FR2924928A1 - Depilatory composition comprises a sulfur-reducing agent in a form of lipophilic/hydrophilic type macroemulsion, and a lipophilic/hydrophilic type nanoemulsion comprising an aqueous phase in which droplets are dispersed in oily phase - Google Patents
Depilatory composition comprises a sulfur-reducing agent in a form of lipophilic/hydrophilic type macroemulsion, and a lipophilic/hydrophilic type nanoemulsion comprising an aqueous phase in which droplets are dispersed in oily phase Download PDFInfo
- Publication number
- FR2924928A1 FR2924928A1 FR0708677A FR0708677A FR2924928A1 FR 2924928 A1 FR2924928 A1 FR 2924928A1 FR 0708677 A FR0708677 A FR 0708677A FR 0708677 A FR0708677 A FR 0708677A FR 2924928 A1 FR2924928 A1 FR 2924928A1
- Authority
- FR
- France
- Prior art keywords
- droplets
- oily phase
- depilatory composition
- macroemulsion
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 102
- 239000012071 phase Substances 0.000 title claims abstract description 63
- 230000002951 depilatory effect Effects 0.000 title claims abstract description 52
- 239000007908 nanoemulsion Substances 0.000 title claims abstract description 29
- 239000004907 Macro-emulsion Substances 0.000 title claims abstract description 23
- 239000003638 chemical reducing agent Substances 0.000 title claims abstract description 20
- 239000008346 aqueous phase Substances 0.000 title claims abstract description 15
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000011593 sulfur Substances 0.000 claims abstract description 17
- 229910052717 sulfur Inorganic materials 0.000 claims abstract description 17
- 238000002156 mixing Methods 0.000 claims abstract description 5
- 238000004519 manufacturing process Methods 0.000 claims abstract description 4
- 235000019645 odor Nutrition 0.000 claims description 11
- 150000001875 compounds Chemical class 0.000 claims description 9
- 239000000126 substance Substances 0.000 claims description 8
- 239000002304 perfume Substances 0.000 claims description 7
- 239000006071 cream Substances 0.000 claims description 5
- 235000018936 Vitellaria paradoxa Nutrition 0.000 claims description 4
- 241001135917 Vitellaria paradoxa Species 0.000 claims description 4
- 229940057995 liquid paraffin Drugs 0.000 claims description 4
- 229940057910 shea butter Drugs 0.000 claims description 4
- 239000004094 surface-active agent Substances 0.000 claims description 4
- CWERGRDVMFNCDR-UHFFFAOYSA-N thioglycolic acid Chemical compound OC(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-N 0.000 claims description 4
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 3
- 239000011707 mineral Substances 0.000 claims description 3
- 150000003839 salts Chemical group 0.000 claims description 3
- 235000013311 vegetables Nutrition 0.000 claims description 3
- 244000144725 Amygdalus communis Species 0.000 claims description 2
- 235000011437 Amygdalus communis Nutrition 0.000 claims description 2
- 235000019493 Macadamia oil Nutrition 0.000 claims description 2
- 239000008168 almond oil Substances 0.000 claims description 2
- 239000010478 argan oil Substances 0.000 claims description 2
- 150000002191 fatty alcohols Chemical class 0.000 claims description 2
- 239000006210 lotion Substances 0.000 claims description 2
- 239000010469 macadamia oil Substances 0.000 claims description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 12
- 238000006243 chemical reaction Methods 0.000 description 11
- HYTYHTSMCRDHIM-UHFFFAOYSA-M potassium;2-sulfanylacetate Chemical compound [K+].[O-]C(=O)CS HYTYHTSMCRDHIM-UHFFFAOYSA-M 0.000 description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
- 238000001179 sorption measurement Methods 0.000 description 7
- GLZPCOQZEFWAFX-UHFFFAOYSA-N Geraniol Chemical compound CC(C)=CCCC(C)=CCO GLZPCOQZEFWAFX-UHFFFAOYSA-N 0.000 description 6
- 239000004615 ingredient Substances 0.000 description 6
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 description 6
- LSDPWZHWYPCBBB-UHFFFAOYSA-N Methanethiol Chemical class SC LSDPWZHWYPCBBB-UHFFFAOYSA-N 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 4
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 4
- 239000003921 oil Substances 0.000 description 4
- 235000019198 oils Nutrition 0.000 description 4
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 description 3
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 description 3
- 239000005792 Geraniol Substances 0.000 description 3
- GLZPCOQZEFWAFX-YFHOEESVSA-N Geraniol Natural products CC(C)=CCC\C(C)=C/CO GLZPCOQZEFWAFX-YFHOEESVSA-N 0.000 description 3
- 102000011782 Keratins Human genes 0.000 description 3
- 108010076876 Keratins Proteins 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 3
- 239000000920 calcium hydroxide Substances 0.000 description 3
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 3
- 229940113087 geraniol Drugs 0.000 description 3
- 230000007794 irritation Effects 0.000 description 3
- 229930007744 linalool Natural products 0.000 description 3
- 238000006386 neutralization reaction Methods 0.000 description 3
- KOZZOZYINRDZOU-UHFFFAOYSA-N 2-octadecoxyethyl 2-methylprop-2-enoate Chemical compound CCCCCCCCCCCCCCCCCCOCCOC(=O)C(C)=C KOZZOZYINRDZOU-UHFFFAOYSA-N 0.000 description 2
- WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 description 2
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 description 2
- WTEVQBCEXWBHNA-UHFFFAOYSA-N Citral Natural products CC(C)=CCCC(C)=CC=O WTEVQBCEXWBHNA-UHFFFAOYSA-N 0.000 description 2
- 239000005770 Eugenol Substances 0.000 description 2
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 description 2
- 206010040880 Skin irritation Diseases 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 229910001860 alkaline earth metal hydroxide Inorganic materials 0.000 description 2
- GUUHFMWKWLOQMM-NTCAYCPXSA-N alpha-hexylcinnamaldehyde Chemical compound CCCCCC\C(C=O)=C/C1=CC=CC=C1 GUUHFMWKWLOQMM-NTCAYCPXSA-N 0.000 description 2
- QUKGYYKBILRGFE-UHFFFAOYSA-N benzyl acetate Chemical compound CC(=O)OCC1=CC=CC=C1 QUKGYYKBILRGFE-UHFFFAOYSA-N 0.000 description 2
- 239000004202 carbamide Substances 0.000 description 2
- 229940073669 ceteareth 20 Drugs 0.000 description 2
- 229940043350 citral Drugs 0.000 description 2
