FR2865399A1 - Cosmetic or dermatological preparations for shaping, firming and tightening the breasts, containing extract of kombucha for increasing adipocyte concentration in tissue - Google Patents

Abstract

Use of an extract (A) of kombucha in cosmetic or dermatological preparations for shaping, firming and tightening the female breasts, is new. Independent claims are also included for: (1) the production of extracts (A) for use above, involving fermenting a kombucha infusion tea with bacteria and yeasts; and (2) extracts (A) obtained as above, containing organic acids (e.g. acetic acid, gluconic acid, lactic acid, other hydroxyacids (e.g. citric or tartaric acid), succinic acid, malonic acid, oxalic acid and glycenoic acid), enzymes, proteins, tannins, lignan hydrolyzates, flavones, saponosides, phytosterols, steroids, sugars, minerals, volatiles and various other constituents such as caffeine, theobromine, vitamins and usnic acid. ACTIVITY : Dermatological. MECHANISM OF ACTION : Adipocyte proliferation stimulant.

Description

The present invention describes the use of a Kombucha extract,

  intended to be incorporated in cosmetic and dermopharmaceutical preparations and having properties of shaping, firming and tensing on the female bust.

  This extract can be used on a young chest after puberty or on the breasts of 5 menopausal women, or after childbirth to restore tonicity to breasts whose volume and firmness decrease.

  Kombucha is a tea drink fermented by bacterial colonies and yeasts. Other herbal infusions can also be used. These colonies interact with each other, depending on environmental conditions and available substrates. From the infused tea supplemented or not by other herbal infusions and sugar, the yeasts will grow, using sugars, vitamins and minerals. This sugar will first give glucose and then will turn into alcohol. The bacteria will use the alcohol produced to form organic acids such as lactic acid, gluconic acid, citric acid, malic acid, etc. It is these bacteria that will also produce the cellulose network. in which the yeasts that produce group B vitamins are lodged. This pure cellulose bread allows the microorganisms to stay on the surface of the tea and thus to be sufficiently oxygenated for their development, to be also more competitive vis- against external microorganisms and thus to protect itself from pathogens and finally to protect itself from the light and in particular UV.It is a type of symbiotic relation in which the bacteria protect the yeasts thanks to their cellulosic network, which in turn, produce nutrients from which bacteria feed and grow. By abuse of language we speak of mushroom producing Kombucha but it is indeed an association of bacteria and yeasts.

  The strains of Kombucha-forming microorganisms may vary depending on its origin and culture conditions, but among the most common ones are: Bacterial strains: Acetobacter aceti Acetobacter xylinum Acetobacter pasteurianum Acetobacter xylinoids - Gluconobacter bluconicum Gluconobacter oxydans E Yeast strains: Pichia Fermentans - Mycoderma - Saccharomycodes ludwigii Schizosaccharomyces pombe Saccharomyces apiculatus Kloeckera apiculata The production of Kombucha is very old. It was reminiscent of the Chinese Empire, under the Qin Dynasty (221 BC), but its Russian origin is also advanced. Later, the drink was introduced in India, Indonesia, then in Eastern Europe and finally in Western Europe and North America.

  Many medicinal properties have been advanced particularly on: the respiratory tract, the digestive tract, the nervous system, the cardiac system, various infections, the effect of kombucha would be felt in most organs and metabolisms. It is also mentioned its properties in cosmetics: strength of hair, prevention of hair loss, cellulite and anti-wrinkle. Recent work has shown that Kombucha extract can densify the adipocyte population which could explain the anti-wrinkle effect previously observed by many consumers of Kombucha.

  Kombucha consists of two parts, a solid surface part, formed by the association of yeasts and bacteria called fungus and a liquid part containing infusions bioconverted by the fungus as a substrate for its growth. This fungus multiplies into layers that can be separated. Each stratum then serving as new inoculums for the production of new crops and production of Kombucha. The two parts, solid and liquid, have identical medicinal properties, the mushroom being more concentrated in active elements but more difficult to consume than the liquid part which will be consumed daily but moderately as a drink. However, the solid part can be pressed or extracted in order to collect a concentrate of active molecules with medicinal and cosmetic properties. The fungus can also be used directly as a poultice on the skin.

  Among the substances produced by the fungus from black or green tea and various infusions, include acetic acid, 0.4 to 3% depending on the starting medium and the duration of fermentation, it is called Kombucha vinegar. There is also gluconic acid, 2% and L-lactic acid, about 1%, which has a stimulatory effect on the enzymatic activity of organisms and other low-hydroxylated acids such as citric acid, tartaric acid , succinic, malonic and oxalic. It is also discussed the presence of glucuronic acid, playing a role in the detoxification of the liver, but especially it is a precursor of mucopolysaccharides. Polymers form a colloid that is found in particular in the skin providing elasticity and firmness, limiting the formation of wrinkles. Finally the fungus produces enzymes: amylase, invertase, lactases, proteinases, alcohol, between 0.2 and 1.2%, proteins, amino acids, tannins and hydrolysates, lignans, flavones, saponosides , phytosterols, steroids, minerals, volatile compounds, sugars and various constituents such as caffeine, theophylline, theobromine, vitamins, usnic acid.

