[go: up one dir, main page]

GB0713259D0 - Pyrazine derivatives 954 - Google Patents

Pyrazine derivatives 954

Info

Publication number
GB0713259D0
GB0713259D0 GBGB0713259.0A GB0713259A GB0713259D0 GB 0713259 D0 GB0713259 D0 GB 0713259D0 GB 0713259 A GB0713259 A GB 0713259A GB 0713259 D0 GB0713259 D0 GB 0713259D0
Authority
GB
United Kingdom
Prior art keywords
pyrazine derivatives
pyrazine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB0713259.0A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Priority to GBGB0713259.0A priority Critical patent/GB0713259D0/en
Publication of GB0713259D0 publication Critical patent/GB0713259D0/en
Priority to PCT/EP2008/058898 priority patent/WO2009007390A2/fr
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GBGB0713259.0A 2007-07-09 2007-07-09 Pyrazine derivatives 954 Ceased GB0713259D0 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GBGB0713259.0A GB0713259D0 (en) 2007-07-09 2007-07-09 Pyrazine derivatives 954
PCT/EP2008/058898 WO2009007390A2 (fr) 2007-07-09 2008-07-09 Dérivés de pyrazine - 954

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0713259.0A GB0713259D0 (en) 2007-07-09 2007-07-09 Pyrazine derivatives 954

Publications (1)

Publication Number Publication Date
GB0713259D0 true GB0713259D0 (en) 2007-08-15

Family

ID=38440612

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB0713259.0A Ceased GB0713259D0 (en) 2007-07-09 2007-07-09 Pyrazine derivatives 954

Country Status (2)

