[go: up one dir, main page]

FR2727678B1 - Derives de l'acide asiatique, leur procede de fabrication et les agents a propriete dermatologique les contenant - Google Patents

Derives de l'acide asiatique, leur procede de fabrication et les agents a propriete dermatologique les contenant

Info

Publication number
FR2727678B1
FR2727678B1 FR9514254A FR9514254A FR2727678B1 FR 2727678 B1 FR2727678 B1 FR 2727678B1 FR 9514254 A FR9514254 A FR 9514254A FR 9514254 A FR9514254 A FR 9514254A FR 2727678 B1 FR2727678 B1 FR 2727678B1
Authority
FR
France
Prior art keywords
manufacturing process
acid derivatives
agents containing
dermatological agents
asian acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9514254A
Other languages
English (en)
Other versions
FR2727678A1 (fr
Inventor
Sang Sup Jew
Hee Doo Kim
Young Hoon Jung
Eun Hee Park
Sung Ki Seo
Tae Gyu Nam
Duc Ky Hahn
Jae Ho Park
Pil Jong Sim
Min Jung Lim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dong Kook Pharmaceutical Co Ltd
Original Assignee
Dong Kook Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dong Kook Pharmaceutical Co Ltd filed Critical Dong Kook Pharmaceutical Co Ltd
Publication of FR2727678A1 publication Critical patent/FR2727678A1/fr
Application granted granted Critical
Publication of FR2727678B1 publication Critical patent/FR2727678B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/28—Unsaturated compounds polycyclic
    • C07C61/29—Unsaturated compounds polycyclic having a carboxyl group bound to a condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66—Methanesulfonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/61—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/05—Alcohols containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/05—Alcohols containing rings other than six-membered aromatic rings
    • C07C33/14—Alcohols containing rings other than six-membered aromatic rings containing six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/32—Unsaturated compounds containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/38—Unsaturated compounds containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/753—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring of polycyclic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
FR9514254A 1994-12-03 1995-12-01 Derives de l'acide asiatique, leur procede de fabrication et les agents a propriete dermatologique les contenant Expired - Fee Related FR2727678B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR19940032697 1994-12-03

Publications (2)

Publication Number Publication Date
FR2727678A1 FR2727678A1 (fr) 1996-06-07
FR2727678B1 true FR2727678B1 (fr) 1998-06-19

Family

ID=19400256

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9514254A Expired - Fee Related FR2727678B1 (fr) 1994-12-03 1995-12-01 Derives de l'acide asiatique, leur procede de fabrication et les agents a propriete dermatologique les contenant

Country Status (9)

Country Link
US (1) US5834437A (fr)
JP (1) JPH10509959A (fr)
KR (1) KR0169547B1 (fr)
CN (1) CN1067976C (fr)
AU (1) AU3995595A (fr)
DE (1) DE19581854T1 (fr)
FR (1) FR2727678B1 (fr)
GB (1) GB2309695B (fr)
WO (1) WO1996017819A1 (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1238692A (zh) 1996-11-27 1999-12-15 东国制药株式会社 包含积雪草酸衍生物并用于治疗痴呆或识别紊乱的药物
WO1998023575A1 (fr) * 1996-11-27 1998-06-04 Dong Kook Pharmaceutical Co., Ltd. Derives d'acide asiatique a noyau a modifie
EP0971873A1 (fr) * 1996-11-27 2000-01-19 Dong Kook Pharmaceutical Co., Ltd. Derives d'acide asiatique et medicaments les contenant aux fins du traitement de plaies
KR100530278B1 (ko) * 1997-02-28 2006-04-06 동국제약 주식회사 아시아트산 유도체를 유효성분으로 하는 간 보호 및치료제
KR100228873B1 (ko) * 1997-03-24 1999-11-01 강재헌 센텔라아시아티카에서 분리한 아시아티코사이드와 마테카소 사이드의 수용성 추출물을 함유한 간세포 및 항간섬유화 치료제
KR100379067B1 (ko) * 2000-04-19 2003-04-08 동국제약 주식회사 병풀 정량 추출물을 함유한 외용제
DE20109044U1 (de) * 2001-05-30 2001-08-09 Weber & Weber GmbH & Co. KG, 82266 Inning Pharmazeutische Zubereitung
CN1228042C (zh) * 2003-01-30 2005-11-23 上海家化联合股份有限公司 积雪草甙脂质体及其用途
US7604978B2 (en) * 2004-07-14 2009-10-20 Sequoia Sciences, Inc. Inhibition of biofilm formation
US20060264411A1 (en) * 2005-05-20 2006-11-23 Eldridge Gary R Control of biofilm formation
US20060014285A1 (en) * 2004-07-14 2006-01-19 Eldridge Gary R Methods and compositions for inhibiting biofilms
WO2006031943A1 (fr) 2004-09-14 2006-03-23 Eldridge Gary R Composes, compositions et procedes destine a reguler des films biologiques et a prevenir des infections bacteriennes
US20070010459A1 (en) * 2005-01-14 2007-01-11 Ying Liu Application of asiatic acid and its derivatives to treat pulmonary fibrosis
US20060228384A1 (en) * 2005-04-06 2006-10-12 Sequoia Sciences, Inc. Control of biofilm with a biofilm inhibitor
US20070014739A1 (en) * 2005-07-14 2007-01-18 Eldridge Gary R Compositions and methods for controlling biofilms and bacterial infections
TWI361074B (en) * 2005-12-22 2012-04-01 Dev Center Biotechnology Plant extracts for enhancing healing of wounds,and the preparation process and use thereof
EP1925310B1 (fr) 2006-11-24 2015-03-25 Development Center For Biotechnology Extraits de Plectranthus et Centella pour les traitment des disordres de la peau et accelerer la guérison des lésions en patients diabétiques
US8449924B2 (en) * 2007-08-29 2013-05-28 Development Center For Biotechnology Process for the preparation of plant extracts for treating skin disorders and enhancing healing of wounds
WO2009089365A2 (fr) * 2008-01-11 2009-07-16 Shanghai Institute Of Pharmaceutical Industry (Sipi) Formulations thérapeutiques à base d'acide asiatique et de certains de ses sels
US8324264B1 (en) 2011-07-22 2012-12-04 Sequoia Sciences, Inc. Inhibitors of bacterial biofilms and related methods
CN102391351B (zh) * 2011-11-03 2013-06-19 沈阳化工大学 一种具有抗肿瘤活性的积雪草酸修饰物及其制备方法
CN104311622B (zh) * 2014-10-08 2016-11-16 四川大学 一种积雪草酸酰胺类衍生物
CN104274504B (zh) * 2014-10-21 2018-01-30 上海交通大学 一种积雪草提取物及其制备与应用
HUE062184T2 (hu) 2016-07-17 2023-09-28 Oneness Biotech Co Ltd Helyileg alkalmazható készítmény a sebgyógyulás elõsegítésére
CN106349319B (zh) * 2016-08-25 2018-03-16 桂林益天成生物科技有限公司 水解积雪草苷制备积雪草酸的方法
JP2021506904A (ja) 2017-12-22 2021-02-22 セージ セラピューティクス， インコーポレイテッド Ｃｎｓ障害の処置のための組成物および方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1530410A (fr) * 1963-08-28 1968-06-28 Nouveaux dérivés de l'acide asiatique et leur procédé de préparation
EP0383171A3 (fr) * 1989-02-11 1991-07-24 Hoechst Aktiengesellschaft Dérivés de 2,3,23 trihydroxy-urs-12-ène pour le traitement des troubles cognitifs
JPH06329537A (ja) * 1993-05-24 1994-11-29 Kobe Steel Ltd 肺癌抑制剤

