[go: up one dir, main page]

FR3025200B1 - Derives de n-aryl-tricyclopyrimidine-2-amine polyethers macrocycliques - Google Patents

Derives de n-aryl-tricyclopyrimidine-2-amine polyethers macrocycliques

Info

Publication number
FR3025200B1
FR3025200B1 FR1458204A FR1458204A FR3025200B1 FR 3025200 B1 FR3025200 B1 FR 3025200B1 FR 1458204 A FR1458204 A FR 1458204A FR 1458204 A FR1458204 A FR 1458204A FR 3025200 B1 FR3025200 B1 FR 3025200B1
Authority
FR
France
Prior art keywords
tricyclopyrimidine
aryl
amine derivatives
macrocyclic polyethers
macrocyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR1458204A
Other languages
English (en)
Other versions
FR3025200A1 (fr
Inventor
El Bachir Kaloun
Serge Grisoni
Anna Kruczynski
Philippe Schmitt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre Medicament SA
Original Assignee
Pierre Fabre Medicament SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR1458204A priority Critical patent/FR3025200B1/fr
Application filed by Pierre Fabre Medicament SA filed Critical Pierre Fabre Medicament SA
Priority to PCT/EP2015/070072 priority patent/WO2016034637A1/fr
Priority to MX2017002747A priority patent/MX2017002747A/es
Priority to US15/508,014 priority patent/US10323043B2/en
Priority to RU2017108937A priority patent/RU2017108937A/ru
Priority to JP2017511996A priority patent/JP2017525733A/ja
Priority to BR112017003880A priority patent/BR112017003880A2/pt
Priority to EP15757491.4A priority patent/EP3189061A1/fr
Priority to CN201580053646.9A priority patent/CN106715445B/zh
Publication of FR3025200A1 publication Critical patent/FR3025200A1/fr
Application granted granted Critical
Publication of FR3025200B1 publication Critical patent/FR3025200B1/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
FR1458204A 2014-09-02 2014-09-02 Derives de n-aryl-tricyclopyrimidine-2-amine polyethers macrocycliques Expired - Fee Related FR3025200B1 (fr)

Priority Applications (9)

Application Number Priority Date Filing Date Title
FR1458204A FR3025200B1 (fr) 2014-09-02 2014-09-02 Derives de n-aryl-tricyclopyrimidine-2-amine polyethers macrocycliques
MX2017002747A MX2017002747A (es) 2014-09-02 2015-09-02 Derivados de polieteres macrociclicos de n-aril-triciclopirimidin- 2-amino como inhibidores de ftl3 y jak.
US15/508,014 US10323043B2 (en) 2014-09-02 2015-09-02 Derivatives of macrocyclic N-aryl-tricyclopyrimidine-2-amine polyethers as inhibitors of FTL3 and JAK
RU2017108937A RU2017108937A (ru) 2014-09-02 2015-09-02 Производные макроциклических полиэфиров n-арил-трициклопиримидин-2-амина в качестве ингибиторов ftl3 и jak
PCT/EP2015/070072 WO2016034637A1 (fr) 2014-09-02 2015-09-02 Derives de n-aryl-tricyclopyrimidine-2-amine polyethers macrocycliques comme inhibiteurs de la ftl3 et jak
JP2017511996A JP2017525733A (ja) 2014-09-02 2015-09-02 Ｆｔｌ３およびｊａｋの阻害剤としての大環状ｎ−アリール−トリシクロピリミジン−２−アミンポリエーテルの誘導体
BR112017003880A BR112017003880A2 (pt) 2014-09-02 2015-09-02 derivados de poliéteres de n-aril-triciclopirimidina-2-amina macrocíclicos como inibidores de ftl3 e jak
EP15757491.4A EP3189061A1 (fr) 2014-09-02 2015-09-02 Derives de n-aryl-tricyclopyrimidine-2-amine polyethers macrocycliques comme inhibiteurs de la ftl3 et jak
CN201580053646.9A CN106715445B (zh) 2014-09-02 2015-09-02 作为ftl3和jak抑制剂的大环n-芳基-三环嘧啶-2-胺聚醚的衍生物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1458204A FR3025200B1 (fr) 2014-09-02 2014-09-02 Derives de n-aryl-tricyclopyrimidine-2-amine polyethers macrocycliques

