR2493845A1 (en) * 1980-11-12 1982-05-14 Menarini Sas SUBSTITUTED BENZOFURAN-2 DERIVATIVES USEFUL AS MEDICAMENTS AND METHODS OF PREPARATION
DE3145004A1 (en) * 1980-11-12 1982-06-16 A. Menarini S.a.s., Firenze 2-SUBSTITUTED BENZOFURANE DERIVATIVES
JPS57109774A (en) * 1980-11-12 1982-07-08 Ei Menarinii Esu Aaru Esu 2-substituted benzfuran derivative, manufacture and medicinal composition containing same
US4485112A (en) * 1980-11-12 1984-11-27 A. Menarini S.A.S. N-[(Benzofuran-2-yl)(phenyl)methyl]-alkylene diamines useful in treating arrhythmic, histaminic and tussive conditions
WO2004017964A1 (en) 2002-08-19 2004-03-04 Pfizer Products Inc. Combination therapy for hyperproliferative diseases
EP2392567A1 (en) 2005-10-21 2011-12-07 Bristol-Myers Squibb Company Benzothiazine derivatives and their use as lxr modulators
WO2007062314A2 (en) 2005-11-23 2007-05-31 Bristol-Myers Squibb Company Heterocyclic cetp inhibitors
WO2008070496A2 (en) 2006-12-01 2008-06-12 Bristol-Myers Squibb Company N- ( (3-benzyl) -2, 2- (bis-phenyl) -propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases
WO2014170786A1 (en) 2013-04-17 2014-10-23 Pfizer Inc. N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
WO2020150473A2 (en) 2019-01-18 2020-07-23 Dogma Therapeutics, Inc. Pcsk9 inhibitors and methods of use thereof
EP4470609A2 (en) 2019-01-18 2024-12-04 Astrazeneca AB Pcsk9 inhibitors and methods of use thereof

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Legal Events

Date Code Title Description
PS Patent sealed
PE Patent expired