FR2847165A1 - Topical cosmetic or pharmaceutical compositions, containing nisin as non-irritating preservative having broad antimicrobial spectrum, also effective against greasy skin and acne - Google Patents
Topical cosmetic or pharmaceutical compositions, containing nisin as non-irritating preservative having broad antimicrobial spectrum, also effective against greasy skin and acne Download PDFInfo
- Publication number
- FR2847165A1 FR2847165A1 FR0214774A FR0214774A FR2847165A1 FR 2847165 A1 FR2847165 A1 FR 2847165A1 FR 0214774 A FR0214774 A FR 0214774A FR 0214774 A FR0214774 A FR 0214774A FR 2847165 A1 FR2847165 A1 FR 2847165A1
- Authority
- FR
- France
- Prior art keywords
- nisin
- composition
- sep
- cosmetic
- acne
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 108010053775 Nisin Proteins 0.000 title claims abstract description 30
- 239000004309 nisin Substances 0.000 title claims abstract description 30
- 235000010297 nisin Nutrition 0.000 title claims abstract description 30
- NVNLLIYOARQCIX-MSHCCFNRSA-N Nisin Chemical compound N1C(=O)[C@@H](CC(C)C)NC(=O)C(=C)NC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@@H](NC(=O)C(=C/C)/NC(=O)[C@H](N)[C@H](C)CC)CSC[C@@H]1C(=O)N[C@@H]1C(=O)N2CCC[C@@H]2C(=O)NCC(=O)N[C@@H](C(=O)N[C@H](CCCCN)C(=O)N[C@@H]2C(NCC(=O)N[C@H](C)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCSC)C(=O)NCC(=O)N[C@H](CS[C@@H]2C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H](CCSC)C(=O)N[C@H](CCCCN)C(=O)N[C@@H]2C(N[C@H](C)C(=O)N[C@@H]3C(=O)N[C@@H](C(N[C@H](CC=4NC=NC=4)C(=O)N[C@H](CS[C@@H]3C)C(=O)N[C@H](CO)C(=O)N[C@H]([C@H](C)CC)C(=O)N[C@H](CC=3NC=NC=3)C(=O)N[C@H](C(C)C)C(=O)NC(=C)C(=O)N[C@H](CCCCN)C(O)=O)=O)CS[C@@H]2C)=O)=O)CS[C@@H]1C NVNLLIYOARQCIX-MSHCCFNRSA-N 0.000 title claims abstract description 29
- 239000003755 preservative agent Substances 0.000 title claims abstract description 25
- 239000002537 cosmetic Substances 0.000 title claims abstract description 20
- 230000000699 topical effect Effects 0.000 title claims abstract description 12
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 11
- 230000002335 preservative effect Effects 0.000 title claims abstract description 9
- 206010000496 acne Diseases 0.000 title claims abstract description 7
- 208000002874 Acne Vulgaris Diseases 0.000 title claims abstract description 6
- 230000000845 anti-microbial effect Effects 0.000 title description 4
- 238000001228 spectrum Methods 0.000 title description 2
- 231100000344 non-irritating Toxicity 0.000 title 1
- 239000000203 mixture Substances 0.000 claims abstract description 45
- 239000006071 cream Substances 0.000 description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- 239000006210 lotion Substances 0.000 description 8
- 239000000047 product Substances 0.000 description 8
- 239000000126 substance Substances 0.000 description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 5
- 235000019441 ethanol Nutrition 0.000 description 5
- 239000002609 medium Substances 0.000 description 5
- 239000002453 shampoo Substances 0.000 description 5
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 4
- 239000000499 gel Substances 0.000 description 4
- 235000011187 glycerol Nutrition 0.000 description 4
- 244000005700 microbiome Species 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 239000004599 antimicrobial Substances 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000003995 emulsifying agent Substances 0.000 description 3
- 235000013336 milk Nutrition 0.000 description 3
- 239000008267 milk Substances 0.000 description 3
- 210000004080 milk Anatomy 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 229920001296 polysiloxane Polymers 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- 206010039792 Seborrhoea Diseases 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 239000000443 aerosol Substances 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 239000012736 aqueous medium Substances 0.000 description 2
- OLGWXCQXRSSQPO-UHFFFAOYSA-N diguanosine tetraphosphate Natural products C1=NC(C(N=C(N)N2)=O)=C2N1C(C(O)C1O)OC1COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OCC(C(O)C1O)OC1N1C=NC2=C1NC(N)=NC2=O OLGWXCQXRSSQPO-UHFFFAOYSA-N 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 239000000975 dye Substances 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 229930195733 hydrocarbon Natural products 0.000 description 2
- 150000002430 hydrocarbons Chemical class 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 230000037312 oily skin Effects 0.000 description 2
- 239000002304 perfume Substances 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 239000003380 propellant Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 210000004761 scalp Anatomy 0.000 description 2
- 230000037307 sensitive skin Effects 0.000 description 2
- 239000001993 wax Substances 0.000 description 2
- XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical class C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 description 1
- PAWSVPVNIXFKOS-IHWYPQMZSA-N (Z)-2-aminobutenoic acid Chemical group C\C=C(/N)C(O)=O PAWSVPVNIXFKOS-IHWYPQMZSA-N 0.000 description 1
