[go: up one dir, main page]

GB1153670A - Isoquinoline Derivatives and preparation thereof - Google Patents

Isoquinoline Derivatives and preparation thereof

Info

Publication number
GB1153670A
GB1153670A GB5537167A GB5537167A GB1153670A GB 1153670 A GB1153670 A GB 1153670A GB 5537167 A GB5537167 A GB 5537167A GB 5537167 A GB5537167 A GB 5537167A GB 1153670 A GB1153670 A GB 1153670A
Authority
GB
United Kingdom
Prior art keywords
compound
carboxyl
formula
esterified
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5537167A
Inventor
Giorgio Ferrari
Cesare Casagrande
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siphar SA
Original Assignee
Siphar SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Siphar SA filed Critical Siphar SA
Publication of GB1153670A publication Critical patent/GB1153670A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1,153,670. Pyrrolo-isoquinolines. SIPHAR S.A. 5 Dec., 1967 [7 Dec., 1966], No. 55371/67. Heading C2C. Novel pyrrole [2,1-a] isoquinolines of the general Formula I in which the pyrrole ring may be unsaturated or saturated, R<SP>1</SP> is a hydrogen atom or a carboxyl or esterified carboxyl group, R<SP>2</SP> is an alkyl, cycloalkyl, aryl, carboxyl, esterified carboxyl, carboxymethyl, esterified carboxymethyl, carboxyamide or substituted carboxyamide group, R<SP>3</SP> is a hydrogen atom or a carboxyl or esterified carboxyl group, or R<SP>2</SP> and R<SP>3</SP> when taken together may form the anhydride of the corresponding dicarboxylic acid, and salts and addition compounds thereof, with pharmacologically acceptable organic or inorganic bases or acids, are prepared by condensing a substituted α-halo carbonyl compound of the formula R<SP>3</SP>-CHXCO-R<SP>2</SP> where X represents a halogen atom, with an appropriately substituted 3,4-dihydro isoquinoline derivative, if desired subjecting the cyclization product so obtained to appropriate transformations of the substituent groups to obtain the desired compound of Formula I and, if desired, subjecting the compound to catalytic hydrogenation to obtain the corresponding pyrrolidene compound. Pharmaceutical compositions comprising a compound of Formula I as active ingredient are administered orally, parenterally or rectally and have hypotensive, sympathicolytic and psychotropic activity.
GB5537167A 1966-12-07 1967-12-05 Isoquinoline Derivatives and preparation thereof Expired GB1153670A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BE690792 1966-12-07

Publications (1)

Publication Number Publication Date
GB1153670A true GB1153670A (en) 1969-05-29

Family

ID=3849828

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5537167A Expired GB1153670A (en) 1966-12-07 1967-12-05 Isoquinoline Derivatives and preparation thereof

Country Status (2)

Country Link
BE (1) BE690792A (en)
GB (1) GB1153670A (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0130069A3 (en) * 1983-06-23 1985-09-11 Mcneilab, Inc. Hexahydropyrrolo (2,1-a) isoquinoline derivatives
EP0150474A3 (en) * 1984-01-13 1985-09-25 Boehringer Ingelheim Kg 5,6-dihydro-pyrrolo-û2,1-a¨isoquinolines and process for their preparation
EP0172692A1 (en) * 1984-08-02 1986-02-26 McNeilab, Inc. Hexahydroindolizine compounds, pharmaceutical compositions and methods and intermediates
US4595688A (en) * 1983-06-23 1986-06-17 Mcneilab, Inc. Hexahydropyrrolo[2,1-a]isoquinoline derivatives and antidepressant use thereof
US4719216A (en) * 1983-06-23 1988-01-12 Mcneilab, Inc. Hexahydropyrrolo(2,1-A)isoquinoline derivatives as antidepressants
EP0303446A1 (en) * 1987-08-11 1989-02-15 May & Baker Limited Pyrroloisoquinolines
WO2002048144A1 (en) * 2000-12-13 2002-06-20 Bayer Aktiengesellschaft Pyrrolo (2.1-a) dihydroisoquinolines and their use as phosphodiesterase 10a inhibitors
WO2003014117A1 (en) * 2001-08-06 2003-02-20 Bayer Corporation 3-substituted pyrrolo[2.1-a]isoquinoline derivatives
JP2009513494A (en) * 2003-06-30 2009-04-02 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング Pyrrodihydroisoquinoline as a PDE10 inhibitor