Also Published As

Publication number Publication date
CN1168662A (zh) 1997-12-24
US5834437A (en) 1998-11-10
GB2309695A (en) 1997-08-06
JPH10509959A (ja) 1998-09-29
WO1996017819A1 (fr) 1996-06-13
KR0169547B1 (ko) 1999-03-20
KR960022435A (ko) 1996-07-18
GB9710644D0 (en) 1997-07-16
DE19581854T1 (de) 1997-12-04
GB2309695B (en) 1998-12-02
FR2727678A1 (fr) 1996-06-07
CN1067976C (zh) 2001-07-04
AU3995595A (en) 1996-06-26

Similar Documents

Publication Publication Date Title
FR2727678B1 (fr) Derives de l'acide asiatique, leur procede de fabrication et les agents a propriete dermatologique les contenant
EP0782399A4 (fr) Concentre d'acide hydroxycitrique et son procede de fabrication
MA23091A1 (fr) Procede de preparation d'agents antiparasitaires .
MA22481A1 (fr) Procede de preparation d'acides imidazolyl - alcenoiques .
MA22668A1 (fr) Procede de preparation d'oxamides .
EP0734586A4 (fr) Procede de fabrication de microstructures d'auto-assemblage
EP0985697A4 (fr) Derives d'oxiranne et leur procede de production
EP0802720A4 (fr) Nouvelles plantes et leur procede d'obtention
EP0656068A4 (fr) Procede d'amplification et de detection.
MA20746A1 (fr) Agents antiparasitaires et leur procede de production
IT1241679B (it) Perfluoropolieteri e processi per la loro preparazione
DE69027021D1 (de) Quinazolin-3-alkancarbonsäurederivat und salz und deren herstellung
FR2630441B1 (fr) Derives d'acide pyridone carboxylique et leurs sels, leur procede de fabrication et agents antibacteriens les comprenant
EP0845457A4 (fr) Acide 2,2-dideutero-5-aminolevulinique
FR2738009B1 (fr) Procede d'obtention de polysaccharides sulfates
DE68909551D1 (de) Fluessige reiniger und deren herstellungsverfahren.
FR2690357B1 (fr) Procédé d'épuration d'air.
FR2657081B1 (fr) Nouveaux derives d'arylvinylamide, leur procede de fabrication et leur application en therapeutique.
FR2764883B1 (fr) Procede de fabrication d'hydrofluoroalcanes
FR2689501B1 (fr) Procede de fabrication d'ethylbenzene.
MA21849A1 (fr) Procede de fabrication d'alkyl - ethoxy - carboxylates .
FR2584018B1 (fr) Procede de fabrication d'un tube composite et produit obtenu
FR2652868B1 (fr) Element d'etancheite et procede de fabrication.
TR27462A (tr) Sübstitüe edilmis sinamik asidi hidroksiamid'leri, bunlarin üretilmesine mahsus usul, bunlari ihtiva eden maddeler ve bunlarin kullanilmasi.
FR2653353B1 (fr) Procede et installation d'epuration d'air.

Legal Events

Date Code Title Description
ST Notification of lapse

Effective date: 20081020