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FR2735777B1 - Derives de 4-phenylaminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant - Google Patents

Derives de 4-phenylaminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant

Info

Publication number
FR2735777B1
FR2735777B1 FR9507437A FR9507437A FR2735777B1 FR 2735777 B1 FR2735777 B1 FR 2735777B1 FR 9507437 A FR9507437 A FR 9507437A FR 9507437 A FR9507437 A FR 9507437A FR 2735777 B1 FR2735777 B1 FR 2735777B1
Authority
FR
France
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
phenylaminothiazole
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR9507437A
Other languages
English (en)
Other versions
FR2735777A1 (fr
Inventor
Daniele Gully
Pierre Marie Albert Roger
Camille George Wermuth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR9507437A priority Critical patent/FR2735777B1/fr
Application filed by Sanofi SA filed Critical Sanofi SA
Priority to CZ974103A priority patent/CZ410397A3/cs
Priority to IL12229396A priority patent/IL122293A0/xx
Priority to US08/945,098 priority patent/US5880135A/en
Priority to PCT/FR1996/000941 priority patent/WO1997000868A1/fr
Priority to NZ312157A priority patent/NZ312157A/en
Priority to KR1019970709640A priority patent/KR19990028325A/ko
Priority to HU9900056A priority patent/HUP9900056A2/hu
Priority to PL96324202A priority patent/PL324202A1/xx
Priority to TR97/01654T priority patent/TR199701654T1/xx
Priority to BR9609420A priority patent/BR9609420A/pt
Priority to JP9503616A priority patent/JP3067807B2/ja
Priority to AU63627/96A priority patent/AU710300B2/en
Priority to EE9700333A priority patent/EE9700333A/xx
Priority to EP96922946A priority patent/EP0833822A1/fr
Priority to RU98100764A priority patent/RU2146253C1/ru
Priority to SK1711-97A priority patent/SK171197A3/sk
Priority to CA002222266A priority patent/CA2222266A1/fr
Priority to ZA9605294A priority patent/ZA965294B/xx
Priority to TW085107427A priority patent/TW416952B/zh
Publication of FR2735777A1 publication Critical patent/FR2735777A1/fr
Application granted granted Critical
Publication of FR2735777B1 publication Critical patent/FR2735777B1/fr
Priority to IS4635A priority patent/IS4635A/is
Priority to MXPA/A/1997/010378A priority patent/MXPA97010378A/xx
Priority to NO975987A priority patent/NO975987L/no
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
FR9507437A 1995-06-21 1995-06-21 Derives de 4-phenylaminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant Expired - Lifetime FR2735777B1 (fr)

Priority Applications (23)

Application Number Priority Date Filing Date Title
FR9507437A FR2735777B1 (fr) 1995-06-21 1995-06-21 Derives de 4-phenylaminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant
EE9700333A EE9700333A (et) 1995-06-21 1996-06-18 Substitueeritud 4-fenüülaminotiasoolid, nende valmistamise meetod ja neid sisaldavad farmakoloogilised kompositsioonid
US08/945,098 US5880135A (en) 1995-06-21 1996-06-18 Substituted 4-phenylaminothiazoles, their process of preparation and the pharmaceutical compositions containing them
PCT/FR1996/000941 WO1997000868A1 (fr) 1995-06-21 1996-06-18 Derives de 4-phenylaminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant
NZ312157A NZ312157A (en) 1995-06-21 1996-06-18 4-phenylaminothiazole derivatives, method for preparing same, and pharmaceutical compositions containing said derivatives
KR1019970709640A KR19990028325A (ko) 1995-06-21 1996-06-18 치환된 4-페닐아미노티아졸, 이의 제조방법 및 이를 포함하는약학적 조성물
HU9900056A HUP9900056A2 (hu) 1995-06-21 1996-06-18 Szubsztituált 4-fenil-amino-tiazol-származékok, eljárás előállításukra és ilyen vegyületeket tartalmazó gyógyászati készítmények
PL96324202A PL324202A1 (en) 1995-06-21 1996-06-18 Derivatives of 4-phenylaminothiazole, method of obtaining them and pharmaceutic compositions containing such derivatives
TR97/01654T TR199701654T1 (xx) 1995-06-21 1996-06-18 4-Fenilaminotiyazol t�revleri.
IL12229396A IL122293A0 (en) 1995-06-21 1996-06-18 Substituted 4-phenylaminothiazoles their preparation and pharmaceutical compositions containing them
JP9503616A JP3067807B2 (ja) 1995-06-21 1996-06-18 ４−フェニルアミノチアゾール誘導体、その製造方法、および該誘導体を含有してなる医薬組成物
RU98100764A RU2146253C1 (ru) 1995-06-21 1996-06-18 Производные 4-фениламинотиазола, способы их получения и фармацевтическая композиция
CZ974103A CZ410397A3 (cs) 1995-06-21 1996-06-18 Deriváty 4-fenylaminothiazolu, způsob jejich přípravy a farmaceutické přípravky, které je obsahují
EP96922946A EP0833822A1 (fr) 1995-06-21 1996-06-18 Derives de 4-phenylaminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant
AU63627/96A AU710300B2 (en) 1995-06-21 1996-06-18 Substituted 4-phenylaminothiazoles, their process for preparation and the pharmaceutical compositions containing them
SK1711-97A SK171197A3 (en) 1995-06-21 1996-06-18 4-phenylaminothiazole derivatives, method for preparing same, and pharmaceutical compositions containing said derivatives
CA002222266A CA2222266A1 (fr) 1995-06-21 1996-06-18 Derives de 4-phenylaminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant
BR9609420A BR9609420A (pt) 1995-06-21 1996-06-18 Derivados de 4-fenilaminotiazol seu processo de preparação e as composições farmacêuticas contendo os mesmos
ZA9605294A ZA965294B (en) 1995-06-21 1996-06-21 Substituted 4-phenylaminothiazoles, their process of preparation and the pharmaceutical compositions containing them.
TW085107427A TW416952B (en) 1995-06-21 1996-07-17 Substituted 4-phenyl-2-aminothiazoles capable of antgonizing the effects of corticotropin releasing factor (CRF) and their process of preparation
IS4635A IS4635A (is) 1995-06-21 1997-12-16 4-fenýlamínóþíasólafleiður, aðferð við að framleiða þær og lyfjablöndur sem innihalda þær
MXPA/A/1997/010378A MXPA97010378A (en) 1995-06-21 1997-12-18 Derivatives of 4-finilaminotiazol, its process of preparation and the pharmaceutical compositions that contains them
NO975987A NO975987L (no) 1995-06-21 1997-12-19 4-Fenylaminotiazol-derivater, fremgangsmåte for fremstilling av disse og farmasöytiske blandinger inneholdende nevnte derivater