- FRPZMMHWLSIFAZ-UHFFFAOYSA-N 10-undecenoic acid Chemical compound OC(=O)CCCCCCCCC=C FRPZMMHWLSIFAZ-UHFFFAOYSA-N 0.000 description 1
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- 208000001840 Dandruff Diseases 0.000 description 1
- UQBOJOOOTLPNST-UHFFFAOYSA-N Dehydroalanine Chemical compound NC(=C)C(O)=O UQBOJOOOTLPNST-UHFFFAOYSA-N 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241000194035 Lactococcus lactis Species 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- OLGWXCQXRSSQPO-MHARETSRSA-N P(1),P(4)-bis(5'-guanosyl) tetraphosphate Chemical compound C1=NC(C(NC(N)=N2)=O)=C2N1[C@@H]([C@H](O)[C@@H]1O)O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]([C@@H](O)[C@H]1O)O[C@H]1N1C(N=C(NC2=O)N)=C2N=C1 OLGWXCQXRSSQPO-MHARETSRSA-N 0.000 description 1
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical group CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 1
- 235000014897 Streptococcus lactis Nutrition 0.000 description 1
- LXNHXLLTXMVWPM-UHFFFAOYSA-N Vitamin B6 Natural products CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
- NBVZMBLJRHUOJR-UHFFFAOYSA-N [amino-[4-[6-[4-[amino(azaniumylidene)methyl]phenoxy]hexoxy]phenyl]methylidene]azanium;2-hydroxyethanesulfonate Chemical compound OCCS(O)(=O)=O.OCCS(O)(=O)=O.C1=CC(C(=N)N)=CC=C1OCCCCCCOC1=CC=C(C(N)=N)C=C1 NBVZMBLJRHUOJR-UHFFFAOYSA-N 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 230000001153 anti-wrinkle effect Effects 0.000 description 1
- 230000000656 anti-yeast Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 239000003429 antifungal agent Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- KHAVLLBUVKBTBG-UHFFFAOYSA-N caproleic acid Natural products OC(=O)CCCCCCCC=C KHAVLLBUVKBTBG-UHFFFAOYSA-N 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- -1 conditioners Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 239000002781 deodorant agent Substances 0.000 description 1
- 230000001877 deodorizing effect Effects 0.000 description 1
- 230000002951 depilatory effect Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- GMSCBRSQMRDRCD-UHFFFAOYSA-N dodecyl 2-methylprop-2-enoate Chemical compound CCCCCCCCCCCCOC(=O)C(C)=C GMSCBRSQMRDRCD-UHFFFAOYSA-N 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000004043 dyeing Methods 0.000 description 1
- 235000004626 essential fatty acids Nutrition 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000000834 fixative Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical group NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 229960001715 hexamidine isethionate Drugs 0.000 description 1
- 229920001519 homopolymer Polymers 0.000 description 1
- 150000001261 hydroxy acids Chemical class 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000003605 opacifier Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 235000011837 pasties Nutrition 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229950001046 piroctone Drugs 0.000 description 1
- BTSZTGGZJQFALU-UHFFFAOYSA-N piroctone olamine Chemical compound NCCO.CC(C)(C)CC(C)CC1=CC(C)=CC(=O)N1O BTSZTGGZJQFALU-UHFFFAOYSA-N 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 239000003352 sequestering agent Substances 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- 239000012265 solid product Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000001589 sorbitan tristearate Substances 0.000 description 1
- 235000011078 sorbitan tristearate Nutrition 0.000 description 1
- 229960004129 sorbitan tristearate Drugs 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000000475 sunscreen effect Effects 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 239000000606 toothpaste Substances 0.000 description 1
- 229940034610 toothpaste Drugs 0.000 description 1
- 229960002703 undecylenic acid Drugs 0.000 description 1
- 239000002966 varnish Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000019158 vitamin B6 Nutrition 0.000 description 1
- 239000011726 vitamin B6 Substances 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229960000306 zinc gluconate Drugs 0.000 description 1
- 239000011670 zinc gluconate Substances 0.000 description 1
- 235000011478 zinc gluconate Nutrition 0.000 description 1
- 229960001763 zinc sulfate Drugs 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Birds (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cosmetics (AREA)
Abstract
Description
<Desc/Clms Page number 1> <Desc / Clms Page number 1>
La présente invention a trait à l'utilisation de la Nisine, comme matière première utilisable dans des compositions cosmétiques, pharmaceutiques ou dermatologiques à usage topique, en tant qu'agent conservateur et plus particulièrement dans des compositions destinées à une application topique pour peaux grasses ou pour peaux sensibles. The present invention relates to the use of Nisin as a raw material for use in cosmetic, pharmaceutical or dermatological compositions for topical use, as a preservative and more particularly in compositions intended for topical application for oily or oily skin. for sensitive skin.