- QMVPMAAFGQKVCJ-UHFFFAOYSA-N citronellol Chemical compound OCCC(C)CCC=C(C)C QMVPMAAFGQKVCJ-UHFFFAOYSA-N 0.000 description 2
- JOZKFWLRHCDGJA-UHFFFAOYSA-N citronellol acetate Chemical compound CC(=O)OCCC(C)CCC=C(C)C JOZKFWLRHCDGJA-UHFFFAOYSA-N 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 230000035617 depilation Effects 0.000 description 2
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 2
- 229960002217 eugenol Drugs 0.000 description 2
- WTEVQBCEXWBHNA-JXMROGBWSA-N geranial Chemical compound CC(C)=CCC\C(C)=C\C=O WTEVQBCEXWBHNA-JXMROGBWSA-N 0.000 description 2
- 210000004209 hair Anatomy 0.000 description 2
- WQDXJRHMOHYMKV-UHFFFAOYSA-N hexamagnesium;trisilicate;hydrate Chemical compound O.[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-] WQDXJRHMOHYMKV-UHFFFAOYSA-N 0.000 description 2
- 229940094522 laponite Drugs 0.000 description 2
- 235000001510 limonene Nutrition 0.000 description 2
- 229940087305 limonene Drugs 0.000 description 2
- UWKAYLJWKGQEPM-LBPRGKRZSA-N linalyl acetate Chemical compound CC(C)=CCC[C@](C)(C=C)OC(C)=O UWKAYLJWKGQEPM-LBPRGKRZSA-N 0.000 description 2
- XCOBTUNSZUJCDH-UHFFFAOYSA-B lithium magnesium sodium silicate Chemical compound [Li+].[Li+].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Na+].[Na+].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3 XCOBTUNSZUJCDH-UHFFFAOYSA-B 0.000 description 2
- NEMFQSKAPLGFIP-UHFFFAOYSA-N magnesiosodium Chemical compound [Na].[Mg] NEMFQSKAPLGFIP-UHFFFAOYSA-N 0.000 description 2
- 239000000391 magnesium silicate Substances 0.000 description 2
- 229910052919 magnesium silicate Inorganic materials 0.000 description 2
- 235000019792 magnesium silicate Nutrition 0.000 description 2
- 230000003472 neutralizing effect Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000037307 sensitive skin Effects 0.000 description 2
- 230000036556 skin irritation Effects 0.000 description 2
- 231100000475 skin irritation Toxicity 0.000 description 2
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 2
- FMYOMWCQJXWGEN-WYRLRVFGSA-M sodium;(2r,3r,4s,5r,6r)-2,3,4,5,6,7-hexahydroxyheptanoate Chemical compound [Na+].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O)C([O-])=O FMYOMWCQJXWGEN-WYRLRVFGSA-M 0.000 description 2
- 229940073743 steareth-20 methacrylate Drugs 0.000 description 2
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 2
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 2
- QMVPMAAFGQKVCJ-SNVBAGLBSA-N (R)-(+)-citronellol Natural products OCC[C@H](C)CCC=C(C)C QMVPMAAFGQKVCJ-SNVBAGLBSA-N 0.000 description 1
- VPKMGDRERYMTJX-CMDGGOBGSA-N 1-(2,6,6-Trimethyl-2-cyclohexen-1-yl)-1-penten-3-one Chemical compound CCC(=O)\C=C\C1C(C)=CCCC1(C)C VPKMGDRERYMTJX-CMDGGOBGSA-N 0.000 description 1
- AILDTIZEPVHXBF-UHFFFAOYSA-N Argentine Natural products C1C(C2)C3=CC=CC(=O)N3CC1CN2C(=O)N1CC(C=2N(C(=O)C=CC=2)C2)CC2C1 AILDTIZEPVHXBF-UHFFFAOYSA-N 0.000 description 1
- JOZKFWLRHCDGJA-LLVKDONJSA-N Citronellyl acetate Natural products CC(=O)OCC[C@H](C)CCC=C(C)C JOZKFWLRHCDGJA-LLVKDONJSA-N 0.000 description 1
- 235000005979 Citrus limon Nutrition 0.000 description 1
- 244000131522 Citrus pyriformis Species 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 1
- 238000012695 Interfacial polymerization Methods 0.000 description 1
- 241000234269 Liliales Species 0.000 description 1
- 244000179970 Monarda didyma Species 0.000 description 1
- 235000010672 Monarda didyma Nutrition 0.000 description 1
- 244000270834 Myristica fragrans Species 0.000 description 1
- 235000009421 Myristica fragrans Nutrition 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 244000308495 Potentilla anserina Species 0.000 description 1
- 235000016594 Potentilla anserina Nutrition 0.000 description 1
- 235000004443 Ricinus communis Nutrition 0.000 description 1
- 244000223014 Syzygium aromaticum Species 0.000 description 1
- 235000016639 Syzygium aromaticum Nutrition 0.000 description 1
- -1 Terpenyl acetate Chemical compound 0.000 description 1
- 229940022663 acetate Drugs 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- UZFLPKAIBPNNCA-UHFFFAOYSA-N alpha-ionone Natural products CC(=O)C=CC1C(C)=CCCC1(C)C UZFLPKAIBPNNCA-UHFFFAOYSA-N 0.000 description 1
- UZFLPKAIBPNNCA-BQYQJAHWSA-N alpha-ionone Chemical compound CC(=O)\C=C\C1C(C)=CCCC1(C)C UZFLPKAIBPNNCA-BQYQJAHWSA-N 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 229940007550 benzyl acetate Drugs 0.000 description 1
- JGQFVRIQXUFPAH-UHFFFAOYSA-N beta-citronellol Natural products OCCC(C)CCCC(C)=C JGQFVRIQXUFPAH-UHFFFAOYSA-N 0.000 description 1
- CNYFJCCVJNARLE-UHFFFAOYSA-L calcium;2-sulfanylacetic acid;2-sulfidoacetate Chemical compound [Ca+2].[O-]C(=O)CS.[O-]C(=O)CS CNYFJCCVJNARLE-UHFFFAOYSA-L 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 235000000484 citronellol Nutrition 0.000 description 1
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- ONKNPOPIGWHAQC-UHFFFAOYSA-N galaxolide Chemical compound C1OCC(C)C2=C1C=C1C(C)(C)C(C)C(C)(C)C1=C2 ONKNPOPIGWHAQC-UHFFFAOYSA-N 0.000 description 1
- FOYKKGHVWRFIBD-UHFFFAOYSA-N gamma-tocopherol acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 FOYKKGHVWRFIBD-UHFFFAOYSA-N 0.000 description 1
- HIGQPQRQIQDZMP-UHFFFAOYSA-N geranil acetate Natural products CC(C)=CCCC(C)=CCOC(C)=O HIGQPQRQIQDZMP-UHFFFAOYSA-N 0.000 description 1
- HIGQPQRQIQDZMP-DHZHZOJOSA-N geranyl acetate Chemical compound CC(C)=CCC\C(C)=C\COC(C)=O HIGQPQRQIQDZMP-DHZHZOJOSA-N 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- ZKVLEFBKBNUQHK-UHFFFAOYSA-N helium;molecular nitrogen;molecular oxygen Chemical compound [He].N#N.O=O ZKVLEFBKBNUQHK-UHFFFAOYSA-N 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- SDQFDHOLCGWZPU-UHFFFAOYSA-N lilial Chemical compound O=CC(C)CC1=CC=C(C(C)(C)C)C=C1 SDQFDHOLCGWZPU-UHFFFAOYSA-N 0.000 description 1
- UWKAYLJWKGQEPM-UHFFFAOYSA-N linalool acetate Natural products CC(C)=CCCC(C)(C=C)OC(C)=O UWKAYLJWKGQEPM-UHFFFAOYSA-N 0.000 description 1
- ZHALCRSGRSWRHV-UHFFFAOYSA-L magnesium;2-sulfanylacetate Chemical compound [Mg+2].[O-]C(=O)CS.[O-]C(=O)CS ZHALCRSGRSWRHV-UHFFFAOYSA-L 0.000 description 1
- 230000000873 masking effect Effects 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 239000001702 nutmeg Substances 0.000 description 1
- 229940067107 phenylethyl alcohol Drugs 0.000 description 1
