FR2811992B1 - MIXTURES OF HEPARIN-DERIVED POLYSACCHARIDES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Google Patents

MIXTURES OF HEPARIN-DERIVED POLYSACCHARIDES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Info

Publication number: FR2811992B1
Authority: FR; France
Prior art keywords: heparin; mixtures; preparation; pharmaceutical compositions; compositions containing
Prior art date: 2000-07-21
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

FR0009572A

Other languages

French (fr)

Other versions

FR2811992A1 (en

Inventor

Jacques Diaz

Christelle Pecquet

Elisabeth Perrin

Christian Viskov

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Aventis Pharma SA

Original Assignee

Aventis Pharma SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-07-21

Filing date

2000-07-21

Publication date

2003-07-04

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8852768&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR2811992(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2000-07-21 Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA

2000-07-21 Priority to FR0009572A priority Critical patent/FR2811992B1/en

2001-07-18 Priority to PT01955436T priority patent/PT1307491E/en

2001-07-18 Priority to HU0300755A priority patent/HUP0300755A3/en

2001-07-18 Priority to DE60142340T priority patent/DE60142340D1/en

2001-07-18 Priority to JP2002514199A priority patent/JP5279160B2/en

2001-07-18 Priority to AT01955436T priority patent/ATE470679T1/en

2001-07-18 Priority to UA2003010495A priority patent/UA74836C2/en

2001-07-18 Priority to PCT/FR2001/002332 priority patent/WO2002008295A1/en

2001-07-18 Priority to DZ013411A priority patent/DZ3411A1/en

2001-07-18 Priority to YU2903A priority patent/YU2903A/en

2001-07-18 Priority to CNB018141870A priority patent/CN1230449C/en

2001-07-18 Priority to MXPA03000579A priority patent/MXPA03000579A/en

2001-07-18 Priority to EP01955436.9A priority patent/EP1307491B2/en

2001-07-18 Priority to ES01955436.9T priority patent/ES2347134T5/en

2001-07-18 Priority to DK01955436.9T priority patent/DK1307491T3/en

2001-07-18 Priority to AU7760201A priority patent/AU7760201A/en

2001-07-18 Priority to HK04102179.5A priority patent/HK1059273B/en

2001-07-18 Priority to OA1200300012A priority patent/OA12340A/en

2001-07-18 Priority to NZ52402801A priority patent/NZ524028A/en

2001-07-18 Priority to AU2001277602A priority patent/AU2001277602B2/en

2001-07-18 Priority to EA200300178A priority patent/EA005995B1/en

2001-07-18 Priority to BRPI0112612-1A priority patent/BR0112612B1/en

2001-07-18 Priority to HR20030019A priority patent/HRP20030019A2/en

2001-07-18 Priority to SI200130977T priority patent/SI1307491T1/en

2001-07-18 Priority to PL365561A priority patent/PL202471B1/en

2001-07-18 Priority to APAP/P/2003/002744A priority patent/AP1703A/en

2001-07-18 Priority to KR1020037000689A priority patent/KR100853585B1/en

2001-07-18 Priority to IL15392201A priority patent/IL153922A0/en

2001-07-18 Priority to CA2416673A priority patent/CA2416673C/en

2001-07-19 Priority to TW090117709A priority patent/TWI307278B/en

2001-07-20 Priority to ARP010103476A priority patent/AR029865A1/en

2001-07-23 Priority to US09/909,797 priority patent/US6969705B2/en

2002-01-25 Publication of FR2811992A1 publication Critical patent/FR2811992A1/en

2003-01-10 Priority to MA26996A priority patent/MA26928A1/en

2003-01-13 Priority to IL153922A priority patent/IL153922A/en

2003-01-20 Priority to EC2003004442A priority patent/ECSP034442A/en

2003-01-20 Priority to NO20030296A priority patent/NO20030296L/en

2003-01-31 Priority to ZA200300898A priority patent/ZA200300898B/en

2003-07-04 Publication of FR2811992B1 publication Critical patent/FR2811992B1/en

2003-07-04 Application granted granted Critical

2004-05-19 Priority to CL200401154A priority patent/CL2004001154A1/en

2005-04-01 Priority to US11/096,146 priority patent/US7812007B2/en

2010-08-25 Priority to US12/868,268 priority patent/US20110152509A1/en

2010-09-09 Priority to CY20101100819T priority patent/CY1110774T1/en

2020-07-21 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
- C08B37/0078—Degradation products
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Materials Engineering (AREA)
Dermatology (AREA)
Polymers & Plastics (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Biochemistry (AREA)
Hematology (AREA)
Diabetes (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)