Country Link
GB (1) GB0713259D0 (fr)
WO (1) WO2009007390A2 (fr)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010054398A1 (fr) 2008-11-10 2010-05-14 Vertex Pharmaceuticals Incorporated Composés utiles comme inhibiteurs de l’atr kinase
AU2009327357C1 (en) * 2008-12-19 2017-02-02 Vertex Pharmaceuticals Incorporated Pyrazine derivatives useful as inhibitors of ATR kinase
JP2013520958A (ja) * 2009-03-13 2013-06-10 ベルゲン テクノロジオヴェルフォリング エイエス 上皮間葉転換のバイオマーカーとしてａｘｌを使用する方法
DE102009056886A1 (de) * 2009-12-03 2011-06-09 Bayer Schering Pharma Aktiengesellschaft cMet-Inhibitoren zur Behandlung der Endometriose
US8962631B2 (en) 2010-05-12 2015-02-24 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of ATR kinase
MX2012013081A (es) 2010-05-12 2013-05-09 Vertex Pharma Compuestos utiles como inhibidores de cinasa atr.
WO2011143399A1 (fr) 2010-05-12 2011-11-17 Vertex Pharmaceuticals Incorporated Composés utiles en tant qu'inhibiteurs de l'atr kinase
WO2011143422A1 (fr) 2010-05-12 2011-11-17 Vertex Pharmaceuticals Incorporated Dérivés de 2-aminopyridine utiles en tant qu'inhibiteurs de la kinase atr
WO2011143423A2 (fr) 2010-05-12 2011-11-17 Vertex Pharmaceuticals Incorporated Composés utilisables en tant qu'inhibiteurs de la kinase atr
JP2013526540A (ja) 2010-05-12 2013-06-24 バーテックス ファーマシューティカルズ インコーポレイテッド Ａｔｒキナーゼ阻害剤として有用な化合物
US8623869B2 (en) 2010-06-23 2014-01-07 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of ATR kinase
US20130315895A1 (en) 2010-07-01 2013-11-28 Takeda Pharmaceutical Company Limited COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET
MX2013011450A (es) 2011-04-05 2014-02-03 Vertex Pharma Compuestos de aminopirazina utiles como inhibidores de la cinasa ataxia telangiectasia mutada y rad3 relacionados (atr).
JP2014517079A (ja) 2011-06-22 2014-07-17 バーテックス ファーマシューティカルズ インコーポレイテッド Ａｔｒキナーゼ阻害剤として有用な化合物
US9096602B2 (en) 2011-06-22 2015-08-04 Vertex Pharmaceuticals Incorporated Substituted pyrrolo[2,3-B]pyrazines as ATR kinase inhibitors
WO2012178123A1 (fr) 2011-06-22 2012-12-27 Vertex Pharmaceuticals Incorporated Composés utiles comme inhibiteurs de la kinase atr
EP2751099B1 (fr) 2011-09-30 2017-06-14 Vertex Pharmaceuticals Incorporated Composés utiles comme inhibiteurs de kinase atr
RS59337B1 (sr) 2011-09-30 2019-10-31 Vertex Pharma Postupak za izradu jedinjenja, korisnih kao inhibitori atr kinaze
WO2013049720A1 (fr) 2011-09-30 2013-04-04 Vertex Pharmaceuticals Incorporated Composés utiles en tant qu'inhibiteurs de kinase atr
SG11201401095YA (en) 2011-09-30 2014-04-28 Vertex Pharma Treating pancreatic cancer and non-small cell lung cancer with atr inhibitors
EP2751088B1 (fr) 2011-09-30 2016-04-13 Vertex Pharmaceuticals Incorporated Composés utiles en tant qu'inhibiteurs de kinase atr
US8841450B2 (en) 2011-11-09 2014-09-23 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of ATR kinase
EP2776419B1 (fr) 2011-11-09 2016-05-11 Vertex Pharmaceuticals Incorporated Composés pyraziniques utiles en tant qu'inhibiteurs de l'atr kinase
WO2013071090A1 (fr) 2011-11-09 2013-05-16 Vertex Pharmaceuticals Incorporated Composés utiles en tant qu'inhibiteurs de la kinase atr
US8846917B2 (en) 2011-11-09 2014-09-30 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of ATR kinase
EP2776429A1 (fr) 2011-11-09 2014-09-17 Vertex Pharmaceuticals Incorporated Composés utiles comme inhibiteurs de kinase atr
PT2810937T (pt) 2012-01-31 2017-03-03 Daiichi Sankyo Co Ltd Derivado de piridona
ES2654670T3 (es) 2012-04-05 2018-02-14 Vertex Pharmaceuticals Incorporated Compuestos útiles como inhibidores de la cinasa ATR y terapias de combinación de los mismos
WO2014055756A1 (fr) 2012-10-04 2014-04-10 Vertex Pharmaceuticals Incorporated Procédé pour la mesure d'augmentations de lésions d'adn à médiation par l'inhibition d'atr
EP2909202A1 (fr) 2012-10-16 2015-08-26 Vertex Pharmaceuticals Incorporated Composés utiles en tant qu'inhibiteurs de la kinase atr
PT4190786T (pt) 2012-12-07 2025-05-29 Vertex Pharma Compostos úteis como inibidores da quinase atr
EP2970286A1 (fr) 2013-03-15 2016-01-20 Vertex Pharmaceuticals Inc. Dérivés de pyrazolopyrimidine fusionnés utiles en tant qu'inhibiteurs de la kinase atr
CN105916506B (zh) 2013-11-20 2020-01-07 圣诺康生命科学公司 作为tam家族激酶抑制剂的喹唑啉衍生物
WO2015081257A2 (fr) 2013-11-27 2015-06-04 Signalchem Lifesciences Corporation Dérivés d'aminopyridine utilisés comme inhibiteurs de kinases de la famille tam
CA2932757C (fr) 2013-12-06 2023-10-31 Vertex Pharmaceuticals Incorporated Compose 2-amino -6-fluoro-n- [5-fluoro-pyridin -3-yl] pyrazolo [1,5-a] pyrimidine-3-carboxamide utile comme inhibiteur de la kinase atr, sa preparation, differentes formes solides et derives radiomarques de celui-ci
US20170027940A1 (en) * 2014-04-10 2017-02-02 Stichting Het Nederlands Kanker Instituut Method for treating cancer
WO2015162461A1 (fr) * 2014-04-24 2015-10-29 Novartis Ag Dérivés de pyrazine utilisables en tant qu'inhibiteurs de la phosphatidylinositol 3-kinase
MX2016013812A (es) 2014-04-24 2017-03-09 Novartis Ag Derivados de amino-pirazina como inhibidores de fosfatidil-inositol-3-cinasa.
EA201692140A1 (ru) 2014-04-24 2017-04-28 Новартис Аг Производные аминопиридина в качестве ингибиторов фосфатидилинозитол 3-киназы
KR102575125B1 (ko) 2014-06-05 2023-09-07 버텍스 파마슈티칼스 인코포레이티드 Atr 키나제의 저해제로서 유용한 2-아미노-6-플루오로-n-[5-플루오로-피리딘-3-일]-피라졸로[1,5-a]피리미딘-3-카복스아미드 화합물의 방사성표지된 유도체, 상기 화합물의 제조 및 이의 다양한 고체 형태
RU2736219C2 (ru) 2014-06-17 2020-11-12 Вертекс Фармасьютикалз Инкорпорейтед Способ лечения рака с использованием комбинации ингибиторов снк1 и atr
TWI723572B (zh) 2014-07-07 2021-04-01 日商第一三共股份有限公司 具有四氫吡喃基甲基之吡啶酮衍生物及其用途
ES2764299T3 (es) 2014-12-09 2020-06-02 Inst Nat Sante Rech Med Anticuerpos monoclonales humanos contra AXL
WO2016135041A1 (fr) 2015-02-26 2016-09-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Protéines de fusion et anticorps les contenant pour favoriser l'apoptose
AU2016331955B2 (en) 2015-09-30 2022-07-21 Vertex Pharmaceuticals Incorporated Method for treating cancer using a combination of DNA damaging agents and ATR inhibitors
ES2896079T3 (es) 2016-02-26 2022-02-23 Ono Pharmaceutical Co Fármaco para la terapia del cáncer, caracterizado por la administración de la combinación entre un inhibidor de Axl y un inhibidor del punto de control inmunitario
US20200197385A1 (en) 2017-08-23 2020-06-25 Ono Pharmaceutical Co., Ltd. Therapeutic agent for cancer containing axl inhibitor as active ingredient
US11826363B2 (en) 2017-10-13 2023-11-28 Ono Pharmaceutical Co., Ltd. Therapeutic agent for solid cancers, which comprises Axl inhibitor as active ingredient
US11306079B2 (en) 2017-12-21 2022-04-19 Incyte Corporation 3-(5-amino-pyrazin-2-yl)-benzenesulfonamide derivatives and related compounds as PI3K-gamma kinase inhibitors
PT3762368T (pt) 2018-03-08 2022-05-06 Incyte Corp Compostos de aminopirazina diol como inibidores de pi3k-y
WO2020010003A1 (fr) 2018-07-02 2020-01-09 Incyte Corporation DÉRIVÉS D'AMINOPYRAZINE UTILISÉS EN TANT QU'INHIBITEURS DE PI3K-γ