Publications (2)

Publication Number Publication Date
FR3025200A1 FR3025200A1 (fr) 2016-03-04
FR3025200B1 true FR3025200B1 (fr) 2016-09-23

Family

ID=51842565

Family Applications (1)

Application Number Title Priority Date Filing Date
FR1458204A Expired - Fee Related FR3025200B1 (fr) 2014-09-02 2014-09-02 Derives de n-aryl-tricyclopyrimidine-2-amine polyethers macrocycliques

Country Status (9)

Country Link
US (1) US10323043B2 (fr)
EP (1) EP3189061A1 (fr)
JP (1) JP2017525733A (fr)
CN (1) CN106715445B (fr)
BR (1) BR112017003880A2 (fr)
FR (1) FR3025200B1 (fr)
MX (1) MX2017002747A (fr)
RU (1) RU2017108937A (fr)
WO (1) WO2016034637A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113735856A (zh) * 2020-05-29 2021-12-03 百极弘烨(南通)医药科技有限公司 大环jak抑制剂及其应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1897950A (zh) * 2003-10-14 2007-01-17 惠氏公司 稠合芳基和杂芳基衍生物及其使用方法
TWI525096B (zh) * 2005-11-16 2016-03-11 Ｃｔｉ生技製藥有限公司 氧連接之嘧啶衍生物

Also Published As

Publication number Publication date
WO2016034637A1 (fr) 2016-03-10
BR112017003880A2 (pt) 2017-12-05
JP2017525733A (ja) 2017-09-07
US20170283432A1 (en) 2017-10-05
EP3189061A1 (fr) 2017-07-12
RU2017108937A (ru) 2018-10-04
FR3025200A1 (fr) 2016-03-04
MX2017002747A (es) 2017-10-20
CN106715445A (zh) 2017-05-24
CN106715445B (zh) 2019-05-31
US10323043B2 (en) 2019-06-18
RU2017108937A3 (fr) 2019-02-25

Similar Documents

Publication Publication Date Title
MA49859A (fr) Immunomodulateurs macrocycliques
CL2016002461A1 (es) Derivados macrocíclicos de pirimidina
DK3466976T3 (da) Anti-her2-antistof-lægemiddelkonjugat
LT3204359T (lt) Tetrahidroizochinolino dariniai
EP3319969A4 (fr) Polymorphe de macrocycle de diaryle
KR102390274B9 (ko) 마크로사이클릭 피리딘 유도체
DK3189056T3 (da) Cytotoksiske benzodiazepinderivater
HUE048321T2 (hu) Karabazol származékok
LT3402792T (lt) Chinolin-2-ono dariniai
LT3457851T (lt) Sobetiromo dariniai
DK3231803T3 (da) Dihydroindolizinonderivat
LT3371168T (lt) Indolin-2-ono dariniai
HRP20180826T1 (hr) Klizni ležajevi za konstrukcije
PT3131898T (pt) Derivados de fluoroalquilfluoreno
MA40836A (fr) Procédures de semi-synthèse
DK3154689T3 (da) Komplekser
EP3140315C0 (fr) Nouveaux dérivés de cath2
FR3023290B1 (fr) Derives de flavaglines
DK3154945T3 (da) Komplekser
LT3097076T (lt) Nauji cip-eikozanoidų dariniai
FR3025199B1 (fr) Derives de n-aryl-2-amino-4-aryl-pyrimidines polyethers macrocycliques
IL252908A0 (en) Fumagillol derivatives
IL248900A0 (en) Pyrazine derivatives
EP2901854C0 (fr) Corps creux
CL2015000871S1 (es) Pieza de rodillo

Legal Events

Date Code Title Description
PLFP Fee payment

Year of fee payment: 2

PLSC Search report ready

Effective date: 20160304

PLFP Fee payment

Year of fee payment: 3

PLFP Fee payment

Year of fee payment: 4

PLFP Fee payment

Year of fee payment: 5

ST Notification of lapse

Effective date: 20200910