FR0009572A 2000-07-21 2000-07-21 MIXTURES OF HEPARIN-DERIVED POLYSACCHARIDES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Expired - Fee Related FR2811992B1 (en)

Priority Applications (41)

Application Number	Priority Date	Filing Date	Title
FR0009572A FR2811992B1 (en)	2000-07-21	2000-07-21	MIXTURES OF HEPARIN-DERIVED POLYSACCHARIDES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
HR20030019A HRP20030019A2 (en)	2000-07-21	2001-07-18	Heparin-derived polysaccharide mixtures, preparation method and pharmaceutical compositions containing same
SI200130977T SI1307491T1 (en)	2000-07-21	2001-07-18	Heparin-derived polysaccharide mixtures, preparation method and pharmaceutical compositions containing same
DE60142340T DE60142340D1 (en)	2000-07-21	2001-07-18	MIXTURES OF POLYSACCHARIDES FROM HEPARIN, THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEREOF
JP2002514199A JP5279160B2 (en)	2000-07-21	2001-07-18	Mixtures of polysaccharides derived from heparin, methods for their production and pharmaceutical compositions containing them
AT01955436T ATE470679T1 (en)	2000-07-21	2001-07-18	MIXTURES OF POLYSACCHARIDES FROM HEPARIN, THEIR PRODUCTION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM
UA2003010495A UA74836C2 (en)	2000-07-21	2001-07-18	A mixture of polysaccharides based on heparin, a method for the preparation thereof and a pharmaceutical composition
PCT/FR2001/002332 WO2002008295A1 (en)	2000-07-21	2001-07-18	Heparin-derived polysaccharide mixtures, preparation method and pharmaceutical compositions containing same
DZ013411A DZ3411A1 (en)	2000-07-21	2001-07-18	MIXTURES OF HEPARIN-DERIVED POLYSACCHARIDES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
YU2903A YU2903A (en)	2000-07-21	2001-07-18	Heparin-derived polysaccharide mixtures, preparation method and pharmaceutical compositions containing same
CNB018141870A CN1230449C (en)	2000-07-21	2001-07-18	Heparin-derived polysaccharide mixtures, process for their preparation and pharmaceutical compositions containing them
MXPA03000579A MXPA03000579A (en)	2000-07-21	2001-07-18	Heparin-derived polysaccharide mixtures, preparation method and pharmaceutical compositions containing same.
EP01955436.9A EP1307491B2 (en)	2000-07-21	2001-07-18	Heparin-derived polysaccharide mixtures, preparation method and pharmaceutical compositions containing same
ES01955436.9T ES2347134T5 (en)	2000-07-21	2001-07-18	Mixtures of polysaccharides derived from heparin, their preparation and the pharmaceutical compositions containing them
APAP/P/2003/002744A AP1703A (en)	2000-07-21	2001-07-18	Heparin-derived polysaccharide mixtures, preparation method and pharmaceutical compositions containing same.
AU7760201A AU7760201A (en)	2000-07-21	2001-07-18	Heparin-derived polysaccharide mixtures, preparation method and pharmaceutical compositions containing same
HU0300755A HUP0300755A3 (en)	2000-07-21	2001-07-18	Heparin-derived polysaccharide mixtures, preparation method and pharmaceutical compositions containing same
OA1200300012A OA12340A (en)	2000-07-21	2001-07-18	Heparin - derived polysaccharide mixtures, their preparation and pharmaceutical compositions containing them.
NZ52402801A NZ524028A (en)	2000-07-21	2001-07-18	Heparin-derived polysaccharide mixtures, preparation method and pharmaceutical compositions containing same