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9507437A FR2735777B1 (fr) 1995-06-21 1995-06-21 Derives de 4-phenylaminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant

Publications (2)

Publication Number Publication Date
FR2735777A1 FR2735777A1 (fr) 1996-12-27
FR2735777B1 true FR2735777B1 (fr) 1997-09-12

Family

ID=9480235

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9507437A Expired - Lifetime FR2735777B1 (fr) 1995-06-21 1995-06-21 Derives de 4-phenylaminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant

Country Status (22)

Country Link
US (1) US5880135A (fr)
EP (1) EP0833822A1 (fr)
JP (1) JP3067807B2 (fr)
KR (1) KR19990028325A (fr)
AU (1) AU710300B2 (fr)
BR (1) BR9609420A (fr)
CA (1) CA2222266A1 (fr)
CZ (1) CZ410397A3 (fr)
EE (1) EE9700333A (fr)
FR (1) FR2735777B1 (fr)
HU (1) HUP9900056A2 (fr)
IL (1) IL122293A0 (fr)
IS (1) IS4635A (fr)
NO (1) NO975987L (fr)
NZ (1) NZ312157A (fr)
PL (1) PL324202A1 (fr)
RU (1) RU2146253C1 (fr)
SK (1) SK171197A3 (fr)
TR (1) TR199701654T1 (fr)
TW (1) TW416952B (fr)
WO (1) WO1997000868A1 (fr)
ZA (1) ZA965294B (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6191131B1 (en) 1997-07-23 2001-02-20 Dupont Pharmaceuticals Company Azolo triazines and pyrimidines
US6060478A (en) * 1996-07-24 2000-05-09 Dupont Pharmaceuticals Azolo triazines and pyrimidines
US6124289A (en) * 1996-07-24 2000-09-26 Dupont Pharmaceuticals Co. Azolo triazines and pyrimidines
US6313124B1 (en) 1997-07-23 2001-11-06 Dupont Pharmaceuticals Company Tetrazine bicyclic compounds
US7094782B1 (en) 1996-07-24 2006-08-22 Bristol-Myers Squibb Company Azolo triazines and pyrimidines
FR2754258B1 (fr) 1996-10-08 1998-12-31 Sanofi Sa Derives d'aminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant
US6187777B1 (en) * 1998-02-06 2001-02-13 Amgen Inc. Compounds and methods which modulate feeding behavior and related diseases
EP1129091B1 (fr) 1998-11-12 2002-10-02 Neurocrine Biosciences, Inc. Antagonistes de recepteurs du crf et methodes associees
US6531475B1 (en) 1998-11-12 2003-03-11 Neurocrine Biosciences, Inc. CRF receptor antagonists and methods relating thereto
ATE240958T1 (de) 1998-11-12 2003-06-15 Neurocrine Biosciences Inc Crf rezeptor-antagonisten und darauf bezogene methoden
FR2796380B3 (fr) * 1999-07-15 2001-08-17 Sanofi Synthelabo Nouveaux derives d'aminothiazoles, leur preparation et les compositions pharmaceutiques les contenant
FR2819508B1 (fr) 2001-01-12 2005-01-21 Sod Conseils Rech Applic Derives de 2-arylimino-2, 3-dihydorthiazoles, leurs procedes de preparation et leur utilisation therapeutiques
US6432989B1 (en) * 1999-08-27 2002-08-13 Pfizer Inc Use of CRF antagonists to treat circadian rhythm disorders
IL139197A0 (en) 1999-10-29 2001-11-25 Pfizer Prod Inc Use of corticotropin releasing factor antagonists and related compositions
WO2001062718A1 (fr) * 2000-02-25 2001-08-30 Japan Tobacco, Inc. Dérivé de benzamide et utilisation de celui-ci
EP1149583A3 (fr) * 2000-04-13 2001-11-14 Pfizer Products Inc. Combinaison des antagonistes de la facteur de la liberation de la corticotropin et des secrétagogues de l hormone de croissance
