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FR2948024B1 - Emulsion activable par ultrasons et son procede de fabrication. - Google Patents

Emulsion activable par ultrasons et son procede de fabrication. Download PDF

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Publication number
FR2948024B1
FR2948024B1 FR0955001A FR0955001A FR2948024B1 FR 2948024 B1 FR2948024 B1 FR 2948024B1 FR 0955001 A FR0955001 A FR 0955001A FR 0955001 A FR0955001 A FR 0955001A FR 2948024 B1 FR2948024 B1 FR 2948024B1
Authority
FR
France
Prior art keywords
emulsion
activable
ultrasound
manufacturing
emulsifier
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0955001A
Other languages
English (en)
Other versions
FR2948024A1 (fr
Inventor
Patrick Tabeling
Mickael Tanter
Nicolas Pannacci
Olivier Couture
Mathias Fink
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Original Assignee
Centre National de la Recherche Scientifique CNRS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0955001A priority Critical patent/FR2948024B1/fr
Application filed by Centre National de la Recherche Scientifique CNRS filed Critical Centre National de la Recherche Scientifique CNRS
Priority to US13/382,745 priority patent/US20120121516A1/en
Priority to PCT/FR2010/051439 priority patent/WO2011007082A1/fr
Priority to EP10742223A priority patent/EP2453875A1/fr
Priority to CN201080041846.XA priority patent/CN102573797B/zh
Priority to JP2012520068A priority patent/JP5856055B2/ja
Publication of FR2948024A1 publication Critical patent/FR2948024A1/fr
Priority to IL217457A priority patent/IL217457A0/en
Application granted granted Critical
Publication of FR2948024B1 publication Critical patent/FR2948024B1/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Clinical applications
    • A61B8/0833—Clinical applications involving detecting or locating foreign bodies or organic structures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/48—Diagnostic techniques
    • A61B8/481—Diagnostic techniques involving the use of contrast agents, e.g. microbubbles introduced into the bloodstream
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Medical Informatics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

Emulsion activable par ultrasons comprenant, en émulsion dans une solution aqueuse, des microparticules (1) de diamètre (D) inférieur à 10 µm comprenant un agent actif et un précurseur gazeux (3) sous forme liquide encapsulés par un premier émulsifiant (4). Les microparticules contiennent des nanoparticules (5) de taille inférieure à 1 µm en émulsion dans le précurseur gazeux, chaque nanoparticule comprenant un liquide interne (6) qui contient l'agent actif et qui est encapsulé par un deuxième émulsifiant (7).
FR0955001A 2009-07-17 2009-07-17 Emulsion activable par ultrasons et son procede de fabrication. Expired - Fee Related FR2948024B1 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
FR0955001A FR2948024B1 (fr) 2009-07-17 2009-07-17 Emulsion activable par ultrasons et son procede de fabrication.
PCT/FR2010/051439 WO2011007082A1 (fr) 2009-07-17 2010-07-07 Emulsion activable par ultrasons et son procede de fabrication
EP10742223A EP2453875A1 (fr) 2009-07-17 2010-07-07 Emulsion activable par ultrasons et son procede de fabrication
CN201080041846.XA CN102573797B (zh) 2009-07-17 2010-07-07 由超声波激活的乳剂及其生产方法
US13/382,745 US20120121516A1 (en) 2009-07-17 2010-07-07 Emulsion Activatable by Ultrasounds and Method for Producing Same
JP2012520068A JP5856055B2 (ja) 2009-07-17 2010-07-07 超音波によって活性化可能なエマルション及びその製造方法
IL217457A IL217457A0 (en) 2009-07-17 2012-01-10 Emulsion activatable by ultrasounds and method for producing same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0955001 2009-07-17
FR0955001A FR2948024B1 (fr) 2009-07-17 2009-07-17 Emulsion activable par ultrasons et son procede de fabrication.

Publications (2)

Publication Number Publication Date
FR2948024A1 FR2948024A1 (fr) 2011-01-21
FR2948024B1 true FR2948024B1 (fr) 2020-01-10

Family

ID=41259370

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0955001A Expired - Fee Related FR2948024B1 (fr) 2009-07-17 2009-07-17 Emulsion activable par ultrasons et son procede de fabrication.