AU2001277602A AU2001277602B2 (en)	2000-07-21	2001-07-18	Heparin-derived polysaccharide mixtures, preparation method and pharmaceutical compositions containing same
EA200300178A EA005995B1 (en)	2000-07-21	2001-07-18	Heparin-derived polysaccharide mixtures, preparation method and pharmaceutical compositions containing same
BRPI0112612-1A BR0112612B1 (en)	2000-07-21	2001-07-18	sulfated polysaccharide mixtures, their preparation process and pharmaceutical compositions.
PT01955436T PT1307491E (en)	2000-07-21	2001-07-18	Heparin-derived polysaccharide mixtures, preparation method and pharmaceutical compositions containing same
PL365561A PL202471B1 (en)	2000-07-21	2001-07-18	Heparin-derived polysaccharide mixtures, preparation method and pharmaceutical compositions containing same
HK04102179.5A HK1059273B (en)	2000-07-21	2001-07-18	Heparin-derived polysaccharide mixtures, preparation method and pharmaceutical compositions containing same
DK01955436.9T DK1307491T3 (en)	2000-07-21	2001-07-18	Mixtures of polysaccharides of heparin, their preparation and pharmaceutical compositions containing them
KR1020037000689A KR100853585B1 (en)	2000-07-21	2001-07-18	Heparin-derived polysaccharide mixtures, preparation methods thereof and pharmaceutical compositions containing the same
IL15392201A IL153922A0 (en)	2000-07-21	2001-07-18	Heparin-derived polysaccharide mixtures, preparation method and pharmaceutical compositions containing same
CA2416673A CA2416673C (en)	2000-07-21	2001-07-18	Heparin-derived polysaccharide mixtures, preparation method and pharmaceutical compositions containing same
TW090117709A TWI307278B (en)	2000-07-21	2001-07-19	Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
ARP010103476A AR029865A1 (en)	2000-07-21	2001-07-20	MIXTURES OF SULFATED POLYSACARIDS DERIVED FROM HEPARINE, ITS PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US09/909,797 US6969705B2 (en)	2000-07-21	2001-07-23	Compositions of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
MA26996A MA26928A1 (en)	2000-07-21	2003-01-10	MIXTURES OF POLYSACCHARIDES DERIVED FROM HEPARIN, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
IL153922A IL153922A (en)	2000-07-21	2003-01-13	Heparin-derived polysaccharide mixtures, preparation method and pharmaceutical compositions containing same
NO20030296A NO20030296L (en)	2000-07-21	2003-01-20	Heparin-derived polysaccharide mixtures, their preparation and pharmaceutical compositions containing the compositions
EC2003004442A ECSP034442A (en)	2000-07-21	2003-01-20	MIXTURES OF POLYACARIDS DERIVED FROM HEPARINE, ITS PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
ZA200300898A ZA200300898B (en)	2000-07-21	2003-01-31	Heparin-derived polysaccharide mixtures, preparation method and pharmaceutical compositions containing same.
CL200401154A CL2004001154A1 (en)	2000-07-21	2004-05-19	BLENDS OF SULFATED OLIFOSACARIDS THAT HAVE GENERAL STRUCTURE OF HEPARINE POLYCHARIZES, THE POLISACARIDS HAVE PM OF 1500-3000 DALTONES, 2 TO 26 SACARIDIC PROVISIONS AND A GLUCURONIC ACID-2-4-INSATED PROVISION
US11/096,146 US7812007B2 (en)	2000-07-21	2005-04-01	Compositions of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
US12/868,268 US20110152509A1 (en)	2000-07-21	2010-08-25	Compositions of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
CY20101100819T CY1110774T1 (en)	2000-07-21	2010-09-09	Polysaccharide Mixtures Coming From Usarin, Their Preparation And The Pharmaceutical Compounds That Contain It