  The substances, especially the hydroxylated acids, will act on the adipocytes. Thus, an increase in the density of the adipocytes in skin cultures has been observed either by a multiplication of these adipocytes, or by increased differentiation into adipocytes or by migration of these adipocytes. These substances could act on the adrenergic channels or on the calcium channels.

  A breast, an organ allowing the breastfeeding of newborns in mammals, but whose presence is perennial in women from puberty, is formed of galactophorous ducts and glandular lobules embedded in an adipose body and the whole is surrounded by a layer of fat more or less thick protective, sub-epidermal. The curve of the whole, forming the female breast, is supported in particular by the pectoral muscles. The adipose portion of the breast represents a large proportion of its volume.

  Under the hormonal effect in particular, but also the pregnancy and the physiological age of the person, the volume of the breast varies inside the epidermal pocket. The variation of this volume causes a firmness of the breast or on the contrary its relaxation, the breasts are then falling.

  The present invention aims precisely to overcome this disadvantage by stimulating the presence of adipocytes to increase and maintain the proportion of adipose tissue to a high level to maintain a smooth curve, firmness and tone to the breasts, thanks to the addition of active compounds extracted from Kombucha increasing the concentration of adipocytes in the tissues. Widely consumed by absorption or application, Kombucha showed no toxicity.

  According to the present invention, the process for obtaining the Kombucha extract is characterized in that the following operations are carried out: The Kombucha mushroom is ground. The grinding is carried out in aqueous medium at a pH ranging from 2 to 6. The aqueous solution can be obtained at a temperature between 5 and 70 C.

  The extractive solution is clarified on paper filter, centrifugation or filter press.

  The solution thus clarified is stabilized by pasteurization or by microwaves or the addition of solvents such as glycerin or glycol ethers.

  The invention can be used as such in liquid form, in concentrated form or in powder form after spray drying, evaporation or lyophilization, or encapsulated in liposomes or other vectors and supports for a better homogeneity of the cosmetic preparation and a better diffusion of the active product on the skin.

  Among the areas of application of Kombucha, jobs in cosmetology and dermopharmacy have been particularly studied.

  The activities of the Kombucha extract have been highlighted by methodologies conventionally used in cosmetology to demonstrate the activities of shaping, firming and tensing of concentrated on the breast.

  These activities will be reinforced when the extract is associated with substances that increase the elasticity of the skin, its firmness or substances that strengthen the tone and firmness of the breast or its development.

  The effectiveness of the Kombucha extract can also be increased if infusion of tea is added infusions of plants known for their action on the development of the breast, its curve, its firmness and its tonicity such as plants known to be galactogenic or containing steroidal saponins or containing molecules with estrogenic activity. These include hops, kigelia africana, fenugreek, sage, soy, yam, sabal serrulata, damiana, dong quai, dandelion, cumin, licorice, blessed thistle, slippery elm , raspberry, lupine, fennel, pepper, malt, dill or any derived extract that can be used as an infusion in the constitution of Kombucha.

  For cosmetic use, the Kombucha extract according to the present invention can be formulated in dosage form: creams, gels, lotions, milks, HIE and E / H emulsions, solutions, foams, ointments, ointments, sprays, body oils and soaps at contents of 0.01 and 5% by weight, preferably between 0.1 and 2.5% in powder form and at contents of between 0.01 and 25%, preferably between 0.5 and 10% in encapsulated form .

  For the preparation of these compositions, the Kombucha extract is mixed with the excipients generally employed in the cosmetic art. The form of the cosmetic composition of the present invention could be a cream in which the Kombucha extract is combined with the excipients commonly used in cosmetology.

  The cosmetic compositions may also be presented in gel form in suitable excipients such as cellulose esters or other gelling agents, such as carbopol, guar gum, etc.

  The cosmetic compositions according to the invention may also take the form of a lotion or solution in which the Kombucha extract is in encapsulated form.

  The microspheres according to the invention may for example consist of fatty substance, agar and water. The Kombucha extract can be incorporated into liposome, glycosphere, chylomicron, macro, micro, nano-particle vectors as well as macro-, micro- and nanocapsules and also be absorbed onto powdery organic polymers, talcs, bentonites and other mineral supports.

  These emulsions have good stability and can be stored for the time necessary for use at temperatures between 0 and 50 C without sedimentation of the constituents or phase separation.

  The cosmetic compositions of the invention may also contain additives or adjuvants which are customary in cosmetology, such as, for example, antibacterial agents or perfumes, but also extraction and / or synthetic lipids, gelling and viscosity polymers, surfactants and the like. active and emulsifying agents, hydro - or liposoluble active ingredients, plant extracts, tissue extracts, marine extracts, synthetic actives.