- SATCULPHIDQDRE-UHFFFAOYSA-N piperonal Chemical compound O=CC1=CC=C2OCOC2=C1 SATCULPHIDQDRE-UHFFFAOYSA-N 0.000 description 1
- 230000000379 polymerizing effect Effects 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
- 229960001860 salicylate Drugs 0.000 description 1
- GNBVPFITFYNRCN-UHFFFAOYSA-M sodium thioglycolate Chemical compound [Na+].[O-]C(=O)CS GNBVPFITFYNRCN-UHFFFAOYSA-M 0.000 description 1
- 229940046307 sodium thioglycolate Drugs 0.000 description 1
- 229940071127 thioglycolate Drugs 0.000 description 1
- CWERGRDVMFNCDR-UHFFFAOYSA-M thioglycolate(1-) Chemical compound [O-]C(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-M 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q9/00—Preparations for removing hair or for aiding hair removal
- A61Q9/04—Depilatories
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/062—Oil-in-water emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/21—Emulsions characterized by droplet sizes below 1 micron
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Nanotechnology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
Description
1 La présente invention concerne une composition dépilatoire comprenant un agent réducteur soufré, qui, lors de son utilisation, n'engendre pas de phénomènes de mauvaises odeurs et qui ne provoque pas, non plus, de phénomènes d'irritation de la peau. The present invention relates to a depilatory composition comprising a sulfur-containing reducing agent which, during its use, does not cause bad odor phenomena and which does not cause skin irritation phenomena either.
Une composition dépilatoire comprenant un agent réducteur soufré se présente généralement sous la forme d'une crème devant être appliquée sur une zone de la peau à épiler durant un temps déterminé nécessaire à la réaction de dépilation. La réaction de dépilation nécessite, d'une part, la rupture de ponts disulfures qui assurent la cohésion des molécules de kératine constitutives des poils par l'agent réducteur soufré, et, d'autre part, la rupture de liaisons hydrogènes qui stabilisent la structure des molécules de kératine, grâce au pH basique de la composition, de façon à favoriser l'accès de l'agent réducteur soufré à la kératine. Suite à la réaction dépilatoire, la partie externe du poil est suffisamment fragilisée pour pouvoir être cassée et retirée de la surface de la peau en même temps que la composition. A depilatory composition comprising a sulfur-containing reducing agent is generally in the form of a cream to be applied to an area of the skin to be depilated for a determined time necessary for the depilation reaction. The depilation reaction requires, on the one hand, the breaking of disulphide bridges which ensure the cohesion of the keratin molecules constituting the hairs by the sulfur-containing reducing agent, and, on the other hand, the breaking of hydrogen bonds which stabilize the structure. keratin molecules, thanks to the basic pH of the composition, so as to promote access of the sulfur-containing reducing agent to the keratin. Following the depilatory reaction, the outer part of the hair is weakened enough to be able to be broken and removed from the surface of the skin at the same time as the composition.
Un des inconvénients lié à ce type de composition dépilatoire est l'odeur désagréable et forte ressentie par l'utilisateur en cours d'utilisation. Celle-ci est due à la fois à la décomposition au cours du temps des agents réducteurs soufrés présents dans la composition, et à la production lors de la réaction dépilatoire de composés mercaptans, tels que le sulfure d'hydrogène et le méthyl mercaptan. One of the drawbacks associated with this type of depilatory composition is the unpleasant and strong odor felt by the user during use. This is due both to the decomposition over time of the sulfur-containing reducing agents present in the composition, and to the production during the depilatory reaction of mercaptan compounds, such as hydrogen sulphide and methyl mercaptan.
Une solution généralement proposée à ce problème d'odeurs désagréables consiste à ajouter des parfums dans la composition dépilatoire. Ces parfums se contentant de masquer l'odeur, sans la supprimer, une telle solution n'est pas totalement satisfaisante. Par ailleurs, et comme expliqué précédemment, le pH des compositions dépilatoires est nécessairement basique et est généralement compris entre 10 et 12,7. Une telle valeur de pH peut alors induire des phénomènes d'irritation de la peau lorsque celle-ci se trouve en contact avec la composition durant le temps nécessaire à la réaction dépilatoire. De façon plus précise, les phénomènes d'irritation sont la conséquence du contact avec la peau de l'agent alcalin, utilisé pour maintenir un pH élevé. Malheureusement, plus le pH est élevé, plus la réaction dépilatoire est rapide et plus il est possible de diminuer le temps d'application de la composition. Cette caractéristique est importante et est recherchée par l'utilisateur. Dans le cas des peaux sensibles, et donc très réactives, une solution souvent proposée consiste à maintenir le pH de la composition à une valeur inférieure à 12. A solution generally proposed to this problem of unpleasant odors consists in adding perfumes in the depilatory composition. Since these perfumes are satisfied with masking the odor, without eliminating it, such a solution is not completely satisfactory. Moreover, and as explained above, the pH of the depilatory compositions is necessarily basic and is generally between 10 and 12.7. Such a pH value can then induce skin irritation phenomena when the latter is in contact with the composition for the time required for the depilatory reaction. More precisely, the irritation phenomena are the consequence of contact with the skin of the alkaline agent, used to maintain a high pH. Unfortunately, the higher the pH, the faster the depilatory reaction and the more it is possible to reduce the time of application of the composition. This feature is important and is sought after by the user. In the case of sensitive skin, and therefore very reactive, a solution often proposed consists in maintaining the pH of the composition at a value below 12.