Il est courant d'introduire dans les compositions à usage topique, des conservateurs chimiques destinés à lutter contre le développement des microorganismes dans ces compositions. Il faut notamment protéger les compositions contre les micro-organismes susceptibles de se développer à l'intérieur de la composition et également contre ceux que l'utilisateur pourrait y introduire en la manipulant, en particulier lors de la préhension avec les doigts de produits conditionnés en pot. It is common to introduce into the compositions for topical use, chemical preservatives for combating the development of microorganisms in these compositions. In particular, it is necessary to protect the compositions against the microorganisms that can develop inside the composition and also against those that the user could introduce by manipulating it, in particular during the gripping with the fingers of products packaged in pot.
Des conservateurs chimiques couramment utilisés sont notamment les parabènes ou les composés libérateurs de formol, le trichlosan, la chorhexidine et ses sels, l'acide undecylenique et ses sels, l'octopirox, le phenoxyéthanol, l'hexamidine iséthionate, les dérivés de kétoconazole et tous les conservateurs faisant partie de la liste autorisée par la Communauté Européenne, listés au journal officiel. Commonly used chemical preservatives include parabens or formalin-releasing compounds, trichlosan, chorhexidine and its salts, undecylenic acid and its salts, octopirox, phenoxyethanol, hexamidine isethionate, ketoconazole derivatives and all the curators on the list authorized by the European Community, listed in the official journal.
Ces conservateurs présentent toutefois l'inconvénient de causer des irritations, en particulier sur les peaux sensibles, lorsqu'ils sont présents à des taux relativement importants. Comme autres conservateurs connus, on peut citer les hydroxyacides organiques. Mais ces composés peuvent également générer des irritations du fait de leur effet desquamant sur la peau. These preservatives, however, have the disadvantage of causing irritation, especially on sensitive skin, when they are present at relatively high rates. Other known preservatives include organic hydroxy acids. But these compounds can also cause irritation because of their desquamating effect on the skin.
Il subsiste donc le besoin d'agents conservateurs, notamment d'agents antimicrobiens, ayant une action au moins aussi efficace que les composés de l'art antérieur, mais n'en présentant pas les inconvénients. There therefore remains the need for preservatives, especially antimicrobial agents, having an action at least as effective as the compounds of the prior art, but without the disadvantages.
La Nisine, polypeptide contenant de la lanthinonine, est un peptide produit par le lactococcus lactis et utilisé comme conservateur dans le domaine de l'alimentation est connu pour avoir un large spectre d'activité antibactérienne. Nisin, a polypeptide containing lanthinonin, is a peptide produced by lactococcus lactis and used as a preservative in the field of diet is known to have a broad spectrum of antibacterial activity.
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La Nisine présente également une bonne solubilité et compatibilité avec les milieux couramment utilisés en cosmétique, les milieux aqueux notamment. Nisin also has good solubility and compatibility with the media commonly used in cosmetics, in particular aqueous media.
