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FR2864091B1 - Derive amphiphile d'heparine forme par couplage de l'heparine avec un acide biliaire - Google Patents

Derive amphiphile d'heparine forme par couplage de l'heparine avec un acide biliaire

Info

Publication number
FR2864091B1
FR2864091B1 FR0315003A FR0315003A FR2864091B1 FR 2864091 B1 FR2864091 B1 FR 2864091B1 FR 0315003 A FR0315003 A FR 0315003A FR 0315003 A FR0315003 A FR 0315003A FR 2864091 B1 FR2864091 B1 FR 2864091B1
Authority
FR
France
Prior art keywords
heparin
bilary
amphiphile
acid
coupling
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0315003A
Other languages
English (en)
Other versions
FR2864091A1 (fr
Inventor
Didier Hoarau
Mahfoud Boustta
Christian Braud
Michel Vert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ethypharm SAS
Original Assignee
Ethypharm SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ethypharm SAS filed Critical Ethypharm SAS
Priority to FR0315003A priority Critical patent/FR2864091B1/fr
Priority to US10/582,989 priority patent/US20070141158A1/en
Priority to PCT/FR2004/003285 priority patent/WO2005061552A1/fr
Publication of FR2864091A1 publication Critical patent/FR2864091A1/fr
Application granted granted Critical
Publication of FR2864091B1 publication Critical patent/FR2864091B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/554—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being a steroid plant sterol, glycyrrhetic acid, enoxolone or bile acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Botany (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
FR0315003A 2003-12-19 2003-12-19 Derive amphiphile d'heparine forme par couplage de l'heparine avec un acide biliaire Expired - Fee Related FR2864091B1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
FR0315003A FR2864091B1 (fr) 2003-12-19 2003-12-19 Derive amphiphile d'heparine forme par couplage de l'heparine avec un acide biliaire
US10/582,989 US20070141158A1 (en) 2003-12-19 2004-12-17 Amphiphilic heparin derivative formed by coupling a heparin with a bile acid
PCT/FR2004/003285 WO2005061552A1 (fr) 2003-12-19 2004-12-17 Derive amphiphile d’heparine forme par couplage de l’heparine avec un acide biliaire

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0315003A FR2864091B1 (fr) 2003-12-19 2003-12-19 Derive amphiphile d'heparine forme par couplage de l'heparine avec un acide biliaire

Publications (2)

Publication Number Publication Date
FR2864091A1 FR2864091A1 (fr) 2005-06-24
FR2864091B1 true FR2864091B1 (fr) 2006-04-07

Family

ID=34630346

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0315003A Expired - Fee Related FR2864091B1 (fr) 2003-12-19 2003-12-19 Derive amphiphile d'heparine forme par couplage de l'heparine avec un acide biliaire

Country Status (3)

Country Link
US (1) US20070141158A1 (fr)
FR (1) FR2864091B1 (fr)
WO (1) WO2005061552A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2173359A2 (fr) 2007-06-29 2010-04-14 Mediplex Corp. Conjugués d'héparine et procédés associés
KR101313894B1 (ko) 2011-04-08 2013-10-01 경북대학교 산학협력단 신규한 탈황산화된 헤파린-담즙산 유도체를 포함하는 염증성 질환의 예방 및 치료용 조성물
EP3474826A4 (fr) * 2016-06-27 2020-03-04 Tamarisk Technologies Group, LLC Préparation pharmaceutique pour l'administration de peptides et de protéines
CN109879977B (zh) * 2019-01-30 2022-03-04 中山大学 一种含有胆固醇和植物凝集素基团的两亲性多糖衍生物及其制备方法和应用
CN112121177B (zh) * 2020-03-25 2021-09-14 健进制药有限公司 负载羧酸抗肿瘤药物的peg化肝素纳米胶束及其制备方法
CN112898440B (zh) * 2021-02-10 2022-05-24 杭州楠大环保科技有限公司 一种多孔材料及在微生物菌剂中的用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0661455B2 (ja) * 1988-11-25 1994-08-17 日本油脂株式会社 多糖誘導体によって安定化された脂肪乳剤
US5817333A (en) * 1991-10-31 1998-10-06 Fujisawa Pharmaceutical Co., Ltd. Liposome preparation containing a tricyclic compound
GB9706195D0 (en) * 1997-03-25 1997-05-14 Univ London Pharmacy Particulate drug carriers
JP3541007B2 (ja) * 1998-05-28 2004-07-07 メディプレックス コーポレイション、コリア 両親媒性ポリサッカリド誘導体
KR100314496B1 (ko) * 1998-05-28 2001-11-22 윤동진 항혈전성이 있는 헤파린 유도체, 그의 제조방법 및 용도

Also Published As

Publication number Publication date
WO2005061552A1 (fr) 2005-07-07
FR2864091A1 (fr) 2005-06-24
WO2005061552A8 (fr) 2005-09-15
US20070141158A1 (en) 2007-06-21

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Legal Events

Date Code Title Description
GC Lien (pledge) constituted

Effective date: 20140519

PLFP Fee payment

Year of fee payment: 13

GC Lien (pledge) constituted

Effective date: 20160120

RG Lien (pledge) cancelled

Effective date: 20160226

PLFP Fee payment

Year of fee payment: 14

RG Lien (pledge) cancelled

Effective date: 20170418

PLFP Fee payment

Year of fee payment: 15

PLFP Fee payment

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PLFP Fee payment

Year of fee payment: 18

PLFP Fee payment

Year of fee payment: 19

ST Notification of lapse

Effective date: 20230808