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0130069A3 (en) * 1983-06-23 1985-09-11 Mcneilab, Inc. Hexahydropyrrolo (2,1-a) isoquinoline derivatives
US4595688A (en) * 1983-06-23 1986-06-17 Mcneilab, Inc. Hexahydropyrrolo[2,1-a]isoquinoline derivatives and antidepressant use thereof
US4719216A (en) * 1983-06-23 1988-01-12 Mcneilab, Inc. Hexahydropyrrolo(2,1-A)isoquinoline derivatives as antidepressants
EP0150474A3 (en) * 1984-01-13 1985-09-25 Boehringer Ingelheim Kg 5,6-dihydro-pyrrolo-û2,1-a¨isoquinolines and process for their preparation
EP0172692A1 (en) * 1984-08-02 1986-02-26 McNeilab, Inc. Hexahydroindolizine compounds, pharmaceutical compositions and methods and intermediates
EP0303446A1 (en) * 1987-08-11 1989-02-15 May & Baker Limited Pyrroloisoquinolines
US4933350A (en) * 1987-08-11 1990-06-12 May & Baker Limited Pyrroloisoquinolines useful as hypercholesterolemic and hyperlipoprotienimic agents
WO2002048144A1 (en) * 2000-12-13 2002-06-20 Bayer Aktiengesellschaft Pyrrolo (2.1-a) dihydroisoquinolines and their use as phosphodiesterase 10a inhibitors
US6930114B2 (en) 2000-12-13 2005-08-16 Bayer Pharmaceuticals Corporation Pyrrolo (2.1a)dihydroisoquinolines and their use as phosphodiesterase 10a inhibitors
WO2003014117A1 (en) * 2001-08-06 2003-02-20 Bayer Corporation 3-substituted pyrrolo[2.1-a]isoquinoline derivatives
WO2003014115A1 (en) * 2001-08-06 2003-02-20 Bayer Aktiengesellschaft 3-substituted pyrrolo (2.1-a) isoquinoline derivatives
JP2009513494A (en) * 2003-06-30 2009-04-02 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング Pyrrodihydroisoquinoline as a PDE10 inhibitor

Also Published As

Publication number Publication date
BE690792A (en) 1967-05-16

Similar Documents

Publication Publication Date Title
GB1153670A (en) Isoquinoline Derivatives and preparation thereof
GB1055055A (en) Improvements in or relating to 4-[1-lower alkyl piperidylidene-(4)]-9,10-dihydro-4h-benzo[4,5]-cyclohepta[1,2-b]thiophene derivatives
SE7705637L (en) PROCEDURE FOR THE PREPARATION OF DIBENSOXEPIN DERIVATIVES WITH THERAPEUTIC EFFECT
IE34314L (en) Dibenzodioxocine derivatives
GB1277789A (en) Improvements in or relating to new polycyclic pyrrole derivatives
GB1395666A (en) Thiophene derivatives processes for their preparation and compositions incorporating them
GB1496491A (en) Dihydroergopeptine derivatives
GB1158868A (en) Novel 2,4-Disubstituted 7- and 8-Chloroquinolines, the preparation thereof and Compositions containing the same
IE39576B1 (en) Derivatives of 3-(p-chlorobenzoyl)-2-methyl-phenylacetic acid
GB1108830A (en) Pyrrole- and pyrroline-derivatives
GB1173711A (en) Diepoxyalkyl Esters of Bicyclo[2,2,1]Heptane-2,3-Dicarboxylic Acids
SE300011B (en)
GB1289209A (en)
GB1504426A (en) Clavulanic acid derivatives
GB1499420A (en) Ergot peptide alkaloids
GB1351526A (en) Tropan-3-ol derivatives and processes for their preparation
GB1195491A (en) 4-Substituted 7- and 8-Chloroquinolines, the Preparation thereof, and Compositions Containing the same
GB1203538A (en) Cubane derivatives
GB1219387A (en) Bicyclo[2.2.2]oct-2-ene-amino acid compounds
GB1467568A (en) Anti-inflammatory and antirheumatic isoglutamine com pounds and preparations
GB1424348A (en) Isoquinoline derivatives
GB1399632A (en) Sulphamoyl-benzoic acids
GB1173577A (en) Improvements in or relating to New Indole Derivatives, Process for Preparing same and Therapeutic Compositions Containing them
GB1158954A (en) N-(4-Carboxy-Phenyl)-Anthranilic Acid, derivatives thereof and a process for their preparation
GB1418831A (en) Reserpine derivatives