La Nisine répond à la formule générale 1 ci-dessous représentée : [CAS. 1414-45-5]
Abu = a-aminobutyric acid
Dha = dehydroalanine
Dhb = dehydrobutyrine
Sa masse moléculaire élevée (3400 Da) permet de réduire la risque de passage de la barrière transcutanée
La présente invention concerne l'utilisation de la Nisine, en tant qu'agent conservateur, seule ou en association avec d'autres conservateurs, dans des compositions cosmétiques et/ou pharmaceutiques à usage topique. Abu = a-aminobutyric acid
Dha = dehydroalanine
Dhb = dehydrobutyrine
Its high molecular weight (3400 Da) reduces the risk of transcutaneous barrier
The present invention relates to the use of Nisin, as a preservative, alone or in combination with other preservatives, in cosmetic and / or pharmaceutical compositions for topical use.
Elle concerne également une composition cosmétique ou pharmaceutique à usage topique, caractérisée en ce qu'elle comprend en tant qu'agent conservateur seul ou en association avec d'autres conservateurs dans un milieu physiologiquement acceptable, la Nisine. It also relates to a cosmetic or pharmaceutical composition for topical use, characterized in that it comprises as preservative alone or in combination with other preservatives in a physiologically acceptable medium, Nisin.
Elle concerne plus particulièrement une composition cosmétique ou pharmaceutique à usage topique, comprenant entre 0,0000001 à 10 % en poids de It relates more particularly to a cosmetic or pharmaceutical composition for topical use, comprising between 0.0000001 to 10% by weight of
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Nisine, de préférence entre 0,0001 et 5 % en poids de Nisine, par rapport au poids total de la composition. Nisin, preferably between 0.0001 and 5% by weight of Nisine, relative to the total weight of the composition.
Dans un mode préférentiel de réalisation, les compositions cosmétiques ou pharmaceutiques, selon l'invention, comprennent entre 0,001 et 0,1 % en poids de Nisine par rapport au poids total de la composition. In a preferred embodiment, the cosmetic or pharmaceutical compositions according to the invention comprise between 0.001 and 0.1% by weight of Nisine relative to the total weight of the composition.
On a constaté que, de manière surprenante et inattendue, la Nisine présentait de bonnes propriétés anti-microbiennes pour la conservation des formulations cosmétiques comme les émulsions, les lotions, que cela soit vis-à-vis des bactéries, des levures ou des champignons/moisissures, sans affecter les propriétés physiques desdites formulations. De par leur spectre anti-microbien, la Nisine peut donc être employée, notamment dans les compositions cosmétiques, comme agent antimicrobien, notamment comme agent anti-bactérien, comme agent anti-levure et/ou comme agent anti fongique seul ou en association avec d'autres conservateurs. It has been found that, surprisingly and unexpectedly, Nisin has good antimicrobial properties for the preservation of cosmetic formulations such as emulsions, lotions, whether against bacteria, yeasts or fungi. mold, without affecting the physical properties of said formulations. By their anti-microbial spectrum, Nisin can therefore be used, especially in cosmetic compositions, as an antimicrobial agent, especially as an anti-bacterial agent, as an anti-yeast agent and / or as an anti fungal agent alone or in combination with other preservatives.
De manière surprenante et inattendue, l'utilisation de la Nisine comme conservateur dans des compositions cosmétiques et/ou pharmaceutiques permet de potentialiser les effets d'autres actifs et de renforcer leur action. Surprisingly and unexpectedly, the use of Nisin as a preservative in cosmetic and / or pharmaceutical compositions makes it possible to potentiate the effects of other active ingredients and to enhance their action.
L'invention concerne également des compositions cosmétiques et/ou pharmaceutiques à action cicatrisante, comprenant de la Nisine et en association avec des oligonucléotides ou nucléotides, et plus particulièrement la diguanosine tetraphosphate. The invention also relates to cosmetic and / or pharmaceutical compositions with healing action, comprising Nisin and in combination with oligonucleotides or nucleotides, and more particularly diguanosine tetraphosphate.
Dans les compositions destinées au traitement des peaux grasses et acnéiques, on note une diminution de la quantité de sébum et une diminution de l'apparition de boutons. In compositions for the treatment of oily and acne skin, there is a decrease in the amount of sebum and a decrease in the appearance of pimples.
Les compositions présentent ainsi une activité antiséborréhique, améliorée du fait de la présence de Nisine. The compositions thus have an antiseborrhetic activity, improved because of the presence of Nisin.
L'invention concerne également des compositions cosmétiques destinées au traitement des peaux grasses et acnéiques comprenant de la Nisine. The invention also relates to cosmetic compositions for the treatment of oily and acne skin comprising Nisin.