Country Status (7)

Country Link
US (1) US20120121516A1 (fr)
EP (1) EP2453875A1 (fr)
JP (1) JP5856055B2 (fr)
CN (1) CN102573797B (fr)
FR (1) FR2948024B1 (fr)
IL (1) IL217457A0 (fr)
WO (1) WO2011007082A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2604253A1 (fr) * 2011-12-13 2013-06-19 Otto Glatter Émulsion eau dans l'huile et leurs procédés de préparation
NL2009335C2 (en) 2012-08-20 2014-02-24 Albert Thijs Poortinga Encapsulation system.
FR3000688B1 (fr) * 2013-01-08 2016-09-30 Centre Nat De La Rech Scient - Cnrs - Procede pour activer une reaction chimique, melange activable par ce procede et dispostiif pour la mise en oeuvre de ce procede
EP3871666A1 (fr) * 2014-03-05 2021-09-01 Evan C. Unger Radiothérapie et chimiothérapie fractionnées faisant intervenir de l'oxygène thérapeutique
FR3043571A1 (fr) 2015-11-18 2017-05-19 Centre Nat De La Rech Scient - Cnrs - Procede et dispositif de fabrication d'emulsions
CN106110340B (zh) * 2016-07-12 2019-09-03 陈传品 一种制备靶向载药微气泡的方法及装置
CN109046483B (zh) * 2018-08-28 2022-04-15 京东方科技集团股份有限公司 流体微粒及制备方法、微流体系统及制备方法、控制方法
WO2020060275A1 (fr) * 2018-09-21 2020-03-26 삼육대학교산학협력단 Système d'administration de médicament induit par ultrasons utilisant un vecteur de médicament comprenant des nanobulles et un médicament
WO2024127054A1 (fr) * 2022-12-16 2024-06-20 Sorbonne Universite Structure à émulsion double pour administration de médicament déclenchée par ultrasons à basses fréquences

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2720943B1 (fr) * 1994-06-09 1996-08-23 Applic Transferts Technolo Emulsions inverses stables à forte concentration en composé(s) fluoré(s) et leur utilisation pour l'administration pulmonaire de médicaments et pour la fabrication d'émulsions multiples.
US5733526A (en) * 1995-12-14 1998-03-31 Alliance Pharmaceutical Corp. Hydrocarbon oil/fluorochemical preparations and methods of use
US20020039594A1 (en) * 1997-05-13 2002-04-04 Evan C. Unger Solid porous matrices and methods of making and using the same
US6416740B1 (en) 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
FR2837724B1 (fr) * 2002-03-28 2005-01-28 Centre Nat Rech Scient Capsules composites biocompatibles
ES2387619T3 (es) * 2004-04-19 2012-09-27 Centre National De La Recherche Scientifique (Cnrs) Suplementos de tensioactivos pulmonares
CN100574809C (zh) * 2005-01-10 2009-12-30 重庆海扶(Hifu)技术有限公司 一种高强度聚焦超声治疗用氟碳乳剂类助剂及其应用
US20080213355A1 (en) * 2005-07-22 2008-09-04 Koninklijke Philips Electronics, N.V. Method and System for in Vivo Drug Delivery
JP2007197403A (ja) * 2006-01-30 2007-08-09 Hitachi Ltd 薬物キャリアー及び超音波装置
WO2007133710A2 (fr) * 2006-05-11 2007-11-22 Raindance Technologies, Inc. Dispositifs microfluidiques et leurs procédés d'utilisation
WO2008021908A2 (fr) * 2006-08-08 2008-02-21 Board Of Regents Of The University Of Texas Administration d'agents actifs à étapes multiples
JP2007044692A (ja) * 2006-09-27 2007-02-22 Japan Science & Technology Agency ダブルエマルション・マイクロカプセル生成装置
WO2009048532A2 (fr) * 2007-10-05 2009-04-16 President And Fellows Of Harvard College Formation de particules pour application d'ultrasons, libération de médicament et autres utilisations, et procédés microfluidiques de préparation

Also Published As

Publication number Publication date
CN102573797B (zh) 2014-10-29
US20120121516A1 (en) 2012-05-17
FR2948024A1 (fr) 2011-01-21
EP2453875A1 (fr) 2012-05-23
JP2012533531A (ja) 2012-12-27
WO2011007082A1 (fr) 2011-01-20
IL217457A0 (en) 2012-02-29
CN102573797A (zh) 2012-07-11
JP5856055B2 (ja) 2016-02-09

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