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR0009572A FR2811992B1 (en)	2000-07-21	2000-07-21	MIXTURES OF HEPARIN-DERIVED POLYSACCHARIDES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Publications (2)

Publication Number	Publication Date
FR2811992A1 FR2811992A1 (en)	2002-01-25
FR2811992B1 true FR2811992B1 (en)	2003-07-04

Family

ID=8852768

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FR0009572A Expired - Fee Related FR2811992B1 (en)	2000-07-21	2000-07-21	MIXTURES OF HEPARIN-DERIVED POLYSACCHARIDES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Country Status (35)

Country	Link
EP (1)	EP1307491B2 (en)
JP (1)	JP5279160B2 (en)
KR (1)	KR100853585B1 (en)
CN (1)	CN1230449C (en)
AP (1)	AP1703A (en)
AR (1)	AR029865A1 (en)
AT (1)	ATE470679T1 (en)
AU (2)	AU7760201A (en)
BR (1)	BR0112612B1 (en)
CA (1)	CA2416673C (en)
CL (1)	CL2004001154A1 (en)
CY (1)	CY1110774T1 (en)
DE (1)	DE60142340D1 (en)
DK (1)	DK1307491T3 (en)
DZ (1)	DZ3411A1 (en)
EA (1)	EA005995B1 (en)
EC (1)	ECSP034442A (en)
ES (1)	ES2347134T5 (en)
FR (1)	FR2811992B1 (en)
HR (1)	HRP20030019A2 (en)
HU (1)	HUP0300755A3 (en)
IL (2)	IL153922A0 (en)
MA (1)	MA26928A1 (en)
MX (1)	MXPA03000579A (en)
NO (1)	NO20030296L (en)
NZ (1)	NZ524028A (en)
OA (1)	OA12340A (en)
PL (1)	PL202471B1 (en)
PT (1)	PT1307491E (en)
SI (1)	SI1307491T1 (en)
TW (1)	TWI307278B (en)
UA (1)	UA74836C2 (en)
WO (1)	WO2002008295A1 (en)
YU (1)	YU2903A (en)
ZA (1)	ZA200300898B (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6969705B2 (en)	2000-07-21	2005-11-29	Aventis Pharma S.A.	Compositions of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
EP1375524B1 (en) *	2002-06-20	2007-03-07	CHEMI S.p.A.	Process for the preparation of esters of heparin
FR2845686B1 (en)	2002-10-10	2013-08-30	Aventis Pharma Sa	MIXTURES OF HEPARIN-DERIVED POLYSACCHARIDES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
AR041555A1 (en)	2002-10-10	2005-05-18	Aventis Pharma Sa	MIXTURES OF POLYACARIDS DERIVED FROM HEPARINE, ITS PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US20040171819A1 (en)	2002-10-10	2004-09-02	Aventis Pharma S.A.	Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
US7956046B2 (en) *	2003-07-24	2011-06-07	Aventis Pharma S.A.	Oligosaccharide mixtures derived from heparin, preparation thereof and pharmaceutical compositions containing them
FR2857971B1 (en) *	2003-07-24	2005-08-26	Aventis Pharma Sa	MIXTURES OF HEPARIN DERIVED OLIGOSACCHARIDES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
DE102004059134B4 (en)	2004-12-08	2011-12-15	Siemens Ag	Expansion device for an X-ray machine and X-ray source
FR2889078B1 (en) *	2005-07-27	2007-11-02	Aventis Pharma Sa	NOVEL CHROMATOGRAPHY METHOD OF AFFINITY OF ANTITHROMBIN III
EP2404939A3 (en) *	2006-05-25	2012-03-21	Momenta Pharmaceuticals, Inc.	Low molecular weight heparin composition and uses thereof
CN101824099B (en) *	2010-02-12	2011-11-30	淮安麦德森化学有限公司	Method for purifying crude product heparin sodium
CN101824446B (en) *	2010-02-24	2012-12-12	淮安麦德森化学有限公司	Method for producing chondroitin sulfate by reverse precipitation
EP2399590A1 (en)	2010-06-25	2011-12-28	Aventis Pharma S.A.	Semuloparin for the prevention of a mortality and/or morbidity event in a patient undergoing major orthopaedic surgery
EP2399592A1 (en)	2010-06-25	2011-12-28	Aventis Pharma S.A.	Semuloparin for use as an antithrombotic treatment in hip replacement surgery with improved safety in terms of clinically relevant bleedings and major bleedings
EP2399591A1 (en)	2010-06-25	2011-12-28	Aventis Pharma S.A.	Semuloparin for the extended prevention of a mortality and/or morbidity event in a patient having undergone hip fracture surgery
EP2399593A1 (en)	2010-06-28	2011-12-28	Aventis Pharma S.A.	Semuloparin for use as an antithrombotic treatment in orthopaedic surgery with improved benefit-risk profile
CN102399379B (en) *	2010-09-09	2016-08-31	上海喜恩医药科技发展有限公司	Polysaccharide mixture of a kind of heparin derivative and preparation method thereof and pharmaceutical composition
CA2811186C (en) *	2010-09-14	2018-12-04	Michio Muguruma	High purity heparin and production method therefor
EP2446891A1 (en)	2010-10-28	2012-05-02	Aventis Pharma S.A.	Semuloparin for use as an antithrombotic treatment in major abdominal surgery with improved safety in terms of clinically relevant bleedings and major bleedings
WO2012055843A1 (en)	2010-10-28	2012-05-03	Aventis Pharma S.A.	Semuloparin for the prevention of major venous thromboembolism in a patient undergoing major abdominal surgery
EP2548561A1 (en)	2011-07-22	2013-01-23	Aventis Pharma S.A.	Semuloparin for improving the survival of patients with locally advanced cancer
ES2445494B1 (en) *	2012-08-02	2015-03-06	Rovi Lab Farmaceut Sa	Procedure for obtaining low and very low molecular weight heparins
CN103175925B (en) *	2013-03-20	2014-12-03	山东辰中生物制药有限公司	Method for detecting esterification rate of heparin benzyl ester in production process of enoxaparin sodium
FR3016632A1 (en) *	2014-01-21	2015-07-24	IFP Energies Nouvelles	PROCESS FOR TRANSFORMING POLYSACCHARIDES TO OXYGENIC MOLECULES IN THE PRESENCE OF NEUTRAL ORGANIC SUPERBASES
CZ306662B6 (en) *	2015-06-26	2017-04-26	Contipro A.S.	Sulphated polysaccharides derivatives, the method of their preparation, the method of their modification and the use