Elle concerne plus particulièrement des compositions cosmétiques destinées au traitement des peaux grasses et acnéiques comprenant de 0,000001 à 10 % en poids de Nisine par rapport au poids total de la composition, de préférence de 0,0001 à 5 % et plus particulièrement de 0,001 à 0,1 % en poids de Nisine par rapport au poids total de la composition. It relates more particularly to cosmetic compositions intended for the treatment of oily and acneic skin comprising from 0.000001 to 10% by weight of Nisin relative to the total weight of the composition, preferably from 0.0001 to 5% and more particularly from 0.001 to 0.1% by weight of Nisine relative to the total weight of the composition.
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De manière avantageuse, la tolérance des produits topiques ainsi fabriqués est grandement améliorée. En effet l'un des inconvénients majeur des produits actifs sur les micro-organismes responsables de l'acné est la mauvaise tolérance cutanée. Advantageously, the tolerance of the topical products thus manufactured is greatly improved. Indeed, one of the major drawbacks of the active products on the micro-organisms responsible for acne is poor skin tolerance.
Il se trouve que dans le cadre de l'invention, les produits sont efficaces sans être irritants pour la muqueuse cutanée. It is found that in the context of the invention, the products are effective without being irritating to the cutaneous mucosa.
Les compositions comprenant la Nisine également comprennent un milieu cosmétiquement ou pharmaceutiquement acceptable, c'est-à-dire compatible avec la peau, les muqueuses, les cheveux et le cuir chevelu. Elles peuvent se présenter sous toutes les formes galéniques appropriées pour une application topique, notamment sous forme de solution aqueuse, hydroalcoolique, organique ou huileuse; de suspension ou de dispersion dans des solvants ou des corps gras, de type lotion ou sérum ; forme de dispersion vésiculaire; sous forme d'émulsion E/H, HIE ou multiple telle qu'une crème ou un lait; sous forme de pommade, de gel, de bâtonnet solide, de produits anhydres pâteux ou solides, de mousse notamment aérosol ou de spray. Compositions comprising Nisin also comprise a cosmetically or pharmaceutically acceptable medium, that is to say compatible with the skin, the mucous membranes, the hair and the scalp. They may be in any of the galenic forms suitable for topical application, especially in the form of aqueous, hydroalcoholic, organic or oily solution; suspension or dispersion in solvents or fatty substances, of lotion or serum type; vesicular dispersion form; in the form of W / O, HIE or multiple emulsion such as cream or milk; in the form of ointment, gel, solid stick, anhydrous pasty or solid products, foam, especially aerosol or spray.
Le milieu physiologiquement acceptable dans lequel la Nisine peut être employée, ainsi que ses constituants, leur quantité, la forme galénique de la composition et son mode de préparation, peuvent être choisis par l'homme du métier sur la base de ses connaissances générales en fonction du type de composition recherchée. The physiologically acceptable medium in which Nisin may be employed, as well as its constituents, their amount, the dosage form of the composition and its method of preparation, may be selected by one skilled in the art on the basis of his general knowledge in function the type of composition sought.
Notamment, la composition peut comprendre tout corps gras usuellement utilisé dans le domaine d'application envisagé. On peut notamment citer les corps gras siliconés tels que les huiles, les gommes et les cires de silicone, ainsi que les corps gras non siliconés tels que les huiles et les cires d'origine végétale, minérale, animale et/ou synthétique. Les huiles peuvent éventuellement être volatiles ou non volatiles. On peut encore citer les hydrocarbures, les esters et les éthers de synthèse, les alcools gras et les acides gras. La composition peut également comprendre un milieu aqueux, un milieu hydro-alcoolique contenant un alcool tel que l'éthanol ou l'isopropanol, ou un milieu organique comprenant des solvants organiques usuels tels que des alcools en C1-C6, notamment l'éthanol et l'isopropanol, des glycols tels que le propylène glycol, des cétones. In particular, the composition may comprise any fatty substance usually used in the intended field of application. Mention may in particular be made of silicone fatty substances such as oils, gums and silicone waxes, as well as non-silicone fatty substances such as oils and waxes of vegetable, mineral, animal and / or synthetic origin. The oils may optionally be volatile or non-volatile. Mention may also be made of hydrocarbons, esters and synthetic ethers, fatty alcohols and fatty acids. The composition may also comprise an aqueous medium, an alcohol-alcoholic medium containing an alcohol such as ethanol or isopropanol, or an organic medium comprising usual organic solvents such as C 1 -C 6 alcohols, in particular ethanol and isopropanol, glycols such as propylene glycol, ketones.