Une autre solution consiste à présenter la composition dépilatoire sous la forme d'une macroémulsion, du type huile-dans-l'eau ou lipophile dans hydrophile (L/H). Une macroémulsion de type huile-dans-l'eau comprend une phase aqueuse dans laquelle sont dispersés des globules d'une phase huileuse. Lorsque la taille des globules est de l'ordre du micromètre, il s'agit d'une macroémulsion. Ces globules de phase huileuse vont se déposer à la surface de la peau et ainsi former un film de protection, isolant la peau des composés alcalins irritants. Dans ce cas, le pH de la composition peut être ajusté à une valeur suffisamment élevée pour permettre une réaction dépilatoire rapide sans provoquer de phénomènes d'irritation. La présente invention a pour but de proposer une composition dépilatoire, comprenant un agent réducteur soufré, qui se présente sous la forme d'une macroémulsion, de type lipophile-dans-hydrophile, dans laquelle des globules de phase huileuse sont dispersés dans une phase aqueuse, et qui n'engendre pas de mauvaises odeurs au cours de son utilisation ou suite à la dégradation de l'agent réducteur soufré au cours du temps. A cet effet une composition dépilatoire, selon l'invention, est remarquable en ce qu'elle comprend, de plus, une nanoémulsion, de type huile-dans-eau, comprenant une phase aqueuse dans laquelle sont dispersées des gouttelettes d'une phase huileuse dont la taille moyenne est comprise entre 10 et 1000 nm et la densité desdites gouttelettes est comprise entre 1010 et 1015 gouttelettes par cm3 de composition. La demanderesse a ainsi observé, de façon surprenante, que les produits issus de la réaction dépilatoire et de la décomposition de l'agent réducteur soufré étaient adsorbés l.. sur~ des gouttelettes phase tes .] UG e phase huileuse de i 1a nanoémulsion / ' à la face uslûll et étaient ainsi neutralisés. La neutralisation de l'ensemble des composés responsables de l'odeur désagréable de la composition n'est possible que si la surface d'adsorption offerte est suffisante. La neutralisation totale des produits responsables d'odeurs désagréables est obtenue avec des gouttelettes de phase huileuse de taille moyenne comprise entre 10 et 1000 nm et dont le nombre est compris entre 1010 et 1015 gouttes par cm3 de composition. Par cm3 de composition dépilatoire, la surface totale disponible pour l'adsorption est alors de l'ordre d'une ou plusieurs dizaines de m2. Préférentiellement, la taille moyenne desdites gouttelettes de phase huileuse est comprise entre 50 et 500 nm, et la densité desdites gouttelettes est comprise entre 1011 et 1013 gouttelettes par cm3 de composition. Another solution consists in presenting the depilatory composition in the form of a macroemulsion, of the oil-in-water or lipophilic in hydrophilic (L / O) type. An oil-in-water macroemulsion comprises an aqueous phase in which globules of an oily phase are dispersed. When the size of the globules is of the order of a micrometer, it is a macroemulsion. These oily phase globules will be deposited on the surface of the skin and thus form a protective film, isolating the skin from irritating alkaline compounds. In this case, the pH of the composition can be adjusted to a sufficiently high value to allow a rapid depilatory reaction without causing irritation phenomena. The object of the present invention is to provide a depilatory composition, comprising a sulfur-containing reducing agent, which is in the form of a macroemulsion, of the lipophilic-in-hydrophilic type, in which globules of the oily phase are dispersed in an aqueous phase. , and which does not generate bad odors during its use or following the degradation of the sulfur-containing reducing agent over time. For this purpose, a depilatory composition according to the invention is remarkable in that it further comprises a nanoemulsion, of oil-in-water type, comprising an aqueous phase in which droplets of an oily phase are dispersed. the average size of which is between 10 and 1000 nm and the density of said droplets is between 1010 and 1015 droplets per cm3 of composition. The Applicant has thus observed, surprisingly, that the products resulting from the depilatory reaction and from the decomposition of the sulfur-containing reducing agent were adsorbed l .. on ~ droplets your phase.] UG e oily phase of i 1a nanoemulsion / 'to the uslûll face and were thus neutralized. Neutralization of all the compounds responsible for the unpleasant odor of the composition is only possible if the adsorption surface offered is sufficient. Total neutralization of the products responsible for unpleasant odors is obtained with droplets of oily phase of average size between 10 and 1000 nm and the number of which is between 1010 and 1015 drops per cm3 of composition. Per cm3 of depilatory composition, the total surface area available for adsorption is then of the order of one or several tens of m2. Preferably, the average size of said oily phase droplets is between 50 and 500 nm, and the density of said droplets is between 1011 and 1013 droplets per cm3 of composition.
Avantageusement, la composition dépilatoire comprend entre 0,001 et 20 %, en poids, de nanoémulsion et entre 80 et 99,999 %, en poids, de macroémulsion, par rapport au poids total de la composition. Selon une caractéristique de l'invention, la taille desdits globules de la phase huileuse de ladite macroémulsion est comprise entre 0,1 et 100 m. De façon avantageuse, la quantité totale de globules de la phase huileuse de la macroémulsion est comprise entre 2 et 20 % en poids, par rapport au poids total de la composition. L'agent réducteur soufré de la composition dépilatoire selon l'invention est un composé comportant un groupe thiol. Un tel composé est bien connu de l'homme du métier et peut être, par exemple, un sel de l'acide thioglycolique, tel que le thioglycolate de potassium, le thioglycolate de calcium, le thioglycolate de sodium, le thioglycolate de magnésium, ou un mélange de ces sels. De façon préférentielle, la quantité de l'agent réducteur soufré présent dans la composition sera comprise entre 1 et 5 % en poids, par rapport au poids total de la composition. Selon une caractéristique de l'invention, la composition dépilatoire comprend entre 2.10"6 et 10"3, préférentiellement entre 2.10-6 et 9.104, moles d'agent réducteur soufré par cm3 de composition et par cm2 de surface totale de gouttelettes de nanoémulsion. L'agent alcalin utilisé pour ajuster le pH de la composition dépilatoire est un hydroxyde de métal alcalino-terreux, tel que l'hydroxyde de calcium, l'hydroxyde de potassium ou l'hydroxyde de sodium. Préférentiellement, la quantité d'hydroxyde de métal alcalino-terreux est comprise entre 1 et 4 % en poids, par rapport au poids total de la composition. Le pH de la composition est avantageusement compris entre 11,5 et 12,7, préférentiellement entre 12 et 12,7. Par exemple, lorsque le pH de la composition est de 12,5, la réaction dépilatoire se déroule en un temps compris entre environ 4 et 8 minutes, c'est-à-dire plus ou moins une ou quelques dizaines de secondes. Si le pH est de 12,7, la réaction dépilatoire se déroule en un temps compris entre environ 3 et 6 minutes, c'est-à-dire plus ou moins une ou quelques dizaines de secondes. Les gouttelettes de phase huileuse peuvent être obtenues par les méthodes de préparations de nanoémulsions connues, telles que l'homogénéisation à haute pression, l'ultrasonification ou encore la microfluidisation. Advantageously, the depilatory composition comprises between 0.001 and 20%, by weight, of nanoemulsion and between 80 and 99.999%, by weight, of macroemulsion, relative to the total weight of the composition. According to one characteristic of the invention, the size of said globules of the oily phase of said macroemulsion is between 0.1 and 100 m. Advantageously, the total quantity of globules of the oily phase of the macroemulsion is between 2 and 20% by weight, relative to the total weight of the composition. The sulfur-containing reducing agent of the depilatory composition according to the invention is a compound comprising a thiol group. Such a compound is well known to those skilled in the art and can be, for example, a salt of thioglycolic acid, such as potassium thioglycolate, calcium thioglycolate, sodium thioglycolate, magnesium thioglycolate, or a mixture of these salts. Preferably, the amount of the sulfur-containing reducing agent present in the composition will be between 1 and 5% by weight, relative to the total weight of the composition. According to one characteristic of the invention, the depilatory composition comprises between 2.10 "6 and 10" 3, preferably between 2.10-6 and 9.104, moles of sulfur-containing reducing agent per cm3 of composition and per cm2 of total surface area of droplets of nanoemulsion. The alkaline agent used to adjust the pH of the depilatory composition is an alkaline earth metal hydroxide, such as calcium hydroxide, potassium hydroxide or sodium hydroxide. Preferably, the amount of alkaline earth metal hydroxide is between 1 and 4% by weight, relative to the total weight of the composition. The pH of the composition is advantageously between 11.5 and 12.7, preferably between 12 and 12.7. For example, when the pH of the composition is 12.5, the depilatory reaction takes place in a time of between approximately 4 and 8 minutes, that is to say more or less one or a few tens of seconds. If the pH is 12.7, the depilatory reaction takes place in a time of between about 3 and 6 minutes, that is to say more or less one or a few tens of seconds. The oily phase droplets can be obtained by known nanoemulsion preparation methods, such as high pressure homogenization, ultrasonification or else microfluidization.
4 Les substances entrant dans la composition de la phase huileuse des gouttelettes peuvent être, par exemple, des huiles d'origine minérale ou végétale, des parfums, ou tout additif liposoluble connu et convenant à la préparation d'une composition dépilatoire. Par exemple, la phase huileuse des gouttelettes peut comporter à la fois des substances parfumantes et des substances neutralisantes. Le tableau 1, ci-dessous, fournit une liste non exhaustive de substances qui peuvent ainsi être utilisées. The substances entering into the composition of the oily phase of the droplets can be, for example, oils of mineral or vegetable origin, perfumes, or any known fat-soluble additive suitable for the preparation of a depilatory composition. For example, the oily phase of the droplets can comprise both perfuming substances and neutralizing substances. Table 1, below, provides a non-exhaustive list of substances which can be used in this way.
Tableau 1 Ingrédients Quantité (%en poids/ poids total nanoémulsion) Substances neutralisantes Héliotropine 1 û 5 Ionone alpha 1 û 5 Galaxolide 1 û 5 Alcool phényléthylique 1 û 5 Hydroxy 1 û 5 Citronellol 5û10 Géraniol 1 û 5 Linalol 1 - 5 Acétate de Benzyle 5 û 10 Acétate de Linalyle 5 û 10 Salicylate Iso Amyle 15 û 20 Méthyl ionone gamma Iso 1 û 5 Acétate de Terpényle 1 û 5 Acétate de Géranyle <1 Acétate de Citronnellyle <1 Substances parfumantes Lilial <1 Celestolide 1 û 5 Vanilline <1 Essence de feuille de Girofle 1 û 5 Essence de Bergamote 5 - 10 Essence Ylang 1 1 û 5 Essence de Noix de Muscade 1 û 5 Essence de citron d'Argentine 1 û 5 De même, les substances entrant dans la composition de la phase huileuse des globules peuvent être, par exemple, des corps gras d'origine minérale ou végétale aux propriétés réputées apaisantes pour la peau, tels que de la paraffine liquide, de l'huile d'argan, de l'huile de macadamia, de l'huile d'amande douce ou du beurre de karité. Table 1 Ingredients Quantity (% w / total nanoemulsion) Neutralizing substances Heliotropin 1 û 5 Alpha ionone 1 û 5 Galaxolide 1 û 5 Phenylethyl alcohol 1 û 5 Hydroxy 1 û 5 Citronellol 5û10 Geraniol 1 û 5 Linalool 1 - 5 Benzyl acetate 5 û 10 Linalyl acetate 5 û 10 Salicylate Iso Amyl 15 û 20 Methyl ionone gamma Iso 1 û 5 Terpenyl acetate 1 û 5 Geranyl acetate <1 Citronellyl acetate <1 Fragrances Lilial <1 Celestolide 1 û 5 Vanillin <1 Clove leaf essence 1 û 5 Bergamot essence 5 - 10 Ylang essence 1 1 û 5 Nutmeg essence 1 û 5 Argentine lemon essence 1 û 5 Likewise, the substances entering into the composition of the oily phase globules can be, for example, fatty substances of mineral or vegetable origin with reputedly soothing properties for the skin, such as liquid paraffin, argan oil, macadamia oil, sweet almond oil or shea butter.
Les tensioactifs utilisés afm de stabiliser les globules huileux et les gouttelettes huileuses de la macroémulsion et de la nanoémulsion, respectivement, peuvent être choisis parmi les tensioactifs de type non-ionique, amphotère, ionique ou même polymérique non ionique, ionique ou amphotère. Il est également possible d'utiliser des agents de polymérisation interfaciale du type utilisé lors de procédés d'encapsulation. Ces agents consistent, par exemple, en deux monomères, l'un soluble dans une phase lipophile, l'autre soluble dans la phase hydrophile, capables de polymériser ensemble. Selon un mode de réalisation préféré de l'invention, la phase huileuse de la macroémulsion, ainsi que la phase huileuse de la nanoémulsion, comprennent au moins un tensioactif de type non-ionique permettant de stabiliser les globules huileux et les gouttelettes huileuses, respectivement. Le tensioactif non-ionique sera avantageusement choisi parmi les éthers polyoxyéthylénés d'alcools gras. D'autres additifs habituellement utilisés en cosmétologie peuvent également être utilisés dans une composition dépilatoire selon l'invention, comme par exemple, des agents hydratants, des parfums, des conservateurs ou des antioxydants. L'homme du métier est en mesure de choisir non seulement ces composés mais également d'en adapter les quantités. Selon un mode de réalisation préféré de l'invention, la composition dépilatoire se présente sous la forme d'une crème, d'une lotion ou dun gel. L'invention concerne encore un procédé de préparation d'une composition dépilatoire telle que décrite précédemment. Le procédé selon l'invention consiste à mélanger, à une température comprise entre 65 et 80 °C, les composants de la phase aqueuse et de la phase huileuse de manière à former une macroémulsion, puis à ajouter, à une température comprise entre 35 et 50 °C, la nanoémulsion et l'agent réducteur soufré. The surfactants used in order to stabilize the oily globules and the oily droplets of the macroemulsion and of the nanoemulsion, respectively, can be chosen from surfactants of nonionic, amphoteric, ionic or even nonionic, ionic or amphoteric polymeric type. It is also possible to use interfacial polymerization agents of the type used in encapsulation processes. These agents consist, for example, of two monomers, one soluble in a lipophilic phase, the other soluble in the hydrophilic phase, capable of polymerizing together. According to a preferred embodiment of the invention, the oily phase of the macroemulsion, as well as the oily phase of the nanoemulsion, comprise at least one surfactant of nonionic type making it possible to stabilize the oily globules and the oily droplets, respectively. The nonionic surfactant will advantageously be chosen from polyoxyethylenated ethers of fatty alcohols. Other additives usually used in cosmetology can also be used in a depilatory composition according to the invention, such as, for example, moisturizing agents, perfumes, preservatives or antioxidants. Those skilled in the art are able to choose not only these compounds but also to adapt the amounts thereof. According to a preferred embodiment of the invention, the depilatory composition is in the form of a cream, a lotion or a gel. The invention also relates to a process for preparing a depilatory composition as described above. The process according to the invention consists in mixing, at a temperature of between 65 and 80 ° C, the components of the aqueous phase and of the oily phase so as to form a macroemulsion, then adding, at a temperature of between 35 and 50 ° C, the nanoemulsion and the sulfur reducing agent.
L'invention sera mieux comprise à la lecture des exemples de réalisation de compositions dépilatoires suivants, qui se veulent illustratifs et non limitatifs. 10 Exemple 1 : Composition dépilatoire pour peau sensible Une composition dépilatoire se présentant sous la forme d'une crème a été préparée à partir des composés répertoriés dans le Tableau 2. The invention will be better understood on reading the following embodiments of depilatory compositions, which are intended to be illustrative and not limiting. Example 1: Depilatory Composition for Sensitive Skin A depilatory composition in the form of a cream was prepared from the compounds listed in Table 2.
Tableau 2: Exemple l Phase Ingrédient Quantité (% poids) Macroémulsion A Eau Biosmosée 25.205 A Gluceptate de sodium 0,100 A Hydroxyde de calcium 2,700 A Hydrate de trisilicate de magnésium 0,500 A Colorant 0,600 B Alcool cétylstéarylique 8,000 B Ceteareth-20 2,500 B Paraffine liquide 2,500 B Beurre de karité 0,500 C Eau Biosmosée 35,600 C Urée 8,000 C Laponite XLS (silicate de sodium magnesium 0,500 pyrophosphate de tetrasodium) C Copolymère d'acrylates/steareth-20 methacrylate 0,100 D Eau Biosmosée 3,550 D Thioglycolate de potassium (solution à 43%) 9,300 D Hydroxyde de potassium 0,050 15 nanoémulsion D 0,295 dont: Phase aqueuse: 0,195 Eau (66,2 %) Phase huileuse: 0,10 Parfum (20%) PPG-266buteth-26 (2,2%) PEG-40 huile de ricin hydrogénée (1,4%) Citral (0,9%) Eugenol (1,67%) Geraniol (2,74%) Hexyl cinnamal (0,9%) Limonene (0,09%) Linalool (1,38%) Dipropylène glycol (2,5%) Mode opératoire: Les phases A, B et C sont préparées de manière indépendante, par mélange de leurs ingrédients. La nanoémulsion est préparée par microfluidisation, à froid, après mélange de chacun des ingrédients. Les phases A et B sont ensuite chauffées séparément à une température de 70°C puis mélangées l'une avec l'autre en maintenant la température à 70°C. La température est abaissée à 50°C et la phase C est alors ajoutée. La température est alors abaissée à 40°C. Chacun des ingrédients de la phase D, y compris la nanoémulsion, sont ensuite ajoutés séparément. Le mélange est réalisé dans une cuve Trimix commercialisée par la société VMI Rayneri. Le pH de la composition dépilatoire mesuré est 12,5. Table 2: Example l Phase Ingredient Quantity (% by weight) Macroemulsion A Biosmosed water 25.205 A Sodium gluceptate 0.100 A Calcium hydroxide 2. 700 A Magnesium trisilicate hydrate 0.500 A Color 0.600 B Cetylstearyl alcohol 8.000 B Ceteareth-20 2.500 B Liquid paraffin 2.500 B Shea butter 0.500 C Biosmosed water 35,600 C Urea 8,000 C Laponite XLS (sodium magnesium silicate 0.500 tetrasodium pyrophosphate) C Copolymer of acrylates / steareth-20 methacrylate 0.100 D Biosmosed water 3.550 D Potassium thioglycolate (43% solution) 9.300 D Potassium hydroxide 0.050 15 nanoemulsion D 0.295 of which: Aqueous phase: 0.195 Water (66.2%) Oily phase: 0.10 Perfume (20%) PPG-266buteth-26 (2.2%) PEG-40 Hydrogenated castor (1.4%) Citral (0.9%) Eugenol (1.67%) Geraniol (2.74%) Hexyl cinnamal (0.9%) Limonene (0.09%) Linalool (1.38%) ) Dipropylene glycol (2.5%) Procedure: Phases A, B and C are prepared independently, by mixing their ingredients. The nanoemulsion is prepared by microfluidization, cold, after mixing each of the ingredients. Phases A and B are then heated separately to a temperature of 70 ° C and then mixed with each other while maintaining the temperature at 70 ° C. The temperature is lowered to 50 ° C and phase C is then added. The temperature is then lowered to 40 ° C. Each of the ingredients in phase D, including the nanoemulsion, are then added separately. The mixture is carried out in a Trimix tank marketed by the company VMI Rayneri. The pH of the depilatory composition measured is 12.5.
La composition obtenue comprend, d'une part, une macroémulsion composée de globules de phase huileuse, dont la taille moyenne est environ 2000 nm, c'est-à-dire 2000 nm plus ou moins une ou plusieurs centaines de nanomètres, dispersés dans une phase aqueuse, et d'autre part, une nanoémulsion composée de gouttelettes de phase huileuse, dont la taille moyenne des gouttelettes de phase huileuse est environ 200 nm, c'est-à-dire 200 nm plus ou moins une ou plusieurs dizaines de nanomètres, dispersées dans une phase aqueuse. The composition obtained comprises, on the one hand, a macroemulsion composed of oily phase globules, the average size of which is approximately 2000 nm, that is to say 2000 nm plus or less one or several hundred nanometers, dispersed in a aqueous phase, and on the other hand, a nanoemulsion composed of oily phase droplets, the average size of the oily phase droplets of which is about 200 nm, that is to say 200 nm plus or minus one or several tens of nanometers , dispersed in an aqueous phase.
Données relatives à la nanoémulsion: De manière à faciliter les calculs suivants, la densité de la phase huileuse de la nanoémulsion est considérée égale à 1. En moyenne, les rayons des gouttelettes de phase huileuse sont : R = 100 nm = 10-7 m. Le volume d'une gouttelette de phase huileuse est donné par la relation suivante: V g = 4/3 JI R3 = 4,18.10-21 m3 = 4,18.10-'' cm3. Le volume total de phase huileuse de la nanoémulsion, pour 100 cm3 de composition, est 0,10 cm3. Ainsi, par cm3 de composition, ce volume est l0-3 cm3. Le nombre de gouttelettes de phase huileuse, par cm3 de composition, est donné par la relation suivante: N = Vphase huileuse/Vgouttelette = 10-3 /4,18.10-15 = 2,39.101' gouttelettes/cm3. La surface d'une gouttelette de phase huileuse est donnée par la relation suivante: Sg=4JIR2= 1,25.10.13 m2. Data relating to the nanoemulsion: In order to facilitate the following calculations, the density of the oily phase of the nanoemulsion is considered equal to 1. On average, the radii of the oily phase droplets are: R = 100 nm = 10-7 m . The volume of an oily phase droplet is given by the following relationship: V g = 4/3 JI R3 = 4.18.10-21 m3 = 4.18.10- '' cm3. The total volume of oily phase of the nanoemulsion, per 100 cm3 of composition, is 0.10 cm3. Thus, per cm3 of composition, this volume is 10-3 cm3. The number of oily phase droplets, per cm3 of composition, is given by the following relationship: N = V oily phase / V droplet = 10-3 / 4.18.10-15 = 2.39.101 droplets / cm3. The area of an oily phase droplet is given by the following relation: Sg = 4JIR2 = 1,25.10.13 m2.
On en déduit que la surface totale d'adsorption, par cm3 de composition, est donnée par la relation suivante: It is deduced that the total adsorption surface area, per cm3 of composition, is given by the following relation:
St = Sg * N = 1,25.10-13 * 2,39.10"= 2,9.10-2 m2 = 290 cm2/cm3 de composition. St = Sg * N = 1.25.10-13 * 2.39.10 "= 2.9.10-2 m2 = 290 cm2 / cm3 of composition.
La composition comprend 4 g de thioglycolate de potassium pour 100 cm3 de composition (solution de thioglycolate de potassium à 43%). La masse moléculaire du thioglycolate de potassium est 130 g/mol. Le nombre de moles de thioglycolate de potassium par cm3 de composition est : 4 / 130 = 0,030 mol/ cm3 de composition. The composition comprises 4 g of potassium thioglycolate per 100 cm3 of composition (43% potassium thioglycolate solution). The molecular mass of potassium thioglycolate is 130 g / mol. The number of moles of potassium thioglycolate per cm3 of composition is: 4/130 = 0.030 mol / cm3 of composition.
Le nombre de moles de thioglycolate de potassium par cm3 de composition et par cm2 de surface de gouttelette de phase huileuse est: 0,030 / 290 = 1.104 mol/cm3 de composition/cm2 de surface totale de gouttelettes de phase huileuse. The number of moles of potassium thioglycolate per cm3 of composition and per cm2 of oily phase droplet surface is: 0.030 / 290 = 1.104 mol / cm3 of composition / cm2 of total surface of oily phase droplets.
Test: Afin de vérifier l'efficacité des gouttelettes de phase huileuse de nanoémulsion dans la neutralisation de l'ensemble des composés responsables d'odeurs désagréables, la composition dépilatoire a été testée dans des conditions réelles d'utilisation par 150 utilisatrices. La composition a été appliquée sur la surface de la peau à épiler pendant 5 minutes, puis enlevée de la surface de la peau. La peau a été ensuite rincée. Selon 86 % des utilisatrices, la composition dépilatoire ne présente pas de phénomène d'odeur désagréable lors de son utilisation. Test: In order to verify the effectiveness of the oily phase droplets of nanoemulsion in the neutralization of all the compounds responsible for unpleasant odors, the depilatory composition was tested under real conditions of use by 150 users. The composition was applied to the surface of the skin to be depilated for 5 minutes, then removed from the surface of the skin. The skin was then rinsed. According to 86% of users, the depilatory composition does not exhibit an unpleasant odor phenomenon when used.
Le volume total de la composition selon cet exemple est de 100 cm3, la surface totale disponible pour l'adsorption des composés mercaptans est de 2,9 m2. Une telle surface permet ainsi l'adsorption de la totalité des composés mercaptans pouvant engendrer des odeurs désagréables. The total volume of the composition according to this example is 100 cm3, the total surface available for the adsorption of the mercaptan compounds is 2.9 m2. Such a surface thus allows the adsorption of all of the mercaptan compounds which can generate unpleasant odors.
Comparativement, si seulement une seule goutte de phase huileuse était présente dans la composition, la surface totale d'adsorption par cm3 de composition serait: Comparatively, if only a single drop of oily phase were present in the composition, the total adsorption surface area per cm3 of composition would be:
S = 4 JI R2 = 4,8.104 m2 = 4,8 cm2/cm3 de composition, avec Vphase huileuse = 10-6 m3/cm3 de composition et Rgoutte unique = 6,2.10-3 m. Suite à la réaction dépilatoire, la zone de la peau est entièrement épilée, sans aucune marque d'irritation. Le pH élevé de la composition est ainsi compensé par la présence, dans la composition, de globules de phase huileuse de dimension importante. Ces globules de phase huileuse se déposent sur la surface de la peau et forment une barrière physique empêchant un contact entre les agents irritants, tels que l'hydroxyde de potassium, et la peau. S = 4 JI R2 = 4.8.104 m2 = 4.8 cm2 / cm3 of composition, with oily phase = 10-6 m3 / cm3 of composition and single drop = 6.2.10-3 m. Following the depilatory reaction, the area of the skin is completely shaved, without any signs of irritation. The high pH of the composition is thus compensated for by the presence, in the composition, of oily phase globules of large size. These oily phase globules settle on the surface of the skin and form a physical barrier preventing contact between irritants, such as potassium hydroxide, and the skin.
Exemple 2 : Composition dépilatoire à action rapide Une composition dépilatoire se présentant sous la forme d'une crème a été préparée à partir des composés répertoriés dans le Tableau 3. Example 2: Rapid-Acting Depilatory Composition A depilatory composition in the form of a cream was prepared from the compounds listed in Table 3.
Tableau 3:30 Exemple 2 Phase Ingrédient Quantité (% poids) Macroémulsion A Eau Biosmosée 25,205 A Gluceptate de sodium 0,100 A Hydroxyde de calcium 2,700 A Hydrate de trisilicate de magnésium 0,500 A Colorant 0,600 B Alcool cétylstéarylique 8,000 B Ceteareth-20 2,500 B Paraffine liquide 2,500 B Acétate de tocophéryle 0,100 B Beurre de karité 0,500 C Eau Biosmosée 33,500 C Urée 10,00 C Laponite XLS (silicate de sodium magnesium 0,500 pyrophosphate de tetrasodium) C Copolymère d'acrylates/steareth-20 methacrylate 0,100 D Eau Biosmosée 1,200 D Thioglycolate de potassium (solution à 43%) 11,600 D Hydroxyde de potassium 0,100 nanoémulsion D 0,295 dont: Phase aqueuse: 0,195 Eau (66,22) Phase huileuse: Parfum (20%) 0,1 PPG-266buteth-26 (2,2%) PEG-40 huile de ricin hydrogénée (1,4%) Citral (0,9%) Eugenol (1,67%) Geraniol (2,74%) Hexyl cinnamal (0,9%) Limonene (0,09%) Linalool (1,38%) Dipropylène glycol (2,5%) Mode opératoire: Le mode opératoire est identique à celui décrit dans l'exemple 1. Le pH de la composition dépilatoire est 12,6. Table 3:30 Example 2 Phase Ingredient Quantity (% by weight) Macroemulsion A Biosmosed water 25.205 A Sodium gluceptate 0.100 A Calcium hydroxide 2. 700 A Magnesium trisilicate hydrate 0.500 A Color 0.600 B Cetylstearyl alcohol 8.000 B Ceteareth-20 2.500 B Liquid paraffin 2,500 B Tocopheryl acetate 0.100 B Shea butter 0.500 C Biosmosed water 33.500 C Urea 10.00 C Laponite XLS (sodium magnesium silicate 0.500 tetrasodium pyrophosphate) C Copolymer of acrylates / steareth-20 methacrylate 0.100 D Biosmosed water 1.200 D Thioglycolate potassium (43% solution) 11.600 D Potassium hydroxide 0.100 nanoemulsion D 0.295 of which: Aqueous phase: 0.195 Water (66.22) Oily phase: Perfume (20%) 0.1 PPG-266buteth-26 (2.2% ) PEG-40 hydrogenated castor oil (1.4%) Citral (0.9%) Eugenol (1.67%) Geraniol (2.74%) Hexyl cinnamal (0.9%) Limonene (0.09%) Linalool (1.38%) Dipropylene glycol (2.5%) Procedure: The procedure is identical to that described in Example 1. The pH of the depilatory composition is 12.6.
Données relatives à la nanoémulsion: Les données concernant le rayon moyen des gouttelettes de phase huileuse de la nanoémulsion, le volume total de phase huileuse, le nombre de gouttelettes de phase huileuse ainsi que la surface totale d'adsorption, par cm3 de composition, sont identiques aux données de l'exemple 1. Data relating to the nanoemulsion: The data concerning the average radius of the oil phase droplets of the nanoemulsion, the total volume of the oil phase, the number of oil phase droplets as well as the total adsorption surface area, per cm3 of composition, are identical to the data in example 1.
Dans cet exemple, la composition comprend 5 g de thioglycolate de potassium pour 100 cm3 de composition (solution de thioglycolate de potassium à 43%). Le nombre de moles de thioglycolate de potassium par cm3 de composition est : 5 / 130 = 0,038 mol/ cm3 de composition. Le nombre de moles de thioglycolate de potassium par cm3 de composition et par cm2 de surface de gouttelette de phase huileuse est: 0,038 / 290 = 1,3.104 mol/cm3 de composition/cm2 de surface totale de gouttelettes de phase huileuse. La composition peut être appliquée sur la surface de la peau à épiler pendant 3 minutes. In this example, the composition comprises 5 g of potassium thioglycolate per 100 cm3 of composition (43% potassium thioglycolate solution). The number of moles of potassium thioglycolate per cm3 of composition is: 5/130 = 0.038 mol / cm3 of composition. The number of moles of potassium thioglycolate per cm3 of composition and per cm2 of oily phase droplet surface is: 0.038 / 290 = 1.3.104 mol / cm3 of composition / cm2 of total surface of oily phase droplets. The composition can be applied to the surface of the skin to be depilated for 3 minutes.
Claims (14)
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| Application Number | Priority Date | Filing Date | Title |
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| FR0708677A FR2924928B1 (en) | 2007-12-13 | 2007-12-13 | DEPILATORY COMPOSITION COMPRISING A NANOEMULSION FOR LIMITING THE PHENOMENA OF BAD ODORS ASSOCIATED WITH THE USE OF THE COMPOSITION |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0708677A FR2924928B1 (en) | 2007-12-13 | 2007-12-13 | DEPILATORY COMPOSITION COMPRISING A NANOEMULSION FOR LIMITING THE PHENOMENA OF BAD ODORS ASSOCIATED WITH THE USE OF THE COMPOSITION |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2559422A1 (en) * | 2011-08-17 | 2013-02-20 | The Procter & Gamble Company | Effective depilatory article |
| WO2012120277A3 (en) * | 2011-03-04 | 2014-02-06 | Reckitt & Colman (Overseas) Limited | A depilatory composition |
| US9216304B2 (en) | 2010-03-26 | 2015-12-22 | The Gillette Company | Method of depilation and depilatory kit |
| US9248085B2 (en) | 2011-08-17 | 2016-02-02 | The Procter & Gamble Company | Effective depilatory article |
| USD957518S1 (en) * | 2019-12-10 | 2022-07-12 | Worklife Brands Llc | Notebook |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020106390A1 (en) * | 1998-05-11 | 2002-08-08 | Dietmar Huglin | Use of nanodispersions in cosmetic end formulations |
| WO2006098966A2 (en) * | 2005-03-09 | 2006-09-21 | Combe Incorporated | Stable mixed emulsions comprising semisolid dispersions of at least two discrete and distinctly different particle size ranges |
| WO2007042824A1 (en) * | 2005-10-14 | 2007-04-19 | Reckitt Benckiser (Uk) Limited | Microemulsion and shaving apparatus comprising a microemulsion |
-
2007
- 2007-12-13 FR FR0708677A patent/FR2924928B1/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020106390A1 (en) * | 1998-05-11 | 2002-08-08 | Dietmar Huglin | Use of nanodispersions in cosmetic end formulations |
| WO2006098966A2 (en) * | 2005-03-09 | 2006-09-21 | Combe Incorporated | Stable mixed emulsions comprising semisolid dispersions of at least two discrete and distinctly different particle size ranges |
| WO2007042824A1 (en) * | 2005-10-14 | 2007-04-19 | Reckitt Benckiser (Uk) Limited | Microemulsion and shaving apparatus comprising a microemulsion |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9216304B2 (en) | 2010-03-26 | 2015-12-22 | The Gillette Company | Method of depilation and depilatory kit |
| WO2012120277A3 (en) * | 2011-03-04 | 2014-02-06 | Reckitt & Colman (Overseas) Limited | A depilatory composition |
| US9271922B2 (en) | 2011-03-04 | 2016-03-01 | Reckitt & Colman (Overseas) Limited | Depilatory cream composition |
| EP2559422A1 (en) * | 2011-08-17 | 2013-02-20 | The Procter & Gamble Company | Effective depilatory article |
| WO2013025871A3 (en) * | 2011-08-17 | 2013-04-18 | The Procter & Gamble Company | Depilatory article |
| US9248085B2 (en) | 2011-08-17 | 2016-02-02 | The Procter & Gamble Company | Effective depilatory article |
| USD957518S1 (en) * | 2019-12-10 | 2022-07-12 | Worklife Brands Llc | Notebook |
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| Publication number | Publication date |
|---|---|
| FR2924928B1 (en) | 2009-12-04 |
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