GB1053504A - - Google Patents
Info
- Publication number
- GB1053504A GB1053504A GB873165A GB873165A GB1053504A GB 1053504 A GB1053504 A GB 1053504A GB 873165 A GB873165 A GB 873165A GB 873165 A GB873165 A GB 873165A GB 1053504 A GB1053504 A GB 1053504A
- Authority
- GB
- United Kingdom
- Prior art keywords
- particles
- march
- cardiolipin
- antigen
- choline chloride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002245 particle Substances 0.000 abstract 3
- 239000001763 2-hydroxyethyl(trimethyl)azanium Substances 0.000 abstract 2
- 235000019743 Choline chloride Nutrition 0.000 abstract 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 229960003178 choline chloride Drugs 0.000 abstract 2
- SGMZJAMFUVOLNK-UHFFFAOYSA-M choline chloride Chemical compound [Cl-].C[N+](C)(C)CCO SGMZJAMFUVOLNK-UHFFFAOYSA-M 0.000 abstract 2
- ZGSPNIOCEDOHGS-UHFFFAOYSA-L disodium [3-[2,3-di(octadeca-9,12-dienoyloxy)propoxy-oxidophosphoryl]oxy-2-hydroxypropyl] 2,3-di(octadeca-9,12-dienoyloxy)propyl phosphate Chemical compound [Na+].[Na+].CCCCCC=CCC=CCCCCCCCC(=O)OCC(OC(=O)CCCCCCCC=CCC=CCCCCC)COP([O-])(=O)OCC(O)COP([O-])(=O)OCC(OC(=O)CCCCCCCC=CCC=CCCCCC)COC(=O)CCCCCCCC=CCC=CCCCCC ZGSPNIOCEDOHGS-UHFFFAOYSA-L 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000011780 sodium chloride Substances 0.000 abstract 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 abstract 1
- 239000004793 Polystyrene Substances 0.000 abstract 1
- 230000004520 agglutination Effects 0.000 abstract 1
- 239000007900 aqueous suspension Substances 0.000 abstract 1
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 1
- 239000004816 latex Substances 0.000 abstract 1
- 229920000126 latex Polymers 0.000 abstract 1
- 229940067606 lecithin Drugs 0.000 abstract 1
- 235000010445 lecithin Nutrition 0.000 abstract 1
- 239000000787 lecithin Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 229920002223 polystyrene Polymers 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
- 239000006228 supernatant Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 238000009600 syphilis test Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/571—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses for venereal disease, e.g. syphilis, gonorrhoea
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
1,053,504. Diagnostic composition for syphilis test. CHAS. PFIZER & CO. Inc. March 1, 1965 [March 17, 1964], No. 8731/65. Heading B1X. A diagnostic composition which gives an agglutination reaction with syphilitic blood serum comprises an aqueous suspension containing 0.1-3% of 0.3-2.0Á polystyrene particles coated with cardiolipin antigen, and 4-6% w/v of choline chloride. The antigen is derived from an ethanolic solution containing 0.03% cardiolipin, 0.9% cholestrol and 0.2% lecithin. The preferred medium is 0.85% saline containing 0.01% MgSO 4 . First the particles may be coated by mixing a suspension of latex in saline with said ethanolic solution, centrifuging, decanting off the supernatant liquid and resuspending the remaining particles in a solution of choline chloride.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35264264A | 1964-03-17 | 1964-03-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1053504A true GB1053504A (en) | 1967-01-04 |
Family
ID=23385912
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB873165A Expired GB1053504A (en) | 1964-03-17 | 1965-03-01 |
Country Status (4)
| Country | Link |
|---|---|
| BR (1) | BR6567756D0 (en) |
| DE (1) | DE1280585B (en) |
| FR (1) | FR1455067A (en) |
| GB (1) | GB1053504A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000075666A1 (en) * | 1999-06-09 | 2000-12-14 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Method for detecting syphilis using synthetic antigens |
| US6815173B1 (en) | 1999-06-09 | 2004-11-09 | The United States Of America As Represented By The Department Of Health And Human Services | Method for detecting syphilis using synthetic antigents |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1086225A (en) * | 1976-03-18 | 1980-09-23 | Masuo Aizawa | Syphilis antibody diagnosis by antigen membrane and potentiometric method |
| US4738932A (en) * | 1985-12-03 | 1988-04-19 | Advanced Polymer Systems, Inc. | Reaginic test for syphilis |
-
1965
- 1965-03-01 GB GB873165A patent/GB1053504A/en not_active Expired
- 1965-03-09 FR FR8539A patent/FR1455067A/en not_active Expired
- 1965-03-12 BR BR16775665A patent/BR6567756D0/en unknown
- 1965-03-12 DE DE1965P0036274 patent/DE1280585B/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000075666A1 (en) * | 1999-06-09 | 2000-12-14 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Method for detecting syphilis using synthetic antigens |
| AU771548B2 (en) * | 1999-06-09 | 2004-03-25 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Method for detecting syphilis using synthetic antigens |
| US6815173B1 (en) | 1999-06-09 | 2004-11-09 | The United States Of America As Represented By The Department Of Health And Human Services | Method for detecting syphilis using synthetic antigents |
| RU2244933C2 (en) * | 1999-06-09 | 2005-01-20 | ПРАВИТЕЛЬСТВО СОЕДИНЕННЫХ ШТАТОВ АМЕРИКИ, представляемое СЕКРЕТАРЕМ МИНИСТЕРСТВА ЗДРАВОХРАНЕНИЯ И СЛУЖБЫ ДЛЯ ЛЮДЕЙ | Antigenic composition and method for detection of presence of treponema pallidum in human |
| USRE43914E1 (en) | 1999-06-09 | 2013-01-08 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention | Method for detecting syphilis using synthetic antigens |
Also Published As
| Publication number | Publication date |
|---|---|
| FR1455067A (en) | 1966-10-14 |
| BR6567756D0 (en) | 1973-07-26 |
| DE1280585B (en) | 1968-10-17 |
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