  When the cosmetic compositions of the present invention contain complementary active ingredients, these are generally present in the composition at a sufficiently high concentration so that they can exert their activity, and / or other compounds having a synergistic action on the tonicity, the curve and firmness of the breast.

  The cosmetic compositions of the present invention are preferably used daily by applying them one or more times per day.

  The cosmetic compositions of the present invention are very well tolerated, they exhibit no phototoxicity and their application to the skin for prolonged periods of time does not imply any systemic effect.

  For dermopharmaceutical use, the Kombucha extract according to the present invention can be formulated in galenic form: paste, gel emulsion, cream, foam, spray in an amount of between 0.01% and 25% by weight.

  For preparations of these compositions, the Kombucha extract is mixed with excipients.

  The dermopharmaceutical compositions using the present invention may contain complementary active ingredients, present in a sufficiently large amount in the preparation so that they can exercise their activity.

Claims (1)

7 CLAIMS   1 - Use of a Kombucha extract in cosmetic and dermopharmaceutical preparations with curving, firming and firming properties on the female bust.   2- Process for obtaining a kombucha according to claim 1 characterized in that it is obtained from the fermentation of the infusion of tea to which can be added infusions of plants known for their action on the development of the breast , its curvature, its firmness and its tonicity such as plants known to be galactogens or containing steroidal saponins or containing molecules with estrogenic activity such as the following plants: hops, kigelia africana, fenugreek, sage, soy, yam, sabal serrulata, damiana, dong quai, dandelion, cumin, licorice, beni thistle, red elm, raspberry, lupine, fennel, pepper, malt, dies or any derivative derived by bacterial strains such as acetobacter aceti, acetobacter xylinum, acetobacter pasteurianum, acetobacter xylinoids, gluconobacter bluconicum, gluconobacter oxydans and yeast strains such as pichia fermentans, mycoderma, saccharomycodes ludwigii, schizosacc pomegranate, Saccharomyces apiculatus, kloeckera apiculata.   3- Process for obtaining a Kombucha extract according to claims 1 and 2 characterized in that the following operations are carried out: Grinding Kombucha mushroom in an aqueous medium at a pH ranging from 2 to 6, at a temperature between 5 and 70 C.   Clarification of the extractive solution.   Stabilization of the clarified solution by pasteurization, microwaves or addition of solvents.   4- Kombucha extract intended to be incorporated into cosmetic, dermocosmetic and dermopharmaceutical preparations obtained according to claims 2 and 3 for defined applications according to claim 1, characterized in that it has an organic acid content such that acetic acid, gluconide acid, lactic acid and other hydroxyl acids such as citric, tartaric, succinic, malonic and oxalic acids as well as glycenic acid, enzymes, proteins, tannins and hydrolysates lignans, flavones, saponosides, phytosterols, steroids, sugars, minerals, volatile compounds, and various constituents such as caffeine, theophylline, theobromine, vitamins, usnic acid.   - Use of Kombucha extract according to claims 1 and 3 in cosmetic compositions and for the manufacture of dermo-pharmaceutical compositions characterized in that the extract is used either in dry form obtained by evaporation, atomization or lyophilization, or under liquid form either in concentrated liquid form, or in encapsulated form in glycospheres, liposomes or other vectors such as chylomicrons, macro-, micro- and nanoparticles as well as macro-, micro- and nanocapsules, or absorbed on organic polymers powdery, talcs, bentonites and other supports.   6- Use of the Kombucha extract according to one of claims 1 to 5 in cosmetic compositions and for the manufacture of dermopharmaceutical compositions characterized in that the Kombucha extract is present in an amount of between 0.01 and 5 %, preferably between 0.1 and 2.5% in powder form and present between 0.01 and 25%, preferably between 0.5 and 10% in encapsulated form.   7- Use of the Kombucha extract according to any one of claims 1 to 6, characterized in that the extract is in any dosage form used in cosmetics or dermopharmacy namely, HIE and E / H emulsions, creams , milks, lotions, gels, ointments, body oils, soaps, sprays, ointments and mousses.   8- Use of the Kombucha extract according to any one of claims 1 to 6 characterized in that the extract is in any pharmaceutical dosage form namely, pasta, emulsions, sprayer.   9- Use of the Kombucha extract according to any one of claims 1 to 7 in cosmetic or dermopharmaceutical compositions characterized in that it is combined with any other ingredient usually used in cosmetics or dermopharmacy: extraction lipids and / or synthetic, gelling and viscosifying polymers, surfactants and emulsifiers, hydro-or liposoluble active ingredients, plant extracts, tissue extracts, marine extracts, active ingredients of synthetic origin, and / or any other compound having a synergistic action on tonicity , the curve and the firmness of the breasts.