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FR2478646A2 (en) *	1980-03-20	1981-09-25	Choay Sa	MUCOPOLYSACCHARIDIC COMPOSITION HAVING A COAGULATION REGULATING ACTIVITY, MEDICAMENT CONTAINING THE SAME, AND METHOD FOR OBTAINING THE SAME
IL61201A (en) *	1979-10-05	1984-09-30	Choay Sa	Oligosaccharides having no more than 8 saccharide moieties,their obtention from heparin and pharmaceutical compositions containing them
FR2482611B1 (en) *	1980-05-14	1986-03-07	Pharmindustrie	NOVEL SULFATED POLYSACCHARIDES, METHODS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS
US4916219A (en) *	1985-03-28	1990-04-10	University Of Iowa Research Foundation	Oligosaccharide heparin fragments as inhibitors of complement cascade
EP0337327A1 (en) *	1988-04-09	1989-10-18	Bioiberica, S.A.	Process for the preparation of new oligosaccharide fractions by controlled chemical depolimerization of heparin
ES2077533B1 (en) *	1994-02-28	1996-07-01	Bioiberica	PROCEDURE FOR OBTAINING OLIGOSACCHARIDE FRACTIONS BY CHEMICAL DEPOLYMERIZATION OF HEPARIN.
JP4897991B2 (en) *	1999-07-23	2012-03-14	ラボラトリオスファルマセウティコスロビソシエダッドアノニマ	Ultra low molecular weight heparin composition
ES2161615B1 (en) *	1999-07-23	2003-03-16	Rovi Lab Farmaceut Sa	COMPOSITIONS OF HEPARINS OF VERY LOW MOLECULAR WEIGHT.