DE10045650A1 (de) * 2000-09-15 2002-03-28 Adolf Wuerth Gmbh & Co Kg Kunststoffdübel
US7153871B2 (en) * 2001-01-22 2006-12-26 Memory Pharmaceuticals Corporation Phosphodiesterase 4 inhibitors, including aminoindazole and aminobenzofuran analogs
US7205320B2 (en) 2001-01-22 2007-04-17 Memory Pharmaceuticals Corp. Phosphodiesterase 4 inhibitors
WO2003015777A1 (fr) * 2001-08-13 2003-02-27 Lion Bioscience Ag Composes de liaison au recepteur nucleaire nr1h4
EP1435999B1 (fr) * 2001-10-18 2012-07-18 Zlatko Ademovic Combinaison de deux regions bioactives de l'hormone pro-opiomelanocortine
CA2492911A1 (fr) * 2002-07-19 2004-01-29 Memory Pharmaceuticals Corporation Composes de 6-amino-1h-indazole et de 4-aminobenzofurane utilises en tant qu'inhibiteurs de phosphodiesterase 4
RU2368604C2 (ru) 2002-07-19 2009-09-27 Мемори Фармасьютиклз Корпорейшн Ингибиторы фосфодиэстеразы 4, включающие n-замещенные аналоги анилина и дифениламина
KR20050075430A (ko) 2002-11-19 2005-07-20 메모리 파마슈티칼스 코포레이션 포스포디에스테라제 4 억제제
US20090048255A1 (en) * 2003-07-21 2009-02-19 Schumacher Richard A Phosphodiesterase 4 inhibitors, including n-substituted aniline and diphenylamine analogs
MY141255A (en) * 2003-12-11 2010-03-31 Memory Pharm Corp Phosphodiesterase 4 inhibitors, including n-substituted diarylamine analogs
WO2007084391A2 (fr) * 2006-01-18 2007-07-26 Amgen Inc. Composes thiazole et procedes d'utilisation
US8252333B2 (en) 2006-01-26 2012-08-28 Jorge Cueto-Garcia Biodegradable, non-toxic biological adhesive for use in abdominal surgery
US20100029689A1 (en) * 2008-07-02 2010-02-04 Memory Pharmaceuticals Corporation Phosphodiesterase 4 inhibitors
US9856263B2 (en) 2014-04-28 2018-01-02 Pfizer Inc. Heteroaromatic compounds and their use as dopamine D1 ligands

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2612187B1 (fr) * 1987-03-12 1989-07-21 Sanofi Sa Derives du thiazole actifs sur le systeme cholinergique, leur procede de preparation et compositions pharmaceutiques en contenant
GB8724566D0 (en) * 1987-10-20 1987-11-25 Roussel Lab Ltd Chemical compounds
FR2656610B1 (fr) * 1989-12-29 1992-05-07 Sanofi Sa Derives d'amino-2 phenyl-4 thiazole, leur procede de preparation et leur application therapeutique.
FR2692893B1 (fr) * 1992-06-24 1994-09-02 Sanofi Elf Dérivés alkylamino ramifiés du thiazole, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
IS4635A (is) 1997-12-16
FR2735777A1 (fr) 1996-12-27
KR19990028325A (ko) 1999-04-15
EP0833822A1 (fr) 1998-04-08
NO975987D0 (no) 1997-12-19
CA2222266A1 (fr) 1997-01-09
ZA965294B (en) 1997-12-22
AU6362796A (en) 1997-01-22
IL122293A0 (en) 1998-04-05
NZ312157A (en) 1999-04-29
HUP9900056A2 (hu) 1999-05-28
AU710300B2 (en) 1999-09-16
RU2146253C1 (ru) 2000-03-10
JP3067807B2 (ja) 2000-07-24
TW416952B (en) 2001-01-01
CZ410397A3 (cs) 1998-04-15
JPH10511693A (ja) 1998-11-10
WO1997000868A1 (fr) 1997-01-09
MX9710378A (es) 1998-07-31
TR199701654T1 (xx) 1998-05-21
SK171197A3 (en) 1998-08-05
US5880135A (en) 1999-03-09
PL324202A1 (en) 1998-05-11
BR9609420A (pt) 1999-05-18
NO975987L (no) 1998-02-19
EE9700333A (et) 1998-06-15

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