La composition peut comprendre au moins un émulsionnant classique, choisi parmi les émulsionnants amphotères, anioniques, cationiques ou non ioniques, utilisés seuls ou en mélange. The composition may comprise at least one conventional emulsifier chosen from amphoteric, anionic, cationic or nonionic emulsifiers, used alone or as a mixture.
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Elle peut également comprendre les adjuvants habituels dans le domaine considéré, tels que les épaississants ou gélifiants hydrophiles ou lipophiles, les additifs hydrophiles ou lipophiles, les actifs notamment cosmétiques, les conservateurs, les antioxydants, les parfums, les charges, les pigments, les filtres UV, les absorbeurs d'odeur, les colorants, les hydratants (glycérine), des vitamines, des acides gras essentiels, des polymères liposolubles notamment hydrocarbonés, les opacifiants, les stabilisants, les séquestrants, les conditionneurs, les agents propulseurs. It may also comprise the usual adjuvants in the field under consideration, such as hydrophilic or lipophilic thickeners or gelling agents, hydrophilic or lipophilic additives, especially cosmetic actives, preservatives, antioxidants, perfumes, fillers, pigments, filters. UV, odor absorbers, dyes, moisturizers (glycerine), vitamins, essential fatty acids, liposoluble polymers including hydrocarbon, opacifiers, stabilizers, sequestering agents, conditioners, propellants.
Bien entendu l'homme du métier veillera à choisir ce ou ces éventuels adjuvants complémentaires et/ou leur quantité de manière telle que les propriétés avantageuses de la composition selon l'invention ne soient pas, ou substantiellement pas, altérées par l'adjonction envisagée. Of course the skilled care to select this or these optional additional adjuvants and / or their amount so that the advantageous properties of the composition according to the invention are not, or not substantially impaired by the addition envisaged.
La Nisine présente une activité anti-microbienne, notamment une activité anti- bactérienne et anti-fongique, remarquable, elle trouve donc une application toute particulière dans des compositions pouvant se présenter : - sous la forme d'un produit de maquillage de la peau du visage, du corps ou des lèvres, tel qu'un fond de teint, un fard à joues ou à paupières, un stick anti- cernes, un stick camouflant, un eye-liner, un mascara, un rouge à lèvres, un vernis à ongles, un soin des ongles, - sous la forme d'un produit de soin dermatologique ou cosmétique de la peau du visage, du corps y compris le cuir chevelu, des lèvres, tel qu'une base de soin pour les lèvres, une base fixante à appliquer sur un rouge à lèvres classique, une composition de protection solaire ou de bronzage artificiel ; produit déodorant ; composition de soin (de jour, de nuit, anti-rides, hydratante, etc. ) pour le visage; une composition matifiante pour le visage ; un gel ou une crème de nettoyage ou de démaquillage; un lait corporel de protection ou de soin; un lait purifiant, - sous la forme d'une composition désodorisante ; d'ungel ou lotion après- rasage; d'une crème dépilatoire, - sous la forme d'une composition pharmaceutique, - sous la forme d'une composition solide telle qu'un savon - sous la forme d'une composition pour aérosol comprenant également un agent propulseur sous pression, - sous la forme d'une composition pour soins capillaires, et notamment un shampooing, une lotion de mise en plis, une lotion traitante, une crème ou un gel coiffant, une composition de teinture (notamment d'oxydation) éventuellement sous Nisin has anti-microbial activity, especially antibacterial and anti-fungal activity, remarkable, it therefore finds a very particular application in compositions that can be: - in the form of a makeup product of the skin of the face, body or lips, such as a foundation, a blush or eyeshadow, a concealer, a camouflaging stick, an eyeliner, a mascara, a lipstick, a nail varnish nails, nail care, - in the form of a dermatological or cosmetic care product for the skin of the face, the body including the scalp, lips, such as a base for care of the lips, a base fixative for applying to a conventional lipstick, a sunscreen or artificial tanning composition; deodorant product; care composition (day, night, anti-wrinkle, moisturizing, etc.) for the face; a mattifying composition for the face; a gel or a cream for cleaning or removing make-up; body milk for protection or care; a purifying milk, in the form of a deodorizing composition; ungel or aftershave; a depilatory cream, - in the form of a pharmaceutical composition, - in the form of a solid composition such as a soap - in the form of an aerosol composition also comprising a propellant under pressure, - under the form of a composition for hair care, and in particular a shampoo, a setting lotion, a treatment lotion, a cream or a styling gel, a dyeing composition (in particular oxidation) possibly under
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forme de shampooing colorant, de lotion restructurante pour cheveux, une composition pour permanente, une lotion ou un gel antichute, un shampooing antiparasitaire ; une lotion ou un shampooing antipelliculaire; un shampooing traitant notamment anti-séborrhéique, - sous la forme d'une composition à usage bucco-dentaire, par exemple une pâte dentifrice. dye shampoo form, restructuring hair lotion, permanent composition, anti-fall lotion or gel, pest control shampoo; an anti-dandruff lotion or shampoo; a shampoo including anti-seborrheic treating, - in the form of a composition for oral use, for example a toothpaste.