2000
- 2000-07-21 FR FR0009572A patent/FR2811992B1/en not_active Expired - Fee Related
2001
- 2001-07-18 AP APAP/P/2003/002744A patent/AP1703A/en active
- 2001-07-18 AT AT01955436T patent/ATE470679T1/en active
- 2001-07-18 DZ DZ013411A patent/DZ3411A1/en active
- 2001-07-18 EP EP01955436.9A patent/EP1307491B2/en not_active Expired - Lifetime
- 2001-07-18 UA UA2003010495A patent/UA74836C2/en unknown
- 2001-07-18 CA CA2416673A patent/CA2416673C/en not_active Expired - Fee Related
- 2001-07-18 OA OA1200300012A patent/OA12340A/en unknown
- 2001-07-18 JP JP2002514199A patent/JP5279160B2/en not_active Expired - Fee Related
- 2001-07-18 ES ES01955436.9T patent/ES2347134T5/en not_active Expired - Lifetime
- 2001-07-18 BR BRPI0112612-1A patent/BR0112612B1/en not_active IP Right Cessation
- 2001-07-18 PT PT01955436T patent/PT1307491E/en unknown
- 2001-07-18 CN CNB018141870A patent/CN1230449C/en not_active Expired - Fee Related
- 2001-07-18 AU AU7760201A patent/AU7760201A/en active Pending
- 2001-07-18 HU HU0300755A patent/HUP0300755A3/en unknown
- 2001-07-18 MX MXPA03000579A patent/MXPA03000579A/en active IP Right Grant
- 2001-07-18 EA EA200300178A patent/EA005995B1/en not_active IP Right Cessation
- 2001-07-18 SI SI200130977T patent/SI1307491T1/en unknown
- 2001-07-18 KR KR1020037000689A patent/KR100853585B1/en not_active Expired - Fee Related
- 2001-07-18 DK DK01955436.9T patent/DK1307491T3/en active
- 2001-07-18 WO PCT/FR2001/002332 patent/WO2002008295A1/en not_active Ceased
- 2001-07-18 PL PL365561A patent/PL202471B1/en not_active IP Right Cessation
- 2001-07-18 IL IL15392201A patent/IL153922A0/en unknown
- 2001-07-18 YU YU2903A patent/YU2903A/en unknown
- 2001-07-18 HR HR20030019A patent/HRP20030019A2/en not_active Application Discontinuation
- 2001-07-18 DE DE60142340T patent/DE60142340D1/en not_active Expired - Lifetime
- 2001-07-18 AU AU2001277602A patent/AU2001277602B2/en not_active Ceased
- 2001-07-18 NZ NZ52402801A patent/NZ524028A/en not_active IP Right Cessation
- 2001-07-19 TW TW090117709A patent/TWI307278B/en not_active IP Right Cessation
- 2001-07-20 AR ARP010103476A patent/AR029865A1/en active IP Right Grant
2003
- 2003-01-10 MA MA26996A patent/MA26928A1/en unknown
- 2003-01-13 IL IL153922A patent/IL153922A/en not_active IP Right Cessation
- 2003-01-20 NO NO20030296A patent/NO20030296L/en not_active Application Discontinuation
- 2003-01-20 EC EC2003004442A patent/ECSP034442A/en unknown
- 2003-01-31 ZA ZA200300898A patent/ZA200300898B/en unknown
2004
- 2004-05-19 CL CL200401154A patent/CL2004001154A1/en unknown
2010
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Also Published As

Publication number	Publication date
YU2903A (en)	2006-03-03
CA2416673C (en)	2011-06-14
KR20030040364A (en)	2003-05-22
KR100853585B1 (en)	2008-08-21
DK1307491T3 (en)	2010-10-11
MXPA03000579A (en)	2003-06-06
HUP0300755A2 (en)	2003-12-29
CN1230449C (en)	2005-12-07
EP1307491B2 (en)	2014-05-07
AP2003002744A0 (en)	2003-03-31
EP1307491B1 (en)	2010-06-09
AU7760201A (en)	2002-02-05
NO20030296D0 (en)	2003-01-20
PL365561A1 (en)	2005-01-10
WO2002008295A1 (en)	2002-01-31
ZA200300898B (en)	2004-04-30
PT1307491E (en)	2010-09-10
AP1703A (en)	2007-02-26
MA26928A1 (en)	2004-12-20
NO20030296L (en)	2003-01-20
UA74836C2 (en)	2006-02-15
TWI307278B (en)	2009-03-11
HUP0300755A3 (en)	2004-03-01
CA2416673A1 (en)	2002-01-31
EA005995B1 (en)	2005-08-25
JP5279160B2 (en)	2013-09-04
OA12340A (en)	2006-05-15
AU2001277602B2 (en)	2007-07-19
IL153922A (en)	2010-05-17
JP2004504451A (en)	2004-02-12
ATE470679T1 (en)	2010-06-15
CN1447820A (en)	2003-10-08
BR0112612B1 (en)	2011-07-12
ES2347134T3 (en)	2010-10-26
DE60142340D1 (en)	2010-07-22
AR029865A1 (en)	2003-07-16
EA200300178A1 (en)	2003-06-26
ECSP034442A (en)	2003-03-10
SI1307491T1 (en)	2010-10-29
PL202471B1 (en)	2009-06-30
HRP20030019A2 (en)	2005-10-31
DZ3411A1 (en)	2002-01-31
CY1110774T1 (en)	2015-06-10
EP1307491A1 (en)	2003-05-07
HK1059273A1 (en)	2004-06-25
NZ524028A (en)	2004-12-24
ES2347134T5 (en)	2014-06-24
FR2811992A1 (en)	2002-01-25
IL153922A0 (en)	2003-07-31
CL2004001154A1 (en)	2005-05-27
BR0112612A (en)	2003-07-29

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