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4656838B2 (ja) * 2002-02-06 2011-03-23 バーテックス ファーマシューティカルズ インコーポレイテッド Ｇｓｋ−３の阻害剤として有用なヘテロアリール化合物
WO2004084813A2 (fr) * 2003-03-21 2004-10-07 Smithkline Beecham Corporation Composes chimiques
EP1828180A4 (fr) * 2004-12-08 2010-09-15 Glaxosmithkline Llc 1h -pyrrolo[2,3-beta]pyridines
GB0619342D0 (en) * 2006-09-30 2006-11-08 Vernalis R&D Ltd New chemical compounds

Also Published As

Publication number Publication date
WO2009007390A2 (fr) 2009-01-15
WO2009007390A3 (fr) 2009-03-19

Similar Documents

Publication Publication Date Title
GB0713259D0 (en) Pyrazine derivatives 954
IL201973A0 (en) 3,3-spiroindolinone derivatives
ZA201001797B (en) 1,1,1-trifluoro-2-hydroxy-3-phenylpropane derivatives
ZA201000107B (en) Pyrimidine derivatives 934
ZA201002213B (en) "6-pyrimidinyl-pyrimid-4-one derivative"
EP2202231A4 (fr) Dérivé de 2,3-dihydroiminoisoindole
GB0716278D0 (en) Pyrazine derivatives
GB0618761D0 (en) Derivatives 2
AU316643S (en) Bed - SE 2
GB0700177D0 (en) Mintop 1
GB0717636D0 (en) Shock-stopper 2
GB0717640D0 (en) Hydrodechlorification 2
GB0717641D0 (en) Hydrodechlorification 3
GB0723129D0 (en) Plug-shield 3
GB0723178D0 (en) 3 EasyHead
GB0703748D0 (en) 4 Way furniture
GB0717753D0 (en) Footsies 100%
GB0705735D0 (en) Finally 023
GB0705736D0 (en) Finally 021
GB0705737D0 (en) Finally 022
GB0705739D0 (en) Finally 014
GB0705740D0 (en) Finally 015
GB0705741D0 (en) Finally 016
GB0705743D0 (en) Finally 018
GB0705749D0 (en) Finally 001

Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)