Des tests de conservations ont été réalisés, ces tests appelés challenge tests, où les produits sont contaminés volontairement par des inoculum calibrés, sont destinés à vérifier l'efficacité du système de conservation. Conservation tests have been carried out, these tests called challenge tests, where products are voluntarily contaminated by calibrated inoculum, are intended to verify the effectiveness of the conservation system.
Lorsque les compositions testées comprennent de la Nisine, celle-ci a été incorporée à raison de 0,005 % en poids par rapport au poids total de la composition. When the compositions tested comprise Nisin, it was incorporated at a rate of 0.005% by weight relative to the total weight of the composition.
Crème A : Base 1 et conservateurs 1
Crème B : Base 1 et conservateurs 1 + nisine
Crème C : Base 1 et nisine
Crème D : Base 2 et conservateurs 2
Crème E : Base 2 et conservateurs 2 + nisine
Crème F : Base 2 et nisine
Cream B: Base 1 and preservatives 1 + nisin
Cream C: Base 1 and Nisin
Cream D: Base 2 and preservatives 2
Cream E: Base 2 and preservatives 2 + nisin
Cream F: Base 2 and Nisin
<tb>
<tb> Bactéries <SEP> Levures <SEP> Moisissures
<tb> CrèmeA <SEP> 14 <SEP> 21 <SEP> > <SEP> 28
<tb> Crème <SEP> B <SEP> 7 <SEP> 21 <SEP> > <SEP> 28
<tb> Crème <SEP> C <SEP> > <SEP> 28 <SEP> > <SEP> 28j <SEP> > <SEP> 28
<tb> Crème <SEP> D <SEP> 7 <SEP> 28j <SEP> > <SEP> 28 <SEP> J
<tb> Crème <SEP> E <SEP> 1 <SEP> 14 <SEP> 21
<tb> Crème <SEP> F <SEP> 3j <SEP> 21j <SEP> 21 <SEP> j
<tb> <Tb>
<tb> Bacteria <SEP> Yeasts <SEP> Molds
<tb> CreamA <SEP> 14 <SEP> 21 <SEP>><SEP> 28
<tb> Cream <SEP> B <SEP> 7 <SEP> 21 <SEP>><SEP> 28
<tb> Cream <SEP> C <SEP>><SEP> 28 <SEP>><SEP> 28d <SEP>><SEP> 28
<tb> Cream <SEP> D <SEP> 7 <SEP> 28d <SEP>><SEP> 28 <SEP> J
<tb> Cream <SEP> E <SEP> 1 <SEP> 14 <SEP> 21
<tb> Cream <SEP> F <SEP> 3d <SEP> 21d <SEP> 21 <SEP> j
<Tb>
On note un allongement significatif du temps nécessaire à la disparition des colonies correspondant aux différents microorganismes contenus dans les inoculums utilisés. There is a significant increase in the time required for the disappearance of the colonies corresponding to the various microorganisms contained in the inocula used.
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La présente invention est illustrée plus en détails dans les exemples suivants. The present invention is further illustrated in the following examples.
