GB1146109A - 5h-dibenzo[a,d]cycloheptene derivatives - Google Patents
5h-dibenzo[a,d]cycloheptene derivativesInfo
- Publication number
- GB1146109A GB1146109A GB1697067A GB1697067A GB1146109A GB 1146109 A GB1146109 A GB 1146109A GB 1697067 A GB1697067 A GB 1697067A GB 1697067 A GB1697067 A GB 1697067A GB 1146109 A GB1146109 A GB 1146109A
- Authority
- GB
- United Kingdom
- Prior art keywords
- dibenzo
- april
- hydrogen atom
- novel compounds
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- QPJORFLSOJAUNL-UHFFFAOYSA-N dibenzo[a,d][7]annulene Chemical class C1=CC2=CC=CC=C2CC2=CC=CC=C21 QPJORFLSOJAUNL-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002841 Lewis acid Substances 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000029936 alkylation Effects 0.000 abstract 1
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- 238000005905 alkynylation reaction Methods 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000008298 dragée Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 150000007517 lewis acids Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000001453 quaternary ammonium group Chemical group 0.000 abstract 1
- 238000006798 ring closing metathesis reaction Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- GSCKMHFCKGEORH-UHFFFAOYSA-N tetracyclo[7.6.1.02,7.010,15]hexadeca-2,4,6,10,12,14-hexaen-8-imine Chemical class C1C2C3=C(C(C1C1=C2C=CC=C1)=N)C=CC=C3 GSCKMHFCKGEORH-UHFFFAOYSA-N 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
1,146,109. 5,11-Methyleneimino-10,11-dihydro - 5H - dibenzo[a,d]cycloheptenes. DR. A. WANDER S.A. 13 April, 1967 [22 April, 1966], No. 16970/67. Heading C2C. Novel compounds of the general formula (and acid addition salts and quaternary ammonium derivatives thereof), wherein R 1 is a hydrogen atom or alkyl radical and R 2 is a hydrogen atom or alkyl, alkenyl or alkynyl radical provided that R 1 and R 2 are not simultaneously hydrogen atoms, are prepared by ring closure of an aminoaldehyde preferably in the acetal form, using a Lewis acid or by alkylation, alkenylation or alkynylation of compounds as presented above in which R 2 is hydrogen. Therapeutic compositions useful in the treatment of nervous diseases contain as the active ingredient the above novel compounds and may be provided in the form of tablets, dragees or solutions.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH589866A CH496716A (en) | 1966-04-22 | 1966-04-22 | 5h-dibenzo a d-cycloheptene derivs centrally active |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1146109A true GB1146109A (en) | 1969-03-19 |
Family
ID=4301185
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1697067A Expired GB1146109A (en) | 1966-04-22 | 1967-04-13 | 5h-dibenzo[a,d]cycloheptene derivatives |
Country Status (12)
| Country | Link |
|---|---|
| AT (2) | AT275540B (en) |
| BE (1) | BE697369A (en) |
| CH (1) | CH496716A (en) |
| DE (1) | DE1720016A1 (en) |
| DK (1) | DK115116B (en) |
| ES (1) | ES339452A1 (en) |
| FR (1) | FR6143M (en) |
| GB (1) | GB1146109A (en) |
| GR (1) | GR36289B (en) |
| IL (1) | IL27785A (en) |
| NL (1) | NL6705570A (en) |
| SE (1) | SE326962B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0470127A4 (en) * | 1989-04-14 | 1992-06-24 | State Of Oregon By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University | Pcp receptor ligands and the use thereof |
| US5688789A (en) * | 1989-04-14 | 1997-11-18 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon | PCP receptor ligands and the use thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4950030A (en) * | 1986-05-30 | 1990-08-21 | Motor Wheel Corporation | Wheel for a track laying vehicle |
-
1966
- 1966-04-22 CH CH589866A patent/CH496716A/en not_active IP Right Cessation
-
1967
- 1967-04-13 DE DE19671720016 patent/DE1720016A1/en active Pending
- 1967-04-13 GB GB1697067A patent/GB1146109A/en not_active Expired
- 1967-04-13 IL IL2778567A patent/IL27785A/en unknown
- 1967-04-17 FR FR102958A patent/FR6143M/fr not_active Expired
- 1967-04-18 ES ES339452A patent/ES339452A1/en not_active Expired
- 1967-04-19 DK DK212167A patent/DK115116B/en unknown
- 1967-04-20 SE SE559267A patent/SE326962B/xx unknown
- 1967-04-20 NL NL6705570A patent/NL6705570A/xx unknown
- 1967-04-21 AT AT1035368A patent/AT275540B/en active
- 1967-04-21 BE BE697369D patent/BE697369A/xx unknown
- 1967-04-21 AT AT379967A patent/AT275538B/en active
- 1967-04-22 GR GR670136289A patent/GR36289B/en unknown
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0470127A4 (en) * | 1989-04-14 | 1992-06-24 | State Of Oregon By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University | Pcp receptor ligands and the use thereof |
| US5688789A (en) * | 1989-04-14 | 1997-11-18 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon | PCP receptor ligands and the use thereof |
| US6017910A (en) * | 1989-04-14 | 2000-01-25 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon | PCP receptor ligands and the use thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| DE1720016A1 (en) | 1971-05-19 |
| CH496716A (en) | 1970-09-30 |
| IL27785A (en) | 1971-03-24 |
| FR6143M (en) | 1968-06-24 |
| DK115116B (en) | 1969-09-08 |
| GR36289B (en) | 1969-01-20 |
| AT275540B (en) | 1969-10-27 |
| ES339452A1 (en) | 1968-05-16 |
| SE326962B (en) | 1970-08-10 |
| NL6705570A (en) | 1967-10-23 |
| BE697369A (en) | 1967-10-23 |
| AT275538B (en) | 1969-10-27 |
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