GB1081551A - Injectable oil compositions - Google Patents
Injectable oil compositionsInfo
- Publication number
- GB1081551A GB1081551A GB2122/65A GB212265A GB1081551A GB 1081551 A GB1081551 A GB 1081551A GB 2122/65 A GB2122/65 A GB 2122/65A GB 212265 A GB212265 A GB 212265A GB 1081551 A GB1081551 A GB 1081551A
- Authority
- GB
- United Kingdom
- Prior art keywords
- surface active
- oils
- oil
- composition
- agents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000203 mixture Substances 0.000 title abstract 7
- 239000003921 oil Substances 0.000 abstract 5
- 235000019198 oils Nutrition 0.000 abstract 5
- 150000002148 esters Chemical class 0.000 abstract 3
- 239000004094 surface-active agent Substances 0.000 abstract 3
- -1 C24 fatty acids Chemical class 0.000 abstract 2
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 229930195729 fatty acid Natural products 0.000 abstract 2
- 239000000194 fatty acid Substances 0.000 abstract 2
- 238000001990 intravenous administration Methods 0.000 abstract 2
- 231100000252 nontoxic Toxicity 0.000 abstract 2
- 230000003000 nontoxic effect Effects 0.000 abstract 2
- 229920000056 polyoxyethylene ether Polymers 0.000 abstract 2
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 abstract 1
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 abstract 1
- BXCRLBBIZJSWNS-UHFFFAOYSA-N 2-hydroxyethyl hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCCO BXCRLBBIZJSWNS-UHFFFAOYSA-N 0.000 abstract 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- 235000017060 Arachis glabrata Nutrition 0.000 abstract 1
- 244000105624 Arachis hypogaea Species 0.000 abstract 1
- 235000010777 Arachis hypogaea Nutrition 0.000 abstract 1
- 235000018262 Arachis monticola Nutrition 0.000 abstract 1
- 241000723346 Cinnamomum camphora Species 0.000 abstract 1
- 229920000742 Cotton Polymers 0.000 abstract 1
- LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 abstract 1
- 241000558306 Gynocardia odorata Species 0.000 abstract 1
- 240000007049 Juglans regia Species 0.000 abstract 1
- 235000009496 Juglans regia Nutrition 0.000 abstract 1
- 240000007817 Olea europaea Species 0.000 abstract 1
- 235000008753 Papaver somniferum Nutrition 0.000 abstract 1
- 239000002202 Polyethylene glycol Substances 0.000 abstract 1
- 235000004443 Ricinus communis Nutrition 0.000 abstract 1
- 241000209140 Triticum Species 0.000 abstract 1
- 235000021307 Triticum Nutrition 0.000 abstract 1
- 150000001298 alcohols Chemical class 0.000 abstract 1
- 238000006136 alcoholysis reaction Methods 0.000 abstract 1
- 239000003080 antimitotic agent Substances 0.000 abstract 1
- 229960000846 camphor Drugs 0.000 abstract 1
- 229930008380 camphor Natural products 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000002872 contrast media Substances 0.000 abstract 1
- 235000012343 cottonseed oil Nutrition 0.000 abstract 1
- 239000002385 cottonseed oil Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 abstract 1
- 229940093471 ethyl oleate Drugs 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 abstract 1
- 239000012530 fluid Substances 0.000 abstract 1
- 239000007972 injectable composition Substances 0.000 abstract 1
- 238000001361 intraarterial administration Methods 0.000 abstract 1
- 239000007928 intraperitoneal injection Substances 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000011630 iodine Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 235000015097 nutrients Nutrition 0.000 abstract 1
- 235000020232 peanut Nutrition 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- 229920000136 polysorbate Polymers 0.000 abstract 1
- 230000002285 radioactive effect Effects 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 235000019155 vitamin A Nutrition 0.000 abstract 1
- 239000011719 vitamin A Substances 0.000 abstract 1
- 235000020234 walnut Nutrition 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