Exemple 1 : crème de soin - Tristéarate de sorbitane 1 - Nisine.............................................................................. 0.00015% - Homopolymère carboxyvinylique ................................... 0,4% - Gomme de xanthane ...................................................... 0,5% - Copolymère diméthacrylate d'éthylèneglycol/méthacrylate de lauryle ........................ 1% - Cyclopentadiméthylsiloxane ........................................... 6% - Glycérine......................................................................... 3% - Emulsionnant.................................................................. 4% - Parfum qsp - Eau déminéralisée .......................................................... qsp 100% Exemple 2 : lotion - Nisine.............................................................................. 0.0002% - Glycérine......................................................................... 2% - Alcool éthylique............................................................... 2% - Cétrimide BP................................................................... 0.4% - Butanol oxyéthyléné (260E) oxypropyléné (260P), huile de ricin hydrogénée oxyéthylénée (40 OE) dans l'eau ....................................................................... 1% - Eau déminéralisée .......................................................... qsp 100% Exemple 3 : Crème de traitement des peaux grasses - Nisine.............................................................................. 0.0004% - Glycérine......................................................................... 2% - Cétrimide BP................................................................... 0. 4% - Sulfate de Zinc................................................................ 0.05% - Gluconate de Zinc.......................................................... 0.1 % - Vitamine B6 .................................................................... 0.01% - Diguanosine Tetraphosphate.......................................... 0.0001%
- Salcare 91 .................................................................... 1 /o - Eau déminéralisée.......................................................... qsp 100%Example 1: Care Cream - Sorbitan Tristearate 1 - Nisine ..................................... ......................................... 0.00015% - Carboxylic homopolymer .... ............................... 0,4% - Xanthan gum ........... ........................................... 0,5% - Dimethacrylate Copolymer ethylene glycol / lauryl methacrylate ....................... 1% - Cyclopentadimethylsiloxane ............... ............................ 6% - Glycerin .................. .................................................. ..... 3% - Emulsifier ......................................... ......................... 4% - Perfume qsp - Demineralized water ................. ......................................... qs 100% Example 2: lotion - Nisin .................................................. ............................ 0.0002% - Glycerin .................. .................................................. ..... 2% - Ethyl alcohol ............... ................................................ 2% - Cetimide BP ............................................... .................... 0.4% - Butylated oxyethylenated (260E) oxypropylene (260P), hydrogenated castor oil oxyethylenated (40 EO) in water .... .................................................. ................. 1% - Demineralized water ............................ .............................. qs 100% Example 3: Cream for the treatment of oily skin - Nisin ...... .................................................. ...................... 0.0004% - Glycerine ........................ ................................................. 2 % - Cetimide BP .............................................. ..................... 0. 4% - Zinc Sulfate ..................... ........................................... 0.05% - Zinc Gluconate. .................................................. ....... 0.1% - Vitamin B6 ...................................... ............................ .. 0.01% - Diguanosine Tetraphosphate .......................................... 0.0001 %
- Salcare 91 ............................................... ..................... 1 / o - Demineralized water ....................... ................................... qs 100%
Claims (6)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0214774A FR2847165A1 (en) | 2002-11-15 | 2002-11-15 | Topical cosmetic or pharmaceutical compositions, containing nisin as non-irritating preservative having broad antimicrobial spectrum, also effective against greasy skin and acne |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0214774A FR2847165A1 (en) | 2002-11-15 | 2002-11-15 | Topical cosmetic or pharmaceutical compositions, containing nisin as non-irritating preservative having broad antimicrobial spectrum, also effective against greasy skin and acne |
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| Publication Number | Publication Date |
|---|---|
| FR2847165A1 true FR2847165A1 (en) | 2004-05-21 |
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| FR0214774A Withdrawn FR2847165A1 (en) | 2002-11-15 | 2002-11-15 | Topical cosmetic or pharmaceutical compositions, containing nisin as non-irritating preservative having broad antimicrobial spectrum, also effective against greasy skin and acne |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2954140A1 (en) * | 2009-12-17 | 2011-06-24 | Oreal | COSMETIC OR DERMATOLOGICAL COMPOSITIONS BASED ON BACTERIOCINS AND PREBIOTICS |
| PL424179A1 (en) * | 2018-01-03 | 2019-07-15 | Prof. Cosmetica Spółka Z Ograniczoną Odpowiedzialnością | Emulsion preservation system and cosmetic gels containing the anti-oxidative complex of active components and nisin peptide |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2954140A1 (en) * | 2009-12-17 | 2011-06-24 | Oreal | COSMETIC OR DERMATOLOGICAL COMPOSITIONS BASED ON BACTERIOCINS AND PREBIOTICS |
| WO2011073437A3 (en) * | 2009-12-17 | 2012-08-23 | L'oreal | Bacteriocin- and prebiotic-based cosmetic or dermatological compositions |
| PL424179A1 (en) * | 2018-01-03 | 2019-07-15 | Prof. Cosmetica Spółka Z Ograniczoną Odpowiedzialnością | Emulsion preservation system and cosmetic gels containing the anti-oxidative complex of active components and nisin peptide |
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