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GB1070120A - Pyridoxine derivative and the preparation thereof - Google Patents

Pyridoxine derivative and the preparation thereof

Info

Publication number
GB1070120A
GB1070120A GB2028266A GB2028266A GB1070120A GB 1070120 A GB1070120 A GB 1070120A GB 2028266 A GB2028266 A GB 2028266A GB 2028266 A GB2028266 A GB 2028266A GB 1070120 A GB1070120 A GB 1070120A
Authority
GB
United Kingdom
Prior art keywords
nicotinoyl
pyridoxine
formula
preparation
alkylidene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2028266A
Inventor
Norio Sugimoto
Sataro Imada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Tanabe Pharma Corp
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Priority to GB2028266A priority Critical patent/GB1070120A/en
Publication of GB1070120A publication Critical patent/GB1070120A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises a 5-O-nicotinoyl-pyridoxine of formula <FORM:1070120/C2/1> The compound is prepared by reacting a 4,3-O-alkylidene-pyridoxine of formula <FORM:1070120/C2/2> where A is an alkylidene group having 3 to 6 carbon atoms, with a nicotinoyl halide or nicotinic anhydride to obtain a 4,3-O-alkylidene-a 5-O-nicotinoyl-pyridoxine of formula <FORM:1070120/C2/3> which is then hydrolysed to a 5-O-nicotinoyl-pyridoxine. Examples are given. a 5-O-Nicotinoyl-pyridoxide may be mixed with a physiologically acceptable carrier and used to prevent lipoidosis, e.g. arteriosclerosis or cholesterolemia.
GB2028266A 1966-05-06 1966-05-06 Pyridoxine derivative and the preparation thereof Expired GB1070120A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB2028266A GB1070120A (en) 1966-05-06 1966-05-06 Pyridoxine derivative and the preparation thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2028266A GB1070120A (en) 1966-05-06 1966-05-06 Pyridoxine derivative and the preparation thereof

Publications (1)

Publication Number Publication Date
GB1070120A true GB1070120A (en) 1967-05-24

Family

ID=10143410

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2028266A Expired GB1070120A (en) 1966-05-06 1966-05-06 Pyridoxine derivative and the preparation thereof

Country Status (1)

Country Link
GB (1) GB1070120A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0033488A1 (en) * 1980-01-22 1981-08-12 D and D S.r.l. Therapeutically active derivatives of nicotinic acid, process for their preparation and related pharmaceutical compositions
EP0282696A3 (en) * 1987-02-18 1989-06-14 Ulrich Dr. Speck Use of pyridoxine derivatives in the prophylaxis and treatment of hyperlipemia and atherosclerosis

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0033488A1 (en) * 1980-01-22 1981-08-12 D and D S.r.l. Therapeutically active derivatives of nicotinic acid, process for their preparation and related pharmaceutical compositions
EP0282696A3 (en) * 1987-02-18 1989-06-14 Ulrich Dr. Speck Use of pyridoxine derivatives in the prophylaxis and treatment of hyperlipemia and atherosclerosis

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