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FR3121360B1 - Formulation for delivery of messenger RNA - Google Patents

Formulation for delivery of messenger RNA Download PDF

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Publication number
FR3121360B1
FR3121360B1 FR2103254A FR2103254A FR3121360B1 FR 3121360 B1 FR3121360 B1 FR 3121360B1 FR 2103254 A FR2103254 A FR 2103254A FR 2103254 A FR2103254 A FR 2103254A FR 3121360 B1 FR3121360 B1 FR 3121360B1
Authority
FR
France
Prior art keywords
formulation
messenger rna
delivery
lipid nanoparticles
nanoemulsion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR2103254A
Other languages
French (fr)
Other versions
FR3121360A1 (en
Inventor
Y Garcia Fabrice Navarro
Patrice Marche
Adrien Nougarede
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut National de la Sante et de la Recherche Medicale INSERM
Commissariat a lEnergie Atomique et aux Energies Alternatives CEA
Original Assignee
Commissariat a lEnergie Atomique CEA
Institut National de la Sante et de la Recherche Medicale INSERM
Commissariat a lEnergie Atomique et aux Energies Alternatives CEA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Commissariat a lEnergie Atomique CEA, Institut National de la Sante et de la Recherche Medicale INSERM, Commissariat a lEnergie Atomique et aux Energies Alternatives CEA filed Critical Commissariat a lEnergie Atomique CEA
Priority to FR2103254A priority Critical patent/FR3121360B1/en
Priority to PCT/EP2022/058466 priority patent/WO2022207736A1/en
Priority to EP22719866.0A priority patent/EP4312989A1/en
Publication of FR3121360A1 publication Critical patent/FR3121360A1/en
Application granted granted Critical
Publication of FR3121360B1 publication Critical patent/FR3121360B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Formulation pour la délivrance d’ARN messager L’invention concerne une formulation sous forme de nanoémulsion, comprenant une phase aqueuse continue et au moins une phase dispersée sous forme de nanoparticules lipidiques dans laquelle au moins un ARN messager est complexé à la surface des nanoparticules lipidiques, son procédé de préparation et ses utilisations pour la prévention et/ou le traitement d’une maladie. Figure pour l'abrégé : 1Formulation for the delivery of messenger RNA The invention relates to a formulation in the form of a nanoemulsion, comprising a continuous aqueous phase and at least one dispersed phase in the form of lipid nanoparticles in which at least one messenger RNA is complexed on the surface of the lipid nanoparticles , its preparation process and its uses for the prevention and/or treatment of a disease. Figure for abstract: 1

FR2103254A 2021-03-30 2021-03-30 Formulation for delivery of messenger RNA Active FR3121360B1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
FR2103254A FR3121360B1 (en) 2021-03-30 2021-03-30 Formulation for delivery of messenger RNA
PCT/EP2022/058466 WO2022207736A1 (en) 2021-03-30 2022-03-30 Formulation for messenger rna delivery
EP22719866.0A EP4312989A1 (en) 2021-03-30 2022-03-30 Formulation for messenger rna delivery

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR2103254 2021-03-30
FR2103254A FR3121360B1 (en) 2021-03-30 2021-03-30 Formulation for delivery of messenger RNA

Publications (2)

Publication Number Publication Date
FR3121360A1 FR3121360A1 (en) 2022-10-07
FR3121360B1 true FR3121360B1 (en) 2024-05-31

Family

ID=75850360

Family Applications (1)

Application Number Title Priority Date Filing Date
FR2103254A Active FR3121360B1 (en) 2021-03-30 2021-03-30 Formulation for delivery of messenger RNA

Country Status (3)

Country Link
EP (1) EP4312989A1 (en)
FR (1) FR3121360B1 (en)
WO (1) WO2022207736A1 (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2830596B1 (en) * 2012-03-29 2020-12-30 Translate Bio, Inc. Lipid-derived neutral nanoparticles
FR2994849B1 (en) 2012-08-30 2015-01-02 Commissariat Energie Atomique FORMULATION FOR THE DELIVERY OF NUCLEOTIDE SEQUENCES LIKELY TO MODULATE ENDOGENOUS MECHANISMS OF INTERFERING RNA

Also Published As

Publication number Publication date
EP4312989A1 (en) 2024-02-07
FR3121360A1 (en) 2022-10-07
WO2022207736A1 (en) 2022-10-06

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