- A61K49/0461—Dispersions, colloids, emulsions or suspensions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Injectable non-aqueous oil compositions for intravenous, intra-arterial or intra-lymphatic administration comprise a sterile mixture of one or more metabolizable, optionally brominated, or iodinated natural or synthetic esters of C11 to C24 fatty acids, being liquid at 37 DEG C., with 0.5 to 5% by weight of the composition of at least one non-toxic surface active agent having a solubility in said ester of at least 0.5% by weight at 37 DEG C. By non-toxic is meant that the toxicity (L.D. 50) of the surface active agent in the mouse is greater than 10 gms./kg. orally and 1 gm./kg. by intraperitoneal injection; such agents are usually non-ionic, and may be partial esters of fatty acids with sorbitan, or polyoxyethylene ethers thereof, or castor oil-polyoxyethylene ethers, e.g. "Span", "Tween" (registered Trade Marks), or Emulsov, respectively. Preferred surface active agents are polyethylene glycol monopalmitate, cotton seed oil monoglyceride-tartaric acid ester, e.g. "Drewmulse" (registered Trade Mark), and mixtures thereof. Oils used may be olive, peanut, poppy seed, cotton seed, walnut, wheat, cod-liver, chaulmoogra, or the products of the alcoholysis of such oils by lower alcohols, e.g. ethyl oleate, and their brominated or iodinated derivatives such as Ultra-Fluid Lipiodol. The oils may themselves form the therapeutic agent of the compositions, e.g. for X-ray contrast or intravenous feeding purposes, or may be carriers for liposoluble drugs, such as camphor, antimitotic agents, or vitamins A, D, E, F, or K. Examples are given for an X-ray contrast medium, a nutrient injectable composition, and a composition of a radio-active iodine labelled oil.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR964156A FR3658M (en) | 1964-02-18 | 1964-02-18 | Oily composition for intravascular injection. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1081551A true GB1081551A (en) | 1967-08-31 |
Family
ID=8823395
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2122/65A Expired GB1081551A (en) | 1964-02-18 | 1965-01-18 | Injectable oil compositions |
Country Status (2)
| Country | Link |
|---|---|
| FR (1) | FR3658M (en) |
| GB (1) | GB1081551A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4775659A (en) * | 1985-08-19 | 1988-10-04 | Eli Lilly And Company | Injectable semi-solid formulations |
| DE3924207A1 (en) * | 1988-07-21 | 1990-01-25 | Biogal Gyogyszergyar | CYCLOSPORIN (E) CONTAINING, INTRAVENOES ADMINISTRABLE MEDICINAL PREPARATIONS AND METHOD FOR THE PRODUCTION THEREOF AND THEIR USE |
| EP1423118A4 (en) * | 2001-07-17 | 2006-03-22 | Unisearch Ltd | Method and composition for treatment of cancer |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1980001244A1 (en) * | 1978-12-19 | 1980-06-26 | Bykgulden Lomberg Chem Fab | X-ray contrast media solutions |
| EP0012926B1 (en) * | 1978-12-19 | 1984-03-07 | Byk Gulden Lomberg Chemische Fabrik GmbH | Solutions of x-ray contrast agents |
| ATE89171T1 (en) * | 1987-06-11 | 1993-05-15 | Kabi Pharmacia Ab | EMULSION CONTAINING IODINE. |
-
1964
- 1964-02-18 FR FR964156A patent/FR3658M/en active Active
-
1965
- 1965-01-18 GB GB2122/65A patent/GB1081551A/en not_active Expired
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4775659A (en) * | 1985-08-19 | 1988-10-04 | Eli Lilly And Company | Injectable semi-solid formulations |
| DE3924207A1 (en) * | 1988-07-21 | 1990-01-25 | Biogal Gyogyszergyar | CYCLOSPORIN (E) CONTAINING, INTRAVENOES ADMINISTRABLE MEDICINAL PREPARATIONS AND METHOD FOR THE PRODUCTION THEREOF AND THEIR USE |
| FR2635265A1 (en) * | 1988-07-21 | 1990-02-16 | Biogal Gyogyszergyar | INTRAVENOUS PHARMACEUTICAL COMPOSITION COMPRISING CYCLOSPORINE AS ACTIVE INGREDIENT AND PROCESS FOR PREPARING THE SAME |
| BE1004323A4 (en) * | 1988-07-21 | 1992-11-03 | Biogal Gyogyszergyar | INTRAVENOUS PHARMACEUTICAL COMPOSITION AND PROCESS FOR ITS PREPARATION. |
| EP1423118A4 (en) * | 2001-07-17 | 2006-03-22 | Unisearch Ltd | Method and composition for treatment of cancer |
Also Published As
| Publication number | Publication date |
|---|---|
| FR3658M (en) | 1965-11-02 |
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