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FR2967673B1 - Synthese de n-heterocycles par alkylation reductrice de derives cyanes - Google Patents

Synthese de n-heterocycles par alkylation reductrice de derives cyanes

Info

Publication number
FR2967673B1
FR2967673B1 FR1059672A FR1059672A FR2967673B1 FR 2967673 B1 FR2967673 B1 FR 2967673B1 FR 1059672 A FR1059672 A FR 1059672A FR 1059672 A FR1059672 A FR 1059672A FR 2967673 B1 FR2967673 B1 FR 2967673B1
Authority
FR
France
Prior art keywords
heterocycles
synthesis
reductive alkylation
cyan
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR1059672A
Other languages
English (en)
Other versions
FR2967673A1 (fr
Inventor
Stephane Laval
Wissam Jean Dayoub
Marc Lemaire
Dominique Delbrayelle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Minakem SAS
Universite Claude Bernard Lyon 1
Original Assignee
Minakem SAS
Universite Claude Bernard Lyon 1
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Minakem SAS, Universite Claude Bernard Lyon 1 filed Critical Minakem SAS
Priority to FR1059672A priority Critical patent/FR2967673B1/fr
Priority to PCT/EP2011/070893 priority patent/WO2012069566A1/fr
Priority to EP11793713.6A priority patent/EP2643309A1/fr
Publication of FR2967673A1 publication Critical patent/FR2967673A1/fr
Application granted granted Critical
Publication of FR2967673B1 publication Critical patent/FR2967673B1/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/023—Preparation; Separation; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/02—Preparation by ring-closure or hydrogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
FR1059672A 2010-11-24 2010-11-24 Synthese de n-heterocycles par alkylation reductrice de derives cyanes Expired - Fee Related FR2967673B1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
FR1059672A FR2967673B1 (fr) 2010-11-24 2010-11-24 Synthese de n-heterocycles par alkylation reductrice de derives cyanes
PCT/EP2011/070893 WO2012069566A1 (fr) 2010-11-24 2011-11-24 Synthese de n-heterocycles par alkylation reductrice de derives cyanes
EP11793713.6A EP2643309A1 (fr) 2010-11-24 2011-11-24 Synthese de n-heterocycles par alkylation reductrice de derives cyanes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1059672A FR2967673B1 (fr) 2010-11-24 2010-11-24 Synthese de n-heterocycles par alkylation reductrice de derives cyanes

Publications (2)

Publication Number Publication Date
FR2967673A1 FR2967673A1 (fr) 2012-05-25
FR2967673B1 true FR2967673B1 (fr) 2012-12-28

Family

ID=43856140

Family Applications (1)

Application Number Title Priority Date Filing Date
FR1059672A Expired - Fee Related FR2967673B1 (fr) 2010-11-24 2010-11-24 Synthese de n-heterocycles par alkylation reductrice de derives cyanes

Country Status (3)

Country Link
EP (1) EP2643309A1 (fr)
FR (1) FR2967673B1 (fr)
WO (1) WO2012069566A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103641769B (zh) * 2013-12-06 2015-11-04 爱斯特（成都）生物制药有限公司 异吲哚啉盐酸盐的制备方法
CN107365257B (zh) * 2017-08-02 2019-04-02 厦门大学 一种2-甲基戊二腈加氢制备2-甲基戊二胺及3-甲基哌啶的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2790804A (en) * 1955-06-04 1957-04-30 Ici Ltd Catalytic hydrogenation
FR2805535B1 (fr) * 2000-02-25 2002-04-12 Adir Nouveau procede de preparation de l'isoindoline
EP1717234A1 (fr) * 2005-04-29 2006-11-02 Bioprojet Phenoxypropylpiperidines and -pyrrolidines et leur utilisation comme ligands du récepteur histaminique H3
WO2007137738A1 (fr) 2006-06-01 2007-12-06 Sanofi-Aventis Nitriles spirocycliques en tant qu'inhibiteurs de protéase
US20080287479A1 (en) 2006-12-20 2008-11-20 Pfizer Inc Inhibitors of serine palmitoyltransferase

Also Published As

Publication number Publication date
WO2012069566A1 (fr) 2012-05-31
FR2967673A1 (fr) 2012-05-25
EP2643309A1 (fr